Muscle weakness is an isolated symptom in about 30% of patients and the presenting symptom in greater than half of patients, suggesting that IBMPFD may commonly be seen in a neuromuscular clinic without its other syndromic features (review by Weihl et al., 2009). ... Clinical Features Tucker et al. (1982) studied a large kindred with a syndrome of lower motor neuron degeneration and polyostotic skeletal disorganization resembling Paget disease of bone (PDB; see 167250). ... One was later found to have a mild dysexecutive syndrome, but neither had evidence of Paget disease.
Inclusion body myopathy associated with Paget disease of bone (PDB) and/or frontotemporal dementia (IBMPFD) is characterized by adult-onset proximal and distal muscle weakness (clinically resembling a limb-girdle muscular dystrophy syndrome), early-onset PDB, and premature frontotemporal dementia (FTD). ... Al-Obeidi et al [2018] Clinical Characteristics Clinical Description Inclusion body myopathy associated with Paget disease of bone and/or frontotemporal dementia (IBMPFD) is characterized by adult-onset proximal and distal muscle weakness (clinically resembling a limb-girdle muscular dystrophy syndrome), early-onset Paget disease of bone (PDB), and premature frontotemporal dementia (FTD). ... Scapuloperoneal myopathy (SPM). Scapuloperoneal syndromes are heterogeneous (see OMIM 616852,181430, and 300695).
Inclusion body myopathy with Paget disease of bone and frontotemporal dementia (IBMPFD) is a multisystem degenerative genetic disorder characterized by adult-onset proximal and distal muscle weakness (clinically resembling limb-girdle muscular dystrophy; see this term); early-onset Paget disease of bone (see this term), manifesting with bone pain, deformity and enlargement of the long-bones; and premature frontotemporal dementia (see this term), manifesting first with dysnomia, dyscalculia and comprehension deficits followed by progressive aphasia, alexia, and agraphia. As the disease progresses, muscle weakness begins to affect the other limbs and respiratory muscles, ultimately resulting in respiratory or cardiac failure.
A number sign (#) is used with this entry because of evidence that inclusion body myopathy with Paget disease (IBMPFD3) is caused by heterozygous mutation in the HNRNPA1 gene (164017) on chromosome 12q13. One such family has been reported. Heterozygous mutations in the HNRNPA1 gene also result in amyotrophic lateral sclerosis (ALS20; 615426). For a general phenotypic description and a discussion of genetic heterogeneity of IBMPFD, see IBMPFD1 (167320). Clinical Features Kottlors et al. (2010) described a German family with 5 affected sibs with a limb girdle muscular dystrophy characterized by progressive predominantly proximal muscle weakness, mildly elevated serum creatine kinase levels, myopathic findings on muscle biopsy, and Paget disease of the bone. All affected individuals showed a pattern of muscle weakness beginning in the lower proximal extremities and later spreading to the foot dorsiflexors.
A number sign (#) is used with this entry because of evidence that inclusion body myopathy with Paget disease and frontotemporal dementia-2 (IBMPFD2) is caused by heterozygous mutation in the HNRNPA2B1 (600124) gene on chromosome 7p15. One such family has been reported. For a general phenotypic description and a discussion of genetic heterogeneity of IBMPFD, see IBMPFD1 (167320). Clinical Features Waggoner et al. (2002) reported a family in which autosomal dominant early-onset Paget disease of bone was associated with a scapuloperoneal type of muscular dystrophy (SPMD). Muscle histology was nonspecific. CPK levels were elevated in active forms of the disorder. PDB in this family presented primarily in the long bones and progressed to the spine and other bones.
