Merkel Cell Carcinoma

Watchlist

(log in to enable)

Retrieved

2023-08-16

Source

Mayo_clinic

Trials

—

Genes

MYC, SDHD, CD274, TP53, KRT20, KIT, PDCD1, C17orf97, CDKN2A, PIK3CA, PIK3CG, PIK3CD, PIK3CB, PDGFRA, TP63, ALK, BCL2, MIR375, ATOH1, INSM1, SST, EZH2, SMUG1, RB1, RPE65, NCAM1, PAX5, SATB2, CTLA4, ASCL1, UVRAG, CKAP4, BMI1, NTRK1, MYCL, MRTFA, FHIT, FOXP3, MUC1, CD200, CD163, MDM2, MCC, DNER, MICA, TTF1, TP73, SYP, EGFR, APC, ETFA, PTPRC, AHR, TLR4, POSTN, RPP14, SDS, TLR2, TWIST1, TNFRSF4, SUB1, IGF2BP3, TMEFF1, TYR, SPHK1, GNLY, VIM, YWHAE, NDRG1, CXCR4, AXIN1, CDK2AP2, ZBTB24, AXIN2, FZD4, RASSF1, GPR65, SELENBP1, VEGFA, ADAM10, SF3B1, MRGPRX1, MRGPRX3, MRGPRX4, FOPNL, CD200R1, GPR151, PRUNE2, OXER1, DDX53, ASXL1, GPRC6A, MMS, SPPL2A, ABCB5, SLC35B2, LINC01194, MIR203A, VN1R17P, GPR166P, KRT8P3, BCC1, COMMD3-BMI1, LOC110806263, LMLN, CCDC54, BRD4, TET2, LPAR3, CLIC4, SGSM3, LAMTOR2, GPR132, NKX2-1, SH3GLB1, SF3B6, SPA17, CCHCR1, IMPAD1, TMPRSS13, IMP3, FBXW7, MMP26, MRTFB, EP400, LGR6, PIEZO2, MMP28, CD276, ARHGAP24, TLR1, S100A9, TERT, GPR4, EWSR1, FCGR3A, FCGR3B, FGFR1, FLI1, FLII, GJA1, GPC3, GLI1, GUCY2D, ERBB2, HLA-A, HLA-DRB1, HRAS, HSPA4, HTC2, IFNA2, IL4, IDO1, KRAS, ERBB3, ENO2, PRDX2, MS4A1, JAG1, AKT1, ALOX15, BIRC5, BAX, CCND1, BRAF, CASP3, CD9, CD68, DUSP2, CD151, CHGA, CLIC1, CLTA, CCR4, COL11A2, CTNNB1, SARDH, ATN1, KRT5, KRT8, LDHB, SDHB, POU4F3, PTPA, MAP2K7, PTEN, PTGS2, PTPRG, REST, PARP1, CCL17, SELE, SMAD4, SHBG, SHH, SLN, SNAI2, SORD, SOX2, STAT3, STAT5B, TDO2, POU3F2, PECAM1, PDGFA, PAFAH1B1, MCL1, MCM4, MCM6, MCM7, MDM4, KITLG, MGMT, CD99, MMP10, MMP12, MSMB, MST1, MST1R, NEUROD1, NGF, NOTCH1, NOTCH2, NOTCH3, PEBP1, H3P8

Drugs

(S)-ethyl 2-amino-3-(4-(2-amino-6((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)- 2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate, Avelumab ( Bavencio ), Gallium [Ga-68]-N-[(4,7,10-tricarboxymethyl-1,4,7,10-tetraazacyclododec-1-yl)acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophanyl-L-lysyl-L-threoninyl-Lcysteinyl-L-threonine-cyclic(2-7)disulfide ( NETSPOT ), Live-attenuated non-replicative Pseudomonas aeruginosa strain expressing large T antigen of Merkel cell polyomavirus, Maytansinoid-conjugated humanized monoclonal antibody against CD56

Interested in hearing about new therapies?

Overview

Merkel cell carcinoma is a rare type of skin cancer that usually appears as a flesh-colored or bluish-red nodule, often on your face, head or neck. Merkel cell carcinoma is also called neuroendocrine carcinoma of the skin.

Merkel cell carcinoma most often develops in older people. Long-term sun exposure or a weak immune system may increase your risk of developing Merkel cell carcinoma.

