Oral And Digital Anomalies With Ichthyosis

In a male and female offspring of healthy first-cousin Pakistani parents, Clayton-Smith and Donnai (1989) described a similar pattern of unusual facial features, limb malformations, and postnatal-onset ichthyosis. The male had a small mouth with thin upper lip and a midline groove in the lower lip. In both children the fingers were tapering and lacked distal flexion creases. The daughter had a large gap between the second and third fingers.