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Placental Abruption
Wikipedia
External links [ edit ] Classification D ICD - 10 : O45 ICD - 9-CM : 641.2 MeSH : D000037 DiseasesDB : 40 External resources MedlinePlus : 000901 eMedicine : med/6 emerg/12 v t e Pathology of pregnancy , childbirth and the puerperium Pregnancy Pregnancy with abortive outcome Abortion Ectopic pregnancy Abdominal Cervical Interstitial Ovarian Heterotopic Embryo loss Fetal resorption Molar pregnancy Miscarriage Stillbirth Oedema , proteinuria and hypertensive disorders Gestational hypertension Pre-eclampsia HELLP syndrome Eclampsia Other, predominantly related to pregnancy Digestive system Acute fatty liver of pregnancy Gestational diabetes Hepatitis E Hyperemesis gravidarum Intrahepatic cholestasis of pregnancy Integumentary system / dermatoses of pregnancy Gestational pemphigoid Impetigo herpetiformis Intrahepatic cholestasis of pregnancy Linea nigra Prurigo gestationis Pruritic folliculitis of pregnancy Pruritic urticarial papules and plaques of pregnancy (PUPPP) Striae gravidarum Nervous system Chorea gravidarum Blood Gestational thrombocytopenia Pregnancy-induced hypercoagulability Maternal care related to the fetus and amniotic cavity amniotic fluid Oligohydramnios Polyhydramnios Braxton Hicks contractions chorion / amnion Amniotic band syndrome Chorioamnionitis Chorionic hematoma Monoamniotic twins Premature rupture of membranes Obstetrical bleeding Antepartum placenta Circumvallate placenta Monochorionic twins Placenta accreta Placenta praevia Placental abruption Twin-to-twin transfusion syndrome Labor Amniotic fluid embolism Cephalopelvic disproportion Dystocia Shoulder dystocia Fetal distress Locked twins Nuchal cord Obstetrical bleeding Postpartum Pain management during childbirth placenta Placenta accreta Preterm birth Postmature birth Umbilical cord prolapse Uterine inversion Uterine rupture Vasa praevia Puerperal Breastfeeding difficulties Low milk supply Cracked nipples Breast engorgement Childbirth-related posttraumatic stress disorder Diastasis symphysis pubis Postpartum bleeding Peripartum cardiomyopathy Postpartum depression Postpartum psychosis Postpartum thyroiditis Puerperal fever Puerperal mastitis Other Concomitant conditions Diabetes mellitus Systemic lupus erythematosus Thyroid disorders Maternal death Sexual activity during pregnancy Category
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Obstructed Labour
Wikipedia
ISBN 9789241546669 . v t e Pathology of pregnancy , childbirth and the puerperium Pregnancy Pregnancy with abortive outcome Abortion Ectopic pregnancy Abdominal Cervical Interstitial Ovarian Heterotopic Embryo loss Fetal resorption Molar pregnancy Miscarriage Stillbirth Oedema , proteinuria and hypertensive disorders Gestational hypertension Pre-eclampsia HELLP syndrome Eclampsia Other, predominantly related to pregnancy Digestive system Acute fatty liver of pregnancy Gestational diabetes Hepatitis E Hyperemesis gravidarum Intrahepatic cholestasis of pregnancy Integumentary system / dermatoses of pregnancy Gestational pemphigoid Impetigo herpetiformis Intrahepatic cholestasis of pregnancy Linea nigra Prurigo gestationis Pruritic folliculitis of pregnancy Pruritic urticarial papules and plaques of pregnancy (PUPPP) Striae gravidarum Nervous system Chorea gravidarum Blood Gestational thrombocytopenia Pregnancy-induced hypercoagulability Maternal care related to the fetus and amniotic cavity amniotic fluid Oligohydramnios Polyhydramnios Braxton Hicks contractions chorion / amnion Amniotic band syndrome Chorioamnionitis Chorionic hematoma Monoamniotic twins Premature rupture of membranes Obstetrical bleeding Antepartum placenta Circumvallate placenta Monochorionic twins Placenta accreta Placenta praevia Placental abruption Twin-to-twin transfusion syndrome Labor Amniotic fluid embolism Cephalopelvic disproportion Dystocia Shoulder dystocia Fetal distress Locked twins Nuchal cord Obstetrical bleeding Postpartum Pain management during childbirth placenta Placenta accreta Preterm birth Postmature birth Umbilical cord prolapse Uterine inversion Uterine rupture Vasa praevia Puerperal Breastfeeding difficulties Low milk supply Cracked nipples Breast engorgement Childbirth-related posttraumatic stress disorder Diastasis symphysis pubis Postpartum bleeding Peripartum cardiomyopathy Postpartum depression Postpartum psychosis Postpartum thyroiditis Puerperal fever Puerperal mastitis Other Concomitant conditions Diabetes mellitus Systemic lupus erythematosus Thyroid disorders Maternal death Sexual activity during pregnancy Category
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Meckel's Diverticulum
Wikipedia
