Other causes may include: megaloblastosis ( vitamin B12 or folate deficiency) hypothyroidism chronic obstructive pulmonary disease (COPD) aplastic anemia reticulocytosis (commonly from hemolysis or a recent history of blood loss ). liver disease myeloproliferative disease myelodysplastic syndrome which most commonly presents with macrocytic anemia [1] chronic exposure to benzene pregnancy (most common, and requires no treatment as the person affected will return to normal post-partum) Certain anti-inflammatory drugs, eg salazopyrin, azothiaprine. ... See also [ edit ] Macrocytic anemia References [ edit ] ^ Greenberg, P. L., et al. "Myelodysplastic syndromes: clinical practice guidelines in oncology." ... Sulfonic acids : Acamprosate Religion and alcohol Christian views on alcohol alcohol in the Bible Islam and alcohol History Bratt System Related Index of alcohol-related articles Austrian syndrome Ban on caffeinated alcoholic beverages Brief intervention Gateway drug effect Last call Mood disorder Non-alcoholic fatty liver disease Self-medication Spins Sober companion Sober living houses Sobering center Town drunk Category Biology portal Medicine portal This article related to pathology is a stub .
Lymphomatoid papulosis (LyP) is a non-contagious, chronic skin condition characterized by the eruption of recurring, self-healing bumps (lesions) on the skin. The lesions typically begin small and then become larger, and they may bleed or ulcerate before becoming scaly and crusty. They often develop a red-brown color. Symptoms associated with lesions may include itching and/or pain, which may be debilitating. The frequency of eruptions varies over time and from person to person. Lesions may be very persistent, or they may go away for long periods of time before coming back.
Lymphomatoid papulosis (LyP) is a rare cutaneous condition characterized by chronic, recurrent, and self-regressing papulonodular skin eruptions. It belongs to the spectrum of primary cutaneous CD30+ lymphoproliferative disorders, along with primary cutaneous anaplastic large cell lymphoma (primary C-ALCL; see this term) with which it shares overlapping clinical and histopathologic features. Epidemiology Exact prevalence is unknown. Clinical description LyP lesions develop at any age, more frequently during adulthood (mean age 45 years), as erythematous papules and nodules of less than 1.5-2 cm, grouped in clusters or disseminated throughout the body. Lesions may become necrotic in the center, show pigmentation and leave scarring. They spontaneously regress within 4 to 8 weeks but new lesions can occur at any time.
Warm autoimmune hemolytic anemia is the most common form of autoimmune hemolytic anemia (see this term) defined by the presence of warm autoantibodies against red blood cells (autoantibodies that are active at temperatures between 37-40°C). Epidemiology Warm auto-antibodies are responsible for 60/70% of AIHA, whose annual incidence is estimated to be between 1/35,000-1/80,000 in North America and Western Europe. Clinical description Warm AIHA is more common in women (female to male ratio approximately 2:1 in adults). The disease is characterized by symptoms due to the anemia including fatigue, exertional dyspnea, and, more rarely, jaundice and dark urine in case of severe hemolysis. If the disease is severe, fever, chest pain, syncope or heart failure may occur.
Warm antibody hemolytic anemia is the most common form of autoimmune hemolytic anemia . It is defined by the presence of autoantibodies that attach to and destroy red blood cells at temperatures equal to or greater than normal body temperature. The disease is characterized by symptoms related to anemia, including fatigue, difficulty breathing , jaundice and dark urine. In severe disease, fever, chest pain, syncope or heart failure may occur. Hemolysis (the breakdown of red blood cells) occurs mainly in the spleen, so mild splenomegaly is relatively common.
The condition may be isolated (occurring with no other conditions or malformations) or may occur with other ear malformations or a number of syndromes. Treatment options may include surgical repair of the defect to prevent recurrent meningitis; amplification aids for those with residual hearing; and cochlear implantation .
Lipedematous scalp may be associated with diseases such as diabetes mellitus, renal failure, loose joints and skin, Sjögren's syndrome , hyperlipidemia, and ovarian cysts.
