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Colorectal Adenoma
Wikipedia
PMID 17167138 . v t e Digestive system neoplasia GI tract Upper Esophagus Squamous cell carcinoma Adenocarcinoma Stomach Gastric carcinoma Signet ring cell carcinoma Gastric lymphoma MALT lymphoma Linitis plastica Lower Small intestine Duodenal cancer Adenocarcinoma Appendix Carcinoid Pseudomyxoma peritonei Colon/rectum Colorectal polyp : adenoma , hyperplastic , juvenile , sessile serrated adenoma , traditional serrated adenoma , Peutz–Jeghers Cronkhite–Canada Polyposis syndromes: Juvenile MUTYH-associated Familial adenomatous / Gardner's Polymerase proofreading-associated Serrated polyposis Neoplasm: Adenocarcinoma Familial adenomatous polyposis Hereditary nonpolyposis colorectal cancer Anus Squamous cell carcinoma Upper and/or lower Gastrointestinal stromal tumor Krukenberg tumor (metastatic) Accessory Liver malignant : Hepatocellular carcinoma Fibrolamellar Hepatoblastoma benign : Hepatocellular adenoma Cavernous hemangioma hyperplasia : Focal nodular hyperplasia Nodular regenerative hyperplasia Biliary tract bile duct : Cholangiocarcinoma Klatskin tumor gallbladder : Gallbladder cancer Pancreas exocrine pancreas : Adenocarcinoma Pancreatic ductal carcinoma cystic neoplasms : Serous microcystic adenoma Intraductal papillary mucinous neoplasm Mucinous cystic neoplasm Solid pseudopapillary neoplasm Pancreatoblastoma Peritoneum Primary peritoneal carcinoma Peritoneal mesothelioma Desmoplastic small round cell tumorAPC, DEFA5, MUTYH, TP53, MRC1, KRAS, CTNNB1, MTHFR, CD44, ABCC1, DNMT3B, RASSF1, MMP9, PTGS2, IGF1, UNC5C, MLH1, MGMT, GDF15, LEP, TIMP1, CCAT1, CDX2, MYB, BCL2, TYMS, SRC, SATB1, SFRP2, SLC10A2, CUL1, CUL2, TRIM21, VDR, SRPX, TGFB1, SLC14A2, MFAP5, VEGFA, NAT2, DCLK1, EIF3A, CFLAR, CCAT2, HULC, ZG16, MIR29A, MIR21, MIR155, PLA2G2C, CCDC66, IL23R, MUC17, WLS, MARCKSL1, MUC3B, TLR9, IL23A, FOXP3, RMC1, SIRT1, BVES, GPA33, ABCG2, ADIPOQ, SLC16A4, BCL10, PER3, RPE, MUC6, PTEN, DHFR, MTOR, FOLH1, FLT4, VEGFD, ESR2, ESR1, ERCC5, ERCC2, ERBB2, SLC26A3, CX3CR1, TAS2R38, CSNK1D, CDKN2A, CD28, CBS, CALR, BCL2L1, BAAT, ALOX5, ALDOB, ALDH1A1, UTS2R, MSH6, HIC1, HIF1A, PLK1, PLG, NTS, MYC, ADH1C, MUC5AC, MUC3A, MUC2, MUC1, COX1, ATP8, MSI1, MMP14, MMP13, MMP7, MMP2, KDR, IL10, CXCL8, IGF2, IGF1R, H3P10
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Cutis Verticis Gyrata
Wikipedia
] in 1843 [5] and it was named by Paul Gerson Unna in 1907. [6] It has also been called Robert-Unna syndrome , bulldog scalp , corrugated skin , cutis verticis plicata , and pachydermia verticis gyrata . [7] Contents 1 Cause 2 Diagnosis 2.1 Classifications 3 Treatment 4 See also 5 References 6 External links Cause [ edit ] At this time, causes are unknown, but it is believed to not be congenital.
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Trio-Related Intellectual Disability
Gene_reviews
Diagnoses that could, however, be considered in individuals with findings suggestive of TRIO -related ID: Angelman syndrome (AS), caused by disruption of maternally imprinted UBE3A . ... The degree of delay is, however, usually less severe in TRIO -related ID, and developmental regression, which is observed in classic Rett syndrome, has not been described to date. Pitt-Hopkins syndrome (PTHS), caused by haploinsufficiency of TCF4 .
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Heart Arrhythmia
Mayo_clinic
Types of bradycardias include: Sick sinus syndrome. The sinus node is responsible for setting the pace of the heart. If it doesn't work properly, the heart rate may alternate between too slow (bradycardia) and too fast (tachycardia). Sick sinus syndrome can be caused by scarring near the sinus node that's slowing, disrupting or blocking the travel of impulses. Sick sinus syndrome is most common among older adults.GJA1, OPRK1, KCNH2, CACNA1C, ACE, KCNJ2, KCNE2, AGT, EDN1, HTR4, PPP1R1A, KCND3, BVES, CTNNA3, CACNA2D1, GYG1, KCNE1, OPRL1, CNNM2, TRH, SGO1, ESR2, AVP, SLC22A5, PTGS2, KNG1, KCNJ8, CD36, ADM, FKBP1B, CACNA2D2, KCNQ1, SOD2, SCN5A, LMNA, GNAI2, OPRD1, PTPN22, PIK3CA, TTR, CAV3, DMD, SCN1B, TRPM4, SCN4A, MECP2, TTN, TBX3, GLA, MYH6, CPT1A, LAMP2, NKX2-5, CPT2, BMP2, NDUFB11, PEX6, PEX10, ND1, ND2, PEX7, PEX13, PEX12, ND4, PEX14, ADA2, PHYH, CYTB, TDP2, COX3, PRTN3, PEX1, PCCB, KRAS, ND5, PSMB8, TRNL1, MEFV, NRAS, TRNK, TRNE, ND6, SALL4, SCN3B, PEX26, TMEM70, LAMA2, PCCA, MYH7, GDAP1, ATP6, RPS24, PTPN11, TTPA, SOS2, SOX10, KAT6B, TAZ, LARS2, SPECC1L, SYNE2, TAB2, TNXB, TOP3A, TSC1, TSC2, MRAS, MTO1, POLG2, VHL, RPL35, AKAP10, LZTR1, NAA10, PEX3, PEX11B, SLC19A2, PHOX2B, FBLN5, PEX16, SOS1, WIPI2, PEX19, RPS10, PEX2, PEX5, RAF1, RASA2, RIT1, RPL5, RPL11, RPL15, RPL18, RPL26, RPL27, RPS7, RPS15A, EFEMP2, RPS17, RPS19, RPS26, RPS27, RPS28, RPS29, RRAS, RYR2, SCNN1A, SCNN1B, SCNN1G, SLC40A1, RPL35A, ND4L, HCCS, GTPBP3, GATA1, HFE, CASR, HLA-B, GPC3, ANK2, HRAS, GNA11, HLA-DPB1, GNAQ, GPX4, BRAF, GSN, HADHA, HADHB, HMBS, HSPG2, FOXC2, FHL1, MYLK2, ACADM, ELN, EP300, A2ML1, HJV, HBB, CTLA4, ERCC6, CREBBP, COX7B, KCNQ1-AS1, MGME1, ERCC8, TSR2, GPC4, HLA-DPA1, FSD1, FSD1L, CASQ2, HCN4, PREP, PAEP, REN, TBX5, PKP2, SCN10A, GJA5, CALM1, HRC, IL6, SLC8A1, CRP, TNF, PIK3CG, TNNI3, PIK3CD, CALM2, PLN, PIK3CB, PITX2, APLN, AGTR1, SCN1A, IDS, KCNJ5, MALAT1, RYR1, ALDH2, KCNA5, BIN1, TRDN, CALM3, DSG2, NOS1AP, CTAA1, ATN1, DSP, SNAP91, CYBB, RGS6, HGS, COPD, HACD1, TSPO, PICALM, CAP1, MMRN1, MIR206, GPD1L, TAL1, BRD4, EDA, SPTBN1, BCHE, TPM1, CALR, SORBS1, VWF, CAT, RANGRF, FGF23, SRSF5, ALB, KRIT1, KCNQ1OT1, SMUG1, KCNE3, HMGB1, LGALS3, SERPINB6, KCNK2, IL10, ERG, IL1B, SCLY, PTPA, NLRP3, KCNK3, CHDH, LNPEP, HARS1, P2RX7, KCNK17, CAMKMT, EPHA3, FLNC, EMD, GATA4, NR3C2, KRT7, SELENON, SNORD118, DPP10, PSIP1, TUSC2, POTEM, ACOT7, PDAP1, VARS2, MIR448, MIR151A, POTEKP, MIR34A, MIR31, TBX20, MIR30A, CHPT1, MIR208A, SESN2, TEC, SIRPA, POLR2M, PGR-AS1, GJC1, PDF, POPDC2, ABCC9, ACE2, TOPORS, GDF11, STX6, SIGMAR1, BET1, PERCC1, CAAP1, RBM25, MIR208B, KLF2, RAPGEF3, ASRGL1, MYZAP, P2RX5-TAX1BP3, FAS-AS1, MRPS30, PAPOLA, KCNIP4, P2RX2, RAPGEF4, ADAMTS13, MIR1231, SIRT1, FAM20C, DCDC2, ACTBL2, ESAM, DUOX1, BTBD8, CAVIN1, TANGO2, KCNIP2, EHD4, XIRP2, MYOZ2, RBM20, DUOX2, TECRL, ZC4H2, PRKAG2, SPRED2, PLB1, GP6, MAPKAP1, GCOM1, RBM45, ALG10B, TNNI3K, CUZD1, PPARGC1B, GATA5, CAVIN4, LRRC10, TERF2IP, SGSM3, ADCY10, OBSCN, MIR200C, ASAP1, MIR19B1, NCS1, MIR182, HOPX, QRSL1, MMD, EBPL, KCNE4, PACC1, MTPAP, PDPR, MOCOS, MIR155, MIR130A, POU2F3, TRPM7, KLHL24, ALG10, SIGLEC7, HSPB7, RABGEF1, CDAN1, SERPINA3, SCO2, HOXD13, HCLS1, GSTP1, GNG11, GCLC, GCG, FGF13, FBN1, PTK2B, FANCC, F2, ETV1, ESRRG, ESR1, EPHX2, ELK3, ELANE, EGF, HLA-DRB1, IL2RA, MMP3, IL2RB, MFAP1, MEF2A, SMCP, MC5R, MAP6, SMAD7, LRP6, LEP, KCNH1, KCND2, KCNC4, KCNA4, ITPR3, ITPR1, ITPKB, IL17A, IL4, DSC2, DRD4, DPP6, DMPK, ATP2A2, ATM, ZFHX3, ARNTL, RHOA, KLK3, APRT, ANGPT2, AMBP, AKT1, ADRB1, ADCYAP1, ADCY6, ACTN2, ACTG2, ACTG1, ACP3, BRCA2, VPS51, CAD, COL4A5, SARDH, DECR1, DCT, CYP19A1, CUX1, CTNNB1, CSF1, COL4A1, CALCR, CLN3, CHI3L1, CD40LG, CD38, RUNX3, CASP1, CAMK2D, MMP1, MPO, PCLAF, SCG2, VEGFA, VCL, UGCG, UCP2, TYRP1, TRPC3, TNNT2, TNFRSF1B, TIMP1, TGFB3, TGFB1, TEAD4, TCF3, TBX2, TACR3, ABCC8, SULT2A1, ZAP70, SHOC2, NGF, DYSF, BAG3, TBPL1, GDF15, FHL5, HAND1, ADIPOQ, SLC33A1, P2RX6, AIP, TRPA1, CACNA1H, NR1I2, ASAP2, CES2, CREG1, PDE5A, KHSRP, STIM1, SQLE, SOD1, SNTA1, PML, PLEC, ABCB1, PGM1, PER1, PDE4D, PCYT1A, REG3A, PAK1, P2RY2, P2RY1, P2RX5, P2RX4, P2RX3, P2RX1, NTRK1, NOS3, POMC, PRKAA2, MAPK3, SGK1, SNRNP70, SLC22A2, SLC6A8, SLC6A4, STIL, PMEL, SHOX2, SELP, MAPK9, SRL, SCD, S100A1, AAVS1, REST, RAP1A, PTH, CERNA3
