Sarcoma

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2023-08-16

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Genes

TP53, SMARCA4, PIK3CA, CIC, MDM2, HRAS, PAX3, MDM4, TNF, RB1, CSF2, SOX2, NF1, MCL1, FLT4, JUN, MAML3, IFNG, ZNF667-AS1, PRAME, GSTP1, EWSR1, KIT, PDGFRA, CDKN2A, MLH1, PMS2, WT1, WRN, IL6

TP53, SMARCA4, PIK3CA, CIC, MDM2, HRAS, PAX3, MDM4, TNF, RB1, CSF2, SOX2, NF1, MCL1, FLT4, JUN, MAML3, IFNG, ZNF667-AS1, PRAME, GSTP1, EWSR1, KIT, PDGFRA, CDKN2A, MLH1, PMS2, WT1, WRN, IL6, ATM, CHEK2, GNAS, SS18, DICER1, TBC1D9, CTNNB1, SYT1, FOXO1, CDK4, SMARCB1, PTEN, RAF1, SSX2, GDF5, ERBB2, SDHA, SDHB, SDHC, EGFR, ABCB1, CD274, BMPR1B, KRAS, DUX4, AKT1, MET, ALK, IGF1R, IGF1, C11orf65, CCNB3, CCND1, VEGFA, FUS, BCOR, BRAF, FLI1, HIF1A, YAP1, SSX2B, MYC, IGF2, ZHX2, ATF1, ERG, BCL2, KDR, SMUG1, PIK3CG, GLI1, PIK3CD, CD248, PIK3CB, BRCA2, CRP, DDIT3, CDKN1A, BRCA1, CD44, FN1, MSH2, MUC4, CD99, H3-3A, EGF, TFE3, NTRK1, RET, NFATC2, H3-3B, H3P10, PARP1, YWHAE, PATZ1, CD34, ETV4, PDCD1, PDGFB, MTOR, TSPAN31, MIR182, NRAS, DES, STAT3, CTAG1A, JAZF1, CAV1, NKX2-2, PTGS2, CD6, ASPSCR1, FOLH1, PROM1, EZR, VEGFC, PAX7, NANS, LAG3, SERPINE1, CTAG1B, COL1A1, TLE1, TERT, RASSF1, MYOG, PLIN1, NUTM1, FGFR4, NME1, HGF, UVRAG, VIM, CSF1R, STS, EZH2, LOC110806263, MAPK14, HTC2, COL18A1, CKAP4, MAPK1, MAP2K7, ANO1, RPE65, ESR1, TNFSF10, SRC, STMN1, TAF15, MGMT, CDKN2B, ALDH1A1, TAZ, TP63, FOXP1, SLC12A9, HBEGF, PDGFRB, MME, ATRX, ITGAM, MMP9, MRC1, S100B, S100A1, LINC01194, FLII, ZNF395, NOS2, CCN3, VGLL3, CREB3L2, KMT2A, PERCC1, KRT7, KLRC4-KLRK1, RPL17-C18orf32, MEF2A, NUTM2A, MIR622, MITF, MIR206, MMP1, NFE2L2, ABCC1, LIN28B, MSH3, MST1R, MTAP, MYCN, MYOD1, CREB3L1, NCAM1, NPM1, TYMS, EGLN1, SNCA, RPL17, ABL1, MBD2, SAI1, CCL2, BCL10, BANF1, TNFRSF10B, SKI, SMARCA1, LGR5, CAVIN2, RNASE3, SPP1, SSX1, NR4A3, CXCR4, AURKA, XPO1, ZEB1, TEK, TGFB1, TGFBR3, THY1, LATS1, RELA, ROR1, TACC3, SERPINA5, PCNA, MAGEC2, PECAM1, LATS2, PART1, KLRK1, OGA, TRIO, PLAU, PLOD2, POU5F1, HDAC9, PTPA, PPP2R5E, MAPK3, MAP2K1, PTK2, PVT1, RAD51, TSPAN1, RAG2, SPATA2, RANBP2, NCOA2, S100A4, CSPG4, DMD, ALB, FOS, IL4, F3, FLT1, IL2, CASP8, FOXM1, CLDN4, CMD1B, ETV6, FAP, DHCR24, FGFR1, ANPEP, FGF2, COL11A2, HSP90AA1, IDH1, APC, CRK, FLT3, GADD45A, GABPA, CDKN1B, EPHB2, CD68, CA9, PLIN2, ERCC2, ERCC1, CD82, ERCC5, C3CER1, POT1, SH2B1, KDM1A, RNF19A, CAMP, ZNF281, CBL, SUZ12, CASR, MGA, CRTC1, CASP3, LPAR3, MAPK8IP2, CASP9, SIRT1, POLDIP2, TARDBP, HEY1, CAPN6, KCNJ4, CALM3, ATRAID, PIWIL2, BTC, LAMTOR1, PTTG1IP, FEV, UGT1A1, KRT20, MOV10L1, CALB2, FGFRL1, TPPP3, GDE1, ISYNA1, CALD1, KLF3, CYFIP2, GP6, PHF11, TMED7, FOXP3, F11R, OBP2A, CALM1, NXT1, DROSHA, SIRT2, POLM, TNFRSF21, B3GAT1, CALM2, EML4, TUSC2, ATF6, GDF15, CLOCK, TCL1B, RGS6, ESPL1, SART3, CD28, HDAC4, PCLAF, KEAP1, MS4A1, MELK, RUSC2, NR1I3, CCS, CD14, EEF1E1, NAPSA, ADGRG2, ABCG2, ENDOU, CD63, CD47, GPRC5A, USP6, CD40, P2RX6, AURKB, PIWIL1, COPB2, KLF4, CD163, SLIT2, GRAP2, KCNK6, G3BP1, ZNF197, MMRN1, LYVE1, OS9, CCNE1, SLC27A5, TDRKH, CNMD, TOPBP1, ZWINT, CCND3, CCND2, DUSP12, FBXW7, CBX3, CHSY1, KRIT1, CCK, SUB1, HPSE, TRIM13, PLK2, TUBB3, MYL9, NDC80, CD247, CD3E, CD3D, CIB2, CIB1, ZNRD2, MRPL28, AHSA1, MYL12A, DCTN6, CD1D, NES, ZNF654, CMAS, LARP6, MIR127, ABCB5, C16orf96, TICAM2, GSTK1, XIAP, ANXA5, MIR130B, CHAMP1, MIR145, MIR149, ANGPT1, MIR210, MIR221, MIR222, FAM83H, MRGPRX1, MIR30C2, DDX53, SIK1, TTL, IRX2, AMOT, AQP5, OXER1, FLCN, BIRC5, RPSAP52, AQP1, GPRC6A, FAS, RICTOR, CASC2, MIR30C1, MIR34B, IMPACT, LINC02210-CRHR1, TMED7-TICAM2, MIR761, ADARB1, PSC, H3P12, SIK1B, ACTB, ACAN, MTCO2P12, ERVK-32, ABL2, MXLPO, H3P9, H3P23, MIR1226, OS4, EIF2AK4, POU5F1P4, VN1R17P, GPR166P, MIR133B, MIR370, MIR375, POU5F1P3, CXADRP1, KLLN, PRB2, AMHR2, AMFR, NUTM2D, CCR2, AHR, PRIMA1, AMER1, CD109, SMURF2, ANKRD36B, CCAR2, PRUNE1, LGR6, ERVK-6, DCLRE1C, ATR, MRTFB, PINK1, C11orf95, ARSF, FSD1, CORO7, LIN28A, MIB1, AHRR, GPR151, KCMF1, ZNF331, BATF3, BPI, DEPDC1, DEPDC1B, FOXL2, PRDM10, ODF2L, BMI1, ACKR3, AZGP1, SLURP1, ABHD6, SCYL1, CAMKMT, GRHL2, PPP1R2C, EXOSC6, MYL12B, NACC1, ARAP1, MRGPRX3, MRGPRX4, ANTXR2, PRAP1, PDCD1LG2, PIK3AP1, TPPP2, RBM45, LRRC15, SLCO6A1, AFAP1L1, MUC16, HAUS8, NAPRT, ATP23, RND3, IL33, ARHGAP1, NKD2, RITA1, MAML2, MINDY4, ABRAXAS1, FSD1L, PARP9, ZFP91, ARR3, MPIG6B, PER2, BAP1, CDH11, PHF1, FRZB, ENPP2, FPR1, PGF, PGR, FOSB, SERPINB9, GAB1, MLANA, PLAGL1, PLAUR, PLD2, PLG, FHIT, FSHR, PDGFA, ESD, OPRM1, NPY1R, GPC3, GHRHR, NTRK3, GH1, ROR2, P4HB, GABRG2, PEBP1, GFAP, GCG, PAX5, GATA3, GAS6, GPC5, POU4F1, PPARG, EXTL3, PTX3, PVR, FABP3, RAC1, RAD51B, F2R, RARA, PPP1R1A, RASA1, ETV5, RBL2, RBP1, ESRRB, REST, PTPRG, PTPRC, PTPN11, ACSL3, ACSL4, PSMD9, PSMD4, FAU, FCGR3A, MAPK8, FCGR3B, FER, PRKDC, PRKAR1A, PRF1, FES, FGF1, GCLC, NPAS2, GLUL, CXCR2, MCM3, MDK, ING1, ILK, IL15, IL10, IL3RA, MMP8, MKI67, IL2RG, FOXO4, RBPJ, IGFBP7, MMP2, MCM2, ING2, MCAM, MAPT, MAGEA3, SMAD4, MAD2L1, LSS, LOX, LMNA, LGALS1, LEP, LCP1, LCK, CXCL10, ITGB3, JAK2, MMP3, IGFBP3, GSK3B, HIC1, MYL2, HSPB1, HNRNPM, HPRT1, HK2, NFATC1, HDGF, MMP11, NFKBIA, NGFR, H2AX, NMB, MSH6, NOS1, IRF8, MYCL, ID2, MXI1, MUC6, MUC1, MTTP, MTHFR, COX2, IDH2, IFI27, MST1, IFNA1, IFNA13, IGFALS, IGFBP2, MMP14, ESR2, ROM1, CDK2, UQCRH, TWIST1, TYK2, CPE, TYRO3, UBE2I, NR1H2, MAP3K8, TTF1, COMP, COL9A3, COL9A2, VIP, VIPR1, WEE1, HIRA, TSG101, ROS1, TLN1, CSF2RA, THBD, THBS1, THBS2, CSF1, TIA1, TM7SF2, TSC2, CRHR1, TOP2A, CREB1, TPM3, TPM4, HSP90B1, WNT1, COL9A1, ABCC2, CUL4A, ARID1A, AXIN1, KIF22, FZD4, ULK1, CDKN2C, CDKN1C, XPA, PLPP2, DYNLL1, IRS2, ABCC3, CDK9, FBP2, CEL, CFL1, HMGA2, SLC25A16, CHEK1, KAT6A, TFPI2, FZD3, MAFK, AIMP2, SCG2, CLU, PAX8, LEPQTL1, ZAP70, CLIC1, YES1, CSF2RB, TGFA, TFPI, SRSF1, ELAVL1, SELE, SELP, SFRP1, SFRP2, SFRP4, FBXW4, FSCN1, ATN1, SLAMF1, SLC9A3, SLC12A3, DPP4, DHFR, CTTN, ENG, CX3CL1, EPAS1, SCN8A, SCN1A, CLEC11A, ATXN2, STOM, SALL2, EPHB4, S100A11, S100A10, RREB1, RRBP1, RPS6, ERN1, SNAI1, SOD1, CSF3, TAF12, STK3, STK4, CXADR, SYN1, CUX1, ADAM17, CTLA4, SOD2, CCN2, TCF21, VPS72, PPP1R11, CSK, TFAP2A, STAT6, STAT5B, STAT5A, CYP3A4, STAT1, DAXX, BRINP1, DCN, SSTR2, SST, DCTN1, SPG7, SP3, SP1, SOX10, SOX9, TIMM8A, AADAC

