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Tinnitus
Wikipedia
These alterations are assumed to result from a disturbed sensory input, caused by hearing loss. [27] Hearing loss could indeed cause a homeostatic response of neurons in the central auditory system, and therefore cause tinnitus. [28] Hearing loss The most common cause of tinnitus is hearing loss . ... "Hearing of microwave pulses by humans and animals: effects, mechanism, and thresholds". Health Physics . 92 (6): 621–28. doi : 10.1097/01.HP.0000250644.84530.e2 . ... Otology & Neurotology . 37 (7): 820–28. doi : 10.1097/MAO.0000000000001090 . ... PMID 21975776 . ^ Hilton, MP; Zimmermann, EF; Hunt, WT (Mar 28, 2013). "Ginkgo biloba for tinnitus".IFNA2, RNR1, BDNF, ARC, ABAT, COCH, CLCNKB, AIFM1, KCNJ5, MPL, MPV17, TMC1, NAGA, PDGFB, SDHB, SDHC, SDHD, SLC12A3, SMARCB1, VHL, DNAH11, FKRP, SLC44A4, KCNQ4, JAK2, MFN2, AFG3L2, DKK1, P2RX2, TUBB6, SLC39A14, STRN4, SUFU, TET2, DIABLO, OSBPL2, NF2, CACNA1A, DSPP, CYP11B2, CYP11B1, CCND1, CACNA1D, TNF, CSF2, LAMC2, SLC17A6, PART1, NT5E, PTPN4, SLC17A7, GDNF, IL2, KCNE3, DCX, SPIN1, CYP2E1, DIAPH1, CRYGD, IL1B, PYCARD, COX8A, COMT, TYMS, CNR1, CNC2, AQP2, ACTG1, ACR, PTCRA, HCCAT5, THEMIS, EPS8, THAS, TRI-AAT9-1, OTC, IL6, IL10, IL1A, KCNE1, HSPA4, KCNQ2, GTF2I, GSTP1, GRM7, GRIN2B, ABR, NHS, GJB2, IL1RN, PEPD, CFP, PRKAR1A, GDF10, GAP43, SLC6A4, SLC8A1, GAD2, SLC18A3, SLC25A1, F11, TCEA1, ERVW-4
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Panic Attack
Wikipedia
This leads to shifts in blood pH ( respiratory alkalosis or hypocapnia ), causing compensatory metabolic acidosis activating chemosensing mechanisms that translate this pH shift into autonomic and respiratory responses. [28] [29] Moreover, this hypocapnia and release of adrenaline during a panic attack cause vasoconstriction resulting in slightly less blood flow to the head which causes dizziness and lightheadedness . [30] [31] A panic attack can cause blood sugar to be drawn away from the brain and toward the major muscles. ... CS1 maint: archived copy as title ( link ) [ full citation needed ] ^ "Hyperventilation Syndrome]" . 28 November 2016. Archived from the original on 13 July 2017 .ADORA2A, ADRA2A, CCKBR, COMT, INS, DNAJC6, SDHC, SDHD, SNCA, TP53, UCHL1, VHL, SLC25A11, SGCE, KIF1B, PARK7, RET, SPART, CIZ1, HTRA2, VPS13C, SDHAF2, TMEM127, PINK1, KCTD17, LRRK2, SDHA, SDHB, SLC25A42, PODXL, PRKN, MDH2, DLST, DRD2, MAX, TOR1A, FH, CCK, PTK7, HTR1A, KRT7, MAOA, TAL1, SCLY, CYP2D6, COPD, TPH2, AGT, DST, DUSP26, SLC6A1, ACE, DBI, IGFBP2, SLC6A4, SNAP25, LEP, HCRTR1, GLO1
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Postpartum Depression
Wikipedia
Hormonal and physical changes, personal and family history of depression, and the stress of caring for a new baby all may contribute to the development of postpartum depression. [28] [29] Evidence suggests that hormonal changes may play a role. [30] Understanding the neuroendocrinology characteristic of PPD has proven to be particularly challenging given the erratic changes to the brain and biological systems during pregnancy and postpartum. ... "Perinatal mental health in lesbian mothers: a review of potential risk and protective factors". Women & Health . 41 (3): 113–28. doi : 10.1300/J013v41n03_07 . PMID 15970579 .SLC6A4, TTC9B, HP1BP3, HTR1A, OPRM1, PER2, MTHFR, GABRD, IL10, OXTR, TPO, BDNF, SAGE1, NR3C1, CCN6, ADIPOQ, FHL5, ACOT7, PART1, MARCHF11, AGO2, POTEKP, TAL1, SCLY, ARID4B, KRT88P, CREB3L1, POTEM, COPD, ACTBL2, VSX1, SERPINA3, PRL, ABO, ACTG1, ACTG2, ATP5F1A, OPN1SW, TSPO, SERPINA6, CRH, CRP, EGR3, ESR1, GALR1, GATA3, HPD, HSD11B1, IL6, KRT7, NR3C2, MPI, NPPA, STIN2-VNTR
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Alcohol And Health
Wikipedia
In addition, damage to the central nervous system and peripheral nervous system can occur from chronic alcohol abuse. [22] [23] The developing adolescent brain is particularly vulnerable to the toxic effects of alcohol. [24] Pregnancy [ edit ] See also: Fetal alcohol spectrum disorders Medical organizations strongly discourage drinking alcohol during pregnancy. [25] [26] [27] Alcohol passes easily from the mother's bloodstream through the placenta and into the bloodstream of the fetus, [28] which interferes with brain and organ development. [29] Alcohol can affect the fetus at any stage during pregnancy, but the level of risk depends on the amount and frequency of alcohol consumed. [29] Regular heavy drinking and heavy episodic drinking (also called drinking binges), entailing four or more measures (a pint of beer or 50 ml drink of a spirit such as whisky corresponds to about two units of alcohol) of alcohol beverages on any one occasion, pose the greatest risk for harm, but lesser amounts can cause problems as well. [29] There is no known safe amount or safe time to drink during pregnancy, and the U.S.ALDH2, AVPR1B, SLC29A1, GGT1, ADH1B, NCALD, PECR, PLGRKT, FSTL5, ANKS1B, PKNOX2, LHPP, SLC39A8, FTO, CSRNP3, IGSF22, AGBL4, C15orf32, RHBDL2, SERINC2, CCSER1, STX18-AS1, LINC02268, LINC01818, LINC02661, AOX3P, MREG, C16orf72, ARL15, NRXN1, ADH4, CTNNA2, ESRRG, GCKR, GRK5, KCNJ6, MICB, ADH1C, BRAP, MBNL2, SEMA3A, STAG3, KLF12, IGSF9B, PPP1R16B, FAM162A, UTP20, AOX3P-AOX2P, GSTM2, GSTM1
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Abdominal Obesity
Wikipedia
But adiponectin , an anti-inflammatory adipokine, which is found in lower concentration in obese and diabetic individuals has shown to be beneficial and protective in type 2 diabetes mellitus (T2DM). [13] [14] Insulin resistance is a major feature of diabetes mellitus type 2 , and central obesity is correlated with both insulin resistance and T2DM itself. [15] [16] Increased adiposity (obesity) raises serum resistin levels, [17] [18] [19] [20] which in turn directly correlate to insulin resistance. [21] [22] [23] [24] Studies have also confirmed a direct correlation between resistin levels and T2DM. [17] [25] [26] [27] And it is waistline adipose tissue (central obesity) which seems to be the foremost type of fat deposits contributing to rising levels of serum resistin. [28] [29] Conversely, serum resistin levels have been found to decline with decreased adiposity following medical treatment. [30] Asthma [ edit ] Developing asthma due to abdominal obesity is also a main concern. ... "Body Image for Women: Conceptualization, Assessment, and a Test of Its Importance to Sexual Dysfunction and Medical Illness" . Journal of Sex Research . 28 (3): 457–78. doi : 10.1080/00224499109551619 . ... Archived from the original on 2011-09-28 . Retrieved 2013-01-05 . ^ Elbers, J.
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Acute Coronary Syndrome
Wikipedia
If there is no evidence of ST segment elevation on the electrocardiogram , delaying urgent angioplasty until the next morning is not inferior to doing so immediately. [26] Using statins in the first 14 days after ACS reduces the risk of further ACS. [27] In a cohort study comparing NSTEMI and STEMI , people with NSTEMI had a similar risk of death at one year after PCI as compared to people with STEMI (3.4% vs 4.4%). [28] However, NSTEMI had significantly more "major cardiac events" (death, myocardial infarction , disabling stroke , or requiring revascularization ) at one year (24.0% vs 16.6%).CRP, IL6, TNNI3, MMP9, PAPPA, TNF, PON1, TLR4, ITGB3, HSPD1, FASN, TNNT2, TUBB1, SERPINC1, PSMB1, ARHGDIB, HSPA8, SOD2, CAPZB, LDHB, CKM, RAB7B, CKB, VCL, GSN, TUBA1C, ACTG1, GAPDH, TPM4, VIM, GSTP1, PDIA3, ENO1, PLA2G7, CST3, APOE, LPA, TMEM231, CELSR2, GABRB1, ACE, TOMM5, GLCCI1, FAM114A1, PCSK9, CYP2C19, FRMD5, CASTOR3, CYP3A7, CYP3A51P, P2RY12, ACCS, MPO, FHIT, SERPINA5, PLA2G15, ADCY9, GDF15, ACSS2, CATSPER2P1, SCARB1, NOS3, BTD, UGT2B7, CYP3A7-CYP3A51P, TP53BP1, ARPC1A, ALB, NPPB, CD40, F3, CETP, ABCB1, APOA1, OLR1, CAD, MMP2, CD40LG, LDLR, FOXP3, IL18, BDNF, TGFB1, IL37, IL10, SERPINE1, PTX3, VASP, CXCL16, VWF, IL1B, ADIPOQ, PLA2G2A, PPIG, ITGA2B, PPARG, EDN1, F10, ADRB2, THBD, PCYT1A, DPP4, MTHFR, HLA-DRB1, SPP1, BSG, VEGFA, CIITA, ST2, MMRN1, P2RY1, CCN1, PLA2G1B, F2R, PLA2G6, TNFSF4, S100A9, TNFRSF4, PTGS2, PTGS1, CCL2, CX3CR1, MMP1, MMP3, PPARA, SELP, PLXNA2, MIR146A, IL1RN, COX1, MSR1, SELENBP1, MIR499A, ACSL5, IL17D, SH2D1A, RCBTB1, CHGA, TIMP2, TLR2, LGALS3, COX2, TNFRSF11B, FSTL1, NFKB1, S100A12, SMUG1, ACSL6, CXCL12, MTHFD1L, PLAT, SELPLG, GREM1, VPS51, FOXD3, APCS, MIR223, NRDC, CD14, CD28, MIR21, NPPA, ANGPTL2, APOB, MIR122, IL27, GOLGA6A, CYP2B6, LCN2, IFNA13, IFNA1, BPIFA4P, CYP3A4, AGTR1, AGT, EHMT1, F2, ALDH2, ADRB1, GPT, GLP1R, NLRP3, LIPG, CERNA3, MTCO2P12, ZNF746, APLN, FABP3, IL2RA, IGF1, ENHO, TTR, LCAT, CPB2, KDR, MAPK14, ISG20, ALOX5AP, REN, BET1, CXCL8, IL17A, TNFRSF9, SIRT1, MIR3149, MPRIP, MIR208B, CLEC16A, KLF2, RIPK3, FADS2, SLC23A2, MIR605, TFG, SLC33A1, TBC1D9, CARM1, ADAMTS4, UGT2A1, MIR486-1, MRAS, WDTC1, ADAMTS7, HDAC9, FCMTE2, DKK1, PGR-AS1, AKR1A1, EMSLR, HPSE, MVP, ABCB6, SCA9, MIR330, APOO, NLRC4, CARD18, ACE2, UBL5, F2RL3, LGR6, PEAR1, HPSE2, VSIR, C16orf58, CRTC3, VKORC1, FTO, TREML4, STARD7, DHX40, ECHDC3, MRGPRX1, GPRC6A, ABCC11, KIF6, DNER, CARD16, FCRL3, MRGPRX3, OXER1, MRGPRX4, GPR151, HAMP, MIR126, LPAR3, MIR224, PADI4, GPR166P, AMACR, KCNE5, VN1R17P, SULT4A1, POU2F3, CARD17, PTPN22, MIR29B2, MIR29B1, HAVCR1, FETUB, PLB1, RETN, MBL3P, MIR19B1, GP6, MIR186, MIR15A, CLEC1B, MIR150, TERF2IP, DGCR8, CCHCR1, ELOVL2, APOM, MYDGF, TBX21, ABO, PER2, FAP, GEM, GCK, GAS6, FLT1, FGB, FBLN1, FABP4, GJA4, F12, F7, EPHX2, EGR1, EGFR, DBP, CBLIF, GLS, CYP2D6, HRH2, IL2, IL1A, IGFBP4, ICAM1, HSPA4, HSPA1A, HMOX1, GNB3, HMGB1, HLA-B, HLA-A, HGF, NR3C1, GPX1, CYP3A5, CYP2C9, IL7R, ANXA5, AVP, ATM, ARSA, FASLG, FAS, APOC3, ANXA1, BCL2, ANGPT2, ALOX5, ALCAM, AKT1, ADRA2B, ADAM10, B2M, BGN, CYP1A1, CDH6, CYBA, CTSD, CTSB, CP, CCR5, CLU, CD70, BRCA1, CD68, CD36, CD34, CD80, CD247, CASP1, IL7, IL9, PROZ, SELL, STAT5B, STAT5A, STAT3, SREBF2, SRI, SHBG, SELE, TRA, CXCL5, CCL21, CCL19, S100A8, PTPRA, PTH, ABCC8, TERC, MAPK8, VCAM1, TNFRSF11A, SOCS1, FZD4, FGF23, CUBN, LAP, UMOD, TFPI, UCP2, TYR, TRAF1, TNNI1, TIMP1, TGM2, PTGER2, PRG2, IL15, LEP, MAZ, CYP4F3, LRP2, LRP1, FADS1, LGALS3BP, RPSA, MBL2, KLK1, KIR3DL1, JUP, JAK2, IRS1, IRF5, MB, MIF, PPBP, PECAM1, ACADS, POR, PLG, PLA2G4A, PI3, SERPINF1, SERPINB2, NR3C2, NPR3, NPR2, NPR1, NPPC, NDUFC2, MMP8, LINC02605
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Vitamin Deficiency
Wikipedia
Decreased urinary excretion of biotin and increased urinary excretion of 3-hydroxyisovaleric acid are better indicators of biotin deficiency than concentration in the blood. [28] Deficiency affects hair growth and skin health. [29] [30] Folate (Vitamin B 9 ) deficiency is common, and associated with numerous health problems, but primarily with neural tube defects (NTDs) in infants when the mother's plasma concentrations were low during the first third of pregnancies. ... MedlinePlus, National Library of Medicine, US National Institutes of Health. 28 January 2019 . Retrieved 15 February 2019 . ^ "Hypervitaminosis D" . MedlinePlus, National Library of Medicine, US National Institutes of Health. 28 January 2019 . Retrieved 15 February 2019 . ^ Katherine Zeratsky (7 February 2018).