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Sptbn4 Disorder
Gene_reviews
Genes of Interest in the Differential Diagnosis of SPTBN4 Disorder View in own window Gene(s) / Genetic Mechanism Disorder MOI Features of Differential Diagnosis Disorder Overlapping w/ SPTBN4 Disorder Distinguishing from SPTBN4 Disorder Abnormal parent-specific imprinting 1 Prader-Willi syndrome See footnote 2. Congenital hypotonia, poor feeding Hyperphagia, obesity, cognitive delay in childhood CRPPA 2 DAG1 FKRP FKTN 3 LARGE1 POMGNT1 POMT1 POMT2 Muscular dystrophy-dystroglycanopathy, type A (OMIM PS236670) AR Congenital hypotonia w/cognitive delays, often assoc w/hyporeflexia ↑ CK Congenital brain malformations on MRI Typically normal hearing DMPK Myotonic dystrophy type 1 AD Congenital hypotonia, weakness, & cognitive delays Myotonia, cataracts SMN1 Spinal muscular atrophy AR Congenital hypotonia, areflexia, & nonspecific dysmorphic features Normal cognition & hearing TBCK Hypotonia, infantile, w/psychomotor delay, & characteristic facies 3 (OMIM 616900) AR Congenital hypotonia w/hyporeflexia, cognitive delays, & seizures White matter changes on MRI Normal hearing UFC1 Neurodevelopmental disorder w/spasticity & poor growth (OMIM 618076) AR Contractures, hypotonia, delayed psychomotor development, inability to sit or walk, poor or absent speech, poor head control, seizures, poor feeding Significant growth deficiency UNC80 UNC80 deficiency AR Congenital hypotonia, developmental delay, seizures, poor feeding Dysmorphic facial features & skull deformities AR = autosomal recessive; AD = autosomal dominant; MOI = mode of inheritance 1. Prader-Willi syndrome (PWS) is caused by an absence of expression of imprinted genes in the paternally derived PWS/Angelman syndrome (AS) region of chromosome 15 by one of several genetic mechanisms (paternal deletion, maternal uniparental disomy 15, and rarely an imprinting defect).TFG, MPZ, VAC14, MAPK14, LINC02841, MAD2L1BP, PMP22, MFN2, UNC5D, NDUFAF6, NEFL, TRDN, GJB1, GNGT1, HSPB1, KIF1B, TRPV4, DNM2, C10orf143, NTRK3, RAB7A, GDAP1, TNF, RNMT, TTR, INF2, VEGFA, MAG, PNPLA6, MTMR2, GARS1, IL10, POLG, NGF, EGR2, FIG4, RAB7B, AKR1B1, SH3TC2, SPTLC1, PRX, CYP2C8, NTF3, AIFM1, MCF2L2, NFASC, CEP72, B3GAT1, TRPA1, PRNP, TLR4, SARM1, GSTP1, BDNF, IL6, CYP3A5, SETX, IGHMBP2, EPO, HSPB2, IL1B, FMR1, BSCL2, DYNC1H1, TWNK, MORC2, YARS1, APOE, GJB3, HSPB3, PMP2, ALB, CASP3, LMNA, GART, SOD1, LRSAM1, HPGDS, MTM1, TRPV1, HSPB8, HMGB1, HINT1, HSP90AA1, GSN, ATL1, HSPA4, GSK3B, IL24, IFNB1, IGF1, TNFRSF1A, ZBTB17, ATXN1, REN, PSMD9, PRPS1, SPTLC2, BAG3, HDAC6, ABCB1, SIGMAR1, FBLN5, NFE2L2, MMP13, MMP9, MAPT, ITIH4, TARDBP, IL4, KRT20, HSP90B2P, FAP, GCG, GAP43, GAD1, GABPA, CDC42, TYMP, KIF1A, CNTN1, TGM6, F2RL1, ESR1, CMTX3, AFP, DPYSL5, HCN1, AGTR2, CNTF, EPHA5, GDNF, EHMT1, GCK, TSPO, GLP1R, CTLA4, MS4A1, ZGLP1, ALDH2, ACTB, FGD4, ACP3, MIR155, MYOM2, LGI1, MIR128-1, C4orf3, GRAP2, SNAP29, ADIPOQ, LONP1, ELP6, CYP7B1, BMS1, IL18BP, XKR4, SCO2, SLC12A6, HT, AP5Z1, OR2AG1, NTN1, IDO2, PGP, IKBKE, EPHA6, MIR146A, LITAF, MIR132, MIR26B, RGN, LOH19CR1, USP5, AIMP2, MBS2, MIR34C, RNF112, CCR2, YY1, XRCC1, WARS1, VRK1, MIR873, C20orf181, TUBB2A, OCLN, TTPA, GAN, CNTNAP1, USP14, KMO, CLDN1, PIAS2, MPZL1, MIR21, SNURF, MUC16, MCM3AP, SGPL1, PER2, ASAP2, HDAC3, TNFRSF11A, AOC3, TNFSF11, MIR27A, NLRP3, NTNG2, C12orf65, CSGALNACT1, ERBIN, TPR, CHMP2B, ATL3, RNF19A, JPH1, PART1, PANX1, DIANPH, MMD, CHMP1B, PAK5, TRIM2, LPIN1, SCYL1, USE1, NGLY1, SPTBN4, DKK2, GINS2, IL23A, GAL, YARS2, SLC47A1, MEG3, AMBRA1, DERL2, DHH, ASAP1, COA3, IGLV1-40, IGLV1-44, DLL1, RPS6KA6, NLN, SLC25A19, WARS2, AFG3L2, PAPOLA, MED25, PPARGC1A, SCRT1, MRPS30, SEPTIN9, TXNIP, AHSA1, MTPAP, PITRM1, DGAT2, SLC9A6, SLC25A46, NDRG1, TUBB4B, SBF2, BTG3, DCLRE1B, ADAMTS12, RAB18, MMRN1, WNK1, CHSY1, NTNG1, UBE2Z, MGLL, TUSC2, TRPM8, PDAP1, SCN11A, WDHD1, LDB3, SPG11, CAPN10, POLDIP2, AARS1, TPM3, CXCL3, GPT, CXCR3, NPBWR1, SFN, GMFB, GCLC, GJA1, GFRA2, GFRA1, GALR1, FXN, FGF2, FDXR, FCGR3A, FAAH, ERCC1, ENO2, EGF, EDN1, DSP, DNMT1, GRM2, GRP, CYP19A1, GSTM1, IL3, IL2, IL1A, IGLL1, IGHM, IGFALS, IFNA13, IFNA1, IDH2, IDH1, IAPP, HSPA9, DNAJB2, HNF4A, HMBS, HLA-DOA, HIF1A, NRG1, HGF, HFE, HADHB, DMRT1, CYP3A4, CXCR2, SERPING1, BCR, HCN2, BCL2A1, BCHE, ATM, ATF3, AR, APRT, APOC3, APOA2, APOA1, AOC2, AMPH, NR0B1, ADORA1, ADM, ADH1B, ACTG2, ACR, ACHE, ACACA, DST, C3, CTSL, CANX, CCN2, NCAN, CSF2, CSF1, CRK, CLDN7, COL4A4, COL4A3, CNN3, CCR5, CCR1, CHIT1, CD86, CD80, CD28, CD14, CD1C, CD1B, CD1A, RUNX3, CAT, CXCL8, IL17A, TPI1, SMN1, CXCL12, CXCL11, CCL5, CCL2, SCN9A, ATXN8OS, ATXN2, SBF1, S100A9, SORT1, ABCA2, RET, REST, RARRES2, PVALB, PTPN11, PTGIS, PSMB6, PRTN3, PRS, PRPH, SLC2A4, SMN2, MAPK3, SNAP25, TP53, TNS1, TNFRSF1B, TMPO, TLR2, TIMP1, TGM2, TGFB2, HNF1A, ADAM17, TAC1, SURF1, STATH, SST, SSRP1, SOX4, SOX2, SOX1, SOS1, SNRPN, SNCA, MAP2K7, MAPK1, CXCL10, NGFR, NF1, NEO1, ATP8, MSR1, MPV17, MNDA, MMP2, MME, ATXN3, MFAP1, LYZ, LY6E, STMN1, LAMC2, KRAS, KLK1, KIF5A, KDR, KCNB1, JUN, IRF3, NF2, NOS3, PPARG, NOTCH1, PON1, POMC, PNOC, PLP1, PLEC, PIK3CG, PIK3CD, PIK3CB, PIK3CA, PGM3, PDK3, REG3A, P2RX3, OPRK1, OPRD1, OPA1, NTRK1, NT5E, NRTN, SLC11A2, NPTX2, RPS19
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Ntrk1 Congenital Insensitivity To Pain With Anhidrosis
Gene_reviews
Anhidrosis (absence of sweating), manifesting as recurrent febrile episodes beginning in early infancy Impairment of the autonomic nervous system, which may be evident by the presence of Horner syndrome and the cold pressor test Intellectual disability Family history consistent with autosomal recessive inheritance , including affected sibs in a single generation, simplex cases (i.e., a single affected family member), and/or parental consanguinity Establishing the Diagnosis The diagnosis of NTRK1 congenital insensitivity to pain with anhidrosis ( NTRK1 -CIPA) is established in a proband with biallelic pathogenic variants in NTRK1 identified by molecular genetic testing (see Table 1). ... Assoc w/other features incl blue sclera, short stature, joint hypermobility, deafness EDA EDAR EDARADD Hypohidrotic ectodermal dysplasia XL AR AD Hypohidrosis Risk of hyperthermia Insensitivity to pain not a feature ELP1 (IKBKAP) Familial dysautonomia (HSAN III) AR ↓ pain from birth GI dysfunction, vomiting crises, recurrent pneumonia, cardiovascular & temperature instability HPRT1 Lesch-Nyhan syndrome XL Progressive self-injurious behavior (biting fingers, hands, lips, cheeks; banging the head or limbs) Hyperuricemia Progressive, severe DD/ID Abnormal involuntary movements MPV17 MPV17 -related hepatocerebral mitochondrial DNA depletion syndrome AR Absent pain responses from birth DD Infantile-onset liver dysfunction typically → liver failure; failure to thrive, lactic acidosis, & hypoglycemia More severe neurologic involvement; may incl white matter abnormalities on MRI & seizures NGF NGF -CIPA 1 (HSAN V) AR Insensitivity to pain, anhidrosis, & ID 1, 2 NGF -CIPA & NTRK1 -CIPA cannot reliably be differentiated on a clinical basis. 2 AD = autosomal dominant; AR = autosomal recessive; CIPA = congenital insensitivity to pain with anhidrosis; DD = developmental delay; GI = gastrointestinal; HSAN = hereditary sensory and autonomic neuropathy; ID = intellectual disability; MOI = mode of inheritance; XL = X-linked 1.