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Overview

Sarcoma is a type of cancer that can occur in various locations in your body.

Sarcoma is the general term for a broad group of cancers that begin in the bones and in the soft (also called connective) tissues (soft tissue sarcoma). Soft tissue sarcoma forms in the tissues that connect, support and surround other body structures. This includes muscle, fat, blood vessels, nerves, tendons and the lining of your joints.

There are more than 70 types of sarcoma. Treatment for sarcoma varies depending on sarcoma type, location and other factors.

Types

Symptoms

Signs and symptoms of sarcoma include:

A lump that can be felt through the skin that may or may not be painful
Bone pain
A broken bone that happens unexpectedly, such as with a minor injury or no injury at all
Abdominal pain
Weight loss

Causes

It's not clear what causes most sarcomas.

In general, cancer forms when changes (mutations) happen in the DNA within cells. The DNA inside a cell is packaged into a large number of individual genes, each of which contains a set of instructions telling the cell what functions to perform, as well as how to grow and divide.

Mutations might tell cells to grow and divide uncontrollably and to continue living when normal cells would die. If this happens, the accumulating abnormal cells can form a tumor. Cells can break away and spread (metastasize) to other parts of the body.

Risk factors

Factors that can increase the risk of sarcoma include:

Inherited syndromes. Some syndromes that increase the risk of cancer can be passed from parents to children. Examples of syndromes that increase the risk of sarcoma include familial retinoblastoma and neurofibromatosis type 1.
Radiation therapy for cancer. Radiation treatment for cancer increases the risk of developing a sarcoma later.
Chronic swelling (lymphedema). Lymphedema is swelling caused by a backup of lymph fluid that occurs when the lymphatic system is blocked or damaged. It increases the risk of a type of sarcoma called angiosarcoma.
Exposure to chemicals. Certain chemicals, such as some industrial chemicals and herbicides, can increase the risk of sarcoma that affects the liver.
Exposure to viruses. The virus called human herpesvirus 8 can increase the risk of a type of sarcoma called Kaposi's sarcoma in people with weakened immune systems.