Merkel cell carcinoma tends to grow fast and to spread quickly to other parts of your body. Treatment options for Merkel cell carcinoma often depend on whether the cancer has spread beyond the skin.

Symptoms

The first sign of Merkel cell carcinoma is usually a fast-growing, painless nodule (tumor) on your skin. The nodule may be skin-colored or may appear in shades of red, blue or purple. Most Merkel cell carcinomas appear on the face, head or neck, but they can develop anywhere on your body, even on areas not exposed to sunlight.

When to see a doctor

If you notice a mole, freckle or bump that is changing in size, shape or color, growing rapidly, or bleeding easily after minor trauma, such as washing your skin or shaving, make an appointment with your doctor.

Causes

It's not clear what causes Merkel cell carcinoma. Merkel cell carcinoma begins in the Merkel cells. Merkel cells are found at the base of the outermost layer of your skin (epidermis). Merkel cells are connected to the nerve endings in the skin that are responsible for the sense of touch.

Researchers recently discovered that a common virus plays a role in causing most cases of Merkel cell carcinoma. The virus (Merkel cell polyomavirus) lives on the skin and doesn't cause any signs or symptoms. Just how this virus causes Merkel cell carcinoma has yet to be determined. Given that the virus is very common and Merkel cell carcinoma is very rare, it's likely that other risk factors play a role in the development of this cancer.

Risk factors

Factors that may increase your risk of Merkel cell carcinoma include:

Excessive exposure to natural or artificial sunlight. Being exposed to ultraviolet light, such as the light that comes from the sun or from tanning beds, increases your risk of Merkel cell carcinoma. The majority of Merkel cell carcinomas appear on skin surfaces frequently exposed to sun.
A weakened immune system. People with weakened immune systems — including those with HIV infection, those taking drugs that suppress the immune response or those with chronic leukemias — are more likely to develop Merkel cell carcinoma.
History of other skin cancers. Merkel cell carcinoma is associated with the development of other skin cancers, such as basal cell or squamous cell carcinoma.
Older age. Your risk of Merkel cell carcinoma increases as you age. This cancer is most common in people older than age 50, though it can occur at any age.
Light skin color. Merkel cell carcinoma usually arises in people who have light-colored skin. Whites are much more likely to be affected by this skin cancer than are blacks.

Complications

Cancer that spreads to other parts of the body

Even with treatment, Merkel cell carcinoma commonly spreads (metastasizes) beyond the skin. Merkel cell carcinoma tends to travel first to nearby lymph nodes. Later it may spread to your brain, bones, liver or lungs, where it can interfere with the functioning of these organs. Cancer that has metastasized is more difficult to treat and can be fatal.

Prevention

While exposure to sunlight isn't proved to cause Merkel cell carcinoma, it is considered a risk factor for this cancer. Reducing your sun exposure may reduce your risk of skin cancer. Try to:

Avoid the sun during peak hours. Avoid sun exposure as much as possible during the strongest sunlight hours of the day — typically from 10 a.m. to 4 p.m. Move your outdoor activities to a time earlier in the morning or later in the day.
Shield your skin and eyes. Wear a wide-brimmed hat, tightly woven clothing and sunglasses with ultraviolet (UV) light protection.
Apply sunscreen liberally and often. Use a broad-spectrum sunscreen with an SPF of at least 30, even on cloudy days. Apply sunscreen generously, and reapply every two hours — or more often if you're swimming or perspiring.
Watch for changes. If you notice a mole, freckle or bump that's changing in size, shape or color, talk to your doctor. Most skin nodules never become cancer, but catching cancer in its early stages increases the chances that treatment will be successful.

Diagnosis

Tests and procedures used to diagnose Merkel cell carcinoma include:

Physical exam. Your doctor will examine your skin for unusual moles, freckles, pigmented spots and other growths.
Removing a sample of suspicious skin. During a procedure called a skin biopsy, your doctor removes the tumor or a sample of the tumor from your skin. The sample is analyzed in a laboratory to look for signs of cancer.

Determining the extent

Your doctor may use the following tests to help determine whether the cancer has spread beyond your skin:

Sentinel node biopsy. A sentinel node biopsy is a procedure to determine whether cancer has spread to your lymph nodes. This procedure involves injecting a dye near the cancer. The dye then flows through the lymphatic system to your lymph nodes.

