Buerger Disease

Watchlist

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Retrieved

2019-09-22

Source

Omim

Trials

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Genes

VCAM1, AGER, UCN, CRHR1, TSHR, IL1B, IL6, CD34, IGF1, ICAM1, TNF, IFNG, IGF1R, IL1A, MTCO2P12, HLA-DRB1, IL13, CXCL8, IL10, HLA-DPB1, IL17A, VEGFA, COX2, NOS3, HLA-DQA1, PTGS2, FGF1, F2, RBM45, MIR21

VCAM1, AGER, UCN, CRHR1, TSHR, IL1B, IL6, CD34, IGF1, ICAM1, TNF, IFNG, IGF1R, IL1A, MTCO2P12, HLA-DRB1, IL13, CXCL8, IL10, HLA-DPB1, IL17A, VEGFA, COX2, NOS3, HLA-DQA1, PTGS2, FGF1, F2, RBM45, MIR21, CD44, HAVCR2, EDN1, MIR146A, STAT1, SPAM1, CCL5, SELE, MICA, ST8SIA1, TLR4, TMX2-CTNND1, THY1, SRP9, STAT3, SRP54, GATD3B, TGFB2, UCP1, TGFB1, TG, SYK, PDCD4, GATD3A, LINC01193, BCAR1, RNU1-1, SS18L1, UBE2C, HPSE, IL21R, SLC38A2, SEMA5B, ZNF263, PTX3, IL23R, SMC3, CASS4, IL17RC, ST3GAL5, PRRT2, SAT2, NLRP3, FOXP1, SLIT2, ACTA2, PTPRC, CTNND1, HLA-B, HLA-A, HGF, CXCL1, NR3C1, GATA3, NR5A1, FLT1, PTK2B, FABP4, CSF1, HMGB1, CSE1L, CD40LG, CD40, CD14, BMP4, OPN1SW, BCL2, APOA1, AKT1, JAG1, HLA-DOA, HOXB2, PSMD1, NOTCH1, MAPK8, PRKCB, PRKCA, PPARG, PIK3CG, PIK3CD, PIK3CB, PIK3CA, SERPINE1, ADAM10, MYD88, HOXB3, MMP3, MKI67, SMAD2, LOX, LGALS9, KNG1, CXCL10, IL16, IL1RN, HES1, OMG

Drugs

Adult human bone-marrow-derived, ex-vivo-expanded, pooled allogeneic mesenchymal stromal cells, Autologous adipose tissue-derived mesenchymal stem cells, Autologous bone marrow-derived mononuclear cell fraction

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Buerger disease is occasionally observed in brothers (Samuel, 1932; McKusick and Harris, 1961) or in father and son (McKusick, unpublished observations). It also has a high frequency in some ethnic groups, e.g., Japanese and Koreans (McKusick and Harris, 1961). De Moerloose et al. (1979) found a deficiency of HLA-B12 in patients with Buerger disease (2.2% vs 28% in controls). Adar et al. (1983) presented evidence for cellular sensitivity to collagen in Buerger disease. This disorder may, like other autoimmune diseases, have a genetic predisposition without a direct 'cause' by a mutant gene.

Olin (2000) suggested that tobacco use plays a central role in the initiation and progression of Buerger disease.

Diehm and Stammler (2001) suggested that in addition to tobacco use, hyperhomocysteinemia (see 603174) may be an important factor in Buerger disease.