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Peripheral Artery Disease
Wikipedia
Other complications of severe PAD include lower limb tissue loss , arterial insufficiency ulcers , erectile dysfunction , and gangrene . [28] People with diabetes are affected by gangrene of the feet at a rate that is 30 times higher than the unaffected population.BMP8A, BMP2, LPA, ABO, F5, LPL, TCF7L2, OSBPL10, TNIK, MACF1, COL4A1, CNNM1, PADI4, MTHFD1L, HDAC9, WWOX, CRP, TRAM2, ZYG11B, FEZ1, MMP3, NDUFB9, VEGFA, UTRN, UGDH, CNOT4, CNTN3, CELSR2, VIT, ATXN2, PPP2R2C, DHX40, PTPN11, LRRTM4, RILPL2, PKN2-AS1, UGDH-AS1, CDKN2B-AS1, PPIEL, PDYN-AS1, HGF, UBAC2, GOT1, NSMCE1, IL6, RBFOX1, SYTL3, PPP4R2, TLR10, PAQR8, TRIM5, CREB3L1, EFHC1, OPN4, ACE, PCSK9, ALB, APOB, MTHFR, TNF, P2RY12, THBS1, CCL2, ARSA, IL1B, F2, HIF1A, TNFRSF11B, NOS3, FABP4, HMGB1, MMP2, LGALS3, ADIPOQ, CST3, SELENBP1, ADA, AHSG, APOE, RETN, CCHCR1, HMOX1, SHBG, STAT3, TLR4, PON1, MIR93, SELENOP, COPD, CXCL8, JAK2, KNG1, PTCRA, LIPC, PCYT1A, SLC5A2, S100A9, GDF15, FURIN, PLA2G7, BEST1, PTX3, CERNA3, AVP, FGF2, EDN1, CHI3L1, GCH1, CDKN1A, F11, ANGPT2, AGTR1, AGER, F2R, F10, DPP4, B2M, SGSM3, EIF3K, SETD2, PADI1, IL22, SDF4, IL1A, BFAR, CETN1, FXYD5, UGT1A1, AGGF1, ADI1, CHDH, ZNF415, ACSS2, ANGPTL8, CEBPA, CHRNA3, FGF21, PPARGC1A, CSF2, CS, ZEB2, NR1H4, CASP8AP2, SH2B3, ABCB6, IL18BP, PSMD14, FBLN5, TCFL5, ADAMTS13, SOSTDC1, ADAMTS5, ADAMTS7, PADI2, NLRP1, COX8A, TRS-AGA2-3, ANGPTL2, MAP3K8, CHRNB4, PLA2G15, FAM20C, SCARB1, SLC52A2, RTN4, MIR125A, ARG2, ABCC6, AR, TET3, PRSS55, APOH, APOA1, ANGPT1, MIRLET7G, MIR106B, MIR140, CSMD1, MIR15B, MIR18A, MIR29A, AGT, ACOD1, ADRB2, HLP, ADD1, ACR, CBSL, ALDH7A1, PWAR1, LRG1, NUS1, CD36, TBPL1, CD34, CD14, CBS, PPP1R2C, SLC2A10, CASR, ANGPTL6, SPRTN, ANTXR1, ZGPAT, SPZ1, TRIM63, ACCS, CAD, BLM, BCL2, CCND1, CARD16, ATP7B, CSF3, IL1RL1, CSTB, CX3CR1, NFE2L2, FOXO1, FGG, NPY, NPPB, NPPC, NPR3, NT5E, NUCB2, FGF1, FGB, SERPINA5, FAP, ENPP1, PECAM1, F13A1, ABCB1, PLG, PODXL, F12, PON3, MAPK1, EIF2AK2, FLNA, MYB, MTTP, LEP, SERPIND1, HARS1, IL10, IL18, GPX4, KDR, GNB3, IPO5, LAMP2, LDLR, GIP, FLT1, GABPA, FSHMD1A, MCAM, MFAP4, FOS, FN1, MMP9, MMP13, MPO, MT1B, PTGS1, PTGS2, F8, CYBB, TNFRSF1A, TNFRSF1B, TP53, CRISP2, DAPK3, CYP2C19, VCAM1, CYP2B6, CYP1A2, WRN, CUBN, TLR2, BRAP, YBX3, PRKRA, TNFSF11, NR1I2, TRPA1, CYBA, HGS, IFNG, ADGRG1, DECR1, THBS4, RAP2A, SFTPD, RBBP6, REN, SORT1, F3, SAA1, EPHB2, CXCL12, SELP, ENG, SRSF5, MARK2, ATN1, SHH, EDNRA, SLC25A1, SRD5A1, SRD5A2, SULT1E1, TAC1, DUSP5, TEK, TERF2, NAT2
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Peptic Ulcer Disease
Wikipedia
More specifically, peptic ulcers erode the muscularis mucosae , at minimum reaching to the level of the submucosa (contrast with erosions, which do not involve the muscularis mucosae). [28] Confirmation of the diagnosis is made with the help of tests such as endoscopies or barium contrast x-rays . ... Archived from the original on 2 April 2015 . Retrieved 28 February 2015 . ^ Rao, S. Devaji (2014). ... Archived from the original on 20 March 2015 . Retrieved 28 February 2015 . ^ a b Snowden FM (October 2008). ... October 2006. Archived from the original on 28 December 2011. ^ "Peptic ulcer" . ... E.; New, M.; Perreault, L.; Purnell, J.; Rebar, R.; Singer, F.; Trence, D. L.; Vinik, A.; Wilson, D. P. (28 November 2013). "Gastrinoma Zollinger-Ellison-Syndrome".GAST, IL1B, EDN1, HPGD, GSR, HMOX1, CNR1, GTF2I, ELN, LIMK1, CXCL8, MEN1, CYP2C19, CDC73, CLIP2, GTF2IRD1, CDKN2C, CDKN2B, CDKN1B, CDKN1A, RFC2, S100A8, BAZ1B, SLCO2A1, TBL2, TNF, TLR4, SERPINE1, ABCB1, PTGS1, SERPINB2, ABO, IL10, TBC1D9, SLCO1B1, NOD1, PTGS2, ALKBH1, IL1RN, ACE, COX2, EGFR, AGTR1, TLR2, TGFB1, MTCO2P12, SCT, PPARG, COX1, ABCC1, CYP2C9, MIR146A, FOXP3, VEGFA, IL1A, DDX53, C20orf181, COX5A, PPIG, ARHGEF2, GGTLC5P, GGTLC3, GGT2, GGTLC4P, LXN, A4GNT, IL22, MGAM, PLAAT1, TP63, GGTLC1, ERVK-6, ERVK-32, WFS1, LOC102724197, ABCG2, CHST2, MIR499A, IL37, ARMH1, STING1, EBNA1BP2, TREM1, MIR155, ASAP3, MIR182, LANCL1, TAS2R64P, PCSK9, IL33, RABEPK, ABCB6, MIR204, MIR27A, MIR146B, NOD2, PLG, TP53, GZMB, GSTP1, GSTM1, CBLIF, GGT1, GABPA, FUT4, F2, CYP3A4, CYP2E1, CYP2C18, CYP2C8, CYP1A2, CYP1A1, CPOX, COX8A, CMA1, CD14, RUNX3, BCL2, ATP4A, ATP12A, ALB, AGT, GSTT1, HRH2, TFF1, IFNG, ADAM17, SST, SI, PSMD7, PSEN2, MAPK1, ADA, SERPINA1, PGC, NFE2L2, MUC5AC, MMP7, MIF, LTA, LDHA, RPSA, KRAS, IRF6, IL17A, IL12B, IL9, IL6, IL4, H3P28
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Atrial Fibrillation
Wikipedia
Sepsis also increases the risk of developing new-onset atrial fibrillation. [26] [27] Disorders of breathing during sleep, such as obstructive sleep apnea (OSA), are also associated with AF. [28] Obesity is a risk factor for AF. [29] Hyperthyroidism and subclinical hyperthyroidism are associated with AF development. [30] Caffeine consumption does not appear to be associated with AF; [15] [31] excessive alcohol consumption (" binge drinking " or " holiday heart syndrome ") is linked to AF. [32] Low-to-moderate alcohol consumption also appears to be associated with an increased risk of developing atrial fibrillation, although the increase in risk associated with drinking less than two drinks daily appears to be small. [32] [33] Tobacco smoking and secondhand tobacco smoke exposure are associated with an increased risk of developing atrial fibrillation. [7] [34] Long-term endurance exercise that far exceeds the recommended amount of exercise (e.g., long-distance cycling or marathon running) appears to be associated with a modest increase in the risk of atrial fibrillation in middle-aged and elderly people. [19] [35] [36] Genetics [ edit ] A family history of AF may increase the risk of AF.KCNH2, KCNN3, CAV1, GJA5, SCN5A, PITX2, ZFHX3, TBX5, HCN4, SCN10A, KCNJ2, NKX2-5, PLN, NEURL1, KCNJ5, TTN, MYH7, SIRT1, SYNE2, CAND2, SOX5, HAND2, PRRX1, AOPEP, TNFSF12, ERBB4, NEBL, RBM20, KCND3, CASQ2, WNT8A, SMAD7, SYNPO2L, ATXN1, RPL3L, GCOM1, RPS2, AGBL4, BEST3, SPATS2L, ARHGAP10, KDM1B, SLC35F1, LRIG1, IGF1R, SLIT3, CDKN1A, CDK6, ARMH3, SLC27A6, ESR2, MYO18B, DGKB, EPHA3, MAPT, NUCKS1, DNAH10, TEX41, GNB4, ZNF462, MYH6, FBRSL1, ACE, PAK2, PTK2, XXYLT1, LRMDA, CASZ1, KCNN2, PKP2, KIF3C, REEP3, PPP2R3A, SLC9B1, MEX3C, TUBA8, FBXO32, LINC01426, CYTH1, UBE4B, MIR1-1HG, VWF, HIP1R, HERC1, WNT3, MYOCD, COG5, TTN-AS1, PHLDB2, PPFIA4, ASAH1, CUL4A, DPF3, LHX3, XPO7, SCMH1, GTF2I, SH3PXD2A, USP3, ZPBP2, USP34, SUN1, THRB, AKAP6, CAMK2D, CEP68, CREB5, GOSR2, GYPC, NAV2, FRMD4B, SSPN, EDN1, KCNA5, NOS3, NPPB, CYP2C19, KCNE2, GATA4, MYOZ1, KCNE5, CAV2, SELE, HTR4, KCNJ8, ABCC9, HSF2, LINC00477, MIR6500, CFL2, OPN1SW, WIPF1, FGF5, PHLDA1, SNRNP27, IRF2BPL, LRRC10, C1orf185, GJA1, MYOT, SGCA, CALU, UST, REEP1, LINC01142, MYPN, MIR30B, SORL1, SOX15, WDR1, MBD5, ARNT2, XPO1, GOPC, DES, HSPG2, PSMB7, NACA, MYO1C, NR3C1, CGA, NPPA, KCNQ1, TFPI, LMNA, IL6R, CACNA1C, ANK2, SMAD3, PPARG, NUP155, MTHFR, GATA5, FAF1, CACNB2, TNFSF12-TNFSF13, CDKN2B-AS1, SNTA1, PRKAG2, IL6, KCNE1, ALPK1, CCDC92, ITPK1, PANCR, TMEM43, LGALS3, RYR2, BSCL2, TCF7L2, TGFB1, SIK3, TNF, TAB2, XK, POLG2, SLC30A3, AGPAT2, ALDH1A2, ZPR1, BAZ1B, FADS2, GDF15, CERT1, PKD2L2, REN, GRHL1, TWNK, LIPC, FADS1, GMCL1, SLC39A8, ABHD17C, SUGP1, CRAMP1, PEX26, RRM2B, ZCCHC8, MAML3, SEMA5B, PLCG1, POLG, SLC25A26, TNNI3K, POLK, FTO, ATP2B1, LINC02269, MYZAP, DCBLD1, SLC25A4, ALB, ANXA4, CEP85L, GCKR, LINC00964, LINC02245, FOS, CELSR2, AGT, HBEGF, DTNA, CAVIN1, LINC01629, CRP, DINOL, PLCXD2, LINC01681, LIPC-AS1, CACNA2D1, LINC02576, DNAH10OS, F10, KCNK3, CYP11B2, CYP2C9, MMP9, VKORC1, F3, TNNI3, SERPINA5, MIR21, TTR, IL1B, CAD, P2RY12, MMP2, SERPINE1, COPD, NR3C2, SMAD2, F2, FSD1, ACE2, DPP4, CREM, ADRB1, AGTR1, FSD1L, ANGPT2, NLRP3, CCL2, TIMP2, TIMP1, IGF1, F2R, FGF23, SELP, VPS51, CCN2, ATP2A2, C20orf181, CST3, KCNE3, MAPK3, THBD, MIR328, ADIPOQ, MIR106B, MYL4, SCN4B, SCN2B, STAT3, DLD, DECR1, PCLAF, SLN, ABCB6, ABCB1, NOC2L, SCN1B, SCN3B, ITGB2, IL10, PCSK9, LAD1, TCFL5, NR1I2, GATA6, BCL2, PLA2G15, NGF, SLC52A2, CD40LG, TNFRSF11B, IL1A, ACSS2, CETP, ACTN2, CYP3A4, MIR150, CAAP1, COL1A1, MIR29A, NLRP6, VEGFA, RAC1, MYBPC3, VCAM1, ACCS, APLNR, CUX2, SIGMAR1, PWAR1, LPA, TRPC3, APLN, CYP4F2, CHI3L1, CXCL12, PRKRA, LYST, BAX, AVP, C1QL1, CALR, WDHD1, TSPAN31, TIMP4, PSMB8, PTH, CALCR, NOX4, ADAMTS13, MINK1, CP, RBBP6, S100B, RNASE1, ROS1, MIR133B, COL4A2, FAS-AS1, SLC30A1, MIR208B, SHBG, MIR499A, SMUG1, PGR-AS1, CD14, CAV3, TAT, ADM, AMACR, CASP8, STK11, KAT2B, TGFBR1, STAR, TH, KCNE4, ST2, SPRY1, CD44, SOD1, ADH1B, RAPGEF3, BDNF, SLC6A3, ACVR1B, SLC5A2, APOE, MIR483, SHOX2, MMRN1, PART1, HIF1A, CRH, PLG, PLAT, MIR155, TRPM7, MIR146A, ZNF415, RETN, OAT, JPH2, NHS, MSR1, GAS5, MAP6, ADGRE4P, KNG1, KCNK1, FCGR3A, FCGR3B, FN1, ITGA2B, INSRR, IL18, CXCL8, GCG, IDE, GRK5, HSPA8, HSPA4, HMOX1, HMGB1, NANS, CHAF1A, MIR223, MAPK9, MIR27B, AHSP, MIR26B, POMC, PON1, HAVCR1, MIR34A, MIR3149, PPARGC1A, MRPS30, FLVCR1, VOPP1, ARID3B, HOTAIRM1, JTB, MFRP, ATG7, TMX2-CTNND1, CAP2, SESN2, JAML, MIR4279, FASTK, UTS2, PAPOLA, POTEKP, EHMT1, SLCO1B3, MIR17HG, IL27, FOLH1B, CRYGEP, WWP1, TRAP, SLC35G1, KCNQ1OT1, LINC00472, PPM1K, STIP1, NPPA-AS1, PRSS21, ECRG4, SPATC1L, RMC1, HOPX, PCAT1, KCNK17, G3BP1, CSAD, GGTLC1, KCNK7, LOC102724197, MIR31, CACNA2D4, NKX2-6, SLCO6A1, MUC16, PRRT2, CERNA3, SIRT1-AS, C1QTNF5, GJC1, KCNK9, TRIM69, EMSLR, TRPM6, NPY4R2, CCDC141, GDF7, ANAPC10, AKR1A1, EBPL, KCNIP2, APBB3, BET1, PDZK1IP1, TICAM1, SESN3, KRT90P, KCNIP1, ATP6AP2, WNT3A, SIRPA, H19, ZGLP1, FILIP1L, HEY2, IL17D, MAP3K7CL, MIR132, SMIM10L2B, PELI1, MIR126, SALL4, GDE1, SLC24A3, LY96, LINC00273, CD2AP, MIR125A, MIR122, MIR10A, NNT, GGTLC5P, ARIH1, SNORD44, KCNK13, MTPAP, TRIM72, MIR206, MIR15B, MIR342, MIR146B, KRT20, FGF21, PRPF31, SH2B1, MIR142, CNTN5, CTNNBL1, KCNQ5, MIR137, POTEM, MIR133A2, MIR106A, NPTXR, MIR20A, MIRLET7B, ASAP1, NIBAN2, AGXT2, TSPAN33, ZHX2, RGPD2, C1QTNF9, PSS, COG2, TUSC2, PDAP1, ACOT7, DESI1, MMP28, TLX1NB, SGSM3, PHB2, GGTLC4P, GSTK1, ISYNA1, GGTLC3, MIR590, MIR92B, CASC15, IL37, PRM3, HAGLR, SNORD118, WWC1, GPD1L, SMIM10L2A, SIL1, GGT2, GREM2, CCR2, SLC22A25, ENHO, ACTBL2, SERPINA3, HDAC5, FGB, FGF13, FGFR4, VEGFD, FKBP1A, FKBP1AP1, FKBP1AP2, FKBP1AP3, FKBP1AP4, FLOT2, FOLH1, GAP43, GC, GCH1, GGCX, GGT1, CBLIF, GJA4, FGF2, FBN1, ELK3, FANCF, EMD, MARK2, ENO2, ENPEP, EPHX2, EPO, ERCC6, ETV1, EZH2, F2RL1, F5, F7, F8, FABP4, FABP3, FANCC, PTK2B, GLA, GLP1R, GLS, GNB3, IFNG, IFNGR2, IGFBP3, IGFBP7, CCN1, IL1RN, IL9, CXCR2, IL16, FOXK2, INCENP, INPP5D, INPPL1, ITGA2, ITGA5, ITGAM, ITPR1, IFNB1, ICAM1, TNC, HLA-C, GNRHR, GPT, GSK3B, GSN, HARS1, HGF, NRG1, HNF4A, HSPD1, AGFG2, HRC, HSD11B1, HSD11B2, HSPA1L, HSPB1, HSPB2, ELN, ELAVL2, SRA1, STS, ATF4, ATM, ATP2A3, ATP7B, BCHE, BCL