External links [ edit ] MeSH C23.300.250 – Choristoma v t e Overview of tumors , cancer and oncology Conditions Benign tumors Hyperplasia Cyst Pseudocyst Hamartoma Malignant progression Dysplasia Carcinoma in situ Cancer Metastasis Primary tumor Sentinel lymph node Topography Head and neck ( oral , nasopharyngeal ) Digestive system Respiratory system Bone Skin Blood Urogenital Nervous system Endocrine system Histology Carcinoma Sarcoma Blastoma Papilloma Adenoma Other Precancerous condition Paraneoplastic syndrome Staging / grading TNM Ann Arbor Prostate cancer staging Gleason grading system Dukes classification Carcinogenesis Cancer cell Carcinogen Tumor suppressor genes / oncogenes Clonally transmissible cancer Oncovirus Carcinogenic bacteria Misc.
Dysmotility is when the strength or coordination of the esophagus , stomach or intestines muscles do not work as they should. [1] Contents 1 Presentation 1.1 Associated illnesses 2 Diagnosis 3 Treatment 4 References 5 Further reading Presentation [ edit ] Associated illnesses [ edit ] Often AGID is a symptom of other problems, including colon cancer , lupus , lung, breast, or ovarian carcinoma or thymoma . or other diseases. Irritable bowel syndrome (IBS) is the most recognized form of AGID [ citation needed ] .
Erythroid dysplasia may be caused by vitamin deficiency or chemotherapy , or it may be a sign of refractory anemia , which is a myelodysplastic syndrome . Also called erythrodysplasia .
ICD10 code: M03.1 v t e Symptoms and signs relating to infectious diseases Bacterial disease syphilis Hutchinson's teeth Hutchinson's triad Westphal's sign Clutton's joints Dennie–Marfan syndrome Viral disease measles Koplik's spots Parasitic disease African trypanosomiasis Winterbottom's sign General Meningism Fever Liebermeister's rule Faget sign v t e Musculoskeletal examination Leg Hip examination Galeazzi test Allis test Barlow maneuver Ober's test Ortolani test Patrick's test Thomas test Trendelenburg's sign Knee examination Ballottement Clarke's test Drawer test Lachman test Patellar tap Pivot-shift test Valgus stress test meniscus Apley grind test McMurray test ligament and meniscus Unhappy triad Foot and ankle Hubscher's maneuver Mulder's sign Simmonds' test Thompson test Ankle Simmonds' test General Straight leg raise Lasègue's sign Gait abnormality Trendelenburg gait Unequal leg length Arm Shoulder examination Apprehension test Jobe's test Neer impingement sign Yergason's test rotator cuff Hawkins–Kennedy test Watson's test Elbow examination Cozen's test Elbow extension test Hand and wrist Durkan's test Finkelstein's test Froment's sign Lunotriquetral shear test Phalen maneuver Tinel sign Watson's test Spine Gaenslen's test Low back pain Waddell's signs Lower back flexibility Schober's test sacroiliitis Larrey's sign Other Range of motion Palpation Codman triangle This medical sign article is a stub .
Multiple tufted angioma and KHE may be associated with Kasabach-Merritt syndrome (141000), which is characterized by severe thrombocytopenia and consumption of coagulation factors (summary by Tille et al., 2003).
Tufted angioma Tufted angioblastoma Specialty Dermatology A tufted angioma (also known as an "Acquired tufted angioma," "Angioblastoma," "Angioblastoma of Nakagawa," "Hypertrophic hemangioma," "Progressive capillary hemangioma," and "Tufted hemangioma" [1] [2] ) usually develops in infancy or early childhood on the neck and upper trunk, and is an ill-defined, dull red macule with a mottled appearance, varying from 2 to 5 cm in diameter. [2] : 596 See also [ edit ] List of cutaneous conditions Skin lesion References [ edit ] ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set . St. Louis: Mosby. p. 1779. ISBN 1-4160-2999-0 . ^ a b James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology . (10th ed.). Saunders. ISBN 0-7216-2921-0 . External links [ edit ] Classification D ICD - 10 : M9161/1 MeSH : C536924 External resources eMedicine : article/1086612 This Dermal and subcutaneous growths article is a stub . You can help Wikipedia by expanding it . v t e
In addition to typical manifestations of the syndrome, the mother presented with carious teeth in the lower jaw, and an edentulous upper jaw due to previous extraction of severely carious teeth.