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Cartilage-Hair Hypoplasia
Omim
Burgert et al. (1965) described a similar syndrome with dyschondroplasia, aregenerative anemia, and celiac syndrome. ... There is a remarkable degree of phenotypic variability in all features of the syndrome. The hair may be seemingly completely unaffected; some patients suffer no apparent immunologic or hematologic defect; Hirschsprung disease of clinically evident severity occurs in a minority.RMRP, MARCKSL1, ABCC1, WLS, ANOS1, FGFR1, CHD7, EBP, GNRHR, AMH, PROK2, CGB5, SPRY2, KLB, POP1, CORO1A, CGB8, FLRT3, FGF21, SPRY4, POP5, IL17RD, RSAD2, RPP25, NTN1, WDR11, POP7, TACR3, HS6ST1, HTC2, CGA, CGB3, CYP3A4, DUSP6, FGF8, FN1, GH1, GNRH1, IL11, FGF17, CXCL10, LHCGR, SMAD2, NR3C2, NME1, SOX4, TAC3, CAT, IGSF10
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Agnosia
Wikipedia
It is present in lesions of the dominant parietal lobe , and is a component of Gerstmann syndrome . Form agnosia Patients perceive only parts of details, not the whole object. ... The person instead processes faces, bodies, objects, rooms, places, pictures in a bit-by-bit fashion. [17] When looking at a picture they can describe the parts of the picture but struggle to comprehend the picture as a whole. Simultagnosia occurs in Bálint syndrome [18] but may also occur in brain injury. ... "Psychoanatomical substrates of Bálint's syndrome" . J. Neurol. Neurosurg. Psychiatry . 72 (2): 162–78. doi : 10.1136/jnnp.72.2.162 .
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Acute Flaccid Myelitis
Wikipedia
Condition of the spinal cord with symptoms of rapid onset of arm or leg weakness Acute flaccid myelitis Other names Acute flaccid paralysis with anterior myelitis, polio-like syndrome [1] Magnetic resonance imaging of the spinal cord in a case of AFM showing cord swelling in (d) which has resolved three weeks later in (e). [2] Specialty Neurology [3] Symptoms Weakness, decreased reflexes, trouble swallowing or speaking [3] Complications Trouble breathing, urinary retention [3] Usual onset Rapid [3] Causes Generally unknown,Thought to be caused by Viral infection [4] Diagnostic method Medical imaging , nerve conduction studies , cerebral spinal fluid testing [3] [5] Differential diagnosis Transverse myelitis , Guillain–Barré syndrome , acute disseminated encephalomyelitis [3] [5] Prevention Polio vaccination , avoiding mosquitoes bites [5] Treatment Supportive care , physical therapy , mechanical ventilation [3] [5] Prognosis Variable [5] Frequency Rare [4] Acute flaccid myelitis ( AFM ) is a serious condition of the spinal cord . [3] [5] Symptoms include rapid onset of arm or leg weakness and decreased reflexes . [3] Difficulty moving the eyes, speaking, or swallowing may also occur. [3] Occasionally, numbness or pain may be present. [3] Complications can include trouble breathing. [3] The cause of most cases is unclear as of 2018. [4] More than 90% of recent cases have followed a mild viral infection such as from enteroviruses . [4] While polio can cause AFM, since 2014, it has not been involved in cases in the United States. [3] [6] The underlying mechanism involves damage to the spinal cord's grey matter . [3] Diagnosis may be supported by medical imaging of the spine, nerve conduction studies , and cerebrospinal fluid testing. [3] [5] Prevention includes polio vaccination and avoiding mosquito bites. [5] Treatment involves supportive care . [5] [3] Physical therapy may be recommended. [3] Occasionally, mechanical ventilation is required to support breathing. [3] Outcomes are variable. [5] The condition is rare and occurs most commonly in children. [4] Fewer than one in 500,000 children is affected per year in the United States. [3] Although the illness is not new, an increase in cases has been seen since 2014 in the United States. [3] In 2018, 233 cases were confirmed in the United States. [7] Contents 1 Signs and symptoms 2 Causes 3 Diagnosis 4 Prevention 5 Treatment 6 Outcomes 7 Epidemiology 8 History 9 References Signs and symptoms [ edit ] Symptoms include: Difficulty moving the eyes or drooping eyelids Facial droop or weakness Difficulty with swallowing or slurred speech Sudden arm or leg weakness [8] A summary of the condition by the Centers for Disease Control and Prevention (CDC) in 2014: [9] Common features included acute focal limb weakness and specific findings on magnetic resonance imaging (MRI) of the spinal cord consisting of nonenhancing lesions largely restricted to the grey matter. ... A seasonal pattern is seen in outbreaks, with a marked increase in cases reported in the late summer and early fall. [23] The CDC has determined and submitted to GenBank complete or nearly complete genomic sequences for three known strains of the virus, which are "genetically related to strains of EV-D68 virus that were detected in previous years in the United States, Europe, and Asia." [24] While rates of paralytic symptoms appear to be correlated with the number of respiratory infections, in initial anecdotal reports, the cases are not clustered within a family or school, suggesting that the paralysis per se is not directly contagious, but arises as a very rare complication of the common respiratory infection. [20] Cases of similar illnesses have been reported in Canada, Northern Europe, and Japan. [18] Over 90% of reported cases are in children. [25] History [ edit ] AFM has only been formally tracked since 2014, since the incidence has spiked in recent years. [ citation needed ] A group in Texas reported having observed a pattern in 2013 of one to four cases per year with similar polio-like characteristics. [20] In 2014, the CDC Morbidity and Mortality Weekly Report [14] and a CDC Clinician Outreach and Communication Activity (COCA) conference call, [26] noted that many cases had neck, back, or extremity pain, but otherwise those affected generally had normal sensation in their limbs. [27] A few participants in the conference call discussed whether pain, later abating, might precede the onset of paralysis. [26] [28] An October 2014 report described outbreaks in California and Colorado, suggesting that the number of cases might be 100 or more nationwide. [29] Diagnosis included a detailed medical history , MRI imaging, and the elimination of transverse myelitis or Guillain–Barré syndrome as potential causes. Physicians were using an online mailing list to communicate about similar cases in Alabama and Kansas .
