Nodal Marginal Zone B-Cell Lymphoma

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Retrieved

2021-01-23

Source

Orphanet

Trials

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Genes

BCL2, IGH, MYD88, TNFRSF13B, LOC102723407, MIR29B2, MIR29B1, MIR29A, MIR223, CYP4V2, IGK, IGHV3-69-1, IGHV3OR16-7, PIM2, BCL6, MALT1, CDR3, ZAP70, PTPRD, MNDA, DDX6, CHIT1, BRAF, LOC102724971

Drugs

Allogeneic multi-virus specific T lymphocytes targeting BK virus, cytomegalovirus, human herpesvirus-6, Epstein Barr virus and adenovirus, Axicabtagene ciloleucel ( YESCARTA ), Bendamustine for 50 ml admixture ( BENDEKA ), Cladribine ( LITAK ), Copanlisib ( ALIQOPA ), Ibrutinib ( IMBRUVICA ), Idelalisib ( ZYDELIG ), Iodine (131I) tositumomab, Lenalidomide ( LENALIDOMIDE ACCORD, REVLIMID ), Lutetium (177LU) lilotomab satetraxetan, Obinutuzumab ( GAZYVA, GAZYVARO ), Parsaclisib, haematopoietic stem cells and blood progenitors umbilical cord-derived expanded with (1R, 4R)-N1-(2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl)cyclohexane-1,4-diamine dihydrobromide dihydrate

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Nodal marginal zone B-cell lymphoma is a rare, indolent B-cell non-Hodgkin lymphoma, characterized by abnormal clonal proliferation of mature B-lymphocytes with involvement of the lymph nodes, sometimes the bone marrow, and rarely the blood. Clinically it presents with disseminated peripheral, abdominal and/or thoracic lymphadenopathy. Cytopenia and bulky tumors (greater than 5 cm) are rare. Association with Hepatitis C virus and chronic inflammation has been reported.