Aneurysm, Intracranial Berry, 2

Description

Intracranial berry aneurysms are saccular outpouchings of the intracranial arteries, most commonly at arterial bifurcations, characterized by arterial wall remodeling. Most cases of ruptured intracranial berry aneurysms result in a subarachnoid hemorrhage, associated with high morbidity and mortality (summary by van der Voet et al., 2004).

For a discussion of genetic heterogeneity of intracranial berry aneurysm, see ANIB1 (105800).

Mapping

In a genomewide scan of 48 affected sib pairs from a Finnish population, Olson et al. (2002) identified a locus for intracranial aneurysms on chromosome 19q13, with a maximum multipoint lod score of 2.6 between markers D19S245 and D19S246. In a follow-up study with a total of 222 affected Finnish relative pairs, van der Voet et al. (2004) refined the ANIB2 locus to a 6.6-cM region on 19q13.3 between markers D19S545 and D19S246 (lod scores greater than 3.0). Families with nonsaccular aneurysms or with predisposing conditions, such as polycystic kidney disease (173900), Ehlers-Danlos syndrome (130000), or Marfan syndrome (154700), were excluded from the study.