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Solar Urticaria
Wikipedia
External links [ edit ] Classification D ICD - 10 : L56.3 ICD - 9-CM : 692.72 DiseasesDB : 29575 External resources eMedicine : article/1050485 v t e Urticaria and erythema Urticaria ( acute / chronic ) Allergic urticaria Urticarial allergic eruption Physical urticaria Cold urticaria Familial Primary cold contact urticaria Secondary cold contact urticaria Reflex cold urticaria Heat urticaria Localized heat contact urticaria Solar urticaria Dermatographic urticaria Vibratory angioedema Pressure urticaria Cholinergic urticaria Aquagenic urticaria Other urticaria Acquired C1 esterase inhibitor deficiency Adrenergic urticaria Exercise urticaria Galvanic urticaria Schnitzler syndrome Urticaria-like follicular mucinosis Angioedema Episodic angioedema with eosinophilia Hereditary angioedema Erythema Erythema multiforme / drug eruption Erythema multiforme minor Erythema multiforme major Stevens–Johnson syndrome , Toxic epidermal necrolysis panniculitis ( Erythema nodosum ) Acute generalized exanthematous pustulosis Figurate erythema Erythema annulare centrifugum Erythema marginatum Erythema migrans Erythema gyratum repens Other erythema Necrolytic migratory erythema Erythema toxicum Erythroderma Palmar erythema Generalized erythema v t e Radiation-related disorders / Photodermatoses Ultraviolet / ionizing Sunburn Phytophotodermatitis Solar urticaria Polymorphous light eruption Benign summer light eruption Juvenile spring eruption Acne aestivalis Hydroa vacciniforme Solar erythema Non-ionizing Actinic rays Actinic keratosis Atrophic actinic keratosis Hyperkeratotic actinic keratosis Lichenoid actinic keratosis Pigmented actinic keratosis Actinic cheilitis Actinic granuloma Actinic prurigo Chronic actinic dermatitis Infrared / heat Erythema ab igne ( Kangri ulcer Kairo cancer Kang cancer Peat fire cancer ) Cutis rhomboidalis nuchae Poikiloderma of Civatte Other Radiation dermatitis Acute Chronic radiodermatitis ) Favre–Racouchot syndrome Photoaging Photosensitivity with HIV infection Phototoxic tar dermatitis
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Chemotherapy-Induced Nausea And Vomiting
Wikipedia
Natural medical cannabis is also used and recommended by some oncologists, though its use is regulated and it is not legal in all jurisdictions. [15] However, Marinol was less effective than megestrol acetate in helping cancer patients regain lost appetites. [16] A phase III study found no difference in effects of an oral cannabis extract or THC on appetite and quality of life (QOL) in patients with cancer-related anorexia - cachexia syndrome (CACS) to placebo . [17] [ third-party source needed ] Dexamethasone , a corticosteroid, is often used alongside other antiemetic drugs, as it has synergistic action with many of them, although its specific antiemetic mechanism of action is not fully understood. ... "Comparison of Orally Administered Cannabis Extract and Delta-9-Tetrahydrocannabinol in Treating Patients With Cancer-Related Anorexia-Cachexia Syndrome: A Multicenter, Phase III, Randomized, Double-Blind, Placebo-Controlled Clinical Trial From the Cannabis-In-Cachexia-Study-Group". ... CS1 maint: archived copy as title ( link ) "How to Prevent CINV, Minimize CINV" v t e Antiemetics ( A04 ) 5-HT 3 serotonin ion channel antagonists Alosetron Azasetron Bemesetron Cilansetron Clozapine Dazopride Dolasetron Granisetron Lerisetron Metoclopramide Mianserin Mirtazapine Olanzapine Ondansetron Palonosetron ( +netupitant ) Quetiapine Ramosetron Ricasetron Tropisetron Zatosetron 5-HT serotonin G-protein receptor antagonists Clozapine Cyproheptadine Hydroxyzine Olanzapine Risperidone Ziprasidone CB 1 agonists ( cannabinoids ) Dronabinol Nabilone Tetrahydrocannabinol ( cannabis ) D 2 /D 3 antagonists Alizapride Bromopride Chlorpromazine Clebopride Domperidone Haloperidol Hydroxyzine Itopride Metoclopramide Metopimazine Prochlorperazine Thiethylperazine Trimethobenzamide H 1 antagonists ( antihistamines ) Cyclizine Dimenhydrinate Diphenhydramine Hydroxyzine Meclizine Promethazine mACh antagonists ( anticholinergics ) Atropine Diphenhydramine Hydroxyzine (very mild) Hyoscyamine Scopolamine NK 1 antagonists Aprepitant Casopitant Ezlopitant Fosaprepitant Maropitant Netupitant Rolapitant Vestipitant Others Cerium oxalate Dexamethasone Lorazepam Midazolam Propofol v t e Intracellular chemotherapeutic agents / antineoplastic agents ( L01 ) SPs / MIs ( M phase ) Block microtubule assembly Vinca alkaloids ( Vinblastine # Vincristine # Vindesine Vinflunine § Vinorelbine # ) Block microtubule disassembly Taxanes ( Cabazitaxel Docetaxel # Larotaxel Ortataxel † Paclitaxel # Tesetaxel ) Epothilones ( Ixabepilone ) DNA replication inhibitor DNA precursors/ antimetabolites ( S phase ) Folic acid Dihydrofolate reductase inhibitor ( Aminopterin Methotrexate # Pemetrexed Pralatrexate ) Thymidylate synthase inhibitor ( Pemetrexed Raltitrexed ) Purine Adenosine deaminase inhibitor ( Pentostatin ) Halogenated / ribonucleotide reductase inhibitors ( Cladribine Clofarabine Fludarabine ) Nelarabine Thiopurine ( Mercaptopurine # Tioguanine # ) Pyrimidine Thymidylate synthase inhibitor ( Capecitabine # Carmofur Doxifluridine Floxuridine Fluorouracil # Tegafur ( +gimeracil/oteracil )) DNA polymerase inhibitor ( Cytarabine # ) Ribonucleotide reductase inhibitor ( Gemcitabine # ) Hypomethylating agent ( Azacitidine Decitabine ) Deoxyribonucleotide Ribonucleotide reductase inhibitor ( Hydroxycarbamide # ) Topoisomerase inhibitors ( S phase ) I Camptotheca ( Belotecan Camptothecin Cositecan † Etirinotecan pegol † Exatecan Gimatecan Irinotecan # Lurtotecan ‡ Rubitecan ‡ Silatecan § Topotecan ) II Podophyllum ( Etoposide # Teniposide ) II + Intercalation Anthracyclines ( Aclarubicin Amrubicin † Daunorubicin # Doxorubicin # Epirubicin Idarubicin Pirarubicin Valrubicin Zorubicin ) Anthracenediones ( Mitoxantrone Losoxantrone Pixantrone ) Crosslinking of DNA ( CCNS ) Alkylating Nitrogen mustards : Bendamustine # Chlormethine Cyclophosphamide # ( Ifosfamide # Trofosfamide ) Chlorambucil # ( Melphalan Prednimustine ) Uramustine Nitrosoureas : Carmustine Fotemustine Lomustine ( Semustine ) Nimustine Ranimustine Streptozocin Alkyl sulfonates : Busulfan ( Mannosulfan Treosulfan ) Aziridines : Carboquone Thiotepa Triaziquone Triethylenemelamine Platinum-based Carboplatin # Cisplatin # Dicycloplatin Nedaplatin Oxaliplatin # Satraplatin Nonclassical Altretamine Hydrazines ( Procarbazine # ) Mitobronitol Pipobroman Triazenes ( Dacarbazine # Temozolomide ) Intercalation Streptomyces ( Actinomycin # Bleomycin # Mitomycins Plicamycin ) Photosensitizers / PDT Aminolevulinic acid Efaproxiral Methyl aminolevulinate Padeliporfin Porphyrin derivatives ( Porfimer sodium Talaporfin Temoporfin Verteporfin ) Other Enzyme inhibitors FI ( Tipifarnib § ) CDK inhibitors ( Abemaciclib Alvocidib † Palbociclib Ribociclib Seliciclib † ) PrI Bortezomib Carfilzomib Oprozomib Ixazomib PhI ( Anagrelide ) IMPDI ( Tiazofurin § ) LI ( Masoprocol ) PARP inhibitor ( Niraparib Olaparib Rucaparib ) HDAC ( Belinostat Entinostat Panobinostat Romidepsin Vorinostat ) PIKI ( Alpelisib Copanlisib Duvelisib Idelalisib ) Receptor antagonists ERA ( Atrasentan ) Retinoid X receptor ( Bexarotene ) Sex steroid ( Testolactone ) Other/ungrouped Amsacrine Arsenic trioxide Asparagine depleters ( Asparaginase # / Pegaspargase ) Celecoxib Demecolcine Elesclomol § Elsamitrucin Eribulin Estramustine phosphate Etoglucid Lonidamine Lucanthone Mitoguazone Mitotane Oblimersen † Omacetaxine mepesuccinate Trabectedin Retinoids ( Alitretinoin Bexarotene Tretinoin # ) Veliparib Venetoclax # WHO-EM ‡ Withdrawn from market Clinical trials : † Phase III § Never to phase III v t e Targeted cancer therapy / antineoplastic agents ( L01 ) CI monoclonal antibodies ("-mab") Receptor tyrosine kinase ErbB : HER1/EGFR ( Cetuximab Panitumumab ) HER2/neu ( Pertuzumab , Trastuzumab ( +hyaluronidase ) Trastuzumab emtansine ) Others for solid tumors EpCAM ( Catumaxomab Edrecolomab ) VEGF-A ( Bevacizumab ) Leukemia / lymphoma lymphoid : CD20 ( Ibritumomab Obinutuzumab Ofatumumab Rituximab Tositumomab ), CD30 ( Brentuximab ), CD52 ( Alemtuzumab ) myeloid : CD33 ( Gemtuzumab ozogamicin ) Other Atezolizumab Avelumab Belantamab mafodotin Bermekimab Blinatumomab Cemiplimab Daratumumab Dinutuximab beta Dostarlimab Durvalumab Elotuzumab Enfortumab vedotin Inotuzumab ozogamicin Ipilimumab Isatuximab Mogamulizumab Moxetumomab pasudotox Necitumumab Nivolumab Olaratumab Pembrolizumab Polatuzumab vedotin Ramucirumab Tafasitamab Trastuzumab deruxtecan Tyrosine kinase inhibitors ("-nib") Receptor tyrosine kinase ErbB : HER1/EGFR ( Afatinib Brigatinib Dacomitinib Erlotinib Gefitinib Icotinib Olmutinib Osimertinib Rociletinib Vandetanib ) HER1/EGFR and HER2/neu Lapatinib Neratinib Tucatinib RTK class III : C-kit and PDGFR ( Axitinib Masitinib Pazopanib Ripretinib Sorafenib Sunitinib Toceranib ) FLT3 ( Lestaurtinib , Gilteritinib (AXL, ALK, LTK)) VEGFR Axitinib Cediranib Lenvatinib Nintedanib Pazopanib Regorafenib Semaxanib Sorafenib Sunitinib Tivozanib Toceranib Vandetanib ALK Alectinib Brigatinib Ceritinib RET inhibitors: Entrectinib (ALK, ROS1, NTRK), Larotrectinib (NTRK), Pemigatinib (FGFR), Pralsetinib , Selpercatinib (VEGFR, FGFR), Vandetanib (VEGFR, EGFR). c-MET inhibitors: Cabozantinib (VEGFR), Capmatinib , Crizotinib (ALK) Non-receptor bcr-abl Bosutinib Dasatinib Imatinib Nilotinib Ponatinib Radotinib Src ( Bosutinib Dasatinib ) Janus kinase Baricitinib Fedratinib Filgotinib Lestaurtinib Momelotinib Pacritinib Ruxolitinib MAP2K Binimetinib Cobimetinib Selumetinib Trametinib EML4 - ALK Crizotinib Entrectinib Lorlatinib Bruton's Acalabrutinib Ibrutinib Zanubrutinib Other fusion protein against VEGF ( Aflibercept ) proapoptotic peptide against ANXA2 and prohibitin ( Adipotide ) exotoxin against IL-2 ( Denileukin diftitox ) mTOR inhibitors Everolimus Ridaforolimus Temsirolimus hedgehog inhibitors Glasdegib Sonidegib Vismodegib CDK inhibitor ( Abemaciclib Palbociclib Ribociclib ) Avapritinib Cabozantinib Capmatinib Entrectinib Erdafitinib Gilteritinib Larotrectinib Lenvatinib Masitinib Midostaurin Nintedanib Pazopanib Pemigatinib Pexidartinib Quizartinib Regorafenib Ripretinib Sorafenib Sunitinib Tepotinib Vandetanib Venetoclax v t e Overview of tumors , cancer and oncology Conditions Benign tumors Hyperplasia Cyst Pseudocyst Hamartoma Malignant progression Dysplasia Carcinoma in situ Cancer Metastasis Primary tumor Sentinel lymph node Topography Head and neck ( oral , nasopharyngeal ) Digestive system Respiratory system Bone Skin Blood Urogenital Nervous system Endocrine system Histology Carcinoma Sarcoma Blastoma Papilloma Adenoma Other Precancerous condition Paraneoplastic syndrome Staging / grading TNM Ann Arbor Prostate cancer staging Gleason grading system Dukes classification Carcinogenesis Cancer cell Carcinogen Tumor suppressor genes / oncogenes Clonally transmissible cancer Oncovirus Carcinogenic bacteria Misc.