2A1, HCN2, BMP7, BTF3P11, BTK, SLC25A20, CAPN1, CAPN2, CASP1, CASP3, CASP9, CAT, SERPINC1, RHOA, EGFR, ARAF, ABO, ACP3, ACTG1, ACTG2, ADA, ADAM10, ADCYAP1R1, PLIN2, PARP1, ADRA2C, AFA, AGER, AKT1, ALDH2, ANPEP, APOA1, APP, MS4A1, CD28, CD40, CD68, CTRL, CYBB, CYP1A2, CYP2J2, CYP3A5, DAB2, CD55, DCC, DDT, NQO1, DMD, ATN1, DUSP2, ECT2, EDN2, EDNRB, EFNA5, CTNND1, CTNNB1, CSH2, COL9A1, CES1, CTSC, CHAT, CHGA, CHRM2, CLIC2, COL1A2, COL9A2, CSH1, COL9A3, COMP, KLF6, CPB1, CPM, CRYGC, CSE1L, KCNB1, KCNJ3, KCNJ11, THBS2, THY1, TIMP3, TSPAN8, TP53, TPO, HSP90B1, TRAF2, TRAF6, TRPC1, TSC1, TSC2, TYRP1, UBC, UCHL1, UCP1, VASP, WNT1, THOP1, TGFBI, KCNK2, TFAP2A, SRSF5, SHC1, SLC2A3, SLC6A8, SMPD1, SNAI1, SOAT1, ABCA4, SULT2A1, ETF1P2, TAC1, TACR3, MAP3K7, CNTN2, TBL1X, TRA, TERT, WNT5A, ZAP70, ZNF143, MANF, TIMELESS, WASF1, HSPB3, HGS, SLC28A1, SLC33A1, NOG, SLC9A3R2, KL, FHL5, TBPL1, BCAR1, RGS6, RAPGEF5, SNX17, MVP, CASP8AP2, ASAP2, HDAC3, CES2, CMAHP, PLA2G7, ARHGEF5, NR4A3, MLLT10, CDK2AP1, USP9X, ARID1A, RECK, TNFRSF11A, DOC2A, KCNAB2, LGR5, PSMG1, TNFSF13, TNFSF10, ADAM15, MAP2K4, SCN8A, SCN2A, PDE4D, MPO, MSRA, MT3, MTR, MYD88, NDUFS4, NFATC3, NFATC4, NOS2, NPPC, NPR1, NTF3, NUCB2, OLR1, OSM, PAK1, REG3A, MMP7, MMP3, MMP1, LOXL2, KIT, LBR, LCAT, LEP, LIMK1, LIPE, LOX, LRP5, MME, EPCAM, MCL1, MET, MFAP4, MIF, ATXN3, MLLT6, PCYT1A, PDGFRA, RRAS, PDGFRB, PROC, PSMB10, PSMD4, PTGS2, PTPN11, PTPRC, PTX3, PVR, PVT1, RAF1, RARRES2, RBP4, REG1A, RENBP, RLN2, RPE, RPS27A, MAP2K1, MAPK1, PRKCD, PIK3CG, PDK4, PENK, PEPD, ABCB4, PIK3CA, PIK3CB, PIK3CD, PKD2, PRKCB, PLEC, PPA1, PPBP, PPOX, PPP1R3A, NPY4R, PRKCA, ST13
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Beckwith–wiedemann Syndrome
Wikipedia
John Bruce Beckwith (born 18 September 1933, Spokane, Washington), [28] who also observed a severe increase in the size of the adrenal glands in some of these patients.CDKN1C, IGF2, H19, KCNQ1OT1, KCNQ1, NSD1, H19-ICR, SPTBN1, PIK3CA, CIB2, TGM1, CTCF, WDR20, UROD, RSS, AFP, IGF1, CORO1A, SMS, PLAGL1, H3P47, GPC3, HRAS, ELN, GTF2I, GNAS, IGF2R, DNMT1, GTF2IRD1, GRB10, DLK1, MYOD1, CALCA, HIC1, PALB2, CD48, NLRP2, ZDBF2, IFT46, IGF1R, ZNF44, ATAD5, TRPM5, C11orf21, PHPT1, PGAP2, TBL2, SMUG1, CEND1, FRA18C, ZNF436, CBS, PERCC1, ASAH1, CBSL, DEL11P13, IH, INS-IGF2, POU5F1P4, POU5F1P3, ZACN, ZFP57, ZNF763, VPS51, NLRP7, ZNF569, AMER1, CMTR1, ZNF501, ZNF629, TBPL1, CD81, DDX11, S100A8, PTH, POU5F1, PLXNA2, PAX6, SLC22A18, NRAS, MTHFR, TRPM1, MAT1A, SMAD3, LMO1, LGALS1, KCNJ11, JBS, SNRPN, SOX2, SOX3, ZNF214, DIO3, HTC2, IL1RL1, SGCE, RASSF7, ZNF215, ZNF143, ABCC8, WT1, WEE1, APC, TP53, TFPI, TERT, TYRP1
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Leukemia
Wikipedia
Transient myeloid leukemia is a pre-leukemic condition. [27] [28] [29] Signs and symptoms [ edit ] Common symptoms of chronic or acute leukemia [30] The most common symptoms in children are easy bruising , pale skin , fever , and an enlarged spleen or liver . [31] Damage to the bone marrow, by way of displacing the normal bone marrow cells with higher numbers of immature white blood cells, results in a lack of blood platelets , which are important in the blood clotting process. ... Archived from the original (PDF) on 28 May 2008 . Retrieved 18 May 2008 . ^ Robak, T; Jamroziak, K; Gora-Tybor, J; Blonski, J.ATM, FANCD2, FANCC, BLM, FANCA, FANCG, FANCE, FANCF, NRAS, BRIP1, BRAF, ERG, TNFSF10, PTEN, STAT3, PTPN11, CDKN2A, PRAME, JAK2, KMT2A, WT1, GSTM1, CSF3R, MSH6, IL2, CCND1, SETD2, ESR1, TOP2A, LIG4, PLK1, HP, NF1, CFLAR, FOXM1, MGMT, KMT2E, PRF1, DDIT4, AR, BIRC2, FGF1, SMPD3, STAG2, BAD, PPP1R13L, LINC00977, PRKCZ, AQP9, GSTO1, NCOA3, BIRC3, SPHK1, SYNCRIP, BAP1, CREBBP, KRAS, MLH1, PIK3CA, BRD4, GATA2, TERT, MSH2, EP300, RB1, MYD88, CFTR, NUTM1, HAX1, KDM1A, CASR, RAF1, CD6, CBFB, FLT3, GEM, CXADRP1, STAT5A, STAT5B, PRMT5, TBC1D9, RUNX1, RUNX1T1, LONP1, MTOR, GATA1, RARA, NOTCH1, MECOM, FANCB, CTRC, SNAP91, ATN1, NR1I3, DNMT3A, CDKN1A, CDKN1B, DNMT1, CDKN2B, NQO1, IKZF1, MIR155, SCN11A, CXADR, CEBPA, CTNNB1, CEBPZ, CSF3, CSF2, SCN10A, SCN9A, CD19, TET2, MS4A1, CD22, EZH2, TCL1B, EVPL, CD33, CD34, ETV6, CD38, KRT20, VEGFA, CD40LG, CD44, ETS1, SPINK1, SPG7, EPO, EIF4E, CASP3, PRSS1, HIF1A, KIR3DL1, MEIS1, MDM2, ANPEP, MCL1, MLLT10, ABCB1, ASRGL1, APC, KAT6A, PIK3CB, LMO2, PIM1, PIK3CD, PIK3CG, HRX, POT1, KIF11, TERC, HLA-A, MEN1, PBX1, PAX5, PICALM, ABL1, NPM1, TNF, NUP98, NCAM1, MYH11, MYC, MYB, MTTP, TP53, PARP1, MTHFR, TCL1A, ABCC1, AKT1, MPO, MME, MLLT1, KIT, ARR3, CCR7, MAPK1, BCR, PRKAR1A, BMI1, DOT1L, TCF3, ALL1, TAL1, TMEM132D, MBD2, TLX1, BRCA2, HOXA@, TRIM13, CCNA1, HOXA10, BUB1B, IDH1, CALM1, CALM2, IDH2, PML, COMMD3-BMI1, PMS2, IL15, CXCR4, IL6, IL3, HOXA9, TRBV20OR9-2, IGH, BCL2, CALM3, IFNA13, IFNA1, NFE2L2, HLA-B, KDR, DNER, MAPK8, MLLT3, CXCL12, FHIT, ASPG, KLRK1, IFNG, IL1B, PROM1, ERVW-1, SPI1, OPN1SW, CD274, KLRC4-KLRK1, H3P10, CDK2, BTK, BRCA1, BAX, FUT4, FAS, FGFR1, PRAM1, MAPK14, MPL, MDM4, CBFA2T3, IRF8, CYP1A1, ELANE, NUP214, MIR21, ABO, GSTT1, JAK3, PTPA, DEK, RAC1, HPGDS, PRDM16, HLA-DPB1, TRIB2, ZBTB16, G6PD, PBX3, BCL11A, SCLY, PCBP4, PAG1, XIAP, TRIM5, HLA-C, IL2RA, SUB1, DHFR, WLS, LEP, AFF1, LIF, ABCG2, HSP90AA1, ZAP70, MAP2K7, NXT1, MRPL28, NBN, KRT7, IL10, SOAT1, FN1, H3P9, TOP1, ERVK-20, HDAC9, XRCC1, MARCKSL1, TPMT, IL7, FLI1, OPN1LW, EWSR1, SRC, IRF1, NCOA2, SCT, GFI1, CDK4, RAG2, RUNX2, HLF, PRTN3, CD80, IL2RG, CD14, S100A4, IL7R, AHI1, GSTK1, FASLG, APRT, MIR150, AFDN, BCL6, NME1, CCR5, NM, NFKB1, SLCO6A1, MAPK3, MIR17HG, MAP2K1, TLX3, MSH3, FLT1, FLII, PPARG, TGFB1, CD47, CIB1, LEF1, CDK6, MSI2, CNTNAP1, DNMT3B, LMO1, MNX1, APEX1, TET1, PDGFRA, SALL4, CD27, HPRT1, GABPA, HRAS, ASXL1, ZNF384, IL24, FLT3LG, IGF1, ICAM1, F2R, FGF2, DLL1, FUT1, AHSA1, RNASE3, HMGB1, GLIS2, PSIP1, POLDIP2, DCC, NR0B2, FBXW7, MFAP1, CD99, RTEL1, NR3C1, ALDH1A1, MIR22, FTO, SLC9A1, MMP9, PTPN6, THY1, MIR29B1, MIR29B2, PTPRC, SEPTIN9, GSTP1, CRK, MIR196B, CREB1, ROR1, CRLF2, PIM3, ABL2, SET, PECAM1, AIMP2, EGFR, ITGAM, HMOX1, EPOR, PHF6, EPHB2, SLC12A9, TP73, ASNS, CDK1, RNF19A, CALR, SAI1, MERTK, GRAP2, ZNF521, DOK1, MIR126, PDIK1L, LGALS3, EBF1, HLA-G, TAT, TRIB1, SIRT1, BUB1, TAC1, PSMB6, HOXA5, ADAM17, YY1, HFE, HOTAIR, HEMGN, TPPP2, JAK1, HTC2, ANXA2, MAFK, FIP1L1, H3P12, ERVK-18, BIRC5, APAF1, ABCB4, LYZ, PDGFRB, MEF2C, LBR, MLF1, MMP2, CD200, ERVK-32, MUC1, ACTB, CDR3, ACHE, TLR4, SOCS1, STMN1, BMP4, IL4, TSLP, IFI27, PDLIM5, BCL2A1, BCHE, INPP4B, IL1A, POU5F1, IL3RA, IL6ST, LETMD1, CXCL8, AXL, IL18, ILK, ATR, IRF4, ITGB2, QRSL1, IGF2BP1, ARHGEF1, CHEK2, CD40, DDX41, CBL, ZEB2, EGR1, WWOX, RUNX3, LRPPRC, CDKN2C, GLB1, MIR223, ZHX2, S100A8, CDA, RAG1, DCDC2, CDX2, ATXN1, TYMS, NAT2, EEF1E1, TYR, MACROD1, REN, RARG, SRSF2, MVP, DAXX, ATRAID, LAMTOR1, AURKA, MIR16-1, VAV1, CFL1, FCER2, F3, GRB2, WDR5, POU5F1P3, PDCD5, POU5F1P4, SYK, UBE2I, COL11A2, VDR, GSK3B, CRKL, ZNF197, CRYZ, SH2B3, PTK2B, CSF1R, RAC2, GPT, RAD51, APP, CCL2, DPY30, KMT2B, CCL3, EPS15, TCHP, KCNH2, LMNA, CDKN1C, SBDS, COL18A1, ABI1, SELL, AKR1C3, LINC01194, GYPE, E2F1, KLK3, TEK, CD79A, RERE, TNFSF13, POGLUT1, PIN1, TICAM2, ERCC2, ITGB3, CIAPIN1, SP100, ARHGAP24, EPHA3, GYPB, RALBP1, KMT2C, NAMPT, EBI3, TAF15, SOD1, CES1, OSM, SLC22A1, GORASP1, H3P23, MYCN, UGCG, SMARCA1, HMGA2, NCL, DCLRE1C, ELL, SMARCA4, COX8A, ERVK-6, NTRK1, NGFR, GDE1, CHEK1, PRG4, AHR, TNFSF13B, TLR9, FOXP3, NR4A3, SMAD4, DECR1, GADD45A, SETBP1, ACE, DCK, SPP1, TMED7, SLC52A2, PCNA, AICDA, CCN2, TFRC, THBS1, CYBB, DCTN6, ALK, AKR1B1, CTSG, KMT2D, THPO, MOS, WNK1, KDM6A, FGFR3, REG1A, BCL2L1, TMED7-TICAM2, CDKN2B-AS1, KLF4, WT1-AS, FPGS, SOCS3, NR4A1, ATG5, FLT4, HMMR, RGPD2, SF3B1, FOXO3, ID1, HOXB3, RELA, TCF7, JMJD1C, NOTCH3, CCNA2, DLEU2, HSPA5, GATA3, HOXB4, WNT5A, BCL10, CNTN2, BSG, EIF2AK2, ZNRD2, TCF4, PIM2, HSF1, NLRP2, HOXD13, KAT2A, AGFG2, PSMD9, HES1, NR1I2, XRCC3, FDXR, CLEC12A, GYPA, PVT1, CD28, B2M, EMB, OSCP1, HDAC1, NT5C2, PTPN2, SYT1, CD9, IL18R1, HIC1, ASH2L, DICER1, CD5, ROCK1, NUDT15, AURKB, GZMB, H4-16, AFF4, FCGR3B, PWAR1, RBPJ, FCGR3A, TNFRSF10B, ROS1, SON, SIRT6, PRKN, PSMA7, HSP90B2P, MRTFA, CD244, PAK3, SNAP25, IL23A, TWIST1, SMPD2, BACH2, A1CF, XIST, PTPRO, ABCC8, XPO1, RAD52, POLD4, PTK7, ZBTB7A, ODC1, PTGS2, TSG101, KLF10, CIP2A, PAEP, RANGAP1, PAFAH1B1, NECTIN2, TLR2, RAP1GAP, PVR, TIMP2, PTPN4, USP7, ATF7IP, PAX3, TRD, TRDD3, S100B, DDX4, PKM, TRBC1, TERF1, ACKR3, S100A9, TRDC, PRDM2, RNF6, SRPK2, SRPK1, PLAGL2, PLAT, TRDJ1, SRI, B3GAT1, TPM3, RXRA, PLAU, RPS19, LEPQTL1, EXOSC5, DLL4, SPIB, METTL3, POLE4, POLD1, ST8SIA4, PIP4K2A, BCOR, STIL, PF4, TGFBI, HIPK2, KDM3B, SH3GL1, PDC, ENOSF1, THUMPD1, IGHV1-12, PDCD1, PDGFB, U2AF1, SPN, WEE1, HNF1A, MAPK7, RET, SELP, PHB, NSD3, TF, TFPI2, SELE, VCAM1, KDM5A, ZFP36, SOX4, TYRO3, SDC1, ETV7, STAT1, TEAD1, KDM5B, GNL3, CSF1, HERPUD1, ABCB5, SETD1A, SLC29A1, ENG, EMD, EIF4A2, EIF4A1, EGR3, ANKRD26, LIN28B, TELO2, DUSP1, MIR125A, DNTT, DNASE1, MIR143, MIR15A, DAPK1, MIR183, MIR193A, CYP3A5, MIR203A, CYP2D6, CYP2B6, CYP1B1, CUX1, CTSB, MIR221, ESPL1, PLA2R1, DKK1, SEPTIN6, HGF, HDC, HDAC2, CCNE2, H2AX, GSN, GRIA3, GPX3, XPR1, PLB1, BTLA, CREBRF, GH1, ADIPOQ, F9, RECQL4, GPR180, NR5A2, KDM6B, NCR1, NOS2, FOXC1, KDM4C, FH, FGF4, FES, BCAR1, ASPM, CTNNA1, MIR34A, HMBS, MIR34B, CASP9, CASP8, CASP2, MAGED4, CALCA, C3, BTG1, BST2, DUX4, ARL6IP5, BCL3, BCAT1, ATRX, RAB40B, ASPA, ASIP, ABCC6, AQP8, ANG, ALPP, ALPI, ALOX5, ALB, EBP, ADAR, H3P13, ACP3, H3P5, ACACA, CAV1, MIR638, CCNB1, CDC42, CNTF, CCR6, OLIG2, GPHN, ABCC4, CEBPB, MIR375, CD52, CDKN2D, CDK9, DLEU1, H4C15, CDH1, CD70, CCNE1, MIR486-1, CD59, CD48, BCRP3, CD36, TNFRSF8, CD8B, CD8A, SCFV, CD3G, CD1D, CD1C, CD1A, GPRC5A, FOS, HSPB1, ABCC11, ISG20, INPP5D, KDM2B, MEF2D, MEIS2, CXCL10, IL17A, ZNF268, H4C5, TNFRSF9, H4C2, IL11, H4C8, TNFRSF10A, HAVCR2, IL5, IL1RN, H4C3, IL1R1, NUDCD1, ZC3H12A, SH3BP4, NRP1, H4C11, H4C12, ITGA2B, MECP2, H4C13, RPSA, LTA, GAS7, ULBP2, SMAD2, SAMHD1, MAGED4B, LIFR, LGALS1, LEPR, LDLR, LCK, BECN1, CD46, LAIR1, ABCC3, BAALC, RIPK1, MAGEA1, ROPN1L, MAGT1, TNFSF9, HMGA1, H4C14, ITGAL, SOCS2, IGFBP7, IFNAR1, NOD2, RBM15, IER3, HOXC5, HOXC4, HOXB7, MYOD1, ATG3, H4C9, HOXB@, CLDN5, HOXA11, HOXA7, HOXA4, HSPB3, NGF, HOXA1, CHAF1B, NOS1, MTRR, HOXC6, HTN3, GFI1B, H4C6, MRC1, IAPP, H4C4, H4C1, LYL1, HSPB2, LATS2, SERINC3, TRPM5, RUVBL2, ESM1, TFPT, HPSE, CCR9, COPS5, MYCBP, CHIC2, MTHFD2, NUDT21, HSPB8, SENP1, ZNF451, PHGDH, CHD5, ABHD2, MLLT11, EHMT2, CNTRL, APOBEC2, RIPK3, TES, PSAT1, BLNK, UHRF1, PAPOLA, FBXO9, TPPP, ADRM1, MRPS30, EPC2, RNU1-1, CKAP2, MAPRE2, TMED2, HEY1, L3MBTL1, MKRN2, RBFOX2, PHF8, LPAR3, PADI4, ZNF423, TRIM35, MYCBP2, SGSM3, SSBP2, NUP62, SETD1B, SETX, DESI1, CEP152, FAM168A, IGHV3-69-1, TRIM32, IGHV3OR16-7, CBX7, TNFRSF13B, KCNH3, FRAT2, POLM, ARHGEF12, SMCHD1, MLC1, SYNE1, FBXW11, KAT6B, WWC1, COBL, TNPO3, APOBEC3C, TRBV16, KAT7, QPCT, LAMP5, ZC3H7A, SIGLEC7, NOX1, DNAJC2, TFIP11, DROSHA, SNF8, PACSIN2, AKAP13, PYCARD, WIF1, IBTK, CORO1A, RGCC, FLVCR1, TRBV7-9, HSPA4L, SIRT2, SMPX, SIGLEC9, SACM1L, INVS, CILK1, LAT, PARK7, IKZF3, TUSC2, PDAP1, SGK3, PHB2, ECD, CHP1, NAT1, KCNIP3, SPINK6, SERINC5, ZBTB38, IL27, GPRC6A, APOBEC3A, CRTC2, ARID2, CLEC4C, DDX53, RASSF6, OXER1, LEXM, ZNF296, SPRED1, SLC5A8, SLC35G1, NKX2-3, NCR3, MRGPRX1, COPD, GOLGA6A, SERP2, MALAT1, GJB7, PWAR4, ARSH, CXorf66, C16orf96, STING1, CSNK2A3, CLEC4D, P2RY8, FRYL, VSTM1, PGP, HECTD4, NEAT1, CBLL2, VPS13B, ESCO2, MIR155HG, MRGPRX3, ARAP1, MRGPRF, CMTM5, LRRC3B, UHRF2, CGAS, DTX2, TWIST2, SLC46A1, IL17F, PRRT2, ZNF300, SLFN11, ESAM, LRSAM1, MRGPRX4, LRRK2, NKAIN2, BRI3BP, MARVELD2, PPM1K, PAQR3, LYPD4, APCDD1, A2ML1, NRSN1, GATA5, B4GALNT2, S100A16, PACRG, GPR151, CD200R1, RBM45, UHMK1, XRCC6P3, LOC390714, MIR107, ZNRD1, MIR10A, ERVK-2, BCL2L2-PABPN1, DEL11P13, TMX2-CTNND1, MICA, OCLN, HOTAIRM1, LINC01672, CD24, VIM2P, BMI1P1, CEMP1, CCR2, SPANXB1, POTEF, ANXA8L1, SSX2B, MIR4739, ERVK-12, ERVK-22, LOC102724971, H3P19, H3P47, LINC02605, LOC110806263, LOC105379528, LUNAR1, BGLT3, U2AF1L5, PARTICL, CBSL, LOC102724334, GATD3B, LOC102723407, LINC01152, AK6, ERVK-11, MIR663A, MIR600, MIR563, MIR146A, MIR29A, MIR27A, MIR23A, MIR222, MIR182, MIR17, MIR149, MIR144, MIR93, MIR142, MIR130A, MIR128-2, MIR128-1, MIR127, MIR125B2, MIR122, MIR29C, MIR98, ANXA8, MIR378A, UCA1, LINC00273, RASSF10, MIR495, MIR146B, MIR511, MIR449A, RBMXL1, EIF2AK4, TARP, MIR345, MIR331, GPR166P, ZFAS1, VN1R17P, NRARP, MLIP, GADD45GIP1, SLC25A21, SIGLEC10, DDX43, TRPV6, MEG3, LARP6, PI4K2B, ASXL2, PACC1, TRIM62, RCBTB1, MTPAP, FANCL, TESC, ANKHD1, WBP1L, SWT1, TRPM7, FBLIM1, SOX6, ZFP64, CNDP2, KYAT3, PMEPA1, LXN, ANKS1B, GPR137, RETN, LTB4R2, TRPV5, RNF20, SEPTIN11, MYDGF, WSB2, PBK, ASH1L, BEX1, DHX32, TMEM30A, PDP1, UGT1A1, EGLN1, DCTN4, UBR5, KLRF1, DACT1, TNFRSF12A, GMPR2, TLR7, HERC5, EGFL7, TRPV2, KMT5B, MLXIPL, GAL, ASAP1, MBL3P, IL22, NOX4, WNT16, CHMP5, ROBO4, MAP3K20, WNT4, H2BS1, A4GALT, S1PR5, MBD3, IL17D, ADA2, ATP8A2, NCKIPSD, ARID4B, CMPK1, GINS2, PIAS4, MED15, HDAC7, SIRT7, SMYD2, KNL1, TIGAR, TSGA10, JAM3, DYNLRB2, SOX7, TCF7L1, AMN, CAB39L, DUSP16, ULBP1, FSD1L, TRABD, SCD5, NANOG, UBA5, EHMT1, LIN28A, SUV39H2, CRISPLD2, USP42, VTCN1, ZFYVE19, LMLN, WNT3A, SLC22A16, EAF1, REPS1, UBL7, MIR22HG, ZNF382, KAT8, C19orf48, CBX2, BEX2, NT5C1A, RHOXF2, ZDHHC16, ARID5B, CCDC51, PGBD5, ZNF695, STIM2, LGR6, SIGIRR, ACE2, IL21, PLEKHB1, TRIB3, METTL14, PCDH10, BCORL1, AHRR, SCYL1, VANGL2, MCOLN1, ZMIZ1, RALGAPB, GOPC, NYX, PRDM14, MUL1, INTS3, NOX5, FSD1, TNIP2, PHF23, PVRIG, CENPM, GGCT, RTN4R, MAGEF1, ACD, BCL11B, CDCP1, MARCHF7, SMYD3, NSD1, SLC39A8, CDC73, SP1, NES, HBG2, HOXA6, HOXA3, HNRNPA1, SLC29A2, HNF4A, HMGCR, HMGB3, HMGB2, HLA-DRB3, HLA-DRB1, HLA-DQB1, HK2, HK1, HIP1, HTT, HCL2, HCFC1, HOXA13, HOXB1, HOXB2, HSPA4, IFIT3, ID4, MRPL58, TNC, HTN1, HSP90AB1, HSPA9, HSD11B2, HOXB5, PRMT1, HOXD3, HOXD@, HOXC10, HOXB9, HOXB8, HOXB6, HBZ, HBG1, IGF1R, HBA2, GATA6, GATA4, GAS6, FUT3, FUS, GAST, NR5A1, FRZB, FRA7G, FRA6F, FXN, FPR1, FOLR1, FOLH1, FMOD, FLNC, FOXO1, GCY, GGT1, B4GALT1, GPR42, HBA1, H2AZ1, GTF2H1, GSTA1, GRM3, GRB10, FFAR2, GPER1, GHRH, GPI, GNB2, GNB1, GLS, GLI2, GLI1, GJA1, IFNB1, IGF2, VEGFD, LRP6, RAB8A, ME2, MDK, MCM7, MCM3, MBL2, MATK, MAL, MAGEA3, SMAD7, SMAD5, EPCAM, SH2D1A, LYN, LY9, LTK, LTF, MET, MIF, MIP, COX1, NAIP, MYBL2, MUSK, MTX1, MTR, CYTB, MTCP1, MSX1, NR3C2, MST1R, MSR1, MOV10, MNDA, MNAT1, MMP7, MMP1, LTB, LRP1, IGFBP2, LRMP, JUND, JUN, JARID2, EIF6, ITGB1, IRF2, ITGA6, IRAK1, INS, IL15RA, IL12B, IL9, CXCR1, IL2RB, IGL, IGHM, IGFBP4, CD82, KCNH1, KIR2DL1, LAMP1, LOX, LLGL1, LIMS1, LIG3, LDHA, LCN2, LAMP2, LAMB3, KIR2DS1, LAG3, AFF3, KRT19, KLRC1, KIR3DL2, KIR2DS5, KIR2DS4, FIM3, FHL2, NEDD8, BMX, CBS, CBR1, CASP10, CASP5, CAMP, CAMLG, CAMK4, SLC25A20, DDR1, CA2, FMNL1, VPS51, C5AR1, C4BPA, BRS3, ZFP36L2, BPHL, CCKBR, CCND2, CCND3, CD79B, CEBPE, CDX4, CDR1, CDK8, CDK5, CDH13, CDC34, CD68, CCNG2, CD58, CD37, TNFSF8, CD86, MS4A3, CD247, CD2, BNIP3, BMP6, CHD1, BMP2, AMH, ALOX15, AKT2, AIC, JAG1, ADRA2B, ADRA1A, PARP4, ADD1, ADCYAP1, ADCY7, ADAM10, ADA, ACVRL1, ACTG1, ACP1, ABR, ANGPT2, ANK1, ANXA7, ATP2A3, PRDM1, BDNF, TNFRSF17, BCL2L2, BAK1, BAG1, ATP7A, ATIC, AOX1, ATF4, SERPINC1, ASS1, ARNTL, APOE, APOBEC1, APCS, RCBTB2, AKR1C4, FGFR2, DOCK2, EPAS1, ENO2, MARK2, EIF5A, EIF4EBP1, EGF, EFNB2, EFNB1, PHC1, EDNRB, EDNRA, DVL2, DVL1, DUSP2, TSC22D3, ARID3A, DPYD, EPHA1, EPHX1, ERBB2, F8, FCGRT, FCGR2B, FCGR2A, FCER1A, FAT1, FASN, FABP4, EZH1, ERBB3, EXT1, ETV5, ETS2, ERN1, ERF, ERCC5, ERCC1, DPP4, DNM2, CHGB, DNA2, CTBP2, CSPG4, CSNK2A2, CSNK2A1, CSHL1, CSF2RB, CSE1L, CRP, CRMP1, CR2, CR1, CNR2, LTB4R, CKB, CHRNA4, CHRM3, CHI3L1, CTF1, CTLA4, CTNND1, DES, DMBT1, DLX4, DLX3, DLD, DLAT, DHODH, DFFB, DEFB1, CTSL, DDIT3, DGKA, DAG1, DACH1, CYP24A1, CYP3A4, CYBA, NDN, NEDD9, GIPC1, RNF217-AS1, THOC5, PIAS1, BLZF1, DGKZ, IKBKG, PARG, PPM1D, SMARCA5, FZD9, FZD4, ARID1A, USP9X, GATD3A, TAM, MIA, COIL, ANC, EIF3A, EIF3D, TNK1, ASAP2, NOL3, SLC5A6, FUBP1, SQSTM1, VNN2, PER2, LDB1, ALKBH1, HRK, KSR1, GGH, NRP2, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF18, RASSF7, LAP, CH25H, CP20, VCP, USP1, UQCRFS1, NR1H2, UNG, UMOD, UGT1A, UFD1, SUMO1, UBE2E2, TYK2, TNFSF4, TTN, TRAF3, TRAF1, TPT1, TP53BP2, VDAC1, VEGFC, VIM, ZFX, PAX8, EVI5, ZYX, ZNF224, ZMYM2, TRIM25, MZF1, YWHAZ, VIP, XRCC4, XPC, WNT7A, NSD2, VWF, VPREB1, VIS1, F2RL3, SPAG9, TNFAIP3, BCL2L11, FST, ARIH2, YAP1, NDC80, KLF2, HMGB1P5, MRVI1, SMYD5, STUB1, ZMPSTE24, MSLN, TNK2, RBM6, TRIM28, TSPAN3, PTPRU, ABCB6, HOXB13, KAT5, ANP32B, KLF1, PLK4, NUDC, NFAT5, USP39, CD226, CTCF, CXCR6, KHDRBS1, GNLY, IGF2BP2, IGF2BP3, POSTN, PDPN, TXNIP, HEXIM1, SH2B2, SMC4, HDAC6, DOK2, SCO2, ADAMTS1, TJP2, LPXN, RAB9A, SLIT2, PDLIM7, UBE2L6, MSC, NOG, PTTG1, DCLK1, IL1RL1, LPAR2, CBFA2T2, INA, FCGR2C, USP10, LITAF, TBPL1, NPEPPS, HDAC4, HNRNPDL, SLC23A2, FCHSD2, SETDB1, GAB2, PCLAF, TOX, SOCS5, BAG3, IKBKE, FEZ1, CLCA2, NCOR2, NCOR1, RIN1, APOBEC3B, TNR, NR2E1, NF2, PLG, PRKAA2, PRKAA1, PPP5C, PPP2R5C, PPIB, PPBP, PPARA, POU4F1, POU3F1, POU2F1, PON2, PON1, POMC, SEPTIN5, PRRX1, PMAIP1, PLN, PRKAB1, PRKCA, PRKCB, PTAFR, PTPRA, PTPN13, PTPN1, PTN, PTGS1, PTGER4, PTCH1, PSEN1, PRKCD, PROS1, PRL, MAP2K5, MAP2K2, MAPK9, MAPK11, PRKDC, PLEK, PLCG2, PVALB, PLCG1, P2RX7, P2RX5, OPRK1, OGG1, OAZ1, NUMA1, ROR2, NT5E, YBX1, NOTCH4, NPY, NME2, NNAT, NHS, NFE2, NFATC3, NFATC2, P2RY1, PAK1, REG3A, SERPINA4, PLAG1, PLA2G1B, PKNOX1, PKD2, PITX2, PIK3R2, PIK3R1, SERPINA1, PAWR, SLC25A3, PGD, PFDN5, PER1, PCM1, PAX6, PAX2, PTX3, RAB27A, TLR3, SMARCA2, SULT2A1, STC1, SSX2, SSTR4, SST, SSRP1, TRIM21, SPARC, SOX12, SOX11, SOX10, SOX2, SOS1, SOD2, SNCA, SIGLEC1, SMPD1, SUV39H1, TACR1, MAP3K7, TERF2, TLE1, TK1, TIE1, THRB, THOP1, TFR2, TFCP2, TMBIM6, TALDO1, TEF, TRGC1, TRG, TRB, TCN2, TCF7L2, TAP1, SMARCD2, SLN, RALA, SLC22A4, RPS6KB1, RPS6KA3, RPS6, RPN1, RPL22, RPL15, RORC, BRD2, RMRP, RHEBP1, RFC1, RBL1, ARID4A, RASGRF1, RARRES1, RARS1, RARB, RRAS, S100A10, S100A11, SHH, SLC19A1, SKP2, SIX1, SIM2, PMEL, SIAH2, SHMT1, SHB, CLEC11A, SH3BP2, SFRP5, SFRP1, SEMG1, SELPLG, SEL1L, CCL18, MIR223HG
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Long Qt Syndrome
Wikipedia
Drug-induced QT prolongation is often a result of treatment by antiarrhythmic drugs such as amiodarone and sotalol , antibiotics such as erythromycin , or antihistamines such as terfenadine . [17] Other drugs which prolong the QT interval include some antipsychotics such as haloperidol and ziprasidone , and the antidepressant citalopram . [27] [16] Lists of medications associated with prolongation of the QT interval such as the CredibleMeds database can be found online. [28] Other causes of acquired LQTS include abnormally low levels of potassium ( hypokalaemia ) or magnesium ( hypomagnesaemia ) within the blood. ... Trends in Cardiovascular Medicine . 28 (7): 453–464. doi : 10.1016/j.tcm.2018.03.003 . ... Trends in Cardiovascular Medicine . 28 (2): 94–99. doi : 10.1016/j.tcm.2017.07.010 . hdl : 10150/627826 .KCNE1, KCNQ1, SCN5A, KCNH2, RYR2, KCNE2, SCN4B, KCNE3, POMC, PTEN, CYP1A1, CACNA1C, CAV3, ANK2, SNTA1, MYBPC3, AKAP9, KCNQ1OT1, DSP, TECRL, SLC2A5, KCNQ1-AS1, SSUH2, KCNJ2, CALM2, HRAS, NOS1AP, KCNA5, KCNA4, KCNK3, CALM1, CALM3, KCND3, SCD, LINC01672, KCND2, KCNQ2, RWS, PICALM, SCN1B, KCNQ4, SNAP91, HCN4, KCNB1, MINK1, PELI1, ACSBG1, TAT, SEC1P, CUZD1, MIR19B1, MIR133A2, KCNE5, MIR133A1, RNF207, CAVIN1, TRDN, LYPD4, ALG10B, TDP2, ABCC8, ALG10, FSD1L, TBX20, ABCC9, FSD1, PRDM6, ACADM, SQLE, HSPA1A, GJB3, GJA5, GAST, FXN, FLNC, DMBT1, CRX, COL4A5, COL4A2, CD59, CAV1, CAD, CACNB3, CACNA1D, AR, HFE, HSPA1B, SLN, HSPA2, SLC18A2, SCN10A, RPGR, PPARD, ADRB1, CNTN3, MYH7, MUC2, ND1, LDLR, KCNQ3, KCNJ11, KCNJ9, KCNJ5, HSPA4, PMP22
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Restless Legs Syndrome
Wikipedia
"Restless legs syndrome and attention-deficit/hyperactivity disorder: A review of the literature" . Sleep . 28 (8): 1007–13. doi : 10.1093/sleep/28.8.1007 . ... Archived from the original on 2015-08-06 . Retrieved 2008-05-28 . ^ Phillips, Barbara A.; Britz, Pat; Hening, Wayne (October 31, 2005). ... "Evidence for further genetic locus heterogeneity and confirmation of RLS-1 in restless legs syndrome". Movement Disorders . 21 (1): 28–33. doi : 10.1002/mds.20627 . PMID 16124010 . ... "Algorithms for the diagnosis and treatment of restless legs syndrome in primary care" . BMC Neurology . 11 : 28. doi : 10.1186/1471-2377-11-28 . PMC 3056753 . ... Archived from the original on 2007-07-28 . Retrieved 2007-07-23 . ^ Lee, Kathryn A.; Zaffke, Mary Ellen; Baratte-Beebe, Kathleen (2001).BTBD9, MEIS1, PTPRD, TF, POMC, DRD3, MAP2K5, SNCA, PRKN, MFN2, LRRK2, PARK7, FTL, HTRA2, VPS13C, DNAJC6, ATXN7, LINC02086, PINK1, UCHL1, RLS1, CASC16, PODXL, MYT1, LINC02520, LINC01478, CCDC148, SKOR1, HMOX1, TOX3, DRD2, VDR, MAOA, RLS3, CHM, FXYD1, TH, CHMP2B, SLC11A2, ATXN1, HAMP, GABRR3, RLS4, RLS6, NTS, ADH1B, HMOX2, CRP, GABRA4, FXN, EEF1A2, DMRT1, KNG1, IL1B, HFE, MPZ, MAOB, NOS1, ATXN3, ZC4H2, MIXL1, REEP1, AVP, PCDHA3, MOCOS, FAT2, GABRR2, NANS, SLC25A37, ATL1, PYCARD, GCH1, FMR1, C3, TRAPPC6B, CAD, TMPRSS6, DRD4, GLO1, C9orf72, DBP, MIR122, LINC00423, MIR330, RLS2, CPT1B, CHKB, RLS5, KCTD18, NPAS2, SPATS2L, MCF2L, NKX2-1, TFRC, IL17A, TRA, AFP, SLC6A3, SLC1A2, L1CAM, ATXN2, LRP2, TSPAN31, REN, LY6E, SMCP, SERPINA1, TNF, TYMS, IGLC2, SCAF11, CNTN3, HNMT, ZEB2, IGHA1, LITAF, SLC9A3R2, APLN, UTRN, RNMT, GEMIN2, ATRN, FGF23, NR4A3, IGKC, TBP
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Zika Fever
Wikipedia