Injury [ edit ] Stroke , loss of brain function due to a sudden interruption of blood supply in the brain Traumatic brain injury Corticosteroid use (There appears to be correlations between degree of dosing with corticosteroids and cerebral atrophy) [3] Environmental pollutants [4] Diseases and disorders [ edit ] Pick's disease showing brain atrophy, Alzheimer's disease (High resolution MRI scans have shown the progression of cerebral atrophy in Alzheimer's disease) [5] Cerebral palsy , in which lesions (damaged areas) may impair motor coordination Senile dementia , fronto-temporal dementia , and vascular dementia Pick's disease , causes progressive destruction of nerve cells in the brain Huntington's disease , and other genetic disorders that cause build-up of toxic levels of proteins in neurons Leukodystrophies, such as Krabbe disease , which destroy the myelin sheath that protects axons Multiple sclerosis , which causes inflammation, myelin damage, and lesions in cerebral tissue Epilepsy , in which lesions cause abnormal electrochemical discharges that result in seizures Anorexia nervosa , bulimia nervosa , and other eating disorders Malnutrition , caused by lack or excess of nutrition from foods Type II diabetes , where the body does not use insulin properly resulting in high blood sugar Bipolar disorder , [6] significant loss of brain tissue during manic episodes; however it's not verified whether the episodes cause brain tissue loss or vice versa Schizophrenia [7] Mitochondrial encephalomyopathies, such as Kearns–Sayre syndrome , which interfere with the basic functions of neurons Posterior cortical atrophy : In the most posterior area of the brain lies the visual cortex , the area of the brain where visual information is received and processed. ... PMID 6250932 . v t e Diseases of the nervous system , primarily CNS Inflammation Brain Encephalitis Viral encephalitis Herpesviral encephalitis Limbic encephalitis Encephalitis lethargica Cavernous sinus thrombosis Brain abscess Amoebic Brain and spinal cord Encephalomyelitis Acute disseminated Meningitis Meningoencephalitis Brain / encephalopathy Degenerative Extrapyramidal and movement disorders Basal ganglia disease Parkinsonism PD Postencephalitic NMS PKAN Tauopathy PSP Striatonigral degeneration Hemiballismus HD OA Dyskinesia Dystonia Status dystonicus Spasmodic torticollis Meige's Blepharospasm Athetosis Chorea Choreoathetosis Myoclonus Myoclonic epilepsy Akathisia Tremor Essential tremor Intention tremor Restless legs Stiff-person Dementia Tauopathy Alzheimer's Early-onset Primary progressive aphasia Frontotemporal dementia / Frontotemporal lobar degeneration Pick's Dementia with Lewy bodies Posterior cortical atrophy Vascular dementia Mitochondrial disease Leigh syndrome Demyelinating Autoimmune Inflammatory Multiple sclerosis For more detailed coverage, see Template:Demyelinating diseases of CNS Episodic/ paroxysmal Seizures and epilepsy Focal Generalised Status epilepticus For more detailed coverage, see Template:Epilepsy Headache Migraine Cluster Tension For more detailed coverage, see Template:Headache Cerebrovascular TIA Stroke For more detailed coverage, see Template:Cerebrovascular diseases Other Sleep disorders For more detailed coverage, see Template:Sleep CSF Intracranial hypertension Hydrocephalus Normal pressure hydrocephalus Choroid plexus papilloma Idiopathic intracranial hypertension Cerebral edema Intracranial hypotension Other Brain herniation Reye syndrome Hepatic encephalopathy Toxic encephalopathy Hashimoto's encephalopathy Both/either Degenerative SA Friedreich's ataxia Ataxia–telangiectasia MND UMN only: Primary lateral sclerosis Pseudobulbar palsy Hereditary spastic paraplegia LMN only: Distal hereditary motor neuronopathies Spinal muscular atrophies SMA SMAX1 SMAX2 DSMA1 Congenital DSMA Spinal muscular atrophy with lower extremity predominance (SMALED) SMALED1 SMALED2A SMALED2B SMA-PCH SMA-PME Progressive muscular atrophy Progressive bulbar palsy Fazio–Londe Infantile progressive bulbar palsy both: Amyotrophic lateral sclerosis
Cerebellar degeneration refers to the deterioration of neurons (nerve cells) in the cerebellum (the area of the brain that controls muscle coordination and balance). Conditions that cause cerebellar degeneration may also affect other areas of the central nervous system, such as the spinal cord, the cerebral cortex (the thin layer of cells covering the brain), and the brain stem. Signs and symptoms of cerebellar degeneration may include a wide-based, uncoordinated walk; a back and forth tremor in the trunk of the body; uncoordinated movements of the arms and legs; slow and slurred speech; and nystagmus. Cerebellar degeneration can be caused by a variety of factors including inherited gene changes (mutations), chronic alcohol abuse, and paraneoplastic disorders . Treatment for cerebellar degeneration varies depending on the underlying cause.