External links [ edit ] Meckel's Diverticulum at eMedicine Classification D ICD - 10 : C17.3 , Q43.0 ICD - 9-CM : 152.3 , 751.0 OMIM : 155140 MeSH : D008467 DiseasesDB : 7903 SNOMED CT : 127962001 External resources MedlinePlus : 000234 eMedicine : med/2797 ped/1389 rad/425 Patient UK : Meckel's diverticulum Wikimedia Commons has media related to Meckel's diverticulum . v t e Congenital malformations and deformations of digestive system Upper GI tract Tongue , mouth and pharynx Cleft lip and palate Van der Woude syndrome tongue Ankyloglossia Macroglossia Hypoglossia Esophagus EA/TEF Esophageal atresia: types A, B, C, and D Tracheoesophageal fistula: types B, C, D and E esophageal rings Esophageal web (upper) Schatzki ring (lower) Stomach Pyloric stenosis Hiatus hernia Lower GI tract Intestines Intestinal atresia Duodenal atresia Meckel's diverticulum Hirschsprung's disease Intestinal malrotation Dolichocolon Enteric duplication cyst Rectum / anal canal Imperforate anus Rectovestibular fistula Persistent cloaca Rectal atresia Accessory Pancreas Annular pancreas Accessory pancreas Johanson–Blizzard syndrome Pancreas divisum Bile duct Choledochal cysts Caroli disease Biliary atresia Liver Alagille syndrome Polycystic liver diseaseAGTR2, FANCL, ZNF41, USP9X, ARHGEF6, FRMPD4, RBM8A, MED12, MAD2L2, MID2, IL1RAPL1, CNKSR2, IQSEC2, FTSJ1, UBE2T, RFWD3, XRCC2, FANCI, FANCM, CXorf56, UPF3B, PALB2, ALG13, BRIP1, SLX4, SLC9A7, RAB39B, PTCHD1, ARX, ZNF81, ZNF711, TSPAN7, BRCA1, SYP, BRCA2, CLCN4, DLG3, DMD, ERCC4, FANCA, FANCC, FANCD2, FANCE, ACSL4, FANCB, FANCF, FANCG, GPC4, FGFR1, FOXF1, GDI1, GPC3, HCFC1, MECP2, PAK3, RAD51, RAD51C, RPS6KA3, USP27X, GAST, EPHB1, ELK3, SLC6A2
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Paratyphoid Fever
Wikipedia
Alberta Health and Wellness: June 2013 https://web.archive.org/web/20130925214850/http://www.health.alberta.ca/documents/Guidelines-Paratyphoid-Fever-2013.pdf Classification D ICD - 10 : A01.1 - A01.4 ICD - 9-CM : 002 MeSH : D010284 DiseasesDB : 33218 External resources Patient UK : Paratyphoid fever v t e Proteobacteria -associated Gram-negative bacterial infections α Rickettsiales Rickettsiaceae / ( Rickettsioses ) Typhus Rickettsia typhi Murine typhus Rickettsia prowazekii Epidemic typhus , Brill–Zinsser disease , Flying squirrel typhus Spotted fever Tick-borne Rickettsia rickettsii Rocky Mountain spotted fever Rickettsia conorii Boutonneuse fever Rickettsia japonica Japanese spotted fever Rickettsia sibirica North Asian tick typhus Rickettsia australis Queensland tick typhus Rickettsia honei Flinders Island spotted fever Rickettsia africae African tick bite fever Rickettsia parkeri American tick bite fever Rickettsia aeschlimannii Rickettsia aeschlimannii infection Mite-borne Rickettsia akari Rickettsialpox Orientia tsutsugamushi Scrub typhus Flea-borne Rickettsia felis Flea-borne spotted fever Anaplasmataceae Ehrlichiosis : Anaplasma phagocytophilum Human granulocytic anaplasmosis , Anaplasmosis Ehrlichia chaffeensis Human monocytotropic ehrlichiosis Ehrlichia ewingii Ehrlichiosis ewingii infection Rhizobiales Brucellaceae Brucella abortus Brucellosis Bartonellaceae Bartonellosis : Bartonella henselae Cat-scratch disease Bartonella quintana Trench fever Either B. henselae or B. quintana Bacillary angiomatosis Bartonella bacilliformis Carrion's disease , Verruga peruana β Neisseriales M+ Neisseria meningitidis/meningococcus Meningococcal disease , Waterhouse–Friderichsen syndrome , Meningococcal septicaemia M− Neisseria gonorrhoeae/gonococcus Gonorrhea ungrouped: Eikenella corrodens / Kingella kingae HACEK Chromobacterium violaceum Chromobacteriosis infection Burkholderiales Burkholderia pseudomallei Melioidosis Burkholderia mallei Glanders Burkholderia cepacia complex Bordetella pertussis / Bordetella parapertussis Pertussis γ Enterobacteriales ( OX− ) Lac+ Klebsiella pneumoniae Rhinoscleroma , Pneumonia Klebsiella granulomatis Granuloma inguinale Klebsiella oxytoca Escherichia coli : Enterotoxigenic Enteroinvasive Enterohemorrhagic O157:H7 O104:H4 Hemolytic-uremic syndrome Enterobacter aerogenes / Enterobacter cloacae Slow/weak Serratia marcescens Serratia infection Citrobacter koseri / Citrobacter freundii Lac− H2S+ Salmonella enterica Typhoid fever , Paratyphoid fever , Salmonellosis H2S− Shigella dysenteriae / sonnei / flexneri / boydii Shigellosis , Bacillary dysentery Proteus mirabilis / Proteus vulgaris Yersinia pestis Plague / Bubonic plague Yersinia enterocolitica Yersiniosis Yersinia pseudotuberculosis Far East scarlet-like fever Pasteurellales Haemophilus : H. influenzae Haemophilus meningitis Brazilian purpuric fever H. ducreyi Chancroid H. parainfluenzae HACEK Pasteurella multocida Pasteurellosis Actinobacillus