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Vaginal Yeast Infection
Wikipedia
Primary pulmonary coccidioidomycosis Histoplasma capsulatum Histoplasmosis Primary cutaneous histoplasmosis Primary pulmonary histoplasmosis Progressive disseminated histoplasmosis Histoplasma duboisii African histoplasmosis Lacazia loboi Lobomycosis Paracoccidioides brasiliensis Paracoccidioidomycosis Other Blastomyces dermatitidis Blastomycosis North American blastomycosis South American blastomycosis Sporothrix schenckii Sporotrichosis Talaromyces marneffei Talaromycosis Yeast -like Candida albicans Candidiasis Oral Esophageal Vulvovaginal Chronic mucocutaneous Antibiotic candidiasis Candidal intertrigo Candidal onychomycosis Candidal paronychia Candidid Diaper candidiasis Congenital cutaneous candidiasis Perianal candidiasis Systemic candidiasis Erosio interdigitalis blastomycetica C. auris C. glabrata C. lusitaniae C. tropicalis Pneumocystis jirovecii Pneumocystosis Pneumocystis pneumonia Mold -like Aspergillus Aspergillosis Aspergilloma Allergic bronchopulmonary aspergillosis Primary cutaneous aspergillosis Exophiala jeanselmei Eumycetoma Fonsecaea pedrosoi / Fonsecaea compacta / Phialophora verrucosa Chromoblastomycosis Geotrichum candidum Geotrichosis Pseudallescheria boydii Allescheriasis Basidiomycota Cryptococcus neoformans Cryptococcosis Trichosporon spp Trichosporonosis Zygomycota ( Zygomycosis ) Mucorales ( Mucormycosis ) Rhizopus oryzae Mucor indicus Lichtheimia corymbifera Syncephalastrum racemosum Apophysomyces variabilis Entomophthorales ( Entomophthoramycosis ) Basidiobolus ranarum Basidiobolomycosis Conidiobolus coronatus / Conidiobolus incongruus Conidiobolomycosis Microsporidia ( Microsporidiosis ) Enterocytozoon bieneusi / Encephalitozoon intestinalis Mesomycetozoea Rhinosporidium seeberi Rhinosporidiosis Ungrouped Alternariosis Fungal folliculitis Fusarium Fusariosis Granuloma gluteale infantum Hyalohyphomycosis Otomycosis Phaeohyphomycosis v t e Female diseases of the pelvis and genitals Internal Adnexa Ovary Endometriosis of ovary Female infertility Anovulation Poor ovarian reserve Mittelschmerz Oophoritis Ovarian apoplexy Ovarian cyst Corpus luteum cyst Follicular cyst of ovary Theca lutein cyst Ovarian hyperstimulation syndrome Ovarian torsion Fallopian tube Female infertility Fallopian tube obstruction Hematosalpinx Hydrosalpinx Salpingitis Uterus Endometrium Asherman's syndrome Dysfunctional uterine bleeding Endometrial hyperplasia Endometrial polyp Endometriosis Endometritis Menstruation Flow Amenorrhoea Hypomenorrhea Oligomenorrhea Pain Dysmenorrhea PMS Timing Menometrorrhagia Menorrhagia Metrorrhagia Female infertility Recurrent miscarriage Myometrium Adenomyosis Parametrium Parametritis Cervix Cervical dysplasia Cervical incompetence Cervical polyp Cervicitis Female infertility Cervical stenosis Nabothian cyst General Hematometra / Pyometra Retroverted uterus Vagina Hematocolpos / Hydrocolpos Leukorrhea / Vaginal discharge Vaginitis Atrophic vaginitis Bacterial vaginosis Candidal vulvovaginitis Hydrocolpos Sexual dysfunction Dyspareunia Hypoactive sexual desire disorder Sexual arousal disorder Vaginismus Urogenital fistulas Ureterovaginal Vesicovaginal Obstetric fistula Rectovaginal fistula Prolapse Cystocele Enterocele Rectocele Sigmoidocele Urethrocele Vaginal bleeding Postcoital bleeding Other / general Pelvic congestion syndrome Pelvic inflammatory disease External Vulva Bartholin's cyst Kraurosis vulvae Vestibular papillomatosis Vulvitis Vulvodynia Clitoral hood or clitoris Persistent genital arousal disorder
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Abdominal Pregnancy
Wikipedia
External links [ edit ] Classification D ICD - 10 : O00.0 O83.3 ICD - 9-CM : 633.00 MeSH : D011269 SNOMED CT : 82661006 v t e Pathology of pregnancy , childbirth and the puerperium Pregnancy Pregnancy with abortive outcome Abortion Ectopic pregnancy Abdominal Cervical Interstitial Ovarian Heterotopic Embryo loss Fetal resorption Molar pregnancy Miscarriage Stillbirth Oedema , proteinuria and hypertensive disorders Gestational hypertension Pre-eclampsia HELLP syndrome Eclampsia Other, predominantly related to pregnancy Digestive system Acute fatty liver of pregnancy Gestational diabetes Hepatitis E Hyperemesis gravidarum Intrahepatic cholestasis of pregnancy Integumentary system / dermatoses of pregnancy Gestational pemphigoid Impetigo herpetiformis Intrahepatic cholestasis of pregnancy Linea nigra Prurigo gestationis Pruritic folliculitis of pregnancy Pruritic urticarial papules and plaques of pregnancy (PUPPP) Striae gravidarum Nervous system Chorea gravidarum Blood Gestational thrombocytopenia Pregnancy-induced hypercoagulability Maternal care related to the fetus and amniotic cavity amniotic fluid Oligohydramnios Polyhydramnios Braxton Hicks contractions chorion / amnion Amniotic band syndrome Chorioamnionitis Chorionic hematoma Monoamniotic twins Premature rupture of membranes Obstetrical bleeding Antepartum placenta Circumvallate placenta Monochorionic twins Placenta accreta Placenta praevia Placental abruption Twin-to-twin transfusion syndrome Labor Amniotic fluid embolism Cephalopelvic disproportion Dystocia Shoulder dystocia Fetal distress Locked twins Nuchal cord Obstetrical bleeding Postpartum Pain management during childbirth placenta Placenta accreta Preterm birth Postmature birth Umbilical cord prolapse Uterine inversion Uterine rupture Vasa praevia Puerperal Breastfeeding difficulties Low milk supply Cracked nipples Breast engorgement Childbirth-related posttraumatic stress disorder Diastasis symphysis pubis Postpartum bleeding Peripartum cardiomyopathy Postpartum depression Postpartum psychosis Postpartum thyroiditis Puerperal fever Puerperal mastitis Other Concomitant conditions Diabetes mellitus Systemic lupus erythematosus Thyroid disorders Maternal death Sexual activity during pregnancy Category
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Typhus
Wikipedia
Classification D ICD - 10 : A75 ICD - 9-CM : 080 – 083 MeSH : D014438 DiseasesDB : 29240 External resources MedlinePlus : 001363 eMedicine : med/2332 Patient UK : Typhus v t e Proteobacteria -associated Gram-negative bacterial infections α Rickettsiales Rickettsiaceae / ( Rickettsioses ) Typhus Rickettsia typhi Murine typhus Rickettsia prowazekii Epidemic typhus , Brill–Zinsser disease , Flying squirrel typhus Spotted fever Tick-borne Rickettsia rickettsii Rocky Mountain spotted fever Rickettsia conorii Boutonneuse fever Rickettsia japonica Japanese spotted fever Rickettsia sibirica North Asian tick typhus Rickettsia australis Queensland tick typhus Rickettsia honei Flinders Island spotted fever Rickettsia africae African tick bite fever Rickettsia parkeri American tick bite fever Rickettsia aeschlimannii Rickettsia aeschlimannii infection Mite-borne Rickettsia akari Rickettsialpox Orientia tsutsugamushi Scrub typhus Flea-borne Rickettsia felis Flea-borne spotted fever Anaplasmataceae Ehrlichiosis : Anaplasma phagocytophilum Human granulocytic anaplasmosis , Anaplasmosis Ehrlichia chaffeensis Human monocytotropic ehrlichiosis Ehrlichia ewingii Ehrlichiosis ewingii infection Rhizobiales Brucellaceae Brucella abortus Brucellosis Bartonellaceae Bartonellosis : Bartonella henselae Cat-scratch disease Bartonella quintana Trench fever Either B. henselae or B. quintana Bacillary angiomatosis Bartonella bacilliformis Carrion's disease , Verruga peruana β Neisseriales M+ Neisseria meningitidis/meningococcus Meningococcal disease , Waterhouse–Friderichsen syndrome , Meningococcal septicaemia M− Neisseria gonorrhoeae/gonococcus Gonorrhea ungrouped: Eikenella corrodens / Kingella kingae HACEK Chromobacterium violaceum Chromobacteriosis infection Burkholderiales Burkholderia pseudomallei Melioidosis Burkholderia mallei Glanders Burkholderia cepacia complex Bordetella pertussis / Bordetella parapertussis Pertussis γ Enterobacteriales ( OX− ) Lac+ Klebsiella pneumoniae Rhinoscleroma , Pneumonia Klebsiella granulomatis Granuloma inguinale Klebsiella oxytoca Escherichia coli : Enterotoxigenic Enteroinvasive Enterohemorrhagic O157:H7 O104:H4 Hemolytic-uremic syndrome Enterobacter aerogenes / Enterobacter cloacae Slow/weak Serratia marcescens