But sometimes, they are part of a systemic disease such as cryoglobulinaemia , polycythaemia , scleroderma , aortic hypoplasia and coarctation , alopecia areata , Peutz-Jeghers syndrome , lichen planus , rapid heartbeat (tachycardia), lymphedema and excessive sweating of the hands (palmar hyperhidrosis).
The spots also appear when the arms are slightly raised from the trunk (angle approx. 45°) and disappear again when the arms are stretched upwards. [3] Treatment [ edit ] It is a physiological phenomenon that requires no treatment. [3] See also [ edit ] Marshall–White syndrome List of cutaneous conditions References [ edit ] ^ a b Freedberg, et al. (2003).
Chronic respiratory distress with surfactant metabolism deficiency is a rare, genetic, primary interstitial lung disease with a highly variable clinical presentation, ranging from neonatal respiratory distress syndrome to mild to severe interstitial lung disease (typical symptoms include cough, tachypnea, hypoxia, clubbing, crackles, failure to thrive).
A rare genetic interstitial lung disease characterized by diffuse lung disease of variable phenotype ranging from severe respiratory insufficiency in infancy to asymptomatic adults, due to surfactant protein C deficiency. Typical presentation in infancy includes dyspnea, cough, wheezing, and gradual cyanosis, with or without failure to thrive. Radiological findings include diffuse ground-glass opacities in neonates, later interstitial thickening associated with lung hyperinflation, intraparenchymal/subpleural cysts, honeycombing, subpleural nodules, or bronchiectasis. Infiltrates and air leaks are frequent complications.
A number sign (#) is used with this entry because of evidence that pulmonary surfactant metabolism dysfunction-2 (SMDP2) is caused by heterozygous mutation in the gene encoding surfactant protein C (SFTPC; 178620) on chromosome 8p21. Description Surfactant protein C (SPC) deficiency is a rare autosomal dominant disease associated with progressive respiratory insufficiency and lung disease with a variable clinical course. The pathophysiology of the disorder is postulated to involve intracellular accumulation of a structurally defective SPC protein (Thomas et al., 2002). For a general phenotypic description and a discussion of genetic heterogeneity of pulmonary surfactant metabolism dysfunction, see SMDP1 (265120). Clinical Features Nogee et al. (2001) reported a female infant who developed severe respiratory insufficiency at 6 weeks of age.
They pointed to a similar condition that had been reported by Wiedemann (1985) and concluded that, although similar to Ohdo syndrome (249620), these cases appeared to represent a distinct clinical entity.
A cerebral malformation characterized by symmetric, bilateral pachygyria with normal head circumference and without polymicrogyria. Clinical manifestations include developmental delay, moderate intellectual disability, normal or slightly decreased muscle tone and deep-tendon reflexes, telecanthus or hypertelorism.
Cases associated with panniculitis may present with hemophagocytic syndrome (abrupt onset of fever, rash, cytopenia, hepatosplenomegaly and neurological compromise).
The authors concluded that the disorder is X-linked and probably distinct from the Wiskott-Aldrich syndrome (301000) and from 'simple' X-linked thrombocytopenia (313900).
The disorder seemed to be separate from any known thrombocytopenic or thrombocytopathic syndrome. Hematologic neoplasms had developed in 6 family members; 2 had neuroblastoma (256700).
Nathan et al. (1994) suggested that this form of GAD is more likely to be involved in the pathogenesis of insulin-dependent diabetes and related autoimmune disorders such as stiff man syndrome (184850) than is soluble GAD.
In hypobetalipoproteinemia the low density lipoprotein (LDL) cholesterol levels are very low, yet people with this syndrome typically have no symptoms nor require treatment.
Noma neonatorum Specialty Dermatology Noma neonatorum is a cutaneous condition, a manifestation of infection, usually Pseudomonas aeruginosa sepsis , and has been reported almost exclusively in developing countries. [1] Despite the similarity of facial lesions, noma neonatorum is not related to noma . [2] See also [ edit ] Green nail syndrome List of cutaneous conditions References [ edit ] ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007).
Please introduce links to this page from related articles ; try the Find link tool for suggestions. ( January 2014 ) Odynorgasmia , or painful ejaculation , is a physical syndrome described by pain or burning sensation of the urethra or perineum during or following ejaculation.