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Non-Hodgkin Lymphoma
Wikipedia
Genetic diseases, like Klinefelter syndrome , Chédiak–Higashi syndrome , ataxia–telangiectasia syndrome. Autoimmune diseases, like Sjögren syndrome , celiac disease , rheumatoid arthritis , and systemic lupus erythematosus . [17] [18] Bone trauma and microfractures associated with diffuse large B-cell lymphoma originating in bone marrow . [19] [20] Implants, made from hard metals or silicone, associated with anaplastic large cell lymphoma . [21] [22] Familial component [ edit ] Familial lymphoid cancer is rare. ... "Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome. Council of State and Territorial Epidemiologists; AIDS Program, Center for Infectious Diseases" (PDF) . ... External links [ edit ] Non-Hodgkin Lymphoma at American Cancer Society Non-Hodgkins Lymphoma from Cancer.net ( American Society of Clinical Oncology ) Patient information on non-Hodgkin lymphoma from The Lymphoma Association Lymphoma Association – Specialist UK charity providing free information and support to patients, their families, friends and carers Classification D ICD - 10 : C82 - C85 ICD - 9-CM : 200 , 202 ICD-O : 9591/3 OMIM : 605027 MeSH : D008228 DiseasesDB : 9065 External resources MedlinePlus : 000581 eMedicine : med/1363 ped/1343 Patient UK : Non-Hodgkin lymphoma NCI : Non-Hodgkin lymphoma v t e Leukaemias , lymphomas and related disease B cell ( lymphoma , leukemia ) (most CD19 CD20 ) By development/ marker TdT+ ALL ( Precursor B acute lymphoblastic leukemia/lymphoma ) CD5 + naive B cell ( CLL/SLL ) mantle zone ( Mantle cell ) CD22 + Prolymphocytic CD11c+ ( Hairy cell leukemia ) CD79a + germinal center / follicular B cell ( Follicular Burkitt's GCB DLBCL Primary cutaneous follicle center lymphoma ) marginal zone / marginal zone B-cell ( Splenic marginal zone MALT Nodal marginal zone Primary cutaneous marginal zone lymphoma ) RS ( CD15 +, CD30 +) Classic Hodgkin lymphoma ( Nodular sclerosis ) CD20+ ( Nodular lymphocyte predominant Hodgkin lymphoma ) PCDs / PP ( CD38 +/ CD138 +) see immunoproliferative immunoglobulin disorders By infection KSHV ( Primary effusion ) EBV Lymphomatoid granulomatosis Post-transplant lymphoproliferative disorder Classic Hodgkin lymphoma Burkitt's lymphoma HCV Splenic marginal zone lymphoma HIV ( AIDS-related lymphoma ) Helicobacter pylori ( MALT lymphoma ) Cutaneous Diffuse large B-cell lymphoma Intravascular large B-cell lymphoma Primary cutaneous marginal zone lymphoma Primary cutaneous immunocytoma Plasmacytoma Plasmacytosis Primary cutaneous follicle center lymphoma T/NK T cell ( lymphoma , leukemia ) (most CD3 CD4 CD8 ) By development/ marker TdT+ : ALL ( Precursor T acute lymphoblastic leukemia/lymphoma ) prolymphocyte ( Prolymphocytic ) CD30+ ( Anaplastic large-cell lymphoma Lymphomatoid papulosis type A ) Cutaneous MF+variants indolent: Mycosis fungoides Pagetoid reticulosis Granulomatous slack skin aggressive: Sézary disease Adult T-cell leukemia/lymphoma Non-MF CD30 -: Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma Pleomorphic T-cell lymphoma Lymphomatoid papulosis type B CD30 +: CD30+ cutaneous T-cell lymphoma Secondary cutaneous CD30+ large-cell lymphoma Lymphomatoid papulosis type A Other peripheral Hepatosplenic Angioimmunoblastic Enteropathy-associated T-cell lymphoma Peripheral T-cell lymphoma not otherwise specified ( Lennert lymphoma ) Subcutaneous T-cell lymphoma By infection HTLV-1 ( Adult T-cell leukemia/lymphoma ) NK cell / (most CD56 ) Aggressive NK-cell leukemia Blastic NK cell lymphoma T or NK EBV ( Extranodal NK-T-cell lymphoma / Angiocentric lymphoma ) Large granular lymphocytic leukemia Lymphoid+ myeloid Acute biphenotypic leukaemia Lymphocytosis Lymphoproliferative disorders ( X-linked lymphoproliferative disease Autoimmune lymphoproliferative syndrome ) Leukemoid reaction Diffuse infiltrative lymphocytosis syndrome Cutaneous lymphoid hyperplasia Cutaneous lymphoid hyperplasia with bandlike and perivascular patterns with nodular pattern Jessner lymphocytic infiltrate of the skin General Hematological malignancy leukemia Lymphoproliferative disorders Lymphoid leukemias Authority control BNF : cb11958249q (data) GND : 4115403-4RAD54L, RAD54B, BCL2, BCL6, FAS, CASP10, CSF3, MTHFR, HLA-DRB1, NPM1, TYMS, NBN, SHMT1, CBS, CD79B, BRAF, CYP2E1, PAX5, TFRC, IFNA2, BCL10, CSF2, CD79A, CHEK2, FPGS, PRF1, BHMT, SPEN, TBL1XR1, EPHX1, IKBKB, CREBBP, S1PR2, MTSS1, ATM, TET2, KIT, ASXL1, NTHL1, LTA, MS4A1, IL10, SRSF2, CD19, TNFRSF8, ABCB1, CCND1, IGH, IL2, KRT20, RTEL1, ALK, SMUG1, EZH2, CDKN2A, PDLIM7, MYC, VEGFA, TP53, TNF, NAT2, IL6, LEP, IL4, GSTP1, NLRP2, CD37, IL2RA, IRF4, CXADR, NAT1, PIK3CD, TRBV20OR9-2, SPG7, ARR3, CXCL12, NR1I3, PRKAR1A, TRIM13, CDR3, CASR, CD274, CXADRP1, FGF2, FCGR3A, ERCC2, GSTT1, RBM45, GSTM1, MTR, STAT3, CD70, LEPR, CD40LG, CD34, CXCL8, TNFSF10, NCAM1, NOS2, AICDA, MDM2, PIK3CA, TBC1D9, FCGR2A, MTRR, PIK3CB, TNFSF13B, TLR2, DLC1, PIK3CG, MAPK1, XRCC1, VDR, H3P10, AKT1, CD22, BCR, CASP8, CD44, CD40, CDKN2B, IL12A, CASP3, CD47, IFI27, ALDH1L1, HPGDS, CASP9, IL13, CXCR4, FOXP3, GPX1, CALM3, DCTN6, TLR9, ZNRD2, CALM2, FOXO1, PLK1, BCL2L11, CLLS2, IL1RN, DLEC1, HDAC9, PON1, CALM1, IGL, CDK2, TMED7, PSMD9, CD28, TP73, H3P23, HLA-DQB1, CTLA4, TMED7-TICAM2, SELL, CD38, MIR21, MRE11, RNASE3, CCR5, LINC01194, MSH2, TICAM2, KRIT1, AHR, NPAS2, NFKB1, CAMKMT, H2AX, SERPING1, RAF1, TNFRSF13C, MYD88, CCL21, BTK, RIT1, PTPN6, PTEN, TSPO, BRCA1, BRD2, PDCD1, PLXNA2, CCND3, MCL1, MGMT, MKI67, MMP2, MMP9, MOS, MPO, ABCC1, MTX1, PIM1, MUC1, MYOD1, NME1, NPR2, CAT, PCNA, SOD2, CASP1, SLC16A1, WRN, CXCR5, AURKA, POLDIP2, MCAT, MCTS1, NXT1, POLE3, MIB1, BACH2, MARCKSL1, WLS, ARHGAP24, TXLNA, IFNL3, CLEC4D, SLC35B2, ASPG, MIR150, MIR155, MIR203A, MIR34A, FAM72B, CCR2, FAM72A, MEF2B, KLRC4-KLRK1, ERVK-32, H3P9, H3P11, RNF19A, TNFAIP8, TOGARAM1, TP63, SYK, TGFB1, TIMP1, TIMP2, TLR1, BCL3, TRAF1, TRAF3, BAX, GPANK1, AIMP2, NR0B2, DYNLL1, ANXA5, TNFRSF10B, SOCS3, GRAP2, KLK3, HDAC6, RAD50, CIB1, MRPL28, AHSA1, SUB1, XIAP, KLRK1, LTB, CRK, FH, CCR7, ERBB2, CYBA, KDR, HLA-G, FN1, ISG20, CYP2B6, CYP2C9, CDKN1B, IL18, HLA-B, HLA-A, CDC25A, CEBPA, FGFR4, EPO, CYP1A1, DDIT3, MAPK14, GBA, CMA1, IRF8, LGALS1, LYVE1, TPX2, GOLGA7, LEF1, CCR9, ACSBG1, HSPH1, ANXA1, FCGR1A, CES1, PLEKHO1, WT1-AS, FCGR2B, FCN2, SF3B1, CCL27, RASSF1, UBE2C, EBNA1BP2, FCGR3B, C1RL, ALPP, ANPEP, ERCC5, GPR132, PSAT1, ERVW-1, DLL1, IGHV1-12, SMARCAL1, IGHV3-69-1, IGHV3OR16-7, CHEK1, PDLIM3, ICOS, EPHX2, ESR1, MASP2, ATRNL1, ETS1, PART1, DERL2, CFL1, ANG, CADM1, LMNA, BIRC5, FRA16B, FASLG, BCLAF1, CDKN2C, RGS6, TCL1B, NCOR2, CYTIP, CLOCK, BAG5, EEF1E1, NPEPPS, ADIPOQ, CD52, KLF4, AR, ARG1, ARHGEF2, FCGR2C, ARTN, MTOR, LIMD1, MBD2, RHOA, PER3, BMS1, SLC23A2, SLC23A1, FLT4, KHDRBS1, SLCO1B1, FGFR1, GDE1, FOXM1, CRTAP, APOH, TUBA1B, TLR6, AKR1A1, TNIP1, LANCL1, DLEU1, SPRY2, RABEPK, APRT, ZNF197, FLT1, EDIL3, SMC4, FLT3, FLT3LG, TANK, ATRAID, TMEM260, ALDH1A1, EPHB2, MIR28, MIR26B, CYP1B1, MIR200B, MIR152, CYP17A1, MIR143, MIR124-1, MIRLET7B, CYP24A1, LOC390714, KMT5A, CYP27B1, GSTK1, CD55, DAPK1, ARMH1, DCC, H19, ACE, CTAG1A, TIGIT, AKR1C1, ACACA, RMDN2, MIR17HG, XRCC6P5, MIR148B, ERVK-20, H3P5, H3P28, CR2, COMT, CSF3R, LOC105379528, UPK3B, LOC102724971, LOC102723407, ERVK-18, H3P12, CTAG1B, KIR2DL5B, CTNNB1, CUX1, CX3CR1, MIR618, OCM, LGALS7B, ACAA1, SCFV, MIR502, MIR202, H4C15, SLCO6A1, PARP1, TPPP2, DHX33, E2F1, IL21, CXCL16, C6orf47, POLD4, CFAP97, EEF2, SCYL1, EIF4A2, KIR2DL5A, GOPC, POLE4, ERVK-6, PCDHGB7, CFC1, CCAR1, AIF1, NAT10, LAMTOR1, GGH, EIF4E, FBLIM1, ALB, EIF4G1, IGAN1, PLEKHG2, H4-16, CARD11, MIR155HG, TIRAP, NLRP3, CDCA5, PRRT2, MUC16, MTDH, TSLP, DIXDC1, PWWP3A, HAVCR2, MIXL1, RAPH1, DDT, TLR10, DEFB126, RNF34, ASRGL1, DECR1, DNMT1, AGRP, VTCN1, BIRC7, DPP4, CDK5R1, RHOH, NRP1, P2RX7, PRKCB, PRKCA, FMNL1, CDH13, IL1B, PMS1, PML, CDC6, PLAG1, IL2RG, CDK11B, IL5, CD59, IL7R, IL9, PDGFRB, PDGFRA, PDE6H, IL10RA, IL12B, SERPINA5, PC, IL12RB1, PAFAH1B1, PAEP, IFNGR2, MAPK3, MAPK8, PTPRC, ICAM1, RMD1, ID4, RING1, RFC1, RCD1, RB1, IDH1, RAC2, NECTIN2, PTPRJ, PTPN13, MAP2K1, PTPN11, IDH2, PTGS2, CDK4, IFNG, PSMD7, PSMB9, PSMB6, RELN, PROS1, PRL, PEBP1, ORC4, RORB, OGG1, MSMB, MSH5, KIR2DS1, KIR3DS1, KRAS, KRT81, MNAT1, LAIR1, MMP3, RPSA, MMP1, MME, KMT2A, LBR, CD33, MFAP1, MDM4, TNFSF8, MDK, MBP, EPCAM, SH2D1A, LTK, LGALS3, LGALS7, MTAP, MTHFD1, CD14, NFKBIL1, NTRK1, IL15, IL16, CAV3, TNFRSF9, NOTCH4, NPY, NOS3, SERPINA6, NOS1, NGF, IDO1, CD5, NEDD9, NCF4, CCK, INSL3, INSR, MYCN, MYCL, CCND2, ISL1, ITGB3, JAK2, RORA, RPS6, CES2, GZMB, ADAM12, MAFK, GPT, GSTM3, PRRC2A, IL1R2, ZMYM2, ZBTB16, ZAP70, YWHAE, YY1, XRCC4, B2M, XPO1, CDKN1A, VIPR1, VIP, MSH6, BCHE, VCAM1, UCP1, UBE2I, TYRO3, BCL2L1, TRAF6, KMT2D, GPR34, TCL1A, H4C14, TNFRSF10A, G6PD, TNFRSF14, LSP1, TNFSF13, NCOA1, AKR1C3, GCHFR, DYRK2, ATHS, GNA15, H4C13, ATIC, H4C5, H4C2, H4C8, H4C3, H4C11, H4C12, H4C6, H4C4, H4C1, H4C9, NCOA3, GUCY2D, TPM3, RRM1, HBB, SRC, SPP1, SPN, HOXC5, HOXC6, SOAT1, SLPI, SLC19A1, HRAS, STIL, PMEL, SHMT2, HSPA1L, BRCA2, SEMG1, HSPA4, SELE, HSPD1, TNC, CCL5, CCL1, SAI1, S100A4, RYR3, RXRB, SST, BLM, STAT6, THY1, HGF, TNFRSF1B, TNFRSF1A, TNFAIP3, BCL7A, TSPAN7, TNFRSF17, HIC1, TJP1, HIF1A, TIA1, TGFBR3, HMGB1, TGFBR2, TGFBR1, CDK6, TFDP1, TERT, TERC, CRY2, TCN1, TCF3, TAT, TAP2, BDNF
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Pneumothorax
Wikipedia
The most common is chronic obstructive pulmonary disease (COPD), which accounts for approximately 70% of cases. [17] Known lung diseases that may significantly increase the risk for pneumothorax are Type Causes Diseases of the airways [12] COPD (especially when emphysema and lung bullae are present), acute severe asthma , cystic fibrosis Infections of the lung [12] Pneumocystis pneumonia (PCP), tuberculosis , necrotizing pneumonia Interstitial lung disease [12] Sarcoidosis , idiopathic pulmonary fibrosis , histiocytosis X , lymphangioleiomyomatosis (LAM) Connective tissue diseases [12] Rheumatoid arthritis , ankylosing spondylitis , polymyositis and dermatomyositis , systemic sclerosis , Marfan's syndrome and Ehlers–Danlos syndrome Cancer [12] Lung cancer , sarcomas involving the lung Miscellaneous [13] Catamenial pneumothorax (associated with the menstrual cycle and related to endometriosis in the chest) In children, additional causes include measles , echinococcosis , inhalation of a foreign body , and certain congenital malformations ( congenital pulmonary airway malformation and congenital lobar emphysema ). [18] 11.5% of people with a spontaneous pneumothorax have a family member who has previously experienced a pneumothorax. The hereditary conditions – Marfan syndrome , homocystinuria , Ehlers–Danlos syndromes , alpha 1-antitrypsin deficiency (which leads to emphysema ), and Birt–Hogg–Dubé syndrome – have all been linked to familial pneumothorax. [19] Generally, these conditions cause other signs and symptoms as well, and pneumothorax is not usually the primary finding. [19] Birt–Hogg–Dubé syndrome is caused by mutations in the FLCN gene (located at chromosome 17p 11.2), which encodes a protein named folliculin . [18] [19] FLCN mutations and lung lesions have also been identified in familial cases of pneumothorax where other features of Birt–Hogg–Dubé syndrome are absent. [18] In addition to the genetic associations, the HLA haplotype A 2 B 40 is also a genetic predisposition to PSP. [20] [21] Traumatic [ edit ] A traumatic pneumothorax may result from either blunt trauma or penetrating injury to the chest wall. [13] The most common mechanism is due to the penetration of sharp bony points at a new rib fracture , which damages lung tissue. [17] Traumatic pneumothorax may also be observed in those exposed to blasts , even though there is no apparent injury to the chest. [9] They may be classified as "open" or "closed". ... Classification D ICD - 10 : J93 , P25.1 , S27.0 ICD - 9-CM : 512 , 860 OMIM : 173600 MeSH : D011030 DiseasesDB : 10195 External resources MedlinePlus : 000087 eMedicine : article/432979 article/424547 article/360796 article/808162 article/827551 article/1003552 Patient UK : Pneumothorax v t e Diseases of the respiratory system Upper RT (including URTIs , common cold ) Head sinuses Sinusitis nose Rhinitis Vasomotor rhinitis Atrophic rhinitis Hay fever Nasal polyp Rhinorrhea nasal septum Nasal septum deviation Nasal septum perforation Nasal septal hematoma tonsil Tonsillitis Adenoid hypertrophy Peritonsillar abscess Neck pharynx Pharyngitis Strep throat Laryngopharyngeal reflux (LPR) Retropharyngeal abscess larynx Croup Laryngomalacia Laryngeal cyst Laryngitis Laryngopharyngeal reflux (LPR) Laryngospasm vocal cords Laryngopharyngeal reflux (LPR) Vocal fold nodule Vocal fold paresis Vocal cord dysfunction epiglottis Epiglottitis trachea Tracheitis Laryngotracheal stenosis Lower RT / lung disease (including LRTIs ) Bronchial / obstructive acute Acute bronchitis chronic COPD Chronic bronchitis Acute exacerbation of COPD ) Asthma ( Status asthmaticus Aspirin-induced Exercise-induced Bronchiectasis Cystic fibrosis unspecified Bronchitis Bronchiolitis Bronchiolitis obliterans Diffuse panbronchiolitis Interstitial / restrictive ( fibrosis ) External agents/ occupational lung disease Pneumoconiosis Aluminosis Asbestosis Baritosis Bauxite fibrosis Berylliosis Caplan's syndrome Chalicosis Coalworker's pneumoconiosis Siderosis Silicosis Talcosis Byssinosis Hypersensitivity pneumonitis Bagassosis Bird fancier's lung Farmer's lung Lycoperdonosis Other ARDS Combined pulmonary fibrosis and emphysema Pulmonary edema Löffler's syndrome / Eosinophilic pneumonia Respiratory hypersensitivity Allergic bronchopulmonary aspergillosis Hamman-Rich syndrome Idiopathic pulmonary fibrosis Sarcoidosis Vaping-associatedFLCN, ELN, TSC1, SMAD3, CLPB, BTNL2, SLC25A24, MFAP5, TSC2, CHST14, LOX, TGFBR2, TGFBR1, TGFB3, TGFB2, ACTA2, MYLK, MYH11, MAT2A, ABL1, PRKG1, COL5A1, HRAS, COL5A2, HLA-DRB1, COL3A1, ATP6V1E1, FOXE3, FBN1, COL1A1, BHD, SLIT2, TECR, RIDA, FASTK, SMUG1, IL10, FEV, PGPEP1, TST, CENPJ, CD40LG, IFIH1, BMP1, EMB, BPIFA2, ALK, TESC, TNF, SMAD2, ERBB2, SMAD4, MMP1, MMP9, MSMB, GABPA, NFE2L2, POMC, PRCP, FGA, PSPN, PSPH, PRPH2, REG1A, SLC12A3, STXBP3, ERBB4, ERBB3, SMIM20