Actinobacillosis Aggregatibacter actinomycetemcomitans HACEK Legionellales Legionella pneumophila / Legionella longbeachae Legionnaires' disease Coxiella burnetii Q fever Thiotrichales Francisella tularensis Tularemia Vibrionaceae Vibrio cholerae Cholera Vibrio vulnificus Vibrio parahaemolyticus Vibrio alginolyticus Plesiomonas shigelloides Pseudomonadales Pseudomonas aeruginosa Pseudomonas infection Moraxella catarrhalis Acinetobacter baumannii Xanthomonadaceae Stenotrophomonas maltophilia Cardiobacteriaceae Cardiobacterium hominis HACEK Aeromonadales Aeromonas hydrophila / Aeromonas veronii Aeromonas infection ε Campylobacterales Campylobacter jejuni Campylobacteriosis , Guillain–Barré syndrome Helicobacter pylori Peptic ulcer , MALT lymphoma , Gastric cancer Helicobacter cinaedi Helicobacter cellulitis
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Sudden Unexpected Death In Epilepsy
Wikipedia
Overlap is seen between these ion channel genes and the different sudden death disorders, including SUDEP, [12] SIDS , [13] Sudden Unexpected Death (SUD), [14] and Sudden Unexpected Death in Youth (SUDY) . [15] Many of the genes are involved in Long QT syndrome . Mutations in the KCNQ1 gene that codes for the voltage-gated potassium channel K V 7.1 have been implicated in cardiac arrhythmias, such as Long QT syndrome 1 (LQT1), and epilepsy. [12] [13] Mutations in potassium channel gene K CNH2 have been identified with LQT2. [13] [12] Mutations in sodium channel gene SCN5A have been identified with LQT3. [12] [13] Mutations in potassium channel gene KCNJ2 have been identified with LQT7. [12] [13] Mutations in calcium channel gene CACNA1C have been identified with LQT8. [12] The sodium ion channel genes SCN1A, SCN1B, SCN2A, and SCN8A and the potassium channel KCNA1 have been implicated in both epilepsy and SUDEP. [16] [12] Mechanism [ edit ] The mechanisms underlying SUDEP are not well understood but probably involve several pathophysiological mechanisms and circumstances. ... S2CID 10155494 . ^ a b c d e Van Niekerk, Chantal; Van Deventer, Barbara Ströh; du Toit-Prinsloo, Lorraine (September 2017). "Long QT syndrome and sudden unexpected infant death" .
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Familial Dysautonomia
Wikipedia
Familial dysautonomia Other names Riley–Day syndrome [1] and Hereditary sensory and autonomic neuropathy type III ( HSAN-III ) Facial features of a patient with familial dysautonomia over time. ... Classification D ICD - 10 : G90.1 ICD - 9-CM : 742.8 OMIM : 223900 MeSH : D004402 DiseasesDB : 11631 External resources MedlinePlus : 001387 eMedicine : oph/678 GeneReviews : Familial dysautonomia v t e Diseases of the autonomic nervous system General Dysautonomia Autonomic dysreflexia Autonomic neuropathy Pure autonomic failure Hereditary Hereditary sensory and autonomic neuropathy Familial dysautonomia Congenital insensitivity to pain with anhidrosis Orthostatic intolerance Orthostatic hypotension Postural orthostatic tachycardia syndrome Other Horner's syndrome Multiple system atrophyELP1, SPTLC2, SPTLC1, MAOA, TNFSF11, SLC6A4, GLA, TUBA1B, NGF, CTNNAL1, DLK1, PROM1, MSC, TECPR2, APOE, VDR, ACTL7A, KDELR2, STMN2, ELP4, SCLY, ELP3, ELP2, LSM2, GER, RBM24, HNRNPA1P10, ACTL7B, TAL1, TNF, HNRNPA1, BGLAP, CEACAM1, DST, CD36, ESR1, FKBP4, GCG, HCRT, HMGCS2, ICAM1, BCHE, KRT7, NOS1, NOVA1, NTRK2, SERPINA1, PRRX1, S100A12, CXCL12, SOD3, DBIL5P2
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Salicylate Poisoning
Wikipedia
Examples of severe poisoning include people with high salicylate blood levels: 7.25 mmol/l (100 mg/dl) in acute ingestions or 40 mg/dl in chronic ingestions, [18] significant neurotoxicity (agitation, coma, convulsions), kidney failure , pulmonary edema, or cardiovascular instability. [14] Hemodialysis also has the advantage of restoring electrolyte and acid-base abnormalities while removing salicylate. [19] Salicylic acid has a small size (low molecular mass), has a low volume of distribution (is more water soluble), has low tissue binding and is largely free (and not protein bound) at toxic levels in the body; all of which make it easily removable from the body by hemodialysis. [8] Indication for dialysis: Salicylate level higher than 90 mg/dL [8] Severe acid base imbalance Severe cardiac toxicity Acute respiratory distress syndrome [8] Cerebral involvement/ neurological signs and symptoms Rising serum salicylate level despite alkalinization/multidose activated charcoal, or people in which standard approaches to treatment ave failed [8] Unable to tolerate fluids with fluid overload Epidemiology [ edit ] Acute salicylate toxicity usually occurs after an intentional ingestion by younger adults, often with