Cleft-Limb-Heart Malformation Syndrome

Verloove-Vanhorick et al. (1981) described a combination of severe malformations, lethal in the newborn period, in a brother and sister. Both showed bilateral cheilognatopalatoschizis, truncus arteriosus, and deformity, including oligopolysyndactyly, of all 4 limbs. Borderline suggestions of prediabetes were found in the mother.