Serratia infection Citrobacter koseri / Citrobacter freundii Lac− H2S+ Salmonella enterica Typhoid fever , Paratyphoid fever , Salmonellosis H2S− Shigella dysenteriae / sonnei / flexneri / boydii Shigellosis , Bacillary dysentery Proteus mirabilis / Proteus vulgaris Yersinia pestis Plague / Bubonic plague Yersinia enterocolitica Yersiniosis Yersinia pseudotuberculosis Far East scarlet-like fever Pasteurellales Haemophilus : H. influenzae Haemophilus meningitis Brazilian purpuric fever H. ducreyi Chancroid H. parainfluenzae HACEK Pasteurella multocida Pasteurellosis Actinobacillus Actinobacillosis Aggregatibacter actinomycetemcomitans HACEK Legionellales Legionella pneumophila / Legionella longbeachae Legionnaires' disease Coxiella burnetii Q fever Thiotrichales Francisella tularensis Tularemia Vibrionaceae Vibrio cholerae Cholera Vibrio vulnificus Vibrio parahaemolyticus Vibrio alginolyticus Plesiomonas shigelloides Pseudomonadales Pseudomonas aeruginosa Pseudomonas infection Moraxella catarrhalis Acinetobacter baumannii Xanthomonadaceae Stenotrophomonas maltophilia Cardiobacteriaceae Cardiobacterium hominis HACEK Aeromonadales Aeromonas hydrophila / Aeromonas veronii Aeromonas infection ε Campylobacterales Campylobacter jejuni Campylobacteriosis , Guillain–Barré syndrome Helicobacter pylori Peptic ulcer , MALT lymphoma , Gastric cancer Helicobacter cinaedi Helicobacter cellulitis
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Osteogenesis Imperfecta, Type Ii
Omim
Steinmann et al. (1982) and Steinmann et al. (1984) studied material from a male newborn with the lethal perinatal form of OI (and avulsion of an arm). The mother had the Marfan syndrome, as did several other members of the kindred including 2 sibs of the OI proband. ... The role of the mother's Marfan syndrome is unclear; the molecular defect underlying the Marfan syndrome in this family had not been determined and it was not known whether the infant inherited the Marfan gene from the mother.
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Methylmalonic Aciduria And Homocystinuria, Cblc Type
Omim
Autopsy showed severe vascular lesions with changes of thrombotic thrombocytopenia in the kidney, suggesting the hemolytic-uremic syndrome. Elevated plasma homocysteine was presumed to be responsible for the vascular lesions. ... In the first weeks of life, all showed failure to thrive, hypotonia, and lethargy associated with pancytopenia and hepatic dysfunction, which progressed to severe respiratory insufficiency and renal failure consistent with hemolytic-uremic syndrome. The infants died at 40, 45, and 75 days of age. ... INHERITANCE - Autosomal recessive GROWTH Other - Failure to thrive HEAD & NECK Head - Microcephaly - Hydrocephalus Face - Long face - High forehead - Flat philtrum Ears - Low-set ears - Large, floppy ears Eyes - Pigmentary retinopathy - Nystagmus - Decreased visual acuity CARDIOVASCULAR Vascular - Vascular lesions - Thrombotic microangiopathy - Thromboembolism ABDOMEN Gastrointestinal - Poor feeding GENITOURINARY Kidneys - Renal failure - Hemolytic-uremic syndrome - Thrombotic microangiopathic nephropathy NEUROLOGIC Central Nervous System - Hypotonia - Lethargy - Developmental delay - Mental retardation - Seizures - Cortical atrophy - Acute neurologic decompensation (in later-onset cases) - Decreased cognition (later-onset) - Confusion (later-onset) - Dementia (later-onset) - Delirium (later-onset) - Extrapyramidal symptoms (later-onset) - Tremor (later-onset) METABOLIC FEATURES - Metabolic acidosis HEMATOLOGY - Megaloblastic anemia - Thrombocytopenia - Anemia - Neutropenia LABORATORY ABNORMALITIES - Homocystinuria - Homocysteinemia - Methylmalonic aciduria - Methylmalonic acidemia - Decreased serum methionine - Cystathioninemia - Cystathioninuria - Uremia - Hematuria - Proteinuria - Decreased methylmalonyl-CoA mutase (MUT, 609058 ) activity - Decreased methionine synthase (MTR, 156570 ) activity - Decreased adenosylcobalamin (AdoCbl) - Decreased methylcobalamin (MeCbl) - Normal serum cobalamin - Decreased cobalamin in liver, kidney, and cultured fibroblasts MISCELLANEOUS - Onset usually in first year of life - Early-onset associated with more severe course and early death - Adolescent or adult onset associated with neuropsychiatric symptoms - Patients with later onset do not have dysmorphic features - Variable response to vitamin B12 therapy - See also CblD ( 277410 ) MOLECULAR BASIS - Caused by mutation in the MMACHC gene (MMACHC gene 609831.0001 ) ▲ Close
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Carnitine Palmitoyltransferase Ii Deficiency
Wikipedia
Some cases of sudden infant death syndrome are attributed to infantile CPT II deficiency at autopsy. ... National Library of Medicine GeneReviews/NCBI/NIH/UW entry on Carnitine Palmitoyltransferase II Deficiency v t e Inborn error of lipid metabolism : dyslipidemia Hyperlipidemia Hypercholesterolemia / Hypertriglyceridemia Lipoprotein lipase deficiency/Type Ia Familial apoprotein CII deficiency/Type Ib Familial hypercholesterolemia/Type IIa Combined hyperlipidemia/Type IIb Familial dysbetalipoproteinemia/Type III Familial hypertriglyceridemia/Type IV Xanthoma/Xanthomatosis Hypolipoproteinemia Hypoalphalipoproteinemia/HDL Lecithin cholesterol acyltransferase deficiency Tangier disease Hypobetalipoproteinemia/LDL Abetalipoproteinemia Apolipoprotein B deficiency Chylomicron retention disease Lipodystrophy Barraquer–Simons syndrome Other Lipomatosis Adiposis dolorosa Lipoid proteinosis APOA1 familial renal amyloidosis v t e Inborn error of lipid metabolism : fatty-acid metabolism disorders Synthesis Biotinidase deficiency (BTD) Degradation Acyl transport Carnitine CPT1 CPT2 CDSP CACTD Adrenoleukodystrophy (ALD) Beta oxidation General Acyl CoA dehydrogenase Short-chain SCADD Medium-chain MCADD Long-chain 3-hydroxy LCHAD Very long-chain VLCADD Mitochondrial trifunctional protein deficiency (MTPD): Acute fatty liver of pregnancy Unsaturated 2,4 Dienoyl-CoA reductase deficiency (DECRD) Odd chain Propionic acidemia (PCC deficiency) Other 3-hydroxyacyl-coenzyme A dehydrogenase deficiency (HADHD) Glutaric acidemia type 2 (MADD) To acetyl-CoA Malonic aciduria (MCD) Aldehyde Sjögren–Larsson syndrome (SLS)
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Hiv/aids In South Africa
Wikipedia
He said: All HIV/AIDS programmes of this government are based on the thesis that HIV causes AIDS. [But...] can a virus cause a syndrome? ... It can't, because a syndrome is a group of diseases resulting from acquired immune deficiency. ... CS1 maint: archived copy as title ( link ) ^ a b Ras GJ, Simson IW, Anderson R, Prozesky OW, Hamersma T. Acquired immunodeficiency syndrome. A report of 2 South African cases. ... Retrieved 15 May 2011 . ^ "How can a virus cause a syndrome? asks Mbeki" . Aegis.com. 21 September 2000. ... AIDSPortal South Africa page – latest research, guidelines and case studies NewsHour: HIV/AIDS and TB in South Africa JournAIDS: A resource on HIV for South African media practitioners HIV and Aids in South Africa – South Africa Gateway v t e South Africa articles History Timeline [ nl ] Years Early history Kingdom of Mapungubwe Kingdom of Mutapa Kaditshwene Dutch Cape Colony Mthethwa Paramountcy Ndwandwe Cape Colony Zulu Kingdom Orange Free State Transvaal Republic First Boer War Second Boer War Great Depression World War II Apartheid Border War Democratic Republic of South Africa By topic Economy Military Geography Biodiversity Climate Climate change Districts Earthquakes Estuaries Forests Islands Lakes Mountain ranges Municipalities National parks Populated places Provinces Rivers Wildlife Politics Constitution Courts Elections Foreign relations Government Human rights Law Law enforcement Military Parliament Political parties President State security Economy Agriculture Companies 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Taiwan (ROC) Thailand United Arab Emirates Turkey Vietnam Europe United Kingdom Russia Ukraine Oceania Australia New Zealand Papua New Guinea List of countries by HIV/AIDS adult prevalence rate List of HIV/AIDS cases and deaths registered by region v t e HIV/AIDS in Africa Sovereign states Algeria Angola Benin Botswana Burkina Faso Burundi Cameroon Cape