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Ataxia
Wikipedia
An example of X-linked ataxic condition is the rare fragile X-associated tremor/ataxia syndrome or FXTAS. Arnold–Chiari malformation (congenital ataxia) [ edit ] Arnold–Chiari malformation is a malformation of the brain . ... "Disorders of the cerebellum: ataxia, dysmetria of thought, and the cerebellar cognitive affective syndrome" . The Journal of Neuropsychiatry and Clinical Neurosciences . 16 (3): 367–78. doi : 10.1176/jnp.16.3.367 . ... ISBN 978-0-8036-1247-1 . ^ Manto M, Mariën P (2015). "Schmahmann's syndrome - identification of the third cornerstone of clinical ataxiology" . ... "A Rare Cause of Dizziness and Gait Ataxia: CLIPPERS Syndrome" . Journal of the Belgian Society of Radiology . 100 (1): 20. doi : 10.5334/jbr-btr.997 . ... "Spatial neglect, Balint-Homes' and Gerstmann's syndrome, and other spatial disorders".ATXN7, FMR1, CUL4B, FXN, SCYL1, TUBB4A, PAK1, PRKCG, DOCK3, PRNP, DARS2, PNPLA6, ITPR1, SETX, AFG3L2, KIF1C, POLG2, DKK1, NOP56, PMPCA, SLC9A6, SYNE1, NUP62, STUB1, PLD3, ADAR, DNAJC6, TECPR2, GPAA1, TRIO, TRPC3, UBTF, VLDLR, RNF113A, PLA2G6, RFXANK, SYNJ1, SACS, SQSTM1, AP1S2, CACNA1G, HERC1, RAB11B, CACNA2D2, RUBCN, ATXN10, RRM2B, BSCL2, COQ2, UBA5, SLC19A3, LMNB2, PPP1R15B, ATCAY, MARS2, TANGO2, UROC1, MPLKIP, BEAN1, BRAT1, RNU12, CHAMP1, TMEM240, TGM6, GTF2H5, CCDC88C, SLC52A2, COA7, SIL1, GDAP2, FLVCR1, TCF4, MECR, WWOX, TMEM106B, GTPBP2, PDP1, APTX, ELOVL5, ANO10, VPS13D, ATAD3A, CWF19L1, ERMARD, TWNK, GBA2, TH, TBP, ADSL, HLA-DQB1, FAT2, FGF14, GCH1, GRID2, GRM1, GTF2E2, HTT, HSD17B4, MPZ, IFRD1, KCNC3, KCND3, MAB21L1, MAN2B1, MECP2, MIPEP, ERCC3, ERCC2, EIF2S3, EEF2, SLC25A4, ARCN1, ATP1A3, ATP6V1A, CACNA1A, CAPN1, CAV1, SCARB2, ERCC8, CLCN2, TPP1, CSF1R, CTBP1, DDX3X, ATN1, MME, CIITA, MRE11, ATXN2, POU3F4, DNAJC3, PSAP, RFC1, RFX5, RFXAP, ATXN8OS, PMP22, SLC2A1, SLC9A1, SLC18A2, SPG7, SPTBN2, ELOVL4, PODXL, POLG, ATXN8, ND1, ND4, ND6, ND3, ND2, TRNK, TRNL1, TRNV, TRNW, OPHN1, ATP6, PDYN, PEX6, ND5, ATXN3, FBXO41, TRH, SAR1A, CBLN1, ELP1, RORB, GAD1, HIP1, PPP2R2B, ZFYVE9, SCA18
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Leukemia, Acute Myeloid
Omim
In 38% of patients with myelodysplastic syndromes (see MDS, 614286) or AML, increased beta-catenin signaling and nuclear accumulation was identified in osteoblasts, and these patients showed increased Notch signaling in hematopoietic cells. ... Cytogenetics Loss of chromosome 5q is observed in 10 to 15% of patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia and in 40% of patients with therapy-related MDS or AML. In addition, patients with 5q deletion syndrome (153550) show hematologic abnormalities, including refractory anemia and abnormal megakaryocytes. ... Mutations in GATA2 Hahn et al. (2011) analyzed 50 candidate genes in 5 families with a predisposition to myelodysplastic syndrome (614286) and acute myeloid leukemia, and in 3 of the families they identified a heritable heterozygous missense mutation in the GATA2 gene (T354M; 137295.0002) that segregated with disease and was not found in 695 nonleukemic ethnically matched controls. ... They identified heterozygous somatic mutations in the ASXL1 gene in 5 (16%) of 38 myelodysplastic syndrome/acute myeloid leukemia samples.