The disease is not caused by overproduction of CSF or obstruction of CSF flow at the ventricles. The syndrome is often divided into two groups, primary (also called idiopathic ) and secondary , based on cause. ... External links [ edit ] The Normal Pressure Hydrocephalus Center at Johns Hopkins Bayview Medical Center Normal Pressure Hydrocephalus at Cleveland Clinic normal_pressure_hydrocephalus at NINDS When it really is NPH at Likvor Classification D ICD - 10 : G91.2 ICD - 9-CM : 331.9 , 331.5 MeSH : D006850 DiseasesDB : 9089 External resources MedlinePlus : 000752 eMedicine : neuro/277 radio/479 Patient UK : Normal pressure hydrocephalus Wikimedia Commons has media related to Normal pressure hydrocephalus . v t e Diseases of the nervous system , primarily CNS Inflammation Brain Encephalitis Viral encephalitis Herpesviral encephalitis Limbic encephalitis Encephalitis lethargica Cavernous sinus thrombosis Brain abscess Amoebic Brain and spinal cord Encephalomyelitis Acute disseminated Meningitis Meningoencephalitis Brain / encephalopathy Degenerative Extrapyramidal and movement disorders Basal ganglia disease Parkinsonism PD Postencephalitic NMS PKAN Tauopathy PSP Striatonigral degeneration Hemiballismus HD OA Dyskinesia Dystonia Status dystonicus Spasmodic torticollis Meige's Blepharospasm Athetosis Chorea Choreoathetosis Myoclonus Myoclonic epilepsy Akathisia Tremor Essential tremor Intention tremor Restless legs Stiff-person Dementia Tauopathy Alzheimer's Early-onset Primary progressive aphasia Frontotemporal dementia / Frontotemporal lobar degeneration Pick's Dementia with Lewy bodies Posterior cortical atrophy Vascular dementia Mitochondrial disease Leigh syndrome Demyelinating Autoimmune Inflammatory Multiple sclerosis For more detailed coverage, see Template:Demyelinating diseases of CNS Episodic/ paroxysmal Seizures and epilepsy Focal Generalised Status epilepticus For more detailed coverage, see Template:Epilepsy Headache Migraine Cluster Tension For more detailed coverage, see Template:Headache Cerebrovascular TIA Stroke For more detailed coverage, see Template:Cerebrovascular diseases Other Sleep disorders For more detailed coverage, see Template:Sleep CSF Intracranial hypertension Hydrocephalus Normal pressure hydrocephalus Choroid plexus papilloma Idiopathic intracranial hypertension Cerebral edema Intracranial hypotension Other Brain herniation Reye syndrome Hepatic encephalopathy Toxic encephalopathy Hashimoto's encephalopathy Both/either Degenerative SA Friedreich's ataxia Ataxia–telangiectasia MND UMN only: Primary lateral sclerosis Pseudobulbar palsy Hereditary spastic paraplegia LMN only: Distal hereditary motor neuronopathies Spinal muscular atrophies SMA SMAX1 SMAX2 DSMA1 Congenital DSMA Spinal muscular atrophy with lower extremity predominance (SMALED) SMALED1 SMALED2A SMALED2B SMA-PCH SMA-PME Progressive muscular atrophy Progressive bulbar palsy Fazio–Londe Infantile progressive bulbar palsy both: Amyotrophic lateral sclerosis
This article includes a list of references , related reading or external links , but its sources remain unclear because it lacks inline citations . Please help to improve this article by introducing more precise citations. ( April 2011 ) ( Learn how and when to remove this template message ) Low pressure hydrocephalus Ventricles position Specialty Neurology Low-pressure hydrocephalus (LPH) is a condition whereby ventricles are enlarged and the individual experiences severe dementia , inability to walk, and incontinence – despite very low intracranial pressure (ICP). Low pressure hydrocephalus appears to be a more acute form of normal pressure hydrocephalus . If not diagnosed in a timely fashion, the individual runs the risk of remaining in the low pressure hydrocephalic state or LPHS. Shunt revisions, even when they are set to drain at a low ICP, are not always effective.