Verde (Cabo Verde) Central African Republic Chad Comoros Democratic Republic of the Congo Republic of the Congo Djibouti Egypt Equatorial Guinea Eritrea Eswatini (Swaziland) Ethiopia Gabon The Gambia Ghana Guinea Guinea-Bissau Ivory Coast (Côte d'Ivoire) Kenya Lesotho Liberia Libya Madagascar Malawi Mali Mauritania Mauritius Morocco Mozambique Namibia Niger Nigeria Rwanda São Tomé and Príncipe Senegal Seychelles Sierra Leone Somalia South Africa South Sudan Sudan Tanzania Togo Tunisia Uganda Zambia Zimbabwe States with limited recognition Sahrawi Arab Democratic Republic Somaliland Dependencies and other territories Canary Islands / Ceuta / Melilla (Spain) Madeira (Portugal) Mayotte / Réunion (France) Saint Helena / Ascension Island / Tristan da Cunha (United Kingdom) v t e Politics of South Africa By province Eastern Cape Free State Gauteng KwaZulu-Natal Limpopo Mpumalanga North West Northern Cape Western Cape Political movements Ideologies African nationalism Afrikaner nationalism Anarchism Anti-war Black consciousness Environmentalism Federalism Feminism Liberalism Libertarianism Pan-Africanism Trotskyism Political parties see South Africa political parties Other political organisations AfriForum Afrikanerbond AWB CONTRALESA COSAS Earthlife Africa Khanya College Koeberg Alert LGEP PAGAD SALSA SASCO South African Wine Initiative VAB ZACF Trade unions and Social movements see South Africa trade unions Equal Education Mandela Park Backyarders PASSOP Poor People's Alliance Abahlali baseMjondolo LPM Western Cape Anti-Eviction Campaign SJC TAC UPM Law see South African law Political culture African Renaissance 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Epidemiology Of Obesity
Wikipedia
Recognition of obesity as an epidemic Part of a series on Human body weight General concepts Obesity ( Epidemiology ) Overweight Underweight Body shape Weight gain Weight loss Gestational weight gain Diet (nutrition) Weight management Overnutrition Childhood obesity ( Epidemiology ) Medical concepts Adipose tissue Classification of obesity Genetics of obesity Metabolic syndrome ( Epidemiology of metabolic syndrome ) Metabolically healthy obesity Obesity paradox Measurements Body adiposity index Body mass index Body fat percentage Body Shape Index Corpulence index Lean body mass Relative Fat Mass Waist–hip ratio Waist-to-height ratio Related conditions Diabetes ( Type 1 ) Eating disorder ( Anorexia • Bulimia • Binge eating disorder ) Food addiction Hyperthyroidism Malnutrition RED-S Starvation ( Starvation response ) PCOS Obesity-associated morbidity Arteriosclerosis Atherosclerosis Fatty liver disease GERD Heart disease Hypertension Obesity and cancer Osteoarthritis Prediabetes Sleep apnea Type 2 diabetes Management of obesity Anti-obesity medication Bariatrics Bariatric surgery Dieting ( List of diets ) Caloric deficit Exercise ( outline ) Liposuction Obesity medicine Weight loss camp Weight loss coaching Yo-yo effect Social aspects Comfort food Fast food ( Criticism ) Fat acceptance movement Fat fetishism Health at Every Size Hunger Obesity and the environment Sedentary lifestyle Social determinants of obesity Social stigma of obesity Weight cutting Weight class v t e See or edit source data . ... Being big has traditionally been associated with health, beauty, and status and many of these beliefs remain prevalent today. [64] See also [ edit ] Epidemiology of childhood obesity Epidemiology of metabolic syndrome Obesogen The Big Issue References [ edit ] ^ Roser, Max; Ritchie, Hannah (11 August 2017). ... "The new BMI criteria for asians by the regional office for the western pacific region of WHO are suitable for screening of overweight to prevent metabolic syndrome in elder Japanese workers" . J Occup Health . 45 (6): 335–43. doi : 10.1539/joh.45.335 .
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Skin Cancer
Wikipedia
Signs include a mole that has changed in size, shape, color, has irregular edges, has more than one color, is itchy or bleeds. [3] More than 90% of cases are caused by exposure to ultraviolet radiation from the Sun . [4] This exposure increases the risk of all three main types of skin cancer. [4] Exposure has increased, partly due to a thinner ozone layer . [5] [12] Tanning beds are another common source of ultraviolet radiation. [4] For melanomas and basal-cell cancers, exposure during childhood is particularly harmful. [6] For squamous-cell skin cancers, total exposure, irrespective of when it occurs, is more important. [4] Between 20% and 30% of melanomas develop from moles. [6] People with lighter skin are at higher risk [1] [13] as are those with poor immune function such as from medications or HIV/AIDS . [5] [14] Diagnosis is by biopsy . [3] Decreasing exposure to ultraviolet radiation and the use of sunscreen appear to be effective methods of preventing melanoma and squamous-cell skin cancer. [6] [7] It is not clear if sunscreen affects the risk of basal-cell cancer. [7] Nonmelanoma skin cancer is usually curable. [5] Treatment is generally by surgical removal but may, less commonly, involve radiation therapy or topical medications such as fluorouracil . [1] Immunotherapy might be the only hope for individuals with multiple malignancies such as Xeroderma Pigmentosum and Gorlin syndrome. [15] Treatment of melanoma may involve some combination of surgery, chemotherapy , radiation therapy and targeted therapy . [3] In those people whose disease has spread to other areas of the body, palliative care may be used to improve quality of life. [3] Melanoma has one of the higher survival rates among cancers, with over 86% of people in the UK and more than 90% in the United States surviving more than 5 years . [16] [17] Skin cancer is the most common form of cancer, globally accounting for at least 40% of cancer cases. [5] [18] The most common type is nonmelanoma skin cancer, which occurs in at least 2–3 million people per year. [6] [19] This is a rough estimate, however, as good statistics are not kept. [1] Of nonmelanoma skin cancers, about 80% are basal-cell cancers and 20% squamous-cell skin cancers. [11] Basal-cell and squamous-cell skin cancers rarely result in death. [6] In the United States, they were the cause of less than 0.1% of all cancer deaths. [1] Globally in 2012, melanoma occurred in 232,000 people and resulted in 55,000 deaths. [6] White people in Australia , New Zealand and South Africa have the highest rates of melanoma in the world. [6] [20] The three main types of skin cancer have become more common in the last 20 to 40 years, especially in those areas with mostly White people. [5] [6] Contents 1 Classification 2 Signs and symptoms 2.1 Basal-cell skin cancer 2.2 Squamous-cell skin cancer 2.3 Melanoma 2.4 Other 3 Causes 4 Pathophysiology 5 Diagnosis 6 Prevention 7 Treatment 7.1 Reconstruction 8 Prognosis 9 Epidemiology 9.1 Melanoma 9.2 Non-melanoma 10 References 11 External links Classification [ edit ] There are three main types of skin cancer: basal-cell skin cancer (basal-cell carcinoma) (BCC), squamous-cell skin cancer (squamous-cell carcinoma) (SCC) and malignant melanoma . ... Other risk factors that play a role include: Light skin color [27] Age [27] Smoking tobacco [27] HPV infections increase the risk of squamous-cell skin cancer. [27] Some genetic syndromes [27] including congenital melanocytic nevi syndrome which is characterized by the presence of nevi (birthmarks or moles) of varying size which are either present at birth, or appear within 6 months of birth. ... "Update on non-acquired immunodeficiency syndrome-defining malignancies". Current Opinion in Oncology . 