a history of psychiatric disease or previous overdose, whereas chronic toxicity usually occurs in older adults who experience inadvertent overdose while ingesting salicylates therapeutically over longer periods of time. [8] During the latter part of the 20th century, the number of poisonings from salicylates declined, mainly because of the increased popularity of other over-the-counter analgesics such as paracetamol (acetaminophen). Fifty-two deaths involving single-ingredient aspirin were reported in the United States in 2000; however, in all but three of these cases, the reason for the ingestion of lethal doses was intentional—predominantly suicidal. [20] History [ edit ] Aspirin poisoning has controversially been cited as a possible cause of the high mortality rate during the 1918 flu pandemic , which killed 50 to 100 million people. [21] See also [ edit ] NSAID hypersensitivity reactions Reye syndrome Salicylate sensitivity References [ edit ] ^ a b c d e f g h i j k l m n o p q r O'Malley, GF (May 2007). ... PMID 16467617 . v t e Poisoning Toxicity Overdose History of poison Inorganic Metals Toxic metals Beryllium Cadmium Lead Mercury Nickel Silver Thallium Tin Dietary minerals Chromium Cobalt Copper Iron Manganese Zinc Metalloids Arsenic Nonmetals Sulfuric acid Selenium Chlorine Fluoride Organic Phosphorus Pesticides Aluminium phosphide Organophosphates Nitrogen Cyanide Nicotine Nitrogen dioxide poisoning CHO alcohol Ethanol Ethylene glycol Methanol Carbon monoxide Oxygen Toluene Pharmaceutical Drug overdoses Nervous Anticholinesterase Aspirin Barbiturates Benzodiazepines Cocaine Lithium Opioids Paracetamol Tricyclic antidepressants Cardiovascular Digoxin Dipyridamole Vitamin poisoning Vitamin A Vitamin D Vitamin E Megavitamin-B 6 syndrome Biological 1 Fish / seafood Ciguatera Haff disease Ichthyoallyeinotoxism Scombroid Shellfish poisoning Amnesic Diarrhetic Neurotoxic Paralytic Other vertebrates amphibian venom Batrachotoxin Bombesin Bufotenin Physalaemin birds / quail Coturnism snake venom Alpha-Bungarotoxin Ancrod Batroxobin Arthropods Arthropod bites and stings bee sting / bee venom Apamin Melittin scorpion venom Charybdotoxin spider venom Latrotoxin / Latrodectism Loxoscelism tick paralysis Plants / fungi Cinchonism Ergotism Lathyrism Locoism Mushrooms Strychnine 1 including venoms , toxins , foodborne illnesses .
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Agrammatism
Wikipedia
Agrammatism is seen in many brain disease syndromes, including expressive aphasia and traumatic brain injury . ... Agrammatism, today seen as a symptom of the Broca's syndrome (Tesak & Code, 2008), has been also referred as 'motor aphasia ' (Goldstein, 1948), 'syntactic aphasia' (Wepman & Jones, 1964), 'efferent motor aphasia' (Luria, 1970), and 'non-fluent aphasia' (Goodglass et al., 1964). ... R. (1970). Traumatic aphasia: Its syndromes, psychology and treatment. The Hague: Mouton.
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Aqueductal Stenosis
Wikipedia
This increased number of cells thus causes the blockage to worsen, necessitating more pressure and velocity, and continuing the cycle of gliosis. [3] Other medical conditions [ edit ] A genetic disorder called “Brickers-Adams-Edwards syndrome” or “X-linked hydrocephalus” has been discovered that leads to aqueductal stenosis. ... The reduced ventricle size can sometimes be due to a condition called slit ventricle syndrome. [9] Another complication is that if the stenosis is caused by tumor compression, there is a possibility that the scan will miss detecting small brainstem tumors. [3] MRI imaging [ edit ] MRI is considered the best method of detecting aqueductal stensosis because it can visualize the entire length of the aqueduct, can clearly depict tumors, and can show ventricle enlargement or other deformations. [2] [3] It is helpful in determining the extent of the aqueductal obstruction, particularly when multiple masses or lesions are present, and thereby aids in determining the most appropriate treatment method (i.e. surgery, shunt, or ETV). [3] When constructive interference in steady state (CISS) or fast imaging employing steady-state acquisition (FIESTA) sequence are used, subtle abnormalities or partial obstructions in the aqueduct can be depicted in the MRI. [1] For example, CISS can be used to determine if a thin membrane interfering with CSF flow is present. [10] Other [ edit ] Phase contrast-MRI is an imaging method which is more sensitive than MRI for analysis of the pulsatile CSF flow in the ventricular system. ... This in turn can lead to headache, hemorrhage , or slit ventricle syndrome. Underdraining occurs when the valve pressure is too high and CSF flows out too slowly.
