Craniofacial Abnormality
Watchlist
Retrieved
2021-01-18
Source
Trials
—
Genes
TCOF1,
SATB2,
LMNA,
FGF8,
MSX2,
FGFR2,
VSX1,
TBX1,
SOX9,
GTF2IRD1,
GPC4,
EYA1,
TP63,
TRPS1,
HSPG2,
NDST1,
DLX5,
PDGFRA,
LTBP3,
SIX1,
MSX1,
RUNX2,
SKI,
PRKRA,
UFD1,
ZIC3,
ALX1,
FZD4,
H4C3,
PITX2
TCOF1,
SATB2,
LMNA,
FGF8,
MSX2,
FGFR2,
VSX1,
TBX1,
SOX9,
GTF2IRD1,
GPC4,
EYA1,
TP63,
TRPS1,
HSPG2,
NDST1,
DLX5,
PDGFRA,
LTBP3,
SIX1,
MSX1,
RUNX2,
SKI,
PRKRA,
UFD1,
ZIC3,
ALX1,
FZD4,
H4C3,
PITX2,
MASP1,
MBTPS1,
PTCH1,
FADD,
PHEX,
UBE3A,
TGFBR2,
THRB,
ACTG1,
PTEN,
TGFB2,
TFAP2B,
TFAP2A,
RAD23B,
TCF4,
TBX15,
RYK,
SIM2,
TBCE,
SURF1,
SRP68,
ITGB1BP1,
KIAA0586,
NRXN1,
CHST14,
SALL4,
ALX4,
STRA6,
COLEC11,
UXS1,
PBX4,
ZIC5,
FOXP2,
RAB39B,
BNC2,
GSC,
UNC45B,
CNTN4,
RDH10,
RAB40AL,
KANSL1,
SH3PXD2B,
FAM83H,
ANKH,
TMCO1,
PAX3,
MSL3,
GPC6,
ATP6AP2,
DCAF7,
SPRY2,
IRX5,
ZMPSTE24,
DLL3,
RAI1,
KIF3A,
RAX,
B4GALT7,
SLC35D1,
NIPBL,
SIN3A,
SETBP1,
B3GAT3,
SALL3,
SEC61A1,
PAX6,
ACTB,
EDNRA,
ERF,
ECE1,
LPAR1,
EDN1,
NOTCH1,
EGFR,
EP300,
ERCC6,
ETS2,
RCAN1,
FGD1,
FGF3,
FGFR1,
FOXI1,
FOXC2,
FMR1,
FOLR1,
SLC26A2,
DNMT3B,
GATA2,
COL2A1,
ANXA1,
APAF1,
RHOA,
ATRX,
BMPR1A,
BMPR1B,
CECR,
COL11A1,
DNMT3A,
COL11A2,
HAPLN1,
CSNK1A1,
CTNNB1,
DLX1,
DLX2,
DLX6,
GABRB3,
HYDIN2,
IDH2,
LRP2,
IRF6,
MMP2,
JAG2,
MMP13,
HOXB1,
HOXA3,
HOXA1,
LETM1,
HMX1,
MECP2,
TRIM37,
MNT,
GNAQ,
SMAD4,
SMAD2,
SMAD3,
GP1BB,
TP53,
PHF21A,
NHLH1,
SETD1B,
MN1,
CSGALNACT1,
RIT1,
CRY2,
TMEM165,
GPATCH3,
CHD8,
CYP2C9,
CYP26B1,
RPE65,
ZNF462,
GREB1L,
UVRAG,
PTH,
ASXL3,
MIR873,
MIR876,
PSS,
GLRA4,
ACAN,
JAG1,
ALX3,
LINGO2,
ESCO2,
NFIA,
BCL2,
FBLN7,
SP7,
PKD2,
TASP1,
TMEM87B,
KDM2B,
CHD7,
ANKRD11,
CHDH,
CDKAL1,
EPHX1,
ETS1,
TGFA,
EIF4A3,
HMGCS1,
HLA-A,
HCFC1,
CCN6,
FLI1,
HYAL2,
CHRD,
DCHS1,
GTF2I,
TWIST1,
BARX2,
AXIN2,
GLI2,
HPD,
EFNB1,
CKAP4,
INTS1,
DHCR7,
DLG1,
SHH,
GLI3,
DCPS,
AGO2,
SOX4,
MMACHC,
TBCA,
POLR1A,
DVL2,
MED13L,
SPECC1L,
DYRK1A,
SCFD1,
IDUA,
PAPPA
Drugs
—
Registered!
Craniofacial abnormalities are congenital musculoskeletal disorders which primarily affect the cranium and facial bones.
They are associated with the development of the pharyngeal arches. Approximately, 5% of the UK or USA population present with dentofacial deformities requiring Orthognathic surgery, jaw surgery, and Orthodontics, brace therapy, as a part of their definitive treatment.
Example
- Platybasia
- Arrhinia