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Excoriation Disorder
Wikipedia
OCD or BDD, and excoriation disorder is merely a bad habit and that by allowing this disorder to obtain its own separate category it would force the DSM to include a wide array of bad habits as separate syndromes, e.g., nail biting and nose-picking. [8] Stein has argued that excoriation disorder does qualify as a separate syndrome and should be classified as its own category because: Excoriation disorder occurs as the primary disorder and not as a subset of a larger disorder. ... Classification as a separate condition would lead to more awareness of the disorder and encourage more people to obtain treatment. [8] However, a review of the scientific literature by Jenkins et al. on excoriation disorder as a separate category in the DSM-5 concluded that such a distinction requires more evidence. [13] Because excoriation disorder is different from other conditions and disorders that cause picking of the skin, it is important that any diagnosis of excoriation disorder take into account various other medical conditions as possible causes before diagnosing the patient with excoriation disorder. [3] There are a variety of conditions that cause itching and skin picking including: eczema , psoriasis , diabetes , liver disease , Hodgkin's disease , polycythemia vera , systemic lupus , and Prader-Willi syndrome . [3] In order to better understand excoriation disorder, researchers have developed a variety of scales to categorize skin-picking behavior. ... These products have shown some ability to reduce other problematic behaviors such as cocaine addiction and trichotillomania. [3] Some case studies and some small studies of NAC have shown a decrease in picking by treatment with NAC compared with placebo. [3] Excoriation disorder and trichotillomania have been treated with inositol . [19] Topiramate , an anti-epileptic drug, has been used to treat excoriation disorder; in a small study of individuals with Prader–Willi syndrome , it was found to reduce skin picking. [7] Counseling [ edit ] Behavioral treatments include habit reversal training , cognitive-behavioral therapy , acceptance-enhanced behavior therapy [3] [6] and acceptance and commitment therapy (ACT). [20] Several studies have shown that habit reversal training associated with awareness training reduces skin-picking behavior in those individuals with excoriation disorder that do not have psychological disabilities. [7] Habit reversal training can include awareness enhancement and competing response training. [7] For example, in one study the competing response training required participants to make a closed fist for one minute instead of picking or in response to a condition that usually provokes picking behavior. [7] Developmentally disabled [ edit ] There are several different behavioral interventions that have been tested to treat excoriation disorder in the developmentally disabled. ... Excoriation disorder is statistically more common in females than in males. [3] [6] Excoriation disorder has a high rate of comorbidity with other psychiatric conditions, especially with mood and anxiety disorders . [8] One survey of patients with excoriation disorder found that 56.7% also had a DSM-IV Axis-I disorder and 38% had alcohol- or drug-abuse problems. [3] Studies have shown the following rates of psychiatric conditions found in patients with excoriation disorder: trichotillomania (38.3%), substance abuse (38%), major depressive disorder (approximately 31.7% to 58.1%), anxiety disorders (approximately 23% to 56%), obsessive-compulsive disorder (approximately 16.7% to 68%), and body dysmorphic disorder (approximately 26.8% to 44.9%). [3] There are also higher rates of excoriation disorder in patients in psychiatric facilities; a study of adolescent psychiatric inpatients found that excoriation disorder was present in 11.8% of patients. [3] It is also present at high rates with some other conditions: 44.9% of patients with body dysmorphic disorder also have excoriation disorder; 8.9% of patients with OCD have excoriation disorder; and 8.3% of patients with trichotillomania have excoriation disorder. [3] Skin picking is also common in those with certain developmental disabilities; for example, Prader–Willi syndrome and Smith–Magenis syndrome . [7] Studies have shown that 85% of people with Prader–Willi syndrome also engage in skin-picking. [7] Children with developmental disabilities are also at an increased risk for excoriation disorder. [7] Excoriation disorder also correlates with "social, occupational, and academic impairments, increased medical and mental health concerns (including anxiety, depression, obsessive–compulsive disorder) ... and financial burden". [7] Excoriation disorder also has a high degree of comorbidity with occupational and marital difficulties. [8] Substance abuse is often present, and individuals with excoriation disorder are twice as likely to have first-degree relatives who have substance abuse disorders than those without the condition. [3] Some cases of body-focused repetitive behaviors found in identical twins also suggest a hereditary factor. [23] History [ edit ] The first known mention of excoriation disorder in the print can be found in 1898 by the French dermatologist Louis-Anne-Jean Brocq , describing an adolescent female patient who had uncontrolled picking of acne. [3] [24] Society and culture [ edit ] Excoriation disorder has been the subject of several episodes of Obsessed , a television documentary series that focuses on treatment of anxiety disorders. ... Cite journal requires |journal= ( help ) External links [ edit ] Classification D ICD - 10 : L98.1 ICD - 9-CM : 312.3 MeSH : D007174 DiseasesDB : 29765 External resources eMedicine : article/1122042 v t e Emotional and behavioral disorders Emotional/behavioral ADHD Conduct disorder Oppositional defiant disorder Emotional/behavioral disorder (EBD) Separation anxiety Social functioning Selective mutism RAD DAD Tic disorders Tourette syndrome Speech disorders Stuttering Cluttering Stereotypic movement disorder Elimination disorders Enuresis Encopresis v t e Mental and behavioral disorders Adult personality and behavior Gender dysphoria Ego-dystonic sexual orientation Paraphilia Fetishism Voyeurism Sexual maturation disorder Sexual relationship disorder Other Factitious disorder Munchausen syndrome Intermittent explosive disorder Dermatillomania Kleptomania