Offline computer addiction is normally used when speaking about excessive gaming behavior, which can be practiced both offline and online. [5] Online computer addiction, also known as Internet addiction , gets more attention in general from scientific research than offline computer addiction, mainly because most cases of computer addiction are related to the excessive use of the Internet. [2] Experts on Internet addiction have described this syndrome as an individual working intensely on the Internet, prolonged use of the Internet, uncontrollable use of the Internet, unable to use the internet in an efficient, timely matter, not being interested in the outside world, not spending time with people from the outside world, and an increase in their loneliness and dejection. [6] Contents 1 Symptoms 2 Effects 3 Causes 4 Types 5 Diagnostic Test 6 Origin of the term and history 7 See also 8 References Symptoms [ edit ] Being drawn by the computer as soon as one wakes up and before one goes to bed Replacing old hobbies with excessive use of the computer and using the computer as one's primary source of entertainment and procrastination Lacking physical exercise and/or outdoor exposure because of constant use of the computer, which could contribute to many health problems such as obesity Effects [ edit ] Excessive computer use may result in, or occur with: Lack of face to face social interaction Computer vision syndrome Causes [ edit ] Kimberly Young [7] indicates that previous research links internet/computer addiction with existing mental health issues, most notably depression. ... Dependence Concepts Physical dependence Psychological dependence Withdrawal Disorders Drugs Alcoholism Amphetamine Barbiturate Benzodiazepine Caffeine Cannabis Cocaine Nicotine Opioid Non-drug stimuli Tanning dependence Treatment and management Detoxification Alcohol detoxification Drug detoxification Behavioral therapies Cognitive behavioral therapy Relapse prevention Contingency management Community reinforcement approach and family training Motivational enhancement therapy Motivational interviewing Motivational therapy Physical exercise Treatment programs Drug rehab Residential treatment center Heroin-assisted treatment Intensive outpatient program Methadone maintenance Smoking cessation Nicotine replacement therapy Tobacco cessation clinics in India Twelve-step program Support groups Addiction recovery groups List of twelve-step groups Harm reduction Category:Harm reduction Drug checking Reagent testing Low-threshold treatment programs Managed alcohol program Moderation Management Needle exchange program Responsible drug use Stimulant maintenance Supervised injection site Tobacco harm reduction See also Addiction medicine Allen Carr Category:Addiction Discrimination against drug addicts Dopamine dysregulation syndrome Cognitive control Inhibitory control Motivational salience Incentive salience Sober companion Category v t e Digital media use and mental health Proposed or recognised diagnostic categories Gaming disorder (Video game addiction) Problematic social media use Internet addiction disorder Problematic smartphone use Nomophobia Computer addiction Television addiction Internet sex addiction Disciplines involved Digital sociology Digital anthropology Psychiatry Psychology Neuroscience Associated psychiatric conditions Depression Anxiety Attention deficit hyperactivity disorder Bipolar disorder Related concepts Electronic media and sleep Screen time Digital detox Smartphone zombie Cyberbullying Media multitasking Online problem gambling Technostress Computer rage
Some subforms of sarcoidosis, such as Löfgren syndrome , may have a particular precipitant and have a specific course. ... External links [ edit ] Classification D ICD - 10 : D86.0 D86.1 D86.2 D86.3 D86.8 D86.9 OMIM : 181000 MeSH : D012507 SNOMED CT : 230193008 External resources MedlinePlus : 000720 eMedicine : neuro/649 Orphanet : 797 v t e Sarcoidosis Skin Lupus pernio Neurosarcoidosis Löfgren syndrome Heerfordt's syndrome