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Gangrene
Wikipedia
Gangrene Other names Gangrenous necrosis Dry gangrene affecting the toes as a result of peripheral artery disease Specialty Infectious disease , surgery Symptoms Change in skin color to red or black, numbness, pain, skin breakdown, coolness [1] Complications Sepsis , amputation [1] [2] Types Dry , wet , gas , internal , necrotizing fasciitis [3] Risk factors Diabetes , peripheral arterial disease , smoking , major trauma , alcoholism , plague , HIV/AIDS , frostbite , Raynaud's syndrome [3] [4] Diagnostic method Based on symptom, With medical imaging used to identify the underlying cause Treatment Depends on underlying cause [5] Prognosis Variable Frequency Unknown [2] Gangrene is a type of tissue death caused by a lack of blood supply . [4] Symptoms may include a change in skin color to red or black, numbness, swelling, pain, skin breakdown, and coolness. [1] The feet and hands are most commonly affected. [1] If the gangrene is caused by an infectious agent it may present with a fever or sepsis . [1] Risk factors include diabetes , peripheral arterial disease , smoking , major trauma , alcoholism , HIV/AIDS , frostbite , influenza , COVID-19 , dengue fever , plague and Raynaud's syndrome . [3] [4] It can be classified as dry gangrene , wet gangrene , gas gangrene , internal gangrene , and necrotizing fasciitis . [3] The diagnosis of gangrene is based on symptoms and supported by tests such as medical imaging . [6] Treatment may involve surgery to remove the dead tissue, antibiotics to treat any infection, and efforts to address the underlying cause. [5] Surgical efforts may include debridement , amputation , or the use of maggot therapy . [5] Efforts to treat the underlying cause may include bypass surgery or angioplasty . [5] In certain cases, hyperbaric oxygen therapy may be useful. [5] How commonly the condition occurs is unknown. [2] Contents 1 Signs and symptoms 2 Causes 2.1 Dry gangrene 2.2 Wet gangrene 2.3 Gas gangrene 2.4 Other types 3 Treatment 3.1 Lifestyle 3.2 Medication 3.3 Surgery 3.4 Other 4 History 5 Etymology 6 References 7 External links Signs and symptoms [ edit ] An illustration showing four different stages of gangrene, including one (Fig. 4 top right) caused by an obstacle to the return of the venous blood due to heart disease. ... "Autoamputation of diabetic toe with dry gangrene: a myth or a fact?" . Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy . 11 : 255–264. doi : 10.2147/DMSO.S164199 .TLR4, RARA, PROC, PRTN3, AGXT, STAT3, STAT4, STAT5B, SULT2B1, MLX, TGM1, TNFRSF1B, ZBTB16, KLRC4, ABCA12, PTPN22, ERAP1, BCOR, ALOXE3, NABP1, TBL1XR1, FIP1L1, SDR9C7, CYP4F22, IL23R, UBAC2, NIPAL4, IRF2BP2, LIPN, PROS1, IL12A-AS1, PRKAR1A, IL10, ALOX12B, FAS, C4A, CD28, CCR1, CTLA4, HLA-B, PML, HLA-DPB1, HLA-DPA1, NUMA1, IL12A, IL12B, KIF11, NPM1, MEFV, CRP, VEGFA, MBL2, ALB, PLAU, SERPINE1, CD14, ACCS, ACE, DHX40, IL6, F5, SPG16, ACSS2, IFT122, IFI16, PLA2G15, PADI4, IGF1, ACR
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Primary Myelofibrosis
Wikipedia
"Some speculations on the myeloproliferative syndromes" . Blood . 6 (4): 372–5. doi : 10.1182/blood.V6.4.372.372 . ... External links [ edit ] Classification D ICD - 10 : C94.4 , D47.4 ICD - 9-CM : 289.83 ICD-O : 9931/3, M9961/3 OMIM : 254450 MeSH : D055728 DiseasesDB : 8616 External resources MedlinePlus : 000531 Patient UK : Primary myelofibrosis v t e Myeloid -related hematological malignancy CFU-GM / and other granulocytes CFU-GM Myelocyte AML : Acute myeloblastic leukemia M0 M1 M2 APL/M3 MP Chronic neutrophilic leukemia Monocyte AML AMoL/M5 Myeloid dendritic cell leukemia CML Philadelphia chromosome Accelerated phase chronic myelogenous leukemia Myelomonocyte AML M4 MD-MP Juvenile myelomonocytic leukemia Chronic myelomonocytic leukemia Other Histiocytosis CFU-Baso AML Acute basophilic CFU-Eos AML Acute eosinophilic MP Chronic eosinophilic leukemia / Hypereosinophilic syndrome MEP CFU-Meg MP Essential thrombocytosis Acute megakaryoblastic leukemia CFU-E AML Erythroleukemia/M6 MP Polycythemia vera MD Refractory anemia Refractory anemia with excess of blasts Chromosome 5q deletion syndrome Sideroblastic anemia Paroxysmal nocturnal hemoglobinuria Refractory cytopenia with multilineage dysplasia CFU-Mast Mastocytoma Mast cell leukemia Mast cell sarcoma Systemic mastocytosis Mastocytosis : Diffuse cutaneous mastocytosis Erythrodermic mastocytosis Adult type of generalized eruption of cutaneous mastocytosis Urticaria pigmentosa Mast cell sarcoma Solitary mastocytoma