Pyromania Trichotillomania Personality disorder Childhood and learning Emotional and behavioral ADHD Conduct disorder ODD Emotional and behavioral disorders Separation anxiety disorder Movement disorders Stereotypic Social functioning DAD RAD Selective mutism Speech Stuttering Cluttering Tic disorder Tourette syndrome Intellectual disability X-linked intellectual disability Lujan–Fryns syndrome Psychological development ( developmental disabilities ) Pervasive Specific Mood (affective) Bipolar Bipolar I Bipolar II Bipolar NOS Cyclothymia Depression Atypical depression Dysthymia Major depressive disorder Melancholic depression Seasonal affective disorder Mania Neurological and symptomatic Autism spectrum Autism Asperger syndrome High-functioning autism PDD-NOS Savant syndrome Dementia AIDS dementia complex Alzheimer's disease Creutzfeldt–Jakob disease Frontotemporal dementia Huntington's disease Mild cognitive impairment Parkinson's disease Pick's disease Sundowning Vascular dementia Wandering Other Delirium Organic brain syndrome Post-concussion syndrome Neurotic , stress -related and somatoform Adjustment Adjustment disorder with depressed mood Anxiety Phobia Agoraphobia Social anxiety Social phobia Anthropophobia Specific social phobia Specific phobia Claustrophobia Other Generalized anxiety disorder OCD Panic attack Panic disorder Stress Acute stress reaction PTSD Dissociative Depersonalization disorder Dissociative identity disorder Fugue state Psychogenic amnesia Somatic symptom Body dysmorphic disorder Conversion disorder Ganser syndrome Globus pharyngis Psychogenic non-epileptic seizures False pregnancy Hypochondriasis Mass psychogenic illness Nosophobia Psychogenic pain Somatization disorder Physiological and physical behavior Eating Anorexia nervosa Bulimia nervosa Rumination syndrome Other specified feeding or eating disorder Nonorganic sleep Hypersomnia Insomnia Parasomnia Night terror Nightmare REM sleep behavior disorder Postnatal Postpartum depression Postpartum psychosis Sexual dysfunction Arousal Erectile dysfunction Female sexual arousal disorder Desire Hypersexuality Hypoactive sexual desire disorder Orgasm Anorgasmia Delayed ejaculation Premature ejaculation Sexual anhedonia Pain Nonorganic dyspareunia Nonorganic vaginismus Psychoactive substances, substance abuse and substance-related Drug overdose Intoxication Physical dependence Rebound effect Stimulant psychosis Substance dependence Withdrawal Schizophrenia , schizotypal and delusional Delusional Delusional disorder Folie à deux Psychosis and schizophrenia-like Brief reactive psychosis Schizoaffective disorder Schizophreniform disorder Schizophrenia Childhood schizophrenia Disorganized (hebephrenic) schizophrenia Paranoid schizophrenia Pseudoneurotic schizophrenia Simple-type schizophrenia Other Catatonia Symptoms and uncategorized Impulse control disorder Klüver–Bucy syndrome Psychomotor agitation Stereotypy
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Apolipoprotein B Deficiency
Wikipedia
External links [ edit ] Classification D OMIM : 107730 MeSH : D052476 DiseasesDB : 34399 v t e Inborn error of lipid metabolism : dyslipidemia Hyperlipidemia Hypercholesterolemia / Hypertriglyceridemia Lipoprotein lipase deficiency/Type Ia Familial apoprotein CII deficiency/Type Ib Familial hypercholesterolemia/Type IIa Combined hyperlipidemia/Type IIb Familial dysbetalipoproteinemia/Type III Familial hypertriglyceridemia/Type IV Xanthoma/Xanthomatosis Hypolipoproteinemia Hypoalphalipoproteinemia/HDL Lecithin cholesterol acyltransferase deficiency Tangier disease Hypobetalipoproteinemia/LDL Abetalipoproteinemia Apolipoprotein B deficiency Chylomicron retention disease Lipodystrophy Barraquer–Simons syndrome Other Lipomatosis Adiposis dolorosa Lipoid proteinosis APOA1 familial renal amyloidosis This cutaneous condition article is a stub .
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Hyperinsulinism Due To Glucokinase Deficiency
Orphanet
GCK alterations are noted in 1.2% of patients with non-syndromic CHI. Clinical description Clinical picture is similar to that described in CHI with mild manifestations leading to a delay in diagnosis until adulthood.
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Spastic Paraplegia 38, Autosomal Dominant
Omim
Orlacchio et al. (2008) noted that the clinical features in this family were similar to those of Silver syndrome (SPG17; 270685). Mapping By genomewide linkage analysis of a large Italian family with autosomal dominant SPG, Orlacchio et al. (2008) found linkage to a 13.1-cM (6.9-Mb) interval on chromosome 4p16-p15 between D4S432 and D4S1599 (maximum 2-point lod score of 3.30 at D4S2935).
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Microcephaly, Growth Retardation, Cataract, Hearing Loss, And Unusual Appearance
Omim
Hansen et al. (2009) postulated autosomal recessive inheritance and noted phenotypic similarities to Dubowitz syndrome (223370). INHERITANCE - Autosomal recessive GROWTH Height - Short stature Weight - Low weight Other - Postnatal growth retardation HEAD & NECK Head - Microcephaly Face - Retrognathia Ears - Simple ear structure - Hearing loss, perceptive Eyes - Cataracts - Epicanthal folds - Almond-shaped eyes Nose - Hypoplasia of the alae nasi - Broad nasal tip - Bulbous nose Teeth - Poor enamel GENITOURINARY External Genitalia (Male) - Genital hypoplasia - Cryptorchidism External Genitalia (Female) - Genital hypoplasia SKELETAL - Delayed bone age Limbs - Generalized shortening of the long bones - Broad metaphyses Hands - Short hands and fingers Feet - Short toes SKIN, NAILS, & HAIR Skin - Dry skin - Eczema - Edema on the dorsum of the hands and feet NEUROLOGIC Central Nervous System - Delayed psychomotor development - Seizures (in 1 patient) - Generalized brain atrophy IMMUNOLOGY - Egg allergy - Dog allergy - Nut allergy MISCELLANEOUS - Two sibs, a boy and a girl, have been reported (as of July 2009) ▲ Close
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Copper Deficiency, Familial Benign
Omim
Photographs showed curly hair and an appearance of the nose and lips reminiscent of that in the infantile hypercalcemia syndrome. The father and 2 brothers were physically and biochemically normal.
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Arbovirus Fever
Orphanet
Classical dengue fever and related syndromes are characterized by a macular rash, polyadenopathy, and minor hemorrhage, after which the symptoms resolve spontaneously.