A very rare acrofacialdysostosis characterized by mild intrauterine growth retardation (IUGR), postnatal short stature, microcephaly, widow's peak, mandibulofacial dysostosis without cleft palate, frequent caries, mild pre- and postaxial limb hypoplasia with brachydactyly, mild interdigital webbing, simian creases, inguinal hernia and cryptorchidism and hypospadias in males.
A number sign (#) is used with this entry because of evidence that acrokeratosis verruciformis is caused by heterozygous mutation in the ATP2A2 gene (108740) on chromosome 12q24, making it allelic to Darier disease (124200). Description Acrokeratosis verruciformis of Hopf is a localized disorder of keratinization affecting the distal extremities. Onset occurs early in life (Dhitavat et al., 2003). Clinical Features In the family with acrokeratosis verruciformis of Hopf reported by Niedelman (1947) and Niedelman and McKusick (1962), the dorsum of the hands was affected first and most conspicuously. Older individuals tended to have hyperkeratosis of the elbows and knees. The nails were pearly white in early years and become horny, brown, ridged, and grooved in later life.
A rare, genetic, acrokeratoderma disease characterized by multiple, symmetrical, asymptomatic, skin-colored (rarely, brownish), flat-topped, wart-like papules located on the dorsal aspects of the hands and feet (occasionally found on other parts of the body, such as knees, elbows and forearms), typically associated with palmoplantar punctate keratosis and variable nail involvement (including leukonychia, thickening, ridging, longitudinal striations and splitting). Histology reveals undulating hyperkeratosis, papillomatosis, hypergranulosis, and acanthosis, creating a characteristic 'church spire' appearance, with no acantholysis nor dyskeratosis associated.
Contents 1 Causes 2 Pathophysiology 3 Diagnosis 4 Prevention 5 Treatment 6 References Causes [ edit ] Acute uric acid nephropathy is usually seen as part of the acute tumour lysis syndrome in patients undergoing chemotherapy or radiation therapy for the treatment of malignancies with rapid cell turnover, such as leukemia and lymphoma .
Chromophobe renal cell carcinoma is a rare subtype of the most common form of kidney cancer called renal cell carcinoma (RCC). This type of cancer forms in the cells lining the small tubules in the kidney. These tubules help filter waste from the blood, making urine. Chromophobe RCC accounts for about 5% of all RCC cases, and it is frequently diagnosed between ages 40 and 50. It is typically diagnosed in stage I or stage II, and has an overall better prognosis than other types of RCC. Treatment generally involves surgery.
Molecular Genetics In 70 patients from New Zealand and Slovenia with premature ovarian failure, defined as cessation of menses for 6 or more months before the age of 40 years, Harris et al. (2002) screened the FOXL2 gene (605597) for mutations based on the finding that FOXL2 is mutated in patients with blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES; 110100), some of whom experience POF.
See also [ edit ] Artemis § As the Lady of Ephesus (fertility goddess with many breasts) Fleischer's syndrome References [ edit ] ^ Laor T, Collins MH, Emery KH, Donnelly LF, Bove KE, Ballard ET (2004).
A rare breast malformation characterized by the presence of accessory breasts with a complete ductal system, areola, and nipple in addition to two normal breasts. The accessory breast tissue mostly lies along the milk lines. It is often not recognized until puberty, when it begins to respond to regular hormonal fluctuations, and may develop the same changes as normal breasts throughout life.