Systemic mastocytosis Xanthelasmoidal mastocytosis Multiple/unknown AML Acute panmyelosis with myelofibrosis Myeloid sarcoma MP Myelofibrosis Acute biphenotypic leukaemiaMPL, JAK2, CALR, TET2, GATA1, NCOR2, MYB, ABL1, JAK1, BCR, THPO, CD34, SOAT1, TGFB1, ASXL1, STAT5A, STAT5B, HMGA2, SRSF2, CXCL8, EPO, MVD, TP53, DERL1, TNFRSF11B, PDGFRA, GLI1, CD177, PRB1, FN1, CXCL12, CDKN2A, VPS45, AURKA, TNF, CXCR4, PDGFRB, LINC01152, NBEAL2, MPIG6B, NOG, WT1, WNT1, AKT1, TAC1, PIK3CB, PIK3CD, VEGFA, INTS2, PIK3CG, FXYD5, SCT, IRAK1, PIK3CA, H3P10, RUNX1, ETV6, CSF3, FGF2, FGF3, FLT1, FLT3, CD47, DNMT3A, IFNA2, IFNA13, IFNA1, ALB, IFNG, MAGT1, SHOC2, SOCS3, HSPB3, IL18R1, ALPI, GFI1B, CHIT1, CRP, CHI3L1, ZMYM2, H3P9, CSF3R, CTNNB1, VDR, TPO, CUX1, TNFRSF1B, DAPK1, MYOM2, CDKN2B, PRSS27, TBK1, ALPP, BORA, AMCN, CIP2A, XIAP, STS, BMP6, BMF, SCLY, PYCARD, EBI3, NXT1, SGSM3, INTS1, SETBP1, SF3B1, TLR4, CDK2, SUB1, MRPL28, TBC1D9, IL1A, THY1, HMGA1, ABCB1, HPGD, HSPB1, PAEP, HSPB2, NRAS, NFE2L2, NFE2, IAPP, IDH1, IDH2, MMP8, LOX, LIG3, LEPR, LEP, KRT7, KIT, CXCR2, IL2RA, IL1RN, HP, NR3C1, THBS2, GABPA, THBS1, TGFBR1, IL1B, TAL1, EDA, ELN, EZH2, STAT3, STAT1, SPP1, SPARC, SLCO2A1, SELP, RPS14, RARS1, RARB, PTHLH, PTH, MAPK8, FZD2, PLK1, ATN1
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Radiation-Induced Lumbar Plexopathy
Wikipedia
People may present with pure lower motor neuron syndrome, a symptom of amyotrophic lateral sclerosis (ALS) . [4] [14] RILP may also be misdiagnosed as leptomeningeal metastasis often showing nodular MRI enhancement of the cauda equina nerve roots or having increased CSF protein content . [4] Other differential diagnoses to consider are Chronic Inflammatory Demyelinating Polyradiculoneuropathy , neoplastic lumbosacral plexopathy, paraneoplastic neuronopathy , diabetic lumbosacral plexopathy , degenerative disk disease ( osteoporosis of the spine ), Osteoarthritis of the spine , Lumbar Spinal Stenosis , post-infectious plexopathy, carcinomatous meningitis (CM) , mononeuritis multiplex , and chemotherapy-induced plexopathy . [1] The testing to resolve a RILP diagnosis involves blood serum analysis , X-rays , EMG , MRI and Cerebrospinal Fluid analysis . [2] [1] [13] Prevention [ edit ] Since RILP's neurological changes are typically irreversible and a curative strategy has yet to be defined, prevention is the best approach. [1] Treating the primary cancer remains an obvious requirement, but lower levels of lumbar plexus radiation dosing will minimize or eliminate RILP. [1] [13] One method to reduce the lumbosacral plexus' dosing is to include it with other at-risk organs that get spared from radiation. [15] [16] Key to prevention is resolving the lack of clinical evidence between radiation treatments and the onset of neurological problems. ... Handicaps may include physical challenges, bowel and/or bladder dysfunction and may occur in multiple settings of work and home. [9] Physical and occupational therapy are important elements in maintaining mobility and use of the lower extremities, along with assistive aides such as Ankle-Foot-Orthotics (AFOs) , cane, walkers, etc. [2] [9] [13] Sensory reeducation techniques may be necessary for balance [2] and lymphedema management may be required. [9] Pharmaceuticals that may be effective for RILP's neuropathic pain are tricyclic antidepressants (TCAs) (amitriptyline) [2] [9] [13] Antiepileptics or anticonvulsants (gabapentin, pregabalin, carbamazepine, valproic acid) [2] [9] [13] Selective serotonin re-uptake inhibitors(SSRIs) (duloxetine) to preserve normal norepinephrine and serotonin levels [2] [9] [13] Analgesic drugs (pregabalin, methadone) [2] [9] Opiates may used singularly or to potentate the concomitant use of TCAs. [2] Antiarrhythmics (mexilitine) for muscle stiffness [9] Non-pharmaceutical RILP considerations are acupuncture for pain [13] massage for pain [1] [13] transcutaneous electrical nerve stimulation (TENS) for pain [2] Benzodiazepines may be used for paraesthesia [1] quinine may be used for cramps [1] Functional impairment and residual pain can lead to social isolation. [9] Cancer support groups are valuable resources to learn about the syndrome and therapeutic options, and are a means to voice emotions related to having cancer and surviving it. [9] [1] [13] Outcomes [ edit ] With increasing cancer treatment survival rates, the quality of life for its survivors has become a public health priority. [1] The effects of RILP can be debilitating. ... "Postradiation lower motor neuron syndrome: case series and literature review".