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Primary Hypertrophic Osteoarthropathy
Orphanet
Differential diagnosis Differential diagnoses include secondary hypertrophic osteoarthropathy, chronic recurrent non-bacterial osteomyelitis, SAPHO and Camurati-Engelman syndromes (see these terms) and chronic bacterial osteomyelitis.
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Obesity Due To Congenital Leptin Deficiency
Orphanet
Diagnostic methods Family history, severe hyperphagia and early-onset obesity may lead to suspicion of a monogenic obesity syndrome. The diagnosis of congenital leptin deficiency can be confirmed by analysis of serum leptin levels or identification of mutations in the ob gene.
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Autosomal Recessive Brachyolmia
Orphanet
Corneal opacities and precocious calcification of the costal cartilage are rare syndromic components. Premature pubarche may occur.
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Physical Disorder
Wikipedia
Find sources: "Physical disorder" – news · newspapers · books · scholar · JSTOR ( September 2018 ) ( Learn how and when to remove this template message ) A physical disorder (as a medical term) is often used as a term in contrast to a mental disorder , in an attempt to differentiate medical disorders that have an available mechanical test (such as chemical tests or brain scans), from those disorders which have no laboratory or imaging test, and are diagnosed only by behavioral syndrome (such as those in the Diagnostic and Statistical Manual of Mental Disorders (DSM).
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Amelia And Terminal Transverse Hemimelia
Omim
Sixty-nine percent of the cases had MCA or syndromes. The most frequent defects associated with amelia were other types of musculoskeletal defects, intestinal defects, some renal and genital defects, oral clefts, defects of cardiac septa, and anencephaly.
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Endometrial Stromal Tumour
Wikipedia
PMID 25299308 . v t e Tumors of the female urogenital system Adnexa Ovaries Glandular and epithelial / surface epithelial- stromal tumor CMS: Ovarian serous cystadenoma Mucinous cystadenoma Cystadenocarcinoma Papillary serous cystadenocarcinoma Krukenberg tumor Endometrioid tumor Clear-cell ovarian carcinoma Brenner tumour Sex cord–gonadal stromal Leydig cell tumour Sertoli cell tumour Sertoli–Leydig cell tumour Thecoma Granulosa cell tumour Luteoma Sex cord tumour with annular tubules Germ cell Dysgerminoma Nongerminomatous Embryonal carcinoma Endodermal sinus tumor Gonadoblastoma Teratoma / Struma ovarii Choriocarcinoma Fibroma Meigs' syndrome Fallopian tube Adenomatoid tumor Uterus Myometrium Uterine fibroids/leiomyoma Leiomyosarcoma Adenomyoma Endometrium Endometrioid tumor Uterine papillary serous carcinoma Endometrial intraepithelial neoplasia Uterine clear-cell carcinoma Cervix Cervical intraepithelial neoplasia Clear-cell carcinoma SCC Glassy cell carcinoma Villoglandular adenocarcinoma Placenta Choriocarcinoma Gestational trophoblastic disease General Uterine sarcoma Mixed Müllerian tumor Vagina Squamous-cell carcinoma of the vagina Botryoid rhabdomyosarcoma Clear-cell adenocarcinoma of the vagina Vaginal intraepithelial neoplasia Vaginal cysts Vulva SCC Melanoma Papillary hidradenoma Extramammary Paget's disease Vulvar intraepithelial neoplasia Bartholin gland carcinoma This medical sign article is a stub .
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Seborrheic-Like Psoriasis
Wikipedia
ISBN 0-7216-2921-0 . v t e Papulosquamous disorders Psoriasis Pustular Generalized pustular psoriasis ( Impetigo herpetiformis ) Acropustulosis / Pustulosis palmaris et plantaris ( Pustular bacterid ) Annular pustular psoriasis Localized pustular psoriasis Other Guttate psoriasis Psoriatic arthritis Psoriatic erythroderma Drug-induced psoriasis Inverse psoriasis Napkin psoriasis Seborrheic-like psoriasis Parapsoriasis Pityriasis lichenoides ( Pityriasis lichenoides et varioliformis acuta , Pityriasis lichenoides chronica ) Lymphomatoid papulosis Small plaque parapsoriasis ( Digitate dermatosis , Xanthoerythrodermia perstans ) Large plaque parapsoriasis ( Retiform parapsoriasis ) Other pityriasis Pityriasis rosea Pityriasis rubra pilaris Pityriasis rotunda Pityriasis amiantacea Other lichenoid Lichen planus configuration Annular Linear morphology Hypertrophic Atrophic Bullous Ulcerative Actinic Pigmented site Mucosal Nails Peno-ginival Vulvovaginal overlap synromes with lichen sclerosus with lupus erythematosis other: Hepatitis-associated lichen planus Lichen planus pemphigoides Other Lichen nitidus Lichen striatus Lichen ruber moniliformis Gianotti–Crosti syndrome Erythema dyschromicum perstans Idiopathic eruptive macular pigmentation Keratosis lichenoides chronica Kraurosis vulvae Lichen sclerosus Lichenoid dermatitis Lichenoid reaction of graft-versus-host disease This cutaneous condition article is a stub .
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Porphyria
Orphanet
Differential diagnosis Differential diagnoses include, when patients present with acute attacks, Guillain-Barré syndrome (see this term) and all causes of acute abdominal pain, and, when patients present with cutaneous signs, photodermatoses.
- Limb Body Wall Complex Wikipedia