The full range of birth defects caused by infection during pregnancy is not known, but they appear to be common, with large scale abnormalities seen in up to 42% of live births. [24] [25] The most common observed associations have been abnormalities with brain and eye development such as microcephaly and chorioretinal scarring. [26] Less commonly there have been systemic abnormalities such as hydrops fetalis , where there is abnormal accumulation of fluid in the fetus. [27] [28] These abnormalities can lead to intellectual problems, seizures , vision problems , hearing problems , problems feeding and slow development. [29] Whether the stage of pregnancy at which the mother becomes infected affects the risk to the fetus is not well understood, nor is whether other risk factors affect outcomes. [5] [6] [9] One group has estimated the risk of a baby developing microcephaly at about 1% when the mother is infected during the first trimester, with the risk of developing microcephaly becoming uncertain beyond the first trimester. [30] Affected babies might appear normal but actually have brain abnormalities; infection in newborns could also lead to brain damage. [31] Cause [ edit ] Reservoir [ edit ] Zika virus is a mosquito - borne flavivirus closely related to the dengue and yellow fever viruses. ... The women were then tested for Zika using PCR, then the progress of the pregnancies were followed using ultrasound. [24] [152] Guillain–Barré syndrome [ edit ] A high rate of the autoimmune disease Guillain–Barré syndrome (GBS), noted in the French Polynesia outbreak, has also been found in the outbreak that began in Brazil. [137] Laboratory analysis found Zika infections in some patients with GBS in Brazil, El Salvador, Suriname and Venezuela, [153] and the WHO declared on 22 March 2016 that Zika appeared to be "implicated" in GBS infection and that if the pattern was confirmed it would represent a global public health crisis. [154] Research [ edit ] Mechanism [ edit ] Research has been ongoing to better understand how Zika virus causes microcephaly and other neurological disorders. [155] It may involve infection of the primary neural stem cells of the fetal brain, known as neural progenitor cells. [156] [28] The main roles of brain stem cells are to proliferate until the correct number is achieved, and then to produce neurons through the process of neurogenesis . [157] Zika proteins NS4A and NS4B have also been shown to directly suppress neurogenesis. [28] Infection of brain stem cells can cause cell death, which reduces the production of future neurons and leads to a smaller brain. [156] Zika also appears to have an equal tropism for cells of the developing eye, leading to high rates of eye abnormalities as well. [28] In addition to inducing cell death, infection of neural progenitor cells may alter the process of cell proliferation, causing a depletion in the pool of progenitor cells. [158] A large number of cases of microcephaly have been associated with inherited gene mutations, and specifically with mutations that lead to dysfunction of the mitotic spindle . ... Walter Reed Biosystematics Unit. Archived from the original on 28 January 2016 . Retrieved 1 February 2016 . ^ Grard, G; Caron, M; Mombo, I M; Nkoghe, D; Ondo, S M; Jiolle, D; Fontenille, D; Paupy, C; Leroy, E M (2014). ... PMID 27031943 . Archived from the original on 28 March 2016. ^ a b Dupont-Rouzeyrol, Myrielle; Biron, Antoine; O'Connor, Olivia; et al. (2016).ERVK-32, RAF1, IVNS1ABP, PTPN11, ERVK-6, IFNA1, IFNA13, STAT2, IFNAR1, IFNAR2, AXL, IL1B, TNF, DDX58, PLAAT4, ROBO3, RSAD2, IFNL1, KRAS, TP53, IFNB1, HPR, IL6, ALB, IFNL2, NLRP3, STAT1, CD40LG, TAM, TLR3, CD14, CXCL10, STING1, SMPD3, HSPA4, G3BP1, IRF3, HMOX1, ITPA, PERCC1, ERVK-20, GAPDH, IFIH1, FGF2, ERVW-1, ISG15, ZBP1, CH25H, NTPCR, PARP1, WWTR1, PHGDH, KPNA6, CEP131, RASSF1, HAVCR1, TUBB3, RIPK3, IFITM3, HSP90B1, TXN, TYRO3, MOGS, RIPK1, GNE, SART3, B3GAT1, ALDH5A1, PPIP5K1, ARTN, NR1I2, FOXD3, PAF1, AGO2, APOBEC3C, EDC3, MAP1LC3B, TRIM56, MFSD2A, SLFN11, NEURL3, TWIST2, TRIM69, WIPF2, TICAM1, MIR34A, MIR34C, CD24, LINC01672, ERVK-18, ZC3H12A, PARP12, TRPV4, SMOX, C19orf53, F11R, CHCHD2, ISYNA1, PHAX, XRN1, DDIT4, MIB1, TFAP2A, ATG16L1, VAC14, PARD3, MAVS, NUFIP2, TFRC, ADAR, TAC3, EIF4G1, EIF5A, EPHB2, EZH2, F3, FCGR3A, FCGR3B, FMR1, GABPA, GDNF, CXCL2, PDIA3, HLA-E, HNRNPA2B1, HNRNPD, IFI16, IFIT1, IFNGR1, EIF4G2, SARDH, STAT5B, DHX9, AP2A1, AGRP, ATF4, ATM, BCL2, BMP6, CASP1, CASP3, CAT, CD48, CHML, COL11A2, CSF2, CUX1, DCX, DDX3X, DDX6, IFNR, IL1A, IDO1, INSR, PIK3CD, PIK3CG, MAPK1, UPF1, RPE, SAT1, SRL, CCL2, ADM, CCL8, CXCL11, SELP, SOAT1, SOD2, SOX2, STAT3, STAT5A, PIK3CB, PIK3CA, PDB1, MDM2, INSRR, IRF1, LAMP1, LAMC2, LCN2, LTBR, CAPRIN1, CXCL9, PCM1, MAP3K11, MS, MSI1, MSX1, NFE2L2, OAS3, PAX7, CCL5
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Mania
Wikipedia
When the causes are physical, it is called secondary mania . [28] Mechanism [ edit ] Further information: Biology of bipolar disorder The mechanism underlying mania is unknown, but the neurocognitive profile of mania is highly consistent with dysfunction in the right prefrontal cortex, a common finding in neuroimaging studies. [29] [30] Various lines of evidence from post-mortem studies and the putative mechanisms of anti-manic agents point to abnormalities in GSK-3 , [31] dopamine, Protein kinase C and Inositol monophosphatase . [32] Meta analysis of neuroimaging studies demonstrate increased thalamic activity, and bilaterally reduced inferior frontal gyrus activation. [33] Activity in the amygdala and other subcortical structures such as the ventral striatum tend to be increased, although results are inconsistent and likely dependent upon task characteristics such as valence.BDNF, SLC6A4, GSK3B, SHANK3, COMT, AKR1C4, NR3C1, PREP, MMP9, CCK, STAB1, ME2, NCAN, SHANK2, HSPA4, ABCB1, GRK3, SRD5A1, GRIK2, STK4, NDUFV2, NTRK1, TENM4, MTHFR, RIMS1, TAC1, SSBP2, TACR1, TRANK1, ITIH1, NTRK2, NTNG1, PC, PDE4B, SNAP25, SLC5A3, CCL2, SCN2A, S100B, HDAC5, RPS6KA2, PVALB, RELN, SRPK2, POU3F2, ADCY2, POMC, CPLX2, CPLX1, PLEKHO1, SERPINA1, INS, ZCCHC2, ZNF592, CD47, DRD5, DRD1, DNAH8, LMAN2L, TRPM2, TSHB, NTNG2, DIXDC1, FSTL5, CACNA1D, CACNA1C, FADS2, THSD7A, ANK3, BHLHE40, ADD3, STARD9, TRPC3, GAD1, GRIN2A, MRPS33, HTR2A, PACS1, GSK3A, GAD2, SP4, SLC25A13, SLC6A3, IL6, EIF4EBP1, DLX4, NRG1, HSD3B2, JAG1, DISC1, TNF, GATA3, NOS2, NOS1, GRIA1, CRP, CLOCK, NR1H4, KL, NR1D1, ACHE, CAMKK2, ZC4H2, DAOA, ANKK1, PRRT2, DTNBP1, PARP9, BICC1, ATF7IP, TBC1D9, MOCOS, BFAR, FGF21, PER2, CD2AP, SIRT1, TIMELESS, PON1, PER3, EGF, IGFBP2, IGF1, IFNG, HINT1, H1-0, GRM2, GDNF, MTOR, FGF9, CYP19A1, IL1RN, CYP2D6, CEACAM5, CDS1, CD28, CALCA, BPI, ARNTL, AGRP, ADRB2, IGFBP3, MAFD2, KMO, PRKCA, BAS, FXR1, TP53, TLR4, TLR2, TERT, SULT2A1, S100A10, PRKCB, PIK3CG, MAOA, PIK3CD, PIK3CB, PIK3CA, P2RX7, NOTCH1, NGF, NFIX, MMP2, SMCP, C20orf181
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Pancreatic Cancer
Wikipedia
Exceptions to this are the functioning PanNETs, where over-production of various active hormones can give rise to symptoms (which depend on the type of hormone). [28] Bearing in mind that the disease is rarely diagnosed before the age of 40, common symptoms of pancreatic adenocarcinoma occurring before diagnosis include: Pain in the upper abdomen or back, often spreading from around the stomach to the back. ... Outcomes [ edit ] Outcomes in pancreatic cancers according to clinical stage [57] Clinical stage U.S. five-year survival (%) for 1992–1998 diagnoses Exocrine pancreatic cancer Neuroendocrine treated with surgery IA / I 14 61 IB 12 IIA / II 7 52 IIB 5 III 3 41 IV 1 16 Pancreatic adenocarcinoma and the other less common exocrine cancers have a very poor prognosis , as they are normally diagnosed at a late stage when the cancer is already locally advanced or has spread to other parts of the body. [2] Outcomes are much better for PanNETs: Many are benign and completely without clinical symptoms, and even those cases not treatable with surgery have an average five-year survival rate of 16%, [57] although the outlook varies considerably according to the type. [28] For locally advanced and metastatic pancreatic adenocarcinomas, which together represent over 80% of cases, numerous trials comparing chemotherapy regimes have shown increased survival times, but not to more than one year. [2] [79] Overall five-year survival for pancreatic cancer in the US has improved from 2% in cases diagnosed in 1975–1977, and 4% in 1987–1989 diagnoses, to 6% in 2003–2009. [101] In the less than 20% of cases of pancreatic adenocarcinoma with a diagnosis of a localized and small cancerous growth (less than 2 cm in Stage T1), about 20% of Americans survive to five years. [17] About 1500 genes are linked to outcomes in pancreatic adenocarcinoma.BRCA2, TP53, CDKN2A, STK11, KRAS, BRCA1, SMAD4, EP300, PALB2, ABO, NR5A2, MYC, CTNNB1, TNF, MMP2, AKT2, APC, PDX1, PTEN, PTGS2, STAT3, ATM, KDR, CXCL8, TYMS, SST, TNFSF10, TERT, EGFR, TGFB1, HIF1A, MSLN, CD44, SPINK1, MMP9, PPARG, CD24, LDHA, PLAU, SOD2, PALLD, SSTR2, SLC29A1, MAP2K4, DPYD, TGM2, AXL, IL24, IFNA1, PTCH1, EPCAM, NR4A1, TFPI2, CDH1, LINC00673, NRP1, RAP1GAP, MEN1, RB1, VHL, WT1, KLF5, TYMP, PTHLH, GADD45A, FGF13, CCL20, EFEMP1, CFLAR, AHR, TNFRSF10B, SSTR1, FXYD3, TP63, BAP1, FOXP1, ANXA10, DAXX, NFKBIA, TSC2, RNF43, BUB1, VEGFB, MIR1179, SSTR3, IFNA2, RABL3, SUGCT, CNR1, IFNA5, CNR2, ETAA1, CLPTM1, SYCP1, RBBP8, GAGE1, CCAT1, BCL2L1, BCAR1, LY6E, ZNRF3, ATRX, COL18A1, CLPTM1L, DAB2, SBF2, HSPB2, ERBB2, CCKBR, HRAS, HSPB1, HSP90AA1, LINC01829, PPFIBP1, EPHB2, PIK3CA, CCK, HGF, ERBB3, MIA, PDHX, PSCA, SIRT1, HSPB3, H3P10, PIM3, NOTCH1, CEACAM5, EGF, SMUG1, PIK3CB, PARP1, MAPK1, MAPK8, MTCO2P12, GPC1, CDK4, HDAC9, CEACAM3, ABCG2, ACTB, CEACAM7, LINC01088, MAPK3, NDRG1, PSG2, YAP1, PIK3CG, TAFA5, SLC19A1, SPARC, PRSS1, PROM1, PIK3CD, HP, GLI1, MAP2K7, F3, NGF, ZEB1, FBXW7, NFE2L2, TEX11, ITGB1, VEGFA, GABPA, BICD1, ANXA2, CD82, GAST, DCLK1, COX2, CCND1, XIAP, MET, BACH1, S100A4, LGALS1, MDM2, DPP6, MUC16, FOXM1, MIR21, SLC39A4, MIR221, IFNG, EZH2, LINC00964, AKT1, ALB, LDLRAD4, C9, MUC5AC, SETD2, CXCR4, VIM, MUC4, CD274, LEPQTL1, XRCC1, IGF1, MUC1, IGF1R, CXCL12, IL1B, IL6, BCL2, HNF1A, SCT, TWIST1, CCN2, TLR4, DNMT1, AURKA, CAV1, PLK1, CASP3, PKM, MTHFR, LGALS3, MTOR, BRAF, PRKAA1, MIR301A, AGER, HOTAIR, EPHA2, MCL1, VTCN1, COL11A2, RAC1, DUSP6, CDKN2B, CRP, MAPK14, RUNX3, MALAT1, FN1, MIR155, MIR210, ERCC2, DCK, AGR2, CFTR, GDF15, CDKN1A, ADIPOQ, PRKN, MIR200C, TIMP1, KIF20A, PTF1A, PSMD9, TGFBR2, TICAM2, RRM1, MIR137, MIR142, ALOX5, MLH1, MIR29A, SOCS3, IFI27, SRC, GLP1R, PRKAA2, SP1, SOX2, TMED7-TICAM2, HMGA1, SOAT1, H3P23, PAK4, CHEK1, ZNRD2, BMI1, HMGA2, RALBP1, PALD1, TMED7, TLR7, BSG, DCTN6, WNT5A, EPAS1, WEE1, POSTN, BNIP3, MST1, FGFR1, ATN1, MST1R, GSK3B, PRKAB1, CD47, NFATC2, HSPA5, FANCG, PVT1, SHH, MBD1, ETS1, NPTX2, ABCB1, SLC2A1, MUC2, IFNA13, MMP7, MRC1, IGF2, CCN1, NQO1, LUM, MDK, IL10, PTPA, ELAVL2, POU5F1, FLT1, CXCR2, GSTT1, AIMP2, DKK3, MIR23A, KLF10, CRK, MIR214, MUL1, MIR203A, MIR200B, MIR195, APEX1, GRAP2, MIR145, CDKN1B, MIR141, RIPK1, TNFRSF6B, NR1I2, LINC01194, TGFA, THBS1, ALDH1A1, POLDIP2, MICA, NES, HOTTIP, UCA1, POU5F1P4, MIR34A, POU5F1P3, RNF19A, CASP8, CBLL2, CTLA4, AHSA1, RUNX2, ERCC1, OGG1, FANCC, ZG16B, DNER, NTRK1, FGF2, F2RL1, MMP14, FOXO3, CD276, NUPR1, RMC1, MSH2, AFAP1-AS1, DCC, LIF, MIR10B, HDAC1, HDAC2, HMGB1, ACTN4, HMOX1, ADM, ADRB2, IAPP, ICAM1, GDNF, MIR96, MIR25, IL1A, IL2, MIR223, MIR212, MIR205, ANXA1, MIR148A, MMRN1, MIR143, LCN2, MIR132, REG3A, TMEM97, UQCRFS1, STAT1, RET, TGFBI, CDC42, DPP4, CDK2, KLF4, CTNND1, IL32, DSPP, BAG3, CUX1, VDR, TAZ, PIM1, PCNA, SOX9, SEMA5A, XPO1, MAP2K1, SUB1, PRKD1, SPP1, JUN, TOP2A, MLRL, XIST, RAF1, IL4, IL4R, VEGFC, MIR222, MIR216A, NAT2, IL13, MOK, RAD51, TP73, JAK2, MIR23B, MIR29C, IGFBP3, MIR506, SMARCA1, SLC5A5, H3P9, COMMD3-BMI1, SNAI1, HK2, HLA-A, SKP2, SSTR5, FOXA2, SDC1, HSF1, CCL5, MIR27A, MIR494, MIR429, TNC, RRM2, MIR335, MIR17HG, TRA, RREB1, ROCK1, MIR30A, L1CAM, TEAD1, NCOA3, IKZF3, STMN1, BHLHE40, ESRP1, NT5C3A, IL22, PLEC, NXT1, SLC22A3, IL17B, ZEB2, NF2, NFATC1, TSPAN1, CIB1, CACYBP, MRPL28, PDPN, NFKB1, WWTR1, IGF2BP3, BRD4, HPSE, NRAS, NTSR1, COPS5, SERPINE1, PAK1, SIRT3, CDK14, PARPBP, PACC1, MSX2, TP53INP1, SOCS1, LEP, TBC1D9, MIR107, LGALS4, DUSP28, MTA1, PRKCA, UPRT, TM4SF1, LPAR2, SMAD2, MAGT1, MUC13, REG4, VMP1, LONP1, EHMT1, MMP1, FTO, TRPM8, GAS5, NDRG2, KEAP1, ACKR3, SLC12A9, ADAM9, NAT1, CDK6, GEM, GCG, CALR, CDKN3, FGFR2, ADH1C, CCR6, GLS, FHIT, CSF2, FOS, ALDH2, ACVR1B, FKBP5, FOXO1, ALPP, ALPI, GATA6, CETN1, ASS1, TIMM8A, CLDN7, F2R, TSACC, GPRC5A, ADH1B, HULC, FOSB, CASR, PCLAF, SMARCA4, DECR1, CDX2, CDK5, EPHX2, RCBTB1, FSCN1, SOX4, FLT3, MIR663A, LGALS9, UGT1A7, MIR217, CEL, CYP17A1, CLDN1, TRPM7, ISG15, CLOCK, MIR345, SET, CDK7, MIR200A, MIR216B, JUNB, JUND, ADAMTS1, KL, ITGAM, SERPINF1, SFTPD, SHC1, SELE, ITGA2, HDAC3, ARNTL, PBK, TUG1, SLC16A1, PDGFRB, DCN, RGN, KISS1, CHI3L1, SREBF1, IQGAP1, BSND, FGF7, ZNF35, VASH2, YY1, ESR1, AGT, PEAK1, TFF1, TFRC, NOTCH3, EZR, COX8A, FBP1, CLDN4, HAVCR2, VAV1, CRYZ, FASN, TIMP2, MUC6, TSPAN8, MYB, MIR196B, TXN, MIR330, ATF2, MIR31, IL33, AGTR1, VSIR, CES2, LOXL2, TNFRSF10C, PGK1, SSTR4, ABCC3, PEBP1, CEMIP, CLIC1, EGLN3, ADRA1A, PRDM14, HHIP, SLC52A2, MIR29B1, CDCP1, ADRA2B, MIR29B2, TAM, KLK7, MAP3K1, CCR7, ALCAM, MAP3K7, MGMT, MIF, CXCL10, EDNRA, NEK2, RASA1, TPX2, NEAT1, EEF1B2P2, PRMT1, GJB2, KDM1A, APLP2, CXCR6, RBM14-RBM4, MIR146A, GJA1, KANK2, NOX4, REG1A, USP22, MIR150, CA9, HTC2, MAP2K2, CD40, GGT1, GPR42, DKK1, MIR15B, E2F1, PDCD4, FAS, AREG, HHLA2, GOLGA6A, HPGDS, BHLHE22, HNRNPA2B1, MCAT, GOT1, SLCO1B3, RGCC, EIF4E, LILRB1, MIR106B, NRG1, PTK2, PHGDH, PWAR1, CCKAR, ARF6, GSTP1, MSH6, MARK2, EBI3, IGFBP1, S100A8, CDK1, S100A9, RBPJ, S100A11, CAT, GATA4, MIR191, SATB1, CDA, MIR1247, ENO1, CBX7, DNM1L, ABCC5, SERPINA1, SCO2, ARL2BP, BRS3, CHST15, CHEK2, GRP, AKR1A1, GSTM1, PLG, ECT2, PRNP, RPL10, SDF4, MIR17, RBM14, MIRLET7B, PLAC8, ADH1A, TRIM29, THY1, NAF1, C17orf97, ASPH, PTPN1, TCF7L2, TWF1, TPD52, PTPN11, TP53BP1, LPAR1, MTDH, TK1, LMLN, TLR1, TNS4, TGFBR1, TFF3, CRY2, CRMP1, AR, FAM83A, PTK6, PTBP1, TFAP2A, E2F3, KISS1R, TGFB2, MAK16, TIAM1, CCL21, TBX2, IDO2, CYP24A1, RFXAP, CASC2, ROBO1, DNM2, ROS1, SMARCA2, RBM45, RPS6KA2, RPS6KB1, RPS27A, ABHD11-AS1, S100A2, RELA, SIX1, TRIM69, SFRP4, ARHGAP4, LDLRAD3, SEL1L, SARDH, RMDN2, CCL2, PDIK1L, TICAM1, CCL18, DNMT3A, LRG1, TAT, DLX6-AS1, TACR1, PTPN14, TAC1, PTPRC, SOX2-OT, RAB5A, SYT1, STING1, GADL1, PRRT2, CDCA5, DUSP1, STK4, CYP2B6, STAT5B, SNHG15, CYP1A1, DPYSL3, DNMT3B, CYP1A2, CYP1B1, OSBPL5, SSAV1, RECQL, SRY, SRF, AZIN2, BHLHE23, TPM3, CD68, IL23A, PRMT3, PSME3, ABCC4, B3GALT5, GOLM1, TUBB3, ING4, PRMT5, WASF2, VAV3, RMDN1, SEMA4D, DESI2, ATG7, ANP32B, CD40LG, FOXP3, GDE1, ZFR, SLIT2, DLL4, MEG3, COX5A, RMDN3, CDH17, HEATR1, SLC52A1, CDH3, PAF1, IQSEC1, NAMPT, MFN2, KRT20, TLR9, BCL2L11, PTPRU, CDC25B, WWOX, CDC20, ASAP1, TXNIP, BTK, PRPF31, KLF8, DDR1, CTRC, BBC3, CILK1, MYOF, ZHX2, NOC2L, SMG1, CD36, SULF1, CASP9, TFIP11, SLC7A8, ANGPTL2, SNHG1, SRRM2, DAPK2, RASSF1, MAP4K1, FSTL1, SRPX2, DELEC1, CELF2, CTCF, CD86, ERO1A, SLC39A3, AP4B1, EEF2K, GIPC1, CD80, UHRF1, TBK1, MCTS1, CD14, SGSM3, RBMS3, WDR5, CDK8, CDK9, TPT1, COL4A2, COL11A1, WNT10B, DHDDS, XPC, XRCC3, XRCC4, BAX, ZFP36, COL1A2, ULBP2, LIN28A, MANF, MCPH1, TUSC3, TCTN1, BHLHE41, CMM, FOSL1, LAT2, VIP, SYBU, UBC, NR2C2, TRAF2, TRAF6, TMPRSS13, CPOX, TTK, ITCH, TYRO3, NUF2, BAG1, ARHGAP24, ATR, AVP, CLDN3, UTRN, KDM6A, UVRAG, VCL, USP5, LTB4R, WNK1, HAP1, KSR1, CDK5R1, PER3, PER2, PNO1, SQSTM1, BNC1, DIABLO, METTL3, USP9X, TM4SF5, ARTN, AIP, DMAP1, SLC16A4, SLC16A3, DYRK1B, BUB3, CES1, CCN5, CFL1, CHPT1, CMA1, GORASP1, ROBO3, CUL4B, IL21, CIP2A, DENR, CLU, DANCR, TP73-AS1, SMURF1, TNFSF13, AKR1B10, CEACAM1, TNFRSF10D, TNFRSF10A, IL18R1, CCR5, PADI4, MIR629, LINC01672, HSPD1, PAWR, HSPG2, PARN, ITGAV, C20orf181, MME, EPS8, ERBB4, FGF10, ITGA3, GFRA2, PRDX1, SNHG16, MIR451A, PAEP, AKR1B1, MMP11, ALDOA, P2RX7, P2RX5, ALDH1B1, GRK2, MIR296, OLR1, MNAT1, MAP3K10, ITGB2, NTS, MIR204, EPHB4, PFN1, MIR483, KCNJ11, KCNH2, MIR509-1, PER1, PDPK1, MIR497, HOXB7, MIR193B, MIR885, MIR373, HSPA4, ITK, HOXD13, GLI3, PDK1, FGFR4, MICOS10-NBL1, PDCD1, ANGPT1, MITF, TMX2-CTNND1, HSPA2, ANG, IFIT3, ROR2, PHB, TMEM238L, FBN2, MIR1231, IL6ST, IL17A, TNFRSF9, MIR135B, GAPDH, MIR1246, IL9, MTRR, FAT1, MIR148B, FAP, MIR424, MIR375, IL12A, CISD2, NEDD9, IL15, NEDD4, NCL, NBN, NBL1, MUTYH, IL13RA2, MIR374A, MTAP, IL2RA, ADAM8, NPY, NTRK2, NTF3, IRF2, FDPS, MIR1290, FCN2, FBL, GCHFR, PNP, IGF2R, ILK, MSMB, ESRRB, NGFR, NOS2, MIR1291, MSN, MIR1181, FCGR3B, MIR99B, AFP, IL18, NME1, MIR1271, FCGR3A, IKBKB, MIR744, MAP3K5, PRRX1, ELAVL1, POTEF, PPIA, GGT2, APOA2, FOXL1, EIF4EBP1, LASP1, RPSA, CCR2, EIF5A, CXCR3, FOXC1, GGTLC4P, MIR144, BIRC5, PODXL, HFE, UPK3B, HIC1, SNHG14, CDKN2B-AS1, PMS1, SMAD7, MIR15A, MR1, MIR139, LDHB, LTB, GSN, RELN, GRB7, PRSS2, AQP3, EEF1A2, MUC5B, CXCL1, GSK3A, FADS1, MIR601, MIR10A, PRKCB, MIR130B, MIR122, ANXA8L1, PRKAR1A, MIR126, GGTLC3, LRP2, GGTLC5P, ANXA8, EIF4A1, FOLR1, LTA, MAGEA3, CEACAM6, KCNN4, MCC, HNF4G, PCAT1, MCAM, GLO1, HNRNPK, KCNQ1, ENG, MIR196A1, MIR192, MIR185, PLAUR, SLC25A3, PLAT, MAP1A, LINC-ROR, MIR455, FKBP4, MIR181C, MIR183, MIR486-1, FOXA1, BMP8B, PIMREG, MTPAP, ZNF654, RHOF, NLRP2, CCL28, LTB4R2, MRGBP, PRPF40A, MIR874, ERO1B, MIR940, EIF5A2, STYK1, MIR646, MIR92B, IL17RB, LXN, MAML3, FERMT1, SMARCAD1, RIPK4, MIR652, TRPV6, ETNK1, TREM1, TERF2IP, KCMF1, SPHK2, BMP3, CHD7, ANLN, GPR137, MIR374B, MIR935, RETN, STK31, BNIP3L, GACAT2, ADPGK-AS1, OGDHL, CEP55, SNHG9, SARS2, CNDP2, OCIAD1, AGAP2-AS1, INTS11, MIR675, NKRF, ZGLP1, MSTO1, SLC35F6, LINC00462, MIR891B, MIR365A, BOK, PSENEN, ANO1, PIWIL2, KDM3A, PRR11, EXOC2, MIR876, CDKAL1, SULF2, SOX6, NSUN5, MIR1225, SLC38A7, BMP2, DIP, PARP14, KDM7A-DT, UGT1A1, MIR760, UGT1A3, PBRM1, ASPN, LOC729970, BPHL, CC2D1A, RADIL, ST7L, ALKBH5, HHAT, SLC25A36, SYCE1L, DST, MYDGF, MED29, KPNA7, PCBP3, GLS2, ERVK-11, MYB-AS1, LSM1, BANCR, LINC01111, HCAR1, GHET1, CA2, AGO2, SERPING1, LOC102723407, GATD3B, DKK4, SIK1B, CDR1-AS, CAD, CALCR, ANKRD1, SPINK4, MIR5100, UBE2S, RABGEF1, ATAD2, HIPK2, MACROD1, NOB1, ERVK-22, MIR2682, MIR4656, LAMTOR2, REM1, DLL1, SPRY4-IT1, SLCO3A1, SLCO4A1, HTRA2, DESI1, PSC, C3, DNAI1, USP21, SNORA74A, LETMD1, LOC112694756, MOB4, ZEBTR, PRPF40B, LNCRNA-ATB, EML2, CADM1, RAB38, SH3BP4, TMEFF2, ACADS, H3P13, H3P8, ABCA4, FAM215A, DDX58, SERPINA3, USP49, CASP7, IRAIN, LOC110806263, EHF, PERCC1, FGF21, PTPN22, CERNA3, KCNK15-AS1, LINC00976, CAPN1, NUTF2P3, CHD5, SIRT1-AS, ACO1, NECTIN3, CAST, CLIC4, MYRIP, TMEM158, C1GALT1C1, LINC00339, DUOX1, ADAM10, PRKAG2, CRLF3, ZMYND10, MIR1301, MIR1180, MIR634, TLR8, BTC, KLF9, C1QBP, CLDN18, CKLF, ZEB2-AS1, HSPA14, LEF1, MIR663B, MIR4306, ACVR2A, YTHDF2, SIRT6, RAB14, NT5DC3, GPR87, LOXL1-AS1, MBD3, IL17D, LINC00994, BCL11A, ADA2, MAP3K20, CDK12, CMPK1, CAB39, RAB23, SF3B6, MIR1297, PIAS4, MIR1243, MIR1266, MIR3686, A4GNT, INSIG2, IL20, DUOX2, ERVW-1, ACTA2, VSX1, KLRC4-KLRK1, ACP3, UBQLN1, BUB1B, ERVK-2, STRN4, NPC1L1, MIR3064, TSPO, BRD7, MYLIP, ERVK-12, PYCARD, ACVR1, IL21R, IRAK4, PXN-AS1, ANGPTL4, MIR642B, MIR3923, APIP, GMNN, MIR3679, ISOC1, LINC01133, BTF3, ASCC1, SMIM31, TRAT1, LINC00958, F11R, TAS2R10, LINC01006, ARHGEF4, SLC25A37, DIO3OS, EMSY, PROKR2, CD109, ADAT2, GPR151, SLCO6A1, EMB, REG3G, ANPEP, MIR208A, ANGPT2, FATE1, MIR211, TMIGD2, SPNS2, MSI2, ARR3, JDP2, SPPL3, H4-16, CCDC26, MUC17, GATA5, ANXA5, LINC00052, MIR198, MIR199A1, PTGR2, PRIMA1, FBXL14, MIR199A2, MIR19A, MIR19B1, SYT9, MIR20A, CACUL1, ANXA11, ANXA6, TMEM37, BRI3BP, SLC32A1, CYP2R1, TMEM45B, PRAP1, MAL2, MCM3AP-AS1, ALDH1A3, IL17F, MIR28, EGLN2, AGTR2, PPP1R14A, MIR302A, ART1, FOXQ1, ASAH1, DMKN, ASNS, MIR30C1, MARVELD3, LRP5L, MIR30C2, NLRP3, MIR155HG, ALPG, MIR224, MIR215, TWIST2, MRGPRX4, MRGPRX3, DCD, ANIB1, TM4SF18, CMTM5, CTHRC1, MIR219A1, NOSTRIN, MIR22, UHRF2, ALOX15, FBXO32, ALK, CSMD2, MIR197, SIK1, APAF1, MIR127, MCIDAS, MIR129-2, RSPO2, KLK3, ANO9, APRT, CHSY3, TRIM59, APOC1, ARG1, LYPD5, LINC00346, LINC01559, OR10A4, BCL9L, APOA1, SLC25A45, MACC1, PWAR4, SBF2-AS1, DNAAF3, CCSER1, PAIP2B, LINC01121, C16orf74, HRNR, MIRLET7C, SERPINA13P, CEP85L, MIRLET7D, LINC-PINT, MIR100, MIR106A, FASLG, ENTPD8, GSTK1, TMPRSS9, MIR125A, H19, ASPM, MIR193A, MUC20, ARID2, B3GNT6, MIR182, ADAMTS18, OIT3, BHLHA15, OXER1, IFNLR1, SLFN5, EML5, CLEC14A, MIR186, SLC5A8, RHOB, FEZF1-AS1, NKAIN2, DAB2IP, MIR181A2, CENPX, MRGPRX1, MED19, MIR149, SGMS1, NPCA1, FAM133B, ARG2, MIR152, RICTOR, IL27, SEMA3D, BIRC2, GPRC6A, FOXK1, KDM1B, MIR18A, ALKBH3, MARCHF8, VWCE, LINC00473, MIR32, SMYD2, SMURF2, NIBAN2, YTHDC2, PORCN, IL25, DEPTOR, ILRUN, S100PBP, SMYD3, TMPRSS3, PNPT1, HIF3A, COP1, RHBDF1, MMS19, LINC01060, BGLAP, MIIP, SAV1, MIR520H, PINK1, MIR519D, MIR181D, BCL6, DHX40, DYNC2H1, TMEM204, MIR489, MIR146B, BCR, MIR202, PLEKHF1, MIR492, BDNF, MIR493, CFB, GGCT, STK33, ADRB3, CDK15, AFAP1, LGR6, ACE2, SLURP1, ADH4, PNPLA2, CXADRP1, CIAPIN1, ADAMTS9, PRDM1, H3P38, MIR539, SNORA25, MIR421, MIR584, KIF15, OTUD7B, MIR607, MIR608, MIR613, MIR623, CD248, NORAD, IL22RA1, ADH6, SNX6, SINHCAF, HAMP, ANKRD36B, KLHL1, MRTFA, CFAP97, PCDH10, CERNA2, CRNDE, MIB1, RPTOR, ARID1B, PPM1H, BGN, AICDA, PARP4, MIR485, MIR410, BCKDHB, VN1R17P, EBPL, GPR166P, FOXB2, XRCC6P5, ZGPAT, NT5C1A, MCHR2, HOPX, MCM8, RAB11FIP4, PROK1, RPAIN, MIR331, AP2A1, MIR340, USP44, MIR367, TRIM63, KDM2B, MIR370, MIAT, TSLP, NKD1, MIR320A, MIR34B, SNHG7, MIR93, JAG1, RAB2B, ATAD1, PARP10, MIR99A, RIOX2, KMT5C, PSRC1, CRISP1, ASTL, HINT2, MYCBPAP, ATF3, SH3D21, PPP1R2C, GRHL2, DUXAP8, JADE1, DUXAP10, NANOG, UBA5, NBDY, MFSD13A, KDM8, MIR448, MIR449A, H4C15, MIR431, MMRN2, MYH14, BCHE, MIR452, NAA25, CEP70, MIR371A, MIR425, RERE, IMMP2L, HASPIN, SUMO1P3, SESN2, VANGL1, NETO2, MIR377, MIR381, MIR384, NECTIN4, AZGP1, ZFP91, ITIH5, SLC44A4, SRCIN1, BAK1, GPX2, HS3ST3B1, LPAR3, PLOD2, EFNB2, PKN1, EGR1, PRKAR2A, PRKACG, EGR3, EIF4A2, PRELP, PPP5C, PPP1R1A, PPID, PPIB, MED1, PPARA, PON2, PON1, POLE, POLD1, PNMT, PNLIP, PMS2, PMS2P3, PMAIP1, PRKCZ, PRKDC, EFNA2, PTAFR, PTPRJ, PTPRG, PTPRA, PTPN13, QSOX1, PTN, E2F2, PTGS1, PTH, PTGER4, PSMD10, EEF1G, PYY, PRTN3, KLK10, HTRA1, KLK6, PRSS3, EDNRB, PROX1, EEF1A1, MAPK9, PLXNA1, CELA1, DYRK1A, PLEK, CDK16, PCBP1, PCBD1, PBX3, PAX6, PAX5, PAK3, PAK2, EREG, SERPINB2, ERCC4, PAFAH1B2, PCSK6, P2RY6, P2RY2, OSM, OSBP, ORM1, OPRM1, OPRD1, TNFRSF11B, ERCC5, ODC1, PCYT1A, PDE8A, PDGFA, PIGR, ELK3, PLCB3, EMD, PLA2G4A, PKLR, PKD1, PIN1, EPHA1, EPHA4, EPHB1, EPHB3, PDGFB, PGR, PFKP, PFKM, PFKFB4, PFDN5, PEG3, PECAM1, PDZK1, ENPP1, PDK4, PVR, RGL2, PSD4, SAFB, SLC1A2, DCX, SKIL, SKI, SIM2, ST3GAL4, ST6GAL1, DDB2, SFRP1, DDT, SELP, CX3CL1, XCL1, CXCL5, DLD, CCL8, CCL7, DMD, SRL, SCTR, SCN10A, SCN9A, SARS1, ACE, SLC5A1, DCTD, DAG1, SPP2, CYP2C19, SPG7, CYP3A4, SOX12, SOX15, CYP51A1, SOS1, SOD3, DACH1, SNCG, SLC6A8, DAP, SMO, SMN2, SMN1, SMARCC1, DAPK1, SLPI, DAPK3, SLC9A1, SLC8A1, SAI1, S100B, RAB27A, S100A10, RGS16, TRIM27, REST, REN, RDX, RBP4, RBP1, RBM3, KDM5A, DPEP1, RASGRF1, PLAAT4, RARB, RAP1B, RAP1A, RALA, RAG2, DRD2, HBEGF, RAD17, DVL2, RABIF, RAB27B, RNASE1, RNASE3, RNASEL, RPS8, S100A7, S100A6, DNA2, SORT1, S100A1, RXRA, DNAH5, DNASE1, DYNC1H1, RPS15A, RPS6KA3, RNF2, RPS6KA1, RPL39, RPL34, RPL29, RPL26, RPE65, RORB, RORA, SNORA73A, BRD2, ERG, NTRK3, ERN1, IARS1, GAS6, GATA1, GATA2, GATA3, IGSF1, GC, IGFBP7, IGFBP2, GCK, GCKR, GCNT1, IFNB1, IFNAR1, IFNA17, GCY, GDF2, GDF10, IFN1@, GFPT1, IDH1, ID2, IRF8, ICAM2, CXCR1, GALNT3, GAD2, ITGB4, KRT8, FRZB, FUS, KCNK2, FUT3, FUT4, GABBR1, JAK1, JAG2, EIF6, GABRA3, GAD1, ITGA5, ITGA1, ISG20, IRS1, IRF1, ITGA6, GABRP, INSR, INPP4A, IDO1, GFRA1, HYAL1, NT5E, HTR1D, HLA-DRB1, HLA-DOA, HLA-C, HLA-B, GOT2, GP2, HGFAC, GPI, HDGF, HCRTR1, HCRT, H2AX, H1-5, H1-4, GUSB, GUCY2C, GPT, GSTM3, GPX1, GRM1, GRIA3, GRB10, GRB2, GNRHR, HMGB2, HMGCR, HPD, HTR1B, HSPE1, GHR, GHRH, HSPA9, GJB1, HES1, AGFG1, GPC3, HPGD, HOXB9, GLUL, HOXB8, HOXB6, HOXB2, HOXA1, HNRNPU, HNRNPC, ONECUT1, HNF4A, GLUD1, HMMR, KRT17, KRT18, KRT19, FPR2, NEDD8, MYH9, MYD88, FANCD2, MMUT, TRIM37, PTK2B, MTR, ND2, FBLN2, MT1M, MRE11, MPST, MPO, MPL, MMP16, MMP15, GPC4, MMP13, MMP12, FER, MMP3, GPC5, NELL1, NEO1, NEU2, NQO2, YBX1, NRTN, NPY2R, NPM1, NPC1, CCN3, NOTCH2, NOS1, NOP2, NNMT, NM, NEUROD1, NHS, ETV4, NFYA, ETV5, EWSR1, EYA2, NFE2, F9, F10, NEUROG1, KMT2A, MAP3K9, MKI67, FLNA, LMO2, LMNB1, LLGL1, LIPE, LIMS1, LIMK2, LIMK1, LIG4, LIG3, LIFR, FLNB, LPA, LGALS3BP, FOLH1, LFNG, LEPR, FOLR2, LBR, LAMC2, LAMP1, LAMB3, LAG3, LOX, LRP1, MICB, VEGFD, MFAP1, FH, MAP3K4, MAP3K3, MEF2D, MEF2A, MECP2, ME2, FHL2, MDH1, MATK, LRP6, MAT1A, MAP2, SMAD6, SMAD3, SMAD1, FOXD1, TACSTD2, FLI1, BCAM, LTA4H, SPOCK1, CYP2B7P, SREBF2, MVP, GDF11, TRIM13, RBM5, RBM6, TRIM28, G3BP1, ARFRP1, FRY, LRPPRC, RAD50, PPIF, ACTR2, ARPC4, EDIL3, IL18BP, ABCB6, GNE, HDAC6, AKT3, HNRNPDL, NUP153, NR1H4, NR1I3, TRIB1, CNKSR1, SF3B4, CD74, DDX17, CD63, SEMA3C, CARM1, CAP1, MERTK, TACC3, GPNMB, BASP1, RACK1, DLC1, CDK2AP2, IRF9, TUBA1B, MICU1, KLF2, WARS2, TLR6, TNIP1, RTN3, SF3A1, STUB1, MED12, USP15, MSC, GPX4, LITAF, MAGED1, ROCK2, ATG5, RASAL2, MAP4K4, AIM2, GSTO1, QKI, NTN1, RECQL5, CD101, KIF3B, SLC9A3R1, SLC9A3R2, CD163, SOCS6, SNORD22, ADGRG1, BCL7B, PIWIL1, MAPKAPK2, AIMP1, SCAMP1, BAG5, CDH13, SDC3, DLEC1, KIF14, NUAK1, TLK1, CDC25C, MTSS1, SETD1A, USP34, CDH5, DCAF1, MDC1, PTGES, SOCS5, TTLL4, WTAP, PRDX6, APOBEC3B, SPAG6, CDH11, CHD1L, CXCL14, EI24, NEBL, CD59, ARPC1A, HTATIP2, KLRK1, ARHGEF15, MLXIP, FASTKD2, NLRP1, VASH1, CCNA2, ITGA11, CBX3, TUSC2, PDAP1, PHB2, GPR182, SLCO2B1, KLF12, FILIP1L, SLC6A14, GALNT5, CCNB1, WIF1, MAP4K5, RPP14, ADAMTS8, KIFAP3, SIRT2, STK38L, NCAPH, ZNF281, PES1, ICMT, CELA3B, GPR161, TPSD1, CAV2, RUNX1, SIRT4, DICER1, NCSTN, CBR1, SATB2, SIN3B, BICD2, MPRIP, CBL, KDM6B, PEG10, KDM4C, PDS5B, TNIK, RER1, TRIM31, TOPBP1, KHDRBS1, PLK2, KDM5B, RBBP9, PLK4, NFAT5, POLQ, USP39, CCT8, DLL3, TNFSF13B, SPINT2, WASF3, SCGB1D2, IGF2BP2, CD34, IGF2BP1, ENTPD1, PDLIM5, SLCO1B1, ENTPD2, SMC2, OLFM4, SEPTIN9, FRS2, UBE2C, STIP1, OGFR, RIPK3, DSTN, RAB31, CCND2, CCND3, KCNQ1OT1, COPS6, FERMT2, CKAP4, CCNG1, CD28, EHMT2, PAPOLA, GADD45G, BRD8, MALT1, PPARGC1A, MRPS30, NMU, ME3, ADAM28, GCNT3, CDKN1C, SRPK2, TNFAIP1, COMP, COMT, SLC31A1, CPE, NR1H2, UCK2, UGT1A, UGP2, UCHL3, UCHL1, UBE2N, CPN1, TULP3, TUFT1, TTR, TRH, HSP90B1, TPO, TPD52L2, CREBBP, CREM, TOP1, TNFRSF1B, BEST1, TRPV1, VTN, XRCC2, NELFE, DEK, SCLC1, PAX8, BTG2, ZNF154, ZBTB16, CNBP, ZFX, YES1, COL5A2, WARS1, COL6A1, XPA, XK, COL6A2, COL6A3, WNT7B, WNT2, WNT1, COL17A1, WAS, TNFRSF1A, CRKL, PTTG1, CLDN5, CTPS1, HNF1B, CTRL, TBX3, TCEA3, TCEA2, TCEA1, CTSB, TAGLN, ADAM17, CTSD, SULT1A1, CTSE, CTSH, STIM1, CX3CR1, STAT2, CXADR, ST13, CYP2A6, CYP2A13, SSR2, TRIM21, CST1, PPP1R11, TDG, CS, TMSB4X, TMPRSS2, TM7SF2, TLR3, TLR2, TLE1, CRY1, THBS2, THBD, THAS, TGIF1, PRDX2, CSF1R, TGFB1I1, CSF3, CSN2, TFF2, TFCP2, TF, CSNK2A2, TERC, VCAN, TFEB, COL1A1, CNC2, ABCC2, SPHK1, ARHGEF7, IER3, ASAP2, DLEU2, CCN6, NRP2, INPP4B, CHGA, RAB11A, CHKA, ADAM15, CHRM3, CHRNA7, TNK1, BECN1, EIF3F, IRS2, DYNLL1, CLCA1, NUMB, PTCH2, RUVBL1, FUBP1, NAE1, MBD2, ATP6V0D1, MTA2, AURKB, CDKN2D, ARHGEF2, SCAF11, TMSB10, EBAG9, EXO1, ATG12, CCNE2, CDO1, WASF1, DIRAS3, CLDN8, CDX1, BRSK2, CLIC3, MAP3K14, F2RL3, CEBPB, P4HA2, CDK5R2, NOP14, AKR7A2, MADD, UBL4A, H4C11, H4C12, H4C6, H4C4, H4C1, FZD6, FZD4, CDC7, H4C9, ARID1A, GATD3A, H4C8, SLC7A5, ANP32A, GPR68, YEATS4, KMT2D, MFAP5, RASSF7, ADAM12, SLC25A16, CUBN, H4C3, H4C2, LMO4, TTF2, HAT1, PARG, PIK3R3, PPFIA4, CLTC, GEMIN2, SEMA7A, OGT, SORBS2, KLF11, DOC2A, H4C5, RAD54L, STK24, TAGLN2, SPARCL1, PIP4K2B, PIP5K1B, PIP5K1A, NME5, H4C14, H4C13, H3P40
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Mood Disorder
Wikipedia
Diagnosis of RBD requires that the episodes occur over the span of at least one year and, in female patients, independently of the menstrual cycle . [26] People with clinical depression can develop RBD, and vice versa, and both illnesses have similar risks. [27] [ clarification needed ] Minor depressive disorder , or simply minor depression, which refers to a depression that does not meet full criteria for major depression but in which at least two symptoms are present for two weeks. [28] Bipolar disorders [ edit ] Bipolar disorder (BD) (also called "manic depression" or "manic-depressive disorder"), an unstable emotional condition characterized by cycles of abnormal, persistent high mood ( mania ) and low mood ( depression ), [29] which was formerly known as "manic depression" (and in some cases rapid cycling, mixed states, and psychotic symptoms). [30] Subtypes include: Bipolar I is distinguished by the presence or history of one or more manic episodes or mixed episodes with or without major depressive episodes.SLC6A4, NR3C1, POLG, ADCY8, DRD2, NCAM1, CREB1, COMT, BDNF, HTR2A, CRH, CLOCK, DISC1, MAOA, TH, HTR1A, FKBP5, P2RX7, DRD4, TPH1, CACNA1C, TPH2, WFS1, NPY, GSK3B, TNF, TAC1, CRHR1, HTR2C, NTRK2, GPR50, ESR1, OPRK1, PRL, DBH, ABO, HP, GABRA1, SLC6A3, SIRT2, MTHFR, DLG4, GRIN2A, DTNBP1, PDYN, AKT1, DRD3, PROKR2, MCHR1, HTR5A, AVPR1B, GNB3, ZNF804A, FGF2, DAOA, S100B, RELN, MAOB, FMR1, GAL, HCRTR1, NTF3, DLG3, IMPA2, GRM3, GRM2, GAD1, GRIK2, MAP2, GAD2, PROK2, HTR3A, FAAH, IL1RN, DISC2, HTR6, CYP2D6, TACR1, SLC6A2, ARNTL, SMS, CRHBP, PLA2G1B, TIMELESS, SERPINA1, ATP2A2, CRHR2, AR, GABRB2, GABRA6, GABRA5, CRTC1, SLC12A5, MAGEL2, SIGMAR1, RARA, VPS13A, ADRA2A, VIP, GABRD, SIRT1, VGF, SAT1, FEV, ANK3, HTR4, SLC1A2, TSNAX, VEGFA, TSNAX-DISC1, SLC5A7, HES6, GPRC5D, HPGDS, ADRB1, GCH1, ARRB2, TSPAN8, IL9R, SPR, FZD3, HCN4, CRYZ, TBX1, NTSR1, DAO, HIF1A, TGFB1, NTRK3, TGOLN2, NQO1, PAWR, NPY2R, HSPA4, DNMT1, DNMT3B, EDN1, PNOC, HTR1B, ADORA2A, ADCY7, MYO5B, PFKL, SST, RNPS1, CHRM2, CHRM3, ABCG1, FTO, SSTR3, SERTAD1, HSP90AA1, OXT, HTR7, NFKB1, TBC1D25, NTS, HDAC4, RGS6, TNFSF13B, PFKFB3, ERDA1, BSCL2, KAT2B, PMCH, PPARG, PRNP, LDHA, S100A10, KCNK9, PTGS2, HDAC2, SMOX, GAP43, FOSB, DUSP6, GLUL, DCTN1, CACNA1D, AMBP, HDAC1, ADRA2C, ADRA1B, ADCY3, HTT, KCTD12, HCN1, LINC02210-CRHR1, ERBB4, PDE4B, NEGR1, DCLK2, LINC01618, CDH8, MAD1L1, DPY19L3, PHF2, AREL1, EGFLAM, KLHL29, PAFAH1B1, CSE1L, RABGAP1L, SPSB4, NR1H3, CSTF3, NAV3, DAG1, BAIAP2, DGKG, KLHDC8B, WNT3, SSPN, SLC44A5, TCF4, LINC02040, GNG12-AS1, NCAM1-AS1, C6orf99, APBB2, UBA7, MAPT-AS1, RERE, LINC00461, SMIM4, RAPSN, RAB27B, C5orf17, PTPRD, PTH2R, VWC2L, VRK2, LINC01122, FAM228B, EYS, KANSL1, MYO1H, DCC, CREB3L1, ATAD2B, MAPT, EXD2, C11orf49, TNC, SOX6, PPP4R3A, NCOA5, ARHGAP15, YLPM1, CELF4, SORCS3, ZHX3, LMOD1, FSTL4, PLCL2, DPP10, KAZN, BBX, CAMTA1, NUP160, GPM6A, PBRM1, FYB1, TTC12, DDB2, LINGO1, ATP5MD, DELEC1, ARPP21, ARFGAP2, BICRA, KIAA1109, PRR16, NLK, TFAP2D, EMCN, CSNK1G1, IGLV10-54, BHLHE41, TMEM106B, ADAMTS6, BAZ1A, RBFOX1, GABBR1, PON1, ACE, IL6, PER3, CRP, IL1B, IGFBP2, LOC110806262, STIN2-VNTR, EPO, IL10, REM1, NR3C2, APOE, C1QL1, KL, TMED2, TPO, TPPP, P2RX5-TAX1BP3, TEMPS, BICC1, PPP1R9B, OPN4, CHP1, NLRP3, MAFD6, YWHAZ, NRSN1, HOMER1, MAFD4, PLB1, P2RX6, DGKH, P2RX2, FXR1, SMC2, H3P19, P2RX3, DST, PIK3CD, PIK3CB, PIK3CA, CD9, CNR1, P2RY2, P2RY1, P2RX5, P2RX4, CRY2, P2RX1, CTNNB1, DNASE1L3, DRD1, NOS1, MAFD2, MAFD1, FKBP4, GLP1R, GPER1, GRIK4, GRIN2B, HCRT, PIK3CG, GRM7, AVP, ADARB1, PVALB, MIR18A, EIF4EBP1, GABPA, FTL, FOS, FOXO3, ADCY9, PINK1, UBE2Z, FGF9, DMTN, MAPKAP1, LIN28A, SLC17A6, ADRA1A, ADRA2B, AGMAT, CAMKMT, RABEP2, EGF, PPP1R2C, PNPLA3, ZNF34, ADRB2, EDNRA, NDRG2, GABRA3, ACKR3, GLI2, LINC02605, GRM5, ACTB, GRIA3, GRIA1, PPP1R12C, GPR42, RN7SL263P, ADCY1, GLO1, GHSR, AP2B1, PLXNA3, GFAP, ATF7IP, CNDP2, GDNF, USE1, LMO3, GPRC5C, GCHFR, GCG, TMPRSS13, DPYD, PPP1R1B, CECR, CD44, KRIT1, CCKAR, CCK, CRTC2, CAT, OPN1SW, MDD1, MIR17HG, C9orf72, CALR, CALM3, IS1, CALM2, DAOA-AS1, CALM1, CALCA, TAAR6, NANOS3, MCIDAS, TSPO, BRS3, BRCA1, CDSN, OSR1, BPI, CHGB, APLNR, DMD, DLX4, DDC, SHANK3, RGS8, LMLN, CYP19A1, WASHC1, CSNK1E, ANGPT1, CSF2, PDIA3, CAMK2N2, SLC25A4, APOH, STS, CRY1, WASH6P, CREBBP, CP, ATP5F1A, BDNF-AS, SYN2, VSX1, GSTM1, ORM1, PLCB4, PLA2G4A, ST8SIA2, PITX2, ELP1, CCN6, PIK3R2, APLN, PIK3R1, ARHGEF7, CBFA2T2, LPAR2, HTR3B, ABCB1, ADIPOQ, ABCG2, EIF2AK3, PGM1, GDF15, NR1D1, PGD, PAX6, SEC24C, HDAC9, KEAP1, CCS, HDAC6, FOSL1, RASSF7, POU3F1, SLC18A2, SULT2A1, STAR, SSTR5, TDGF1P3, TFRC, SSTR4, SSB, THBS3, SOD2, TM7SF2, SOD1, SOAT1, TRPM2, PTPA, SEMG1, TTN, TYR, CCL11, CCL2, S100A12, VIPR2, PTGS1, VTN, PSMB6, PRKCZ, YY1, TOM1, TUBA1B, GSTT1, RAPGEF3, INSRR, PPP1R13B, IL7, SIRT3, IL4, IL2, IGHG1, ATP2C1, AGO2, IFNG, IFNA13, PCDH17, IFNA1, PCLO, DLL1, HTR1F, IGLV3-25, HSD11B2, SETD2, HRAS, HPX, SLC40A1, VAMP7, HPD, HLA-C, CRYL1, HINT1, ITGA2B, ITIH1, PLCB1, NGF, NUP98, DEAF1, NTRK1, PDLIM5, NRAS, CXCR6, NPAS2, NRG3, NOTCH4, NOS3, PPARGC1A, UTS2, METAP2, ITIH3, RAPGEF4, NFE2L2, MST1, MSMB, MAS1, LTBP3, IGSF9B, LEP, LBP, TBC1D9, STAB1, LAMC2, ABAT