Causes [ edit ] Buildup of calcium phosphate in the ankle joints has been found in about 50% of the general population, and may be associated with osteoarthritis . [2] Another common cause of chondrocalcinosis is calcium pyrophosphate dihydrate crystal deposition disease (CPPD). [3] CPPD is estimated to affect 4% to 7% of the adult populations of Europe and the United States. [4] Previous studies have overestimated the prevalence by simply estimating the prevalence of chondrocalcinosis regardless of cause. [4] A magnesium deficiency may cause chondrocalcinosis, and magnesium supplementation may reduce or alleviate symptoms. [5] In some cases, arthritis from injury can cause chondrocalcinosis. [6] Other causes of chondrocalcinosis include: [3] Hypercalcaemia , especially when caused by hyperparathyroidism Arthritis Pseudogout Wilson disease Hemochromatosis Ochronosis Hypophosphatasia Hypothyroidism Hyperoxalemia Acromegaly Gitelman syndrome . Diagnosis [ edit ] Chondrocalcinosis can be visualized on projectional radiography , CT scan , MRI , US , and nuclear medicine . [1] CT scans and MRIs show calcific masses (usually within the ligamentum flavum or joint capsule), however radiography is more successful. [1] At ultrasound, chondrocalcinosis may be depicted as echogenic foci with no acoustic shadow within the hyaline cartilage. [7] As with most conditions, chondrocalcinosis can present with similarity to other diseases such as ankylosing spondylitis and gout . [1] References [ edit ] ^ a b c d Rothschild, Bruce M Calcium Pyrophosphate Deposition Disease (radiology) ^ Hubert, Jan; Weiser, Lukas; Hischke, Sandra; Uhlig, Annemarie; Rolvien, Tim; Schmidt, Tobias; Butscheidt, Sebastian Karl; Püschel, Klaus; Lehmann, Wolfgang; Beil, Frank Timo; Hawellek, Thelonius (2018).
Differential diagnosis Differential diagnosis includes other genetic conditions causing secondary CC such as chronic hypomagnesaemia (particularly the Gitelman syndrome), hereditary hemochromatosis and hypophosphatasia.
For a general phenotypic description and a discussion of genetic heterogeneity of chondrocalcinosis, also known as calcium pyrophosphate dihydrate deposition disease (CPPDD), see CCAL2 (118600). Clinical Features Baldwin et al. (1995) described a 6-generation New England family (family BU91) in which many members had early-onset CPPDD and severe degenerative osteoarthritis. Onset occurred between ages 25 and 40 years and males and females were equally affected. The authors stated that it was unclear whether the primary event causing the disease was deposition of calcium-containing crystals in joint tissue (caused by a defect in a 'CPPDD gene') that progressed to severe degenerative osteoarthritis or whether degenerative changes in cartilage (resulting from mutation in an 'osteoarthritis gene') enhanced deposition of calcium-containing crystals. Inheritance The transmission pattern of chondrocalcinosis and osteoarthritis in the family reported by Baldwin et al. (1995) supported autosomal dominant inheritance.
A number sign (#) is used with this entry because chondrocalcinosis-2 (CCAL2) is caused by heterozygous mutation in the ANKH gene (605145) on chromosome 5p15. Description Chondrocalcinosis, or cartilage calcification, is a common condition that usually results from deposition of crystals of calcium pyrophosphate dihydrate (CPPD) in articular hyaline and fibro-cartilage. CPPD crystal deposition may be asymptomatic or associated with characteristic acute attacks ('pseudogout') or chronic arthritis. It can be detected radiographically. Chondrocalcinosis occurs in 3 forms: a primary hereditary form (e.g., CCAL2); a form associated with metabolic disorders (e.g., hyperparathyroidism, hemochromatosis, and hypomagnesemia), and a sporadic form, which may in some cases represent the hereditary form (summary by Hughes et al., 1995 and Richette et al., 2009). Genetic Heterogeneity of Chondrocalcinosis Another form of chondrocalcinosis (CCAL1; 600668) has been mapped to chromosome 8q.
Description Idiopathic CD4 lymphopenia (ICL) is a rare and heterogeneous syndrome defined by a reproducible reduction in the CD4 T-lymphocyte count (less than 300 cells per microliter or less than 20% of total T cells) in the absence of HIV infection or other known causes of immunodeficiency.