Diagnosis

Tests and procedures used to diagnose sarcoma and determine its extent (stage) include:

A physical exam. Your doctor will likely do a physical exam to better understand your symptoms and look for other clues that will help with your diagnosis.
Imaging tests. Which imaging tests are right for you will depend on your situation. Some tests, such as X-rays, are better for seeing bone problems. Other tests, such as MRI, are better for seeing connective tissue problems. Other imaging tests might include ultrasound, CT, bone scans and positron emission tomography (PET) scans.
Removing a sample of tissue for testing (biopsy). A biopsy is a procedure to remove a piece of suspicious tissue for lab testing. Sophisticated lab tests can determine whether the cells are cancerous and what kind of cancer they represent. Tests can also reveal information that's helpful for choosing the best treatments.

How a biopsy sample is collected depends on your particular situation. It could be removed with a needle passed through the skin or cut away during an operation. Sometimes a biopsy is done at the same time as surgery to remove the cancer.

Once your doctor determines you have sarcoma, he or she might recommend additional tests to look for signs that the cancer has spread.

Treatment

Sarcoma is usually treated with surgery to remove the cancer. Other treatments might be used before or after surgery. Which treatments are best for you will depend on the type of sarcoma, its location, how aggressive the cells are and whether cancer has spread to other parts of your body.

Treatment for sarcoma might involve:

Surgery. The goal of surgery for sarcoma is to remove all of the cancer cells. Sometimes it's necessary to amputate an arm or leg to remove all of the cancer, but surgeons try to preserve limb function when possible. Sometimes all of the cancer can't be removed without hurting important structures, such as nerves or organs. In these situations, the surgeons work to remove as much of the sarcoma as possible.
Radiation therapy. Radiation therapy uses high-powered energy beams, such as X-rays and protons, to kill cancer cells. The radiation can come from a machine that moves around your body directing the beams of energy (external beam radiation). Or the radiation might be placed in your body temporarily (brachytherapy). Sometimes radiation is done during an operation to remove the cancer (intraoperative radiation).
Chemotherapy. Chemotherapy is a drug treatment that uses chemicals to kill cancer cells. Some types of sarcoma are more likely to respond to chemotherapy treatment than others.
Targeted therapy. Targeted therapy is a drug treatment that uses medicines that attack specific weaknesses in cancer cells. Your doctor may have your sarcoma cells tested to see if they are likely to respond to targeted therapy drugs.
Immunotherapy. Immunotherapy is a drug treatment that uses your immune system to fight cancer. Your body's disease-fighting immune system may not attack your cancer because the cancer cells produce proteins that blind the immune system cells. Immunotherapy drugs work by interfering with that process.
Ablation therapy. Ablation therapy treatments destroy cancer cells by applying electricity to heat the cells, very cold liquid to freeze the cells or high-frequency ultrasound waves to damage the cells.

Clinical trials

Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.

Coping and support

With time, you'll find what helps you cope with the uncertainty and distress that comes with a cancer diagnosis. Until then, you may find that it helps to:

Learn enough about sarcoma to make decisions about your care. Ask your doctor about your cancer, including your test results, treatment options and, if you like, your prognosis. As you learn more about cancer, you may become more confident in making treatment decisions.
Keep friends and family close. Keeping your close relationships strong will help you deal with your cancer. Friends and family can provide the practical support you'll need, such as helping take care of your home if you're in the hospital. And they can serve as emotional support when you feel overwhelmed by cancer.
Find someone to talk with. Find a good listener who is willing to hear you talk about your hopes and fears. This may be a friend or family member. The concern and understanding of a counselor, medical social worker, clergy member or cancer support group also may be helpful.

Ask your doctor about support groups in your area. Other sources of information include the National Cancer Institute and the American Cancer Society.

Preparing for your appointment

Start by making an appointment with your primary care provider if you have any signs or symptoms that worry you.

Here's some information to help you get ready for your appointment.

What you can do

When you make the appointment, ask if there's anything you need to do in advance, such as fasting before having a specific test. Make a list of:

Your symptoms, including any that seem unrelated to the reason for your appointment
Key personal information, including major stresses, recent life changes and family medical history
All medications, vitamins or other supplements you take, including the doses
Questions to ask your doctor

Bring a family member or friend with you, if possible, to help remember the information you're given.

For sarcoma, some basic questions to ask your doctor include:

What's likely causing my symptoms?
Other than the most likely cause, what are other possible causes for my symptoms?
What tests do I need?
What's the best course of action?
What are the alternatives to the primary approach you're suggesting?
I have other health conditions. How can I best manage them together?
Are there restrictions I need to follow?
Should I see a specialist?
Are there brochures or other printed material I can have? What websites do you recommend?

Don't hesitate to ask other questions.

What to expect from your doctor

Your doctor is likely to ask you several questions, such as:

When did your symptoms begin?
Have your symptoms been continuous or occasional?
How severe are your symptoms?
What, if anything, seems to improve your symptoms?
What, if anything, appears to worsen your symptoms?