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B-Cell Prolymphocytic Leukemia
Wikipedia
Furthermore, it is often not a feasible option due to the presence of other systemic diseases/conditions. [10] [21] Prognosis [ edit ] Despite advancements in treatments and deeper understanding of pathogenesis , the prognosis for B-PLL patients is poor [25] , with early relapse and median survival time between 3–5 years. [26] [27] References [ edit ] ^ "France - Lymphoproliferative Syndrome B-Cell Prolymphocytic Leukemia |" . icgc.org . ... External links [ edit ] Classification D ICD-O : M9833/3 MeSH : D054403 v t e Leukaemias , lymphomas and related disease B cell ( lymphoma , leukemia ) (most CD19 CD20 ) By development/ marker TdT+ ALL ( Precursor B acute lymphoblastic leukemia/lymphoma ) CD5 + naive B cell ( CLL/SLL ) mantle zone ( Mantle cell ) CD22 + Prolymphocytic CD11c+ ( Hairy cell leukemia ) CD79a + germinal center / follicular B cell ( Follicular Burkitt's GCB DLBCL Primary cutaneous follicle center lymphoma ) marginal zone / marginal zone B-cell ( Splenic marginal zone MALT Nodal marginal zone Primary cutaneous marginal zone lymphoma ) RS ( CD15 +, CD30 +) Classic Hodgkin lymphoma ( Nodular sclerosis ) CD20+ ( Nodular lymphocyte predominant Hodgkin lymphoma ) PCDs / PP ( CD38 +/ CD138 +) see immunoproliferative immunoglobulin disorders By infection KSHV ( Primary effusion ) EBV Lymphomatoid granulomatosis Post-transplant lymphoproliferative disorder Classic Hodgkin lymphoma Burkitt's lymphoma HCV Splenic marginal zone lymphoma HIV ( AIDS-related lymphoma ) Helicobacter pylori ( MALT lymphoma ) Cutaneous Diffuse large B-cell lymphoma Intravascular large B-cell lymphoma Primary cutaneous marginal zone lymphoma Primary cutaneous immunocytoma Plasmacytoma Plasmacytosis Primary cutaneous follicle center lymphoma T/NK T cell ( lymphoma , leukemia ) (most CD3 CD4 CD8 ) By development/ marker TdT+ : ALL ( Precursor T acute lymphoblastic leukemia/lymphoma ) prolymphocyte ( Prolymphocytic ) CD30+ ( Anaplastic large-cell lymphoma Lymphomatoid papulosis type A ) Cutaneous MF+variants indolent: Mycosis fungoides Pagetoid reticulosis Granulomatous slack skin aggressive: Sézary disease Adult T-cell leukemia/lymphoma Non-MF CD30 -: Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma Pleomorphic T-cell lymphoma Lymphomatoid papulosis type B CD30 +: CD30+ cutaneous T-cell lymphoma Secondary cutaneous CD30+ large-cell lymphoma Lymphomatoid papulosis type A Other peripheral Hepatosplenic Angioimmunoblastic Enteropathy-associated T-cell lymphoma Peripheral T-cell lymphoma not otherwise specified ( Lennert lymphoma ) Subcutaneous T-cell lymphoma By infection HTLV-1 ( Adult T-cell leukemia/lymphoma ) NK cell / (most CD56 ) Aggressive NK-cell leukemia Blastic NK cell lymphoma T or NK EBV ( Extranodal NK-T-cell lymphoma / Angiocentric lymphoma ) Large granular lymphocytic leukemia Lymphoid+ myeloid Acute biphenotypic leukaemia Lymphocytosis Lymphoproliferative disorders ( X-linked lymphoproliferative disease Autoimmune lymphoproliferative syndrome ) Leukemoid reaction Diffuse infiltrative lymphocytosis syndrome Cutaneous lymphoid hyperplasia Cutaneous lymphoid hyperplasia with bandlike and perivascular patterns with nodular pattern Jessner lymphocytic infiltrate of the skin General Hematological malignancy leukemia Lymphoproliferative disorders Lymphoid leukemias
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Mastocytoma
Wikipedia
External links [ edit ] Classification D ICD - 10 : C96.2 , D47.0 ICD - 9-CM : 238.5 ICD-O : M9740/1 MeSH : D034801 DiseasesDB : 34450 External resources eMedicine : derm/258 Mast Cell Tumors from The Pet Health Library Mast Cell Tumors in Dogs from Pet Cancer Center Mast Cell Tumors in Cats from Pet Cancer Center v t e Myeloid -related hematological malignancy CFU-GM / and other granulocytes CFU-GM Myelocyte AML : Acute myeloblastic leukemia M0 M1 M2 APL/M3 MP Chronic neutrophilic leukemia Monocyte AML AMoL/M5 Myeloid dendritic cell leukemia CML Philadelphia chromosome Accelerated phase chronic myelogenous leukemia Myelomonocyte AML M4 MD-MP Juvenile myelomonocytic leukemia Chronic myelomonocytic leukemia Other Histiocytosis CFU-Baso AML Acute basophilic CFU-Eos AML Acute eosinophilic MP Chronic eosinophilic leukemia / Hypereosinophilic syndrome MEP CFU-Meg MP Essential thrombocytosis Acute megakaryoblastic leukemia CFU-E AML Erythroleukemia/M6 MP Polycythemia vera MD Refractory anemia Refractory anemia with excess of blasts Chromosome 5q deletion syndrome Sideroblastic anemia Paroxysmal nocturnal hemoglobinuria Refractory cytopenia with multilineage dysplasia CFU-Mast Mastocytoma Mast cell leukemia Mast cell sarcoma Systemic mastocytosis Mastocytosis : Diffuse cutaneous mastocytosis Erythrodermic mastocytosis Adult type of generalized eruption of cutaneous mastocytosis Urticaria pigmentosa Mast cell sarcoma Solitary mastocytoma Systemic mastocytosis Xanthelasmoidal mastocytosis Multiple/unknown AML Acute panmyelosis with myelofibrosis Myeloid sarcoma MP Myelofibrosis Acute biphenotypic leukaemia v t e Connective / soft