Intermediate Uveitis

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Retrieved

2021-01-23

Source

Orphanet

Trials

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Genes

IL2RA, IL6, IL10, CTLA4, HLA-DRB1, IL17A, PTEN, TGFBR3, TNF, TNFRSF1A

Drugs

4-((E)-(5-(2-(2-((S)-2-((S)-1-(L-threonyl-L-lysyl)pyrrolidine-2-carboxamido)-5-guanidinopentanamido)acetamido)-2-carboxyethyl)-2-hydroxyphenyl)diazenyl)phenyl (2-(trimethylammonio)ethyl) phosphate, Adalimumab ( CYLTEZO, AMGEVITA, AMSPARITY, HALIMATOZ, HEFIYA, HULIO, HUMIRA, HYRIMOZ, KROMEYA, IDACIO, IMRALDI ), Cyclo {{(E,Z)-(2S,3R,4R)-3-hydroxy-4-methyl-2-(methylamino)nona-6,8-dienoyl}-L-2-aminobutyryl-N-methyl-glycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-Dalanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl}, DNA plasmid encoding a recombinant fusion protein consisting of the extracellular domain of human TNFalpha p55 receptor linked to the human IgG1 Fc domain, Fluocinolone acetonide (prolonged-release intravitreal implant), Gevokizumab, HLA-B27 derived peptide (amino acid 125-138), Recombinant human monoclonal antibody to human Interleukin (IL)-17A of the IgG1/k class, Sirolimus ( RAPAMUNE ), Triamcinolone, Voclosporin

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A rare ophthalmic disorder characterized by intraocular inflammation primarily localized to the vitreous and peripheral retina. It incorporates pars planitis, posterior cyclitis, and hyalitis. Patients present with painless floaters, decreased or blurred vision, less frequently with pain, redness, and photophobia. On examination, snow banking, vitreous snowballs, peripheral retinal vascular sheathing, vitreous cells, and vitreous haze can be seen. Complications include epiretinal membrane formation, cataract formation, cystoid macular edema, or band keratopathy, among others. The condition may be idiopathic or occur in the context of infectious or systemic diseases.