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Atypical Teratoid Rhabdoid Tumor
Wikipedia
However, the long-term outcomes of AT/RT are so poor that some protocols call for upfront radiation therapy, often in spite of young age. [28] The dose and volume of radiation had not been standardized, but radiation does appear to improve survival. ... "Germ-line INI1 mutations in a patient with a central nervous system atypical teratoid tumor and renal rhabdoid tumor". Genes Chromosomes Cancer . 28 (1): 31–7. doi : 10.1002/(SICI)1098-2264(200005)28:1<31::AID-GCC4>3.0.CO;2-Y . ... American Journal of Neuroradiology . 28 (4): 603–7. PMID 17416804 . ^ Squire SE, Chan MD, Marcus KJ (2007). ... Journal of Clinical Oncology . 23 (28): 7152–60. doi : 10.1200/JCO.2005.01.214 .SMARCB1, TP53, LIN28A, MYC, PROM1, CCND1, SMARCA4, BRAF, TSPO, SPP1, NF2, EWSR1, CLDN6, LIN28B, HMGA2, CHRM3, RASSF1, CXCL13, BMS1, ACACA, MLRL, XRS, VIM, TLE1, TEAD4, TBX5, TYR, CD274, FBXW11, MIRLET7B, LINC01672, MIR601, SMIM10L2B, MIR34A, MIR221, MIR155, MIR142, SMIM10L2A, SUN2, CHDM, PHF5A, MAP1LC3B, PRDM16, PID1, TBX1, GPKOW, CNTN2, SMARCA1, TAGLN, ACTB, IGF1, HTC2, H2AX, MTOR, F8, F3, EZH2, EREG, EGFR, TIMM8A, CNN1, BTF3, BCL2, ATM, ADA, IGF1R, CXCL8, INSR, SERPINF2, SHH, RPL10, RPL5, RHD, MAP2K7, PLK1, PIP, CD99, PIK3CG, PIK3CD, PIK3CB, PIK3CA, NPM1, MYCN, PERCC1
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Autism Spectrum
Wikipedia
The restricting of onset age has also been loosened from 3 years of age to "early developmental period", with a note that symptoms may manifest later when social demands exceed capabilities. [28] Signs and symptoms [ edit ] Autism spectrum disorder (ASD) is characterized by persistent challenges with social communication and social interaction, and by the presence of restricted, repetitive patterns of behavior, interests, or activities. [29] These symptoms begin in early childhood, and can impact function. [30] There is also a unique disorder called savant syndrome that can co-occur with autism. [31] As many as one in 10 children with autism and savant syndrome can have outstanding skills in music, art, and mathematics. [31] Self-injurious behavior (SIB) is more common and has been found to correlate with intellectual disability. [32] [4] Approximately 50% of those with ASD take part in some type of SIB (head-banging, self-biting). [33] Other characteristics of ASD include restricted and repetitive behaviors (RRBs).CHD8, NRXN2, CNTNAP2, SHANK3, NLGN3, NRXN1, EN2, DLG4, GABRB3, SCN1A, MEF2C, NLGN4X, BDNF, AVPR1A, PTCHD1, SHANK2, PTEN, OXTR, RELN, TSC2, GRIN2B, FOXP1, ITGB3, IL1RAPL1, DPP6, DPYD, RAI1, ANKRD11, CHD2, NRXN3, TRIP12, CEP41, JARID2, RYR2, GPR50, MTNR1A, SLC1A1, TSHZ3, CDH10, RARB, DIPK2A, DLX1, DIPK2B, SIN3A, DNMT3A, DIP2A, PAH, PCDH9, MTNR1B, HFE, FEV, GTF2I, USH2A, GLRA2, DPP10, UPP2, TET1, LRRN3, CIRBP, SNTG2, NSUN2, DHCR24, GABRQ, CIC, DIO2, LAMC3, SLC6A4, SLC16A2, SOX9, TBL1X, NEMF, GABRA5, MYT1L, DIO3, EPHX2, SFSWAP, HEY1, DNMT3B, MET, NTSR1, FMR1, SOX5, ROGDI, UNC80, LRRTM3, CTTNBP2, IQGAP3, MIR486-1, TET3, CA2, DDHD1, TBR1, CADPS2, TSC1, EIF4E, SYN1, NBEA, OPRM1, MAPK1, SLC9A9, TBX1, CTNNB1, NRP2, SYN2, JAKMIP1, ARID1B, NRCAM, SLC7A5, BRINP1, CAMK2A, ARHGEF10, ITPR3, ARHGAP32, DLGAP4, PAK2, CREBBP, EXT1, GRIN1, VRK3, CHRNB2, TAFA3, WDFY3, LRFN2, SYN3, GSTM5, PREX1, EIF4EBP2, BCKDK, POGZ, DEAF1, EHMT1, HEPACAM, PPP2R5D, IL17A, SCN2A, MTOR, IL6, CADPS, SLC2A1, IL1B, RNF135, RSS, SMS, SLC6A3, ARSD, IL10, SBF1, AVP, IQSEC2, MTHFR, UBE4A, CD38, MECP2, GRM5, PHB, UBE3A, MAP2K1, SHANK1, RBFOX1, NF1, ACTB, TOP2B, TNF, ADNP, CYFIP1, ASMT, NUFIP2, HTR2A, MAOA, IL4, VDR, MBD5, CNTN4, CHAT, IL18, TPH2, CXCL8, FOXP2, KIRREL3, EBPL, SLC25A12, DRD3, PVALB, FOXC1, PITX2, PIK3CA, ELK3, PSD, IL1A, COMT, CADM1, TGFB1, PIK3CG, DYRK1A, CACNA1C, CACNA1D, TBL1XR1, PRKN, HTC2, PIK3CD, PIK3CB, CARS1, GRM7, NLGN1, CASK, SEMA5A, NRG1, HOXA1, GRIN2A, IFNG, SYNGAP1, ELAVL2, PRL, CHRNA7, CHD7, PAX6, CYP1B1, CYP2D6, CNTN5, CYP11B2, GREM1, AKT1, PTGS2, SLC12A5, DRD2, DRD4, CRP, ESCO2, CHRNA4, CAPS2, ESR2, PHB2, GPHN, SIL1, CCL2, AFF2, CLOCK, HLA-DRB1, ERICD, PAFAH1B1, NGF, OXT, IGF1, TCF4, MAOB, GSTK1, KCNJ10, HP, S100B, CDKL5, SNAP25, SLC12A2, IL5, HGF, APBA2, ZNF804A, CPB2, ESR1, GLO1, GFAP, CS, SETD5, AUTS2, TIMELESS, CC2D1A, SYNM, MAGEL2, GAD1, SLCO6A1, AR, WWOX, CNTN6, FOLR1, SETD2, IMMP2L, TRIM32, CDX2, DNMT1, GRIA2, GRIK2, BCL2, ANK3, EGF, PCDH19, ST8SIA2, GSTP1, CDH13, ARHGEF9, PCDH10, CHD5, RAC1, PPARG, ELMOD3, HAVCR1, NCS1, ATP13A4, PON1, CMIP, PPARA, PEX7, POMC, MRTFB, LOC110806262, NCAM1, NLGN2, MIB1, NR4A2, PTLS, CLEC7A, MIR34A, FOXP3, NBEAL1, MIR137, CHDH, MUL1, MIR132, MCPH1, PHF21A, NEXMIF, ABCA13, ASTN2, TAC1, SMARCA2, SMARCA4, CACNA1H, SOD1, SOD2, CBLL2, LRRC4, IRS2, STX1A, KDM5C, RORA, VPS13B, TCF20, TERT, ARHGEF5, USP7, TLL1, WNT2, WNT1, TPI1, SLC19A1, PRICKLE2, PRICKLE1, DLGAP1, ROS1, RPL10, SH2D6, PHLDA2, ZNF292, SCD, MSN, KDM5B, SCN3A, DCD, DGCR2, PIEZO1, SCN9A, SETD1A, SEMA3F, NR1D1, OSR1, TAOK2, MACROD2, KMT2C, AANAT, CAT, GRP, DPYSL3, MBNL1, CAPRIN1, FGA, DPP4, DMD, LRP1, CRH, ACAN, IFNA1, BST1, IFNA13, LEP, IGF2, BMP4, MIF, ALDH1A3, GRM1, OPN1SW, IL2, BAG1, IL9, IL13, KIF1A, CUX1, GRIA1, ASNS, GPR37, CYBB, APOE, MEF2A, CYP2E1, MMP9, HMGB1, CDH11, HNRNPU, CDH9, CLN8, COL9A3, HLA-B, CD5L, EPHB2, CDH2, HOXB1, MKI67, HLA-C, CAMK4, CD69, HLA-G, MOCOS, FEZF2, TUG1, CTSC, TESC, FAM120C, RPP25, SENP7, CDH8, ELOVL2, CSF2, VPS18, SEMA6A, NKX2-5, AHI1, FBLIM1, CTNND2, CX3CR1, UGT1A1, GNB1L, ZNF462, RMDN3, CHD4, SBNO1, CYP1A2, ATP10A, PCBP4, ACKR3, ERMN, ARNTL2, CELF4, RETN, DIABLO, CORD1, COMP, CPOX, ASH1L, PAG1, TRERF1, CREB1, COX8A, COL4A1, SLF2, SYBU, CNTF, CHRNA3, ZNF407, POMGNT1, ELMOD1, CHM, CRK, UBA6, TMLHE, TAOK1, MAPK14, LRP2BP, PRKAG2, CYP2C19, DLX6, SATB2, CUX2, DTNA, SYNE1, DRD5, ATP13A2, SIRT1, DRD1, SLC7A8, SLC35A3, TNPO3, MAPK8IP2, SEZ6L, PSD4, TSPAN12, BACE1, IL17RA, PART1, RNF19A, DMXL2, ADGRL3, EDNRA, ERC1, RIMS1, ERBB4, MYO16, EPS8, WDTC1, KIF21B, NCOA6, KDM4C, PEG10, PLCB1, TNRC6B, EPHA5, ENO2, TBC1D9, MARK2, KANK1, EGFR, EEF1A2, DNASE1, DLX5, STX18, RAB11FIP5, NXPH1, ARHGEF3, NTM, DAB1, CYP27A1, ASCC1, KMT5B, RMDN1, AADAT, CYP19A1, PLAC8, CYP11B1, PLA1A, HRH4, PRRX2, SCLY, IL23A, CYP11A1, ARID4B, DNMT3L, DAO, DBI, DECR1, POLDIP2, ZBTB20, NOC2L, IL1RAPL2, SEZ6L2, DLX2, ELP4, DHCR7, LAT, RPS6KA6, SND1, DDT, INTU, IL37, DISC2, DISC1, DDIT3, HPGDS, CD79A, MRC1, ZNF335, KCTD13, DAOA, NEAT1, WDR62, AGRP, MIF-AS1, AFP, ADRB2, TAAR6, ADRA2C, NANOS1, TGM6, ADRA2B, SERINC2, ZNF713, ADRA1A, PTCHD3, EFCAB5, NEGR1, JMJD1C, C4orf3, AHR, APC, GPR155, ANK2, ANGPT1, AMY1C, AMY1B, AMY1A, AMT, DDX53, ARX, HTR3C, ARID2, METTL21C, WDR90, ALDH1A1, PRSS55, AIF1, LINC-PINT, MIR124-1, LIN7B, LINC01672, PTCHD1-AS, NLGN4Y-AS1, IFNG-AS1, OPN1MW3, PANDAR, EMSLR, MIR6126, LOC102723407, LOC102724971, ACTC1, PERCC1, CERNA3, RN7SL263P, MTCO2P12, LOC107987479, ACACA, LINC02605, DEL11P13, MIR1290, ADORA2A, ERVMER34-1, ADCYAP1R1, MIR140, MIR21, ADAM10, MIR34B, MDD1, BDNF-AS, MIR451A, MIR484, ADA, LGALS7B, MIR656, OPN1MW2, ACTN4, HOTAIR, FMR1-AS1, MIR873, RMDN2, COMMD1, IL23R, CALB2, CAD, RBFA, RABEP2, CNTNAP3, NAA15, FUZ, CACNB2, CPEB4, PPP1R2C, CACNA1B, ASXL3, CACNA1A, SLC38A1, PLA2G12A, MAP1LC3B, KATNAL2, ARHGAP24, FBXO31, MSANTD2, CBLN2, CAPG, TFB2M, TOR3A, NSD1, CD40, GALNT17, P2RY12, EYA1, RTN4R, UPF3B, PCDH15, GGCT, MBOAT7, FA2H, SLC52A2, CARS2, CASP7, CASP1, TTC25, KLF16, TSPO, BUB1, RAB39B, CYP2R1, STS, ARSA, CNTNAP5, RBM45, ARNTL, APP, SLC32A1, APOD, RPS10P2, APOC1, APCS, B3GLCT, LRFN5, PWAR1, RBFOX3, GPRASP2, CDCA5, PRRT2, DST, PPP1R1B, BRS3, SLF1, BRCA1, SYVN1, SRRM4, TMEM185A, SPZ1, RERE, BMP1, HAVCR2, SLC7A3, CNTNAP4, UBXN11, ATP2B2, SYTL4, ERCC2, SUPT16H, FAN1, SCT, SAA2, SAFB, ACSM3, SAT1, IL16, IL15, IL7, SCN8A, IL1RN, KCNMA1, CCL7, CCL11, CCL17, SDC4, CXCL12, IL1RAP, SET, IGFBP5, SAA1, INS, SORT1, S100A1, KCNJ2, RANBP1, RANGAP1, JAK2, KDM5A, OPN1LW, REST, RFC1, RHCE, RHD, RIT2, ITPR1, IRS1, IRF1, RPS6, CLIP1, INSR, SHBG, SKIL, SLC1A2, SOAT1, HES1, SOD3, SOX3, ABAT, AGFG1, SPAST, SPINT1, SPN, SRF, SRY, SSTR4, ST14, STAT5A, STAT5B, HRAS, HOXD11, HOXD@, HSPA1A, SNRPN, SLC2A3, SNRNP70, SLC3A2, SLC6A1, SLC6A2, IDS, SLC6A8, ICA1, SLC12A3, HTR7, SLC18A1, HTR2C, HTR1B, HTR1A, SMARCB1, HSPA4, HSPA1B, SNCB, SNCG, RAB2A, PTPRG, TAL1, OGG1, NOS2, NOTCH1, NPY, NPPA, MLF1, NTRK1, NTS, MIP, OPRK1, PTPRA, OTX1, MEFV, P2RX7, MDK, MARK1, PAM, MAPT, PAX3, NOS1, NGFR, NR3C2, NFKB1, MSX1, MSX2, COX2, MOG, MNT, MTRR, MUSK, MYH6, MYH10, MMP3, NCAM2, NDUFS1, NDUFV1, NEO1, MME, NFE2L2, NFIB, LYZ, SERPINA5, PCYT1A, LDHB, LAMB1, PRKCB, L1CAM, MAPK3, MAPK7, KRT7, KNG1, PRLR, PRODH, KLRC2, KIR3DL1, PSEN2, PSMD12, KIR2DS1, PTGS1, KCNQ2, PTPN4, PPL, POU3F2, PDZK1, POR, PER1, SH2D1A, PF4, CFP, ABCB1, LTA, LRP2, LNPEP, LMNA, FADS1, PITX3, PKD2, PLAUR, PLG, SEPTIN5, LIG4, LGALS7, HOXB8, CNTN2, SBNO2, BMS1, IQCB1, DEPDC5, NOS1AP, DOCK4, FOXF1, FOXG1, HDAC4, FKBP5, KIAA0319, OPN1MW, SETDB1, TLK1, NUAK1, ARNT2, FH, ABCB6, DHRS9, OLIG2, FOXE3, NCOR1, FOLR2, FRA7A, SLC16A7, SLC33A1, GATA4, MSC, GAD2, GABRG1, GABRA4, CER1, GABPA, XRCC6, COX5A, FYN, FRAXE, GRAP2, FADS2, AIM2, PTGES, FGFR2, FGF2, RTN3, SUB1, TLK2, RAPGEF4, PTPRT, FABP1, WDR45, FAM107A, MSNP1, KLF12, PARK7, FAAH, XRN2, COBLL1, F2R, FNDC3A, EZH2, TRAPPC8, ARHGEF15, SLC27A4, PPARGC1A, ABCA7, SLC26A1, ATP8A1, BAIAP2, ZBTB18, FAP, ATG7, ARFGEF1, SLU7, PRPF8, AHSA1, LBX1, CXCR6, CD226, FABP7, PTGES3, FABP5, FABP3, PDE10A, LPAR2, AIFM1, TAZ, HAGH, CRISP2, TRH, TRHR, TRIO, TRPC5, TRPC6, TRPM2, UBE2K, TSNAX, CLDN12, H1-4, TWIST1, GZMB, UCP3, UROD, GSTT1, VCP, GSTM1, HLA-A, TPH1, TOP1, TNFRSF1A, NR4A1, HMGN1, HNF1B, TCN2, PRDX2, TERF1, HLA-DPB1, TGFB2, TGM2, THAS, THBS1, THRB, TIMP4, HLA-DPA1, TLR4, TM7SF2, CLDN5, VEGFA, VIP, GSTA1, FOXN1, NR3C1, GRIK4, PLA2G4C, GPR42, STX16, MPDZ, GLUL, NR1I2, ARHGEF7, GEM, CACNA1G, GDNF, HERC2, HERC1, WASF1, GDI1, ARTN, MKNK1, CUL3, GSR, TMEM187, WT1, XPO1, XRCC4, YWHAE, ZIC2, SEMA3B, GSK3B, AIMP2, GRPR, STAM, FOSL1, GAN, GRM8, MIA, NRIP1, DGCR6, GRM2, H3P40