tissue tumors and sarcomas Not otherwise specified Soft-tissue sarcoma Desmoplastic small-round-cell tumor Connective tissue neoplasm Fibromatous Fibroma / fibrosarcoma : Dermatofibrosarcoma protuberans Desmoplastic fibroma Fibroma / fibromatosis : Aggressive infantile fibromatosis Aponeurotic fibroma Collagenous fibroma Diffuse infantile fibromatosis Familial myxovascular fibromas Fibroma of tendon sheath Fibromatosis colli Infantile digital fibromatosis Juvenile hyaline fibromatosis Plantar fibromatosis Pleomorphic fibroma Oral submucous fibrosis Histiocytoma / histiocytic sarcoma : Benign fibrous histiocytoma Malignant fibrous histiocytoma Atypical fibroxanthoma Solitary fibrous tumor Myxomatous Myxoma / myxosarcoma Cutaneous myxoma Superficial acral fibromyxoma Angiomyxoma Ossifying fibromyxoid tumour Fibroepithelial Brenner tumour Fibroadenoma Phyllodes tumor Synovial -like Synovial sarcoma Clear-cell sarcoma Lipomatous Lipoma / liposarcoma Myelolipoma Myxoid liposarcoma PEComa Angiomyolipoma Chondroid lipoma Intradermal spindle cell lipoma Pleomorphic lipoma Lipoblastomatosis Spindle cell lipoma Hibernoma Myomatous general: Myoma / myosarcoma smooth muscle : Leiomyoma / leiomyosarcoma skeletal muscle : Rhabdomyoma / rhabdomyosarcoma : Embryonal rhabdomyosarcoma Sarcoma botryoides Alveolar rhabdomyosarcoma Leiomyoma Angioleiomyoma Angiolipoleiomyoma Genital leiomyoma Leiomyosarcoma Multiple cutaneous and uterine leiomyomatosis syndrome Multiple cutaneous leiomyoma Neural fibrolipoma Solitary cutaneous leiomyoma STUMP Complex mixed and stromal Adenomyoma Pleomorphic adenoma Mixed Müllerian tumor Mesoblastic nephroma Wilms' tumor Malignant rhabdoid tumour Clear-cell sarcoma of the kidney Hepatoblastoma Pancreatoblastoma Carcinosarcoma Mesothelial Mesothelioma Adenomatoid tumor
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Occupational Asthma
Wikipedia
Unlike those with sensitizer-induced occupational asthma, subjects with irritant-induced occupational asthma do not develop work-related asthma symptoms after re-exposure to low concentrations of the irritant that initiated the symptoms. [2] Reactive airways dysfunction syndrome (RADS) is a severe form of irritant induced asthma where respiratory symptoms usually develop in the minutes or hours after a single accidental inhalation of a high concentration of irritant gas, aerosol, vapor, or smoke. [3] Another type of work-related asthma is work-exacerbated asthma (WEA) which is asthma worsened by workplace conditions but not caused by it. ... A number of diseases have symptoms that mimic occupational asthma, such as asthma due to nonoccupational causes, chronic obstructive pulmonary disease (COPD), irritable larynx syndrome, hyperventilation syndrome , hypersensitivity pneumonitis , and bronchiolitis obliterans .
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Triosephosphate Isomerase Deficiency
Omim
Many patients die from respiratory failure in childhood. The neurologic syndrome is variable, but usually includes lower motor neuron dysfunction with hypotonia, muscle weakness and atrophy, and hyporeflexia. ... The patients, aged 7 and 4 years at the time of the report, developed hemolytic anemia in early infancy, followed by a progressive neuromuscular syndrome beginning at about age 2 years.
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Spontaneous Coronary Artery Dissection (Scad)
Mayo_clinic
Genetic diseases that cause problems with the body's connective tissues, such as vascular Ehlers-Danlos syndrome and Marfan syndrome, have been found to occur in people who have had SCAD .
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H1n1 Flu (Swine Flu)
Mayo_clinic
People on long-term aspirin therapy and who are younger than 19 years of age are at risk of Reye syndrome if infected with influenza. Pregnancy. ... This is due to the risk of Reye syndrome, a rare but potentially life-threatening condition.ABCF1, APLP1, TEKT1, L3MBTL3, BUD13, MEDAG, CFAP74, RRP7BP, ARAP2, PNLIPRP3, ENPP6, PXDNL, SLITRK4, CEP128, LINGO2, SPRED2, SERHL2, TMPRSS11F, TEX26-AS1, LINC01811, LINC02334, CEP290, ESYT2, MAN1C1, NUMA1, BRAF, DLG2, DMD, ACSL3, HLA-DQA2, AGFG1, MITF, MMP9, PIP4K2A, TBC1D2, PTPRR, ADAM12, GTF2IRD1, TUBGCP2, SPINK4, LRP1B, ATAD2B, GIPC2, LINC02336
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Transverse Myelitis
Mayo_clinic
These disorders include lupus, which can affect multiple body systems, and Sjogren's syndrome, which causes severe dryness of the mouth and eyes. ... The prognosis and responsiveness to treatment is strongly determined by the cause of the syndrome and to some extent by how early treatment is administered.
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Leukocyte Adhesion Deficiency, Type Iii
Omim
Robert et al. (2011) described a 33-month-old first son of consanguineous Gypsy parents with LAD3 syndrome characterized by a serious bleeding defect and immune deficiency. ... In a 33-month-old first son of consanguineous Gypsy parents with LAD3 syndrome, Robert et al. (2011) identified a homozygous splice-site mutation in the FERMT3 gene (607901.0009).