Fragile Site 10q23

This is a folic acid-sensitive fragile site; that at 10q25 is the unique BrdU-sensitive fragile site. Sutherland et al. (1982) studied 2 families in which the same homolog of chromosome pair 10 expressed both the fragile sites on the long arm at 10q23 and 10q25. Recombination between the fragile sites was observed in 3 of 27 offspring. The genetic length of the interval between the 2 fragile sites was estimated to be 11 female centimorgans (95% probability interval: 4-28 cM). The estimate is comparable to those obtained by other methods.