Idiopathic CD4 lymphocytopenia is a rare primary immunodeficiency disorder characterized by persistent CD4 T-cell lymphopenia (less than 300 cells/µL on multiple occasions) not associated with any other underlying primary or secondary immune deficiency. Patients typically present opportunistic infections (with cryptococcal, mycobacterial, candidal, varicella zoster virus infections and progressive multifocal leukoencephalopathy being the most prevalent), malignancies (mainly lymphoproliferative disorders), or autoimmune disorders. Some individuals are asymptomatic and incidentally diagnosed.
Idiopathic CD4 positive T-lymphocytopenia (ICL) is a rare disorder of the immune system. People with ICL have low levels of a type of white blood cell, called a CD4+ T cell . These low levels can not be explained by other causes of immunodeficiency, including HIV infection . T cells have many jobs in our immune system, such as attacking bacteria and viruses. CD4 is a protein found on the surface of many different cells within your immune system.
Nickel allergy Specialty Allergology , immunology Nickel allergy or nickel allergic contact dermatitis ( Ni-ACD ) is a form of allergic contact dermatitis (ACD) caused by exposure to the chemical element nickel . Contents 1 Physiology 2 Syndromes 3 History 4 Sources of Ni-ACD 4.1 Foods 4.2 Workplace 5 Effects 6 Prevention 7 Diagnosis 8 Treatment 9 Regulation 10 References 11 Further reading Physiology [ edit ] Nickel allergy results in a skin response after the skin comes in contact with an item that releases a large amount of nickel from its surface. ... In Ni-ACD other cells are involved including: Th17 , Th22, Th1/ IFN and the innate immune responses consistent with toll-like receptor 4 . [8] [9] Syndromes [ edit ] Josef Jadassohn described the first case of metal contact dermatitis in 1895, to a mercurial-based therapeutic cream, and confirmed the cause by epi-cutaneous patch testing. [10] Systemic contact dermatitis (SCD) is defined as a dermatitis occurring in an epi-cutaneously contact-sensitized person when exposed to haptens systemically such as orally, per rectum, intravesically, transcutaneously, intrauterinely, intravenously, or by inhalation. [11] Systemic nickel allergy syndrome (SNAS) pathophysiology is extremely complex and not well understood. ... Examples of systemic reactions can include hand dermatitis , baboon syndrome , or generalized eczematous reactions. [28] Prevention [ edit ] Nickel has a wide utility of application in manufactured metals because it is both strong and malleable, leading to ubiquitous presence and the potential for consumers to be in contact with it daily. ... "Nickel oral hyposensitization in patients with systemic nickel allergy syndrome" . Annals of Medicine . 46 (1): 31–7. doi : 10.3109/07853890.2013.861158 .
Recurrent respiratory papillomatosis is a rare respiratory disease characterized by the development of exophytic papillomas, affecting the mucosa of the upper aero-digestive tract (with a strong predilection for the larynx), caused by an infection with human papilloma virus. Symptoms at presentation may include hoarseness, chronic cough, dyspnea, recurrent upper respiratory tract infections, pneumonia, dysphagia, stridor, and/or failure to thrive. Epidemiology The prevalence of recurrent respiratory papillomatosis (RRP) is estimated at about 1/70,400 in the United Kingdom. Annual incidence of the disease is about 1/23,300 in children and 1/55,500 in adults in the United States. The adult form affects males more often than females. Clinical description A bimodal age distribution is characteristic, with the disease affecting either young children or young adults.
Recurrent respiratory papillomatosis (RRP) is a rare viral disease where tumors (papillomas) grow in the air passages leading from the nose and mouth into the lungs (respiratory tract). There are two types, a juvenile-onset form and an adult-onset form. The tumors can cause a hoarse voice, chronic cough, and difficulty breathing. They may vary in size and grow very quickly, and may grow back even when removed. These tumors rarely become cancerous, but can cause long-term airway and voice complications. RRP is caused by two types of human papillomavirus (HPV) , called HPV 6 and HPV 11.