Examples of these causes are physical trauma, acoustic neuroma , maternal prenatal illness such as measles, labyrinthitis , microtia , meningitis , Ménière's disease , Waardenburg syndrome , mumps (epidemic parotitis), and mastoiditis . ... The effect is also similar to talking on the phone to someone who is in a noisy environment (see also: King-Kopetzky syndrome ) Inability to filter out background noise or selectively listen to only the important portion of the noise in the environment. ... PMID 15148171 . ^ OS X Mavericks: Audio pane of Accessibility preferences ^ Apple - Accessibility - iOS External links [ edit ] Classification D ICD - 10 : H90.1 , H90.4 , H90.7 MeSH : D046088 Profound Unilateral Hearing Loss FAQ's and Flash Animation BoysTownHospital.org Unilateral Hearing Loss - Notes v t e Diseases of the outer and middle ear Outer ear Otitis externa Otomycosis Middle ear and mastoid Otitis media Mastoiditis Bezold's abscess Gradenigo's syndrome Tympanosclerosis Cholesteatoma Perforated eardrum Symptoms Ear pain Hearing loss Tests Otoscope pneumatic tympanometry
Clinical Features Smith (1939) described a sibship of 8 children, 4 of whom had total deafness in one or the other ear. The tympanic membranes were normal. Labyrinthine testing was normal. There was no history of consanguinity, mumps, or syphilis. The mother, her father, and her sister also had unilateral deafness while another sister became deaf and lost speech after measles. This latter sister married a deaf and dumb man. One of their 3 children, a girl, had unilateral deafness. She had 2 children, one of whom has unilateral deafness. Thus there were 9 persons with total unilateral deafness in 4 generations.
Contents 1 Causes 2 Diagnosis 3 Management 4 History 5 See also 6 References 7 External links Causes [ edit ] Causes of pulmonary hypoplasia include a wide variety of congenital malformations and other conditions in which pulmonary hypoplasia is a complication. [1] These include congenital diaphragmatic hernia , congenital cystic adenomatoid malformation , fetal hydronephrosis , caudal regression syndrome , mediastinal tumor , and sacrococcygeal teratoma with a large component inside the fetus. [3] [4] [5] [6] Large masses of the neck (such as cervical teratoma ) also can cause pulmonary hypoplasia, presumably by interfering with the fetus's ability to fill its lungs. ... Meakins showed that pulmonary hypoplasia was part of the differential diagnosis of dextrocardia . [31] In 1920, decades before the advent of prenatal imaging, the presence of pulmonary hypoplasia was taken as evidence that diaphragmatic hernias in babies were congenital, not acquired. [32] See also [ edit ] Potter sequence Prune belly syndrome References [ edit ] ^ a b Cadichon, Sandra B. (2007), "Chapter 22: Pulmonary hypoplasia" , in Kumar, Praveen; Burton, Barbara K. ... "HLXB9 homeobox gene and caudal regression syndrome". Birth Defects Research. Part A, Clinical and Molecular Teratology . 76 (3): 205–9. doi : 10.1002/bdra.20234 .
Seek immediate medical attention if you notice numbness or circulation problems. Compartment syndrome. Excessive swelling of the injured arm can cut off the blood supply to part of the arm, causing pain and numbness. Typically occurring 24 to 48 hours after the injury, compartment syndrome is a medical emergency that requires surgery.
Older individuals developed episodes of vertigo and ataxia with vertical oscillopsia, similar to an episodic ataxia syndrome. Of all 5 affected family members, 2 showed developmental delay and learning difficulties. Using genomewide microarray analysis, Jen et al. (2006) excluded linkage of the family reported by Furman et al. (1985) to chromosome 3p, as well as other loci reported for dominantly inherited SCA syndromes. Jen et al. (2006) found suggestive linkage (lod scores near 1.8) to chromosomes 1q44, 5q35, 7q36, and 9q31-q32.
An autosomal dominant cerebellar ataxia type I that is characterized by very slowly progressive or non-progressive ataxia, dysarthria, oculomotor abnormalities and intellectual disability. Epidemiology Spinocerebellar ataxia type 29 (SCA29) prevalence is unknown. More than 50 cases have been reported in the literature to date. Clinical description SCA29 presents at birth, or shortly after, with manifestations including very slowly progressive or non-progressive gait and limb ataxia causing delayed walking and frequent falling in children. Mild developmental delay, learning difficulties, and language dysfunction are frequently reported. Other manifestations include nystagmus, dysarthria, dysmetria, and dysdiadochokinesia.