The first lymph nodes that receive the dye are called the sentinel nodes. Your doctor removes these lymph nodes and looks for cancerous cells under a microscope.
Imaging tests. Your doctor may recommend a chest X-ray and a CT scan of your chest and abdomen to help determine whether the cancer has spread to other organs.

Your doctor may also consider other imaging tests such as a positron emission tomography (PET) scan or an octreotide scan — a test that uses an injection of a radioactive tracer to check for the spread of cancer cells.

Treatment

Treatments for Merkel cell carcinoma can include:

Surgery. During surgery, your doctor removes the tumor along with a border of normal skin surrounding the tumor. If there's evidence that the cancer has spread to lymph nodes in the area of the skin tumor, those lymph nodes are removed (lymph node dissection).

The surgeon most often uses a scalpel to cut away the cancer. In some cases, your doctor may use a procedure called Mohs surgery.

During Mohs surgery, thin layers of tissue are methodically removed and analyzed under a microscope to see whether they contain cancer cells. If cancer is found, the surgical process is repeated until cancer cells are no longer visible in the tissue. This type of surgery takes out less normal tissue — thereby reducing scarring — but ensures a tumor-free border of skin.
Radiation therapy. Radiation therapy involves directing high-energy beams, such as X-rays and protons, at cancer cells. During radiation treatment, you're positioned on a table and a large machine moves around you, directing the beams to precise points on your body.

Radiation therapy is sometimes used after surgery to destroy any cancer cells that remain after the tumor is removed.

Radiation may also be used as the sole treatment in people who choose not to undergo surgery. Radiation can also be used to treat areas where the cancer has spread.
Immunotherapy. In immunotherapy, drugs are used to help your immune system fight cancer. Most often, immunotherapy is used to treat Merkel cell carcinoma that has spread to other areas of your body.
Chemotherapy. Chemotherapy uses drugs to kill the cancer cells. Chemotherapy drugs can be administered through a vein in your arm or taken as a pill or both.

Chemotherapy is not used often, but your doctor may recommend it if your Merkel cell carcinoma has spread to your lymph nodes or other organs in your body, or if it has returned despite treatment.

Clinical trials

Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.

Preparing for your appointment

If you have a mole, freckle or bump on your skin that concerns you, start by making an appointment with your doctor. If your doctor suspects that you may have skin cancer, you'll likely be referred to a skin specialist (dermatologist).

Because appointments can be brief, and because there's often a lot to discuss, it's a good idea to be well-prepared. Here's some information to help you get ready, and what to expect from your doctor.

What you can do

Write down any symptoms you're experiencing, including any that may seem unrelated to the reason for which you scheduled the appointment.
Write down key personal information, including any major stresses or recent life changes.
Make a list of all medications, vitamins or supplements that you're taking.
Consider taking along a family member or friend. Sometimes it can be difficult to remember all the information provided during an appointment. Someone who accompanies you may remember something that you missed or forgot.
Write down questions to ask your doctor.

Your time with your doctor is limited, so preparing a list of questions can help you make the most of your time together. List your questions from most important to least important in case time runs out. For Merkel cell carcinoma, some basic questions to ask your doctor include:

What is likely causing my symptoms or condition?
Are there other possible causes for my symptoms or condition?
What kinds of diagnostic tests do I need? How are these tests performed?
What are my treatment options?
How will you check my response to treatment?
How likely is my condition to recur? What treatment options would be available in that case?
What follow-up tests will I need to monitor for recurrence?
I have other health conditions. How can I best manage them together?
Are there any restrictions that I need to follow?
Should I see a specialist? What will that cost, and will my insurance cover it?
Are there any brochures or other printed material that I can take with me? What websites do you recommend?

In addition to the questions that you've prepared to ask your doctor, don't hesitate to ask questions during your appointment.

What to expect from your doctor

Your doctor is likely to ask you a number of questions. Being ready to answer them may reserve time to go over points you want to spend more time on. Your doctor may ask:

When did you first notice your symptoms?
How have your symptoms changed over time?
Does anything seem to improve your symptoms?
Have you spent a lot of time in the sun, or have you used tanning beds?
Do you have a history of other skin conditions, such as skin cancer or psoriasis? What treatments have you received for those conditions?
Have you been diagnosed with any immune system disorders? If so, what treatments have you received?
Have you been diagnosed or treated for any other health conditions?