He developed an acute abdominal syndrome, anemia, and a grave toxic disorder of porphyrin metabolism, which was diagnosed as acute lead intoxication. ... Doss et al. (1984) reported a 30-year-old painter with an acute abdominal-neurologic syndrome and anemia due to lead poisoning, despite only moderate levels of blood lead.
Porphyria of doss or deficiency of delta-aminolevulinic acid dehydratase (DALAD) is an extremely rare form of acute hepatic porphyria (see this term) characterized by neuro-visceral attacks without cutaneous manifestations. Epidemiology To date, fewer than 10 cases have been described in the literature. Clinical description The disease occurs in children. Patients suffer acute neuro-visceral attacks, which persist for several weeks and manifest as intense abdominal pain, and neurological and psychological symptoms. Etiology Porphyria of Doss is caused by a deficiency of delta-aminolevulinic acid dehydratase (ALA-D, the second enzyme in the heme biosynthesis pathway) that leads to an accumulation of the precursors of porphyrins in the liver (delta-aminolevulinic acid, ALA). The enzyme deficiency is caused by mutations in the ALAD gene coded for ALA-D (to date, 9 mutations are known and expressed).
External links [ edit ] Listen to this article (3.9 megabytes) This audio file was created from a revision of this article dated 16 August 2019 ( 2019-08-16 ) , and does not reflect subsequent edits. ( Audio help · More spoken articles ) Classification D ICD - 10 : H81 , R42 ICD - 9-CM : 780.4 v t e Disorders of hearing and balance Hearing Symptoms Hearing loss Excessive response Tinnitus Hyperacusis Phonophobia Disease Loss Conductive hearing loss Otosclerosis Superior canal dehiscence Sensorineural hearing loss Presbycusis Cortical deafness Nonsyndromic deafness Other Deafblindness Wolfram syndrome Usher syndrome Auditory processing disorder Spatial hearing loss Tests Hearing test Rinne test Tone decay test Weber test Audiometry pure tone visual reinforcement Balance Symptoms Vertigo nystagmus Disease Balance disorder Peripheral Ménière's disease Benign paroxysmal positional vertigo Labyrinthitis Labyrinthine fistula Tests Dix–Hallpike test Unterberger test Romberg's test Vestibulo–ocular reflex
Acoustic neuroma is a rare condition. Ramsay Hunt syndrome. Also known as herpes zoster oticus, this condition occurs when a shingles-like infection affects the facial, auditory and vestibular nerves near one of your ears.
Physical examination of the patient showed intention tremor, action-induced negative myoclonus, slow horizontal saccades, and a hypokinetic syndrome. Brain MRI showed T2-weighted hyperintensities in the supratentorial white matter, most pronounced around the frontal and parietal lobes. ... Najmabadi et al. (2011) performed homozygosity mapping followed by exon enrichment and next-generation sequencing in 136 consanguineous families (over 90% Iranian and less than 10% Turkish or Arabic) segregating syndromic or nonsyndromic forms of autosomal recessive intellectual disability.
L-2-hydroxyglutaric aciduria is a primarily neurological form of 2-hydroxyglutaric aciduria (see this term) characterized by psychomotor retardation, cerebellar ataxia and variable macrocephaly or epilepsy. Epidemiology Exact prevalence and incidence of this disorder are not known but about 140 cases have been reported to date. The disorder appears to be pan-ethnic with cases reported worldwide. Clinical description Onset is often insidious in the first year of life. Presenting symptoms include motor retardation and epilepsy. The disease course is progressive leading to mental deterioration such as speech difficulties and motor deficits such as loss of independent walking. Most reported patients had macrocephaly. Other signs include hypotonia in the early stages and spasticity later in the course of the disease, extrapyramidal symptoms and behavioral disorders.
L-2-hydroxyglutaric aciduria is an inherited metabolic condition that is associated with progressive brain damage. Signs and symptoms of this condition typically begin during infancy or early childhood and may include developmental delay, seizures, speech difficulties, macrocephaly and abnormalities in a part of the brain called the cerebellum, which is involved in coordinating movement (i.e. balance and muscle coordination). L-2-hydroxyglutaric aciduria is caused by changes (mutations) in the L2HGDH gene and is inherited in an autosomal recessive manner. Treatment is focused on alleviating the signs and symptoms of the condition, such as medications to control seizures.
At age 9 months he had epileptic spasms, and EEG showed hypsarrhythmia, consistent with a clinical diagnosis of 'West syndrome.' He developed progressive microcephaly and showed severe neurologic impairment with poor visual following and generalized hypotonia. The finding suggested that both MMPSI and West syndrome represent a phenotypic continuum of infantile epileptic encephalopathy and probably share a common pathophysiology relating to hyperexcitability.
Malignant migrating partial seizures of infancy (MMPSI) is a severe form of epilepsy that begins very early in life. Recurrent seizures begin before the age of 6 months but commonly start within a few weeks of birth. The seizures do not respond well to treatment. Although affected individuals may develop normally at first, progression stalls and skills decline when seizures begin; as a result, affected individuals have profound developmental delay. The seizures in MMPSI are described as partial (or focal) because the seizure activity occurs in regions of the brain rather than affecting the entire brain. Seizure activity can appear in multiple locations in the brain or move (migrate) from one region to another during an episode.
Malignant migrating partial seizures of infancy (MMPSI) is a severe form of epilepsy, a condition characterized by recurrent seizures. In MMPSI, specifically, partial seizures generally begin shortly after birth and are often not responsive to treatment. Although the seizures may occur relatively infrequently in the beginning, within a few months the frequency increases drastically with some affected people experiencing clusters of 5 to 30 seizures several times per day. Signs and symptoms associated with these episodes vary based on which part of the brain is affected during a given seizure. Although the seizures associated with MMPSI do eventually become less frequent, the long-term consequences of the condition may include profound developmental delay, microcephaly (unusually small head size), intellectual disability and a shortened lifespan (many do not survive past infancy or early childhood).
Heavy alcohol use is also associated with nutritional deficiencies. [1] A disease called Plummer–Vinson syndrome , a genetic disorder that causes a long-term iron deficiency, may also lead to hypopharyngeal cancer. ... Hypopharyngeal Cancer Treatment (PDQ) External links [ edit ] Classification D ICD - 10 : C13 v t e Overview of tumors , cancer and oncology Conditions Benign tumors Hyperplasia Cyst Pseudocyst Hamartoma Malignant progression Dysplasia Carcinoma in situ Cancer Metastasis Primary tumor Sentinel lymph node Topography Head and neck ( oral , nasopharyngeal ) Digestive system Respiratory system Bone Skin Blood Urogenital Nervous system Endocrine system Histology Carcinoma Sarcoma Blastoma Papilloma Adenoma Other Precancerous condition Paraneoplastic syndrome Staging / grading TNM Ann Arbor Prostate cancer staging Gleason grading system Dukes classification Carcinogenesis Cancer cell Carcinogen Tumor suppressor genes / oncogenes Clonally transmissible cancer Oncovirus Carcinogenic bacteria Misc.
Believing that the behavior of others is in reference to an abnormal, offensive body odor, which in reality is non-existent and cannot be smelled or detected by others (see: olfactory reference syndrome ). Literary analogues [ edit ] In Mrs Dalloway (1925), as a plane flies over a shell-shocked soldier: "So, thought Septimus, they are signalling to me...smoke words". [23] The author, Virginia Woolf , recorded in a memoir how she herself "had lain in bed...thinking that the birds were singing Greek choruses and that King Edward was using the foulest possible language among Ozzie Dickinson's azaleas". [24] In Margaret Mahy 's Memory (1987), the confused adolescent hero decides "to abandon himself to the magic of chance. ... CS1 maint: multiple names: authors list ( link ) ^ Schopler, Eric; Mesibov, Gary B.; Kunce, Linda J. (1998-04-30). Asperger Syndrome or High-Functioning Autism? . Springer Science & Business Media.