15 (5): 389–97. doi : 10.1097/00001622-200309000-00008 . ... Skin cancer at Curlie Skin cancer procedures: text, images and videos v t e Overview of tumors , cancer and oncology Conditions Benign tumors Hyperplasia Cyst Pseudocyst Hamartoma Malignant progression Dysplasia Carcinoma in situ Cancer Metastasis Primary tumor Sentinel lymph node Topography Head and neck ( oral , nasopharyngeal ) Digestive system Respiratory system Bone Skin Blood Urogenital Nervous system Endocrine system Histology Carcinoma Sarcoma Blastoma Papilloma Adenoma Other Precancerous condition Paraneoplastic syndrome Staging / grading TNM Ann Arbor Prostate cancer staging Gleason grading system Dukes classification Carcinogenesis Cancer cell Carcinogen Tumor suppressor genes / oncogenes Clonally transmissible cancer Oncovirus Carcinogenic bacteria Misc. Research Index of oncology articles History Cancer pain Cancer and nausea v t e Skin cancer of nevi and melanomas Melanoma Mucosal melanoma Superficial spreading melanoma Nodular melanoma lentigo Lentigo maligna / Lentigo maligna melanoma Acral lentiginous melanoma Amelanotic melanoma Desmoplastic melanoma Melanoma with features of a Spitz nevus Melanoma with small nevus-like cells Polypoid melanoma Nevoid melanoma Melanocytic tumors of uncertain malignant potential Nevus / melanocytic nevus Nevus of Ito / Nevus of Ota Spitz nevus Pigmented spindle cell nevus Halo nevus Pseudomelanoma Blue nevus of Jadassohn–Tièche Cellular Epithelioid Deep penetrating Amelanotic Malignant Congenital melanocytic nevus ( Giant Medium-sized Small-sized ) Balloon cell nevus Dysplastic nevus / Dysplastic nevus syndrome Acral nevus Becker's nevus Benign melanocytic nevus Nevus spilus v t e Skin cancer of the epidermis Tumor Carcinoma BCC Forms Aberrant Cicatricial Cystic Fibroepithelioma of Pinkus Infltrative Micronodular Nodular Pigmented Polypoid Pore-like Rodent ulcer Superficial Nevoid basal cell carcinoma syndrome SCC Forms Adenoid Basaloid Clear cell Signet-ring-cell Spindle-cell Marjolin's ulcer Bowen's disease Bowenoid papulosis Erythroplasia of Queyrat Actinic keratosis Adenocarcinoma Aggressive digital papillary adenocarcinoma Extramammary Paget's disease Ungrouped Merkel cell carcinoma Microcystic adnexal carcinoma Mucinous carcinoma Primary cutaneous adenoid cystic carcinoma Verrucous carcinoma Malignant mixed tumor Benign tumors Acanthoma Forms Large cell Fissuring Clear cell Epidermolytic Melanoacanthoma Pilar sheath acanthoma Seboacanthoma Seborrheic keratosis Warty dyskeratoma Keratoacanthoma Generalized eruptive Keratoacanthoma centrifugum marginatum Multiple Solitary Wart Verruca vulgaris Verruca plana Plantar wart Periungual wart Other Epidermal nevus Syndromes Epidermal nevus syndrome Schimmelpenning syndrome Nevus comedonicus syndrome Nevus comedonicus Inflammatory linear verrucous epidermal nevus Linear verrucous epidermal nevus Pigmented hairy epidermal nevus syndrome Systematized epidermal nevus Phakomatosis pigmentokeratotica Other nevus Nevus unius lateris Patch blue nevus Unilateral palmoplantar verrucous nevus Zosteriform speckled lentiginous nevus Ungrouped Cutaneous horn v t e Skin cancer of the dermis Dermis Benign fibrous histiocytoma / dermatofibrosarcoma protuberans Dermatofibrosarcoma protuberans Subcutaneous tumors Connective and vascular see Template:Soft tissue tumors and sarcomas , Template:Vascular tumors , Template:Myeloid malignancy (for mastocytosis ) Other urogenital: Hirsuties coronae glandis neuro: Solitary neurofibroma Cutaneous meningioma Ganglioneuroma Schwannoma Palisaded encapsulated neuroma Infantile neuroblastoma Neuroma cutis bone/cartilage: Chordoma Extraskeletal chondroma nevus: Nevus anemicus Nevus flammeus Nevus flammeus nuchae Nevus lipomatosus superficialis Nevus oligemicus Connective tissue nevus Midline nevus flammeus Porokeratotic eccrine ostial and dermal duct nevus histiocytoma : Pleomorphic undifferentiated sarcoma Plexiform fibrohistiocytic tumor Progressive nodular histiocytoma Teratoma Adenoma sebaceum Metastatic carcinoma Giant-cell tumor of the tendon sheath Glomus tumor Granular cell tumor Carcinoid Desmoid tumor Neurothekeoma Angiokeratoma Zosteriform metastasis Keratinizing metaplasia Epithelioid sarcoma v t e Cancers of skin and associated structures Glands Sweat gland Eccrine Papillary eccrine adenoma Eccrine carcinoma Eccrine nevus Syringofibroadenoma Spiradenoma Apocrine Cylindroma Dermal cylindroma Syringocystadenoma papilliferum Papillary hidradenoma Hidrocystoma Apocrine gland carcinoma Apocrine nevus Eccrine / apocrine Syringoma Hidradenoma or Acrospiroma / Hidradenocarcinoma Ceruminous adenoma Sebaceous gland Nevus sebaceous Muir–Torre syndrome Sebaceous carcinoma Sebaceous adenoma Sebaceoma Sebaceous nevus syndrome Sebaceous hyperplasia Mantleoma Hair Pilomatricoma / Malignant pilomatricoma Trichoepithelioma Multiple familial trichoepithelioma Solitary trichoepithelioma Desmoplastic trichoepithelioma Generalized trichoepithelioma Trichodiscoma Trichoblastoma Fibrofolliculoma Trichilemmoma Trichilemmal carcinoma Proliferating trichilemmal cyst Giant solitary trichoepithelioma Trichoadenoma Trichofolliculoma Dilated pore Isthmicoma Fibrofolliculoma Perifollicular fibroma Birt–Hogg–Dubé syndrome Hamartoma Basaloid follicular hamartoma Folliculosebaceous cystic hamartoma Folliculosebaceous-apocrine hamartoma Nails Neoplasms of the nailbed A medical condition involving uncontrolled growth of skin cellsTP53, PTGS2, ERCC2, XPA, HRAS, NFE2L2, GSTT1, PTCH1, NOTCH1, PPARD, XRCC3, TYR, HIF1A, AQP3, SOD2, ERBB3, POT1, EPHX1, HCAR2, MMP9, ASIP, SP1, IGF1, ODC1, CEBPA, AKT1, TGFB1, NOTCH3, CSNK2A1, CSNK2A2, CSNK2B, NPPA, NOTCH2, POLE, CSF3, IGF1R, ERBB4, LORICRIN, PTK2B, KRT10, KRT1, KIT, IVL, FLT1, IL1A, GJA1, GJB2, GJB5, GLI2, KRT17, NOTCH4, GYPA, AIRE, CASP10, HCAR3, SMO, RELA, CASP8, TGFBR1, SNAI1, CDKN2A, MC1R, VDR, XPC, POLH, COX2, MTCO2P12, POLQ, IL10, STAT3, EGFR, TNF, BCL2, GTF2H1, GABPA, SMAD4, XRCC1, ATF3, NR1H2, POMC, GSTM1, NLRP1, BMI1, ERCC3, IRF4, NUP62, HPGDS, DCTN4, FERMT1, MAPK1, CD44, KHDRBS1, PLAT, MTHFR, LRRK2, TMC8, TP63, CHUK, KLF4, SQSTM1, OCA2, IL6, AHSA1, SIRT6, CXCR6, CD274, STAT2, MMP14, UBE2B, SSTR4, PTEN, STK11, HLA-B, TERF2, PSEN1, HCL2, PBK, TBPL1, GRAP2, PAK1, POLDIP2, LPAR2, AIMP2, FZD4, MMP1, CABIN1, MMP19, MDM2, PRKCA, MRC1, LPAR3, MSH2, SMAD2, MMP12, CKAP4, RPE65, RHCE, RNF19A, LGALS3, PDE5A, VEGFA, GTF2H4, UVRAG, SEC14L2, PPARG, GTF2H3, LGR6, CCND1, BRCA1, MAPK14, MRGPRX3, OXER1, NBEAL1, FGFR2, BRS3, GTF2H5, BSG, EZH2, CTLA4, CYLD, EPHB2, GPR151, CD27, EDNRA, IL33, DDB2, CAT, MRGPRX4, DLX3, GPR166P, GTF2H2, BRAF, CRK, LOC110806263, GSTP1, SULF2, GPR42, ADRA1A, ADRA2B, CDX2, CDKN1A, CDK4, AHR, VN1R17P, ANGPT1, GPRC6A, ACKR3, ZNF410, MRGPRX1, COMMD3-BMI1, MTOR, AR, MIR34A, EI24, TSPAN1, HERC2, PDCD5, MIR17HG, AKAP12, PHF14, MIRLET7C, MIR23B, IL32, GPR55, GSTK1, MIR148A, MIR143, TICAM2, MIR17, FOXN1, RAB11A, APOBEC3A_B, VEGFC, TMED7-TICAM2, FAS-AS1, H3P41, MICA, LGTN, TP53COR1, PTCH2, TWIST1, TRAF1, H3P13, H3P8, TLR4, H3P23, TRAP, XRCC2, BTG2, MIR365A, SEM1, ADAM12, XRS, GGTLC4P, CUL4A, ATRN, CDK2AP2, GGT2, GGTLC3, CDC42BPA, GGTLC5P, PPM1D, LNCR1, DPH3, APOBEC3A, RTN3, CASP14, AGO2, TGIF2, NOX1, GREM1, AGO1, GAS5, CSMD1, E2F8, CAMKMT, WWTR1, SPHKAP, TNKS2, SMPX, CLPTM1L, DOCK8, LAMTOR2, RGCC, HRH4, ADA2, NPDC1, CDC42SE1, FBXW7, DUSP22, CCHCR1, DGCR8, INPP5K, TMED7, SLC12A9, THBS1, SF3B6, IL23A, AICDA, ZNF398, BRIP1, MINDY4, RACK1, FOXD2-AS1, ERP29, SUB1, KDM5B, E2F7, IL34, PAQR3, DCTN6, CTCF, NEAT1, PDPN, TRIM16, ENDOV, ZNRD2, YAP1, PEMT, SDS, RPP14, PADI2, OXNAD1, HAVCR2, TSLP, SIRT1, SASH1, PLEKHM2, SNW1, SIRT2, SLCO6A1, TP53RK, NLRP3, ZHX2, RRAS2, TMC6, PIGU, THBS2, ABO, TGM3, EPHA1, FOXM1, FGFR4, FGFR3, F9, ETV1, ERCC6, ERCC5, ERCC1, ERBB2, EP300, FOXO3, EIF4E, EIF4B, E2F1, SARDH, DMBT1, NQO1, DHFR, DECR1, ACE, FOXO1, FLT4, IL17A, HGF, IL2RA, IL1B, IKBKB, RBPJ, IFI27, ICAM1, HSD11B2, HSD11B1, HMGB1, HBM, FN1, GSTM3, GPX4, GLI1, GPC3, GGT1, GEM, GCH1, NR5A2, FOS, CYP27B1, CYP27A1, CYP24A1, ATP7A, CASP3, CASP1, CALM3, CALM2, CALM1, CA1, BRCA2, BAG1, ATR, ATOX1, CTNNB1, AREG, AQP1, FAS, KLK3, AMFR, ALDH1A1, NR0B1, AGT, PARP1, CAV1, RUNX1, RUNX3, KRIT1, VCAN, CSHL1, CSH2, CSH1, CRYZ, MAP3K8, COL7A1, CCR4, CIRBP, CEBPB, CDKN2D, CDK3, CDK2, CDC25C, CDC25B, CDC25A, CD81, CD70, CD34, IL4, CXCL10, TGM2, PTPRC, RPS6, RPL15, TRIM27, REG1A, PLAAT4, RARB, RAF1, RAD9A, RAC1, PTPN3, S100A7, PTPN2, PTH, PTAFR, PSMD9, KLK6, PPIB, PPIA, ACTG1, PMS2, RPS6KA3, S100A9, INPP5A, SORD, TERF1, TDG, TAZ, TARBP2, TALDO1, SYK, AURKA, SPARC, SOX10, SNAP25, SAFB, SMARCA4, SMARCA2, SNAI2, SLC5A2, SKP1, SRSF6, SDHB, SDC1, SERPINB4, PMP22, PLG, PKM, LTA4H, MMP10, MMP8, MMP2, CD99, MET, MDM4, MCM4, MAL, SMAD3, LMNA, PIK3CG, LIFR, LGALS9, KRT19, KIR3DL1, STT3A, EIF6, ISG20, ITGA6, INSRR, MPO, MPZ, ABCC1, MSH3, PIK3CD, PIK3CB, PIK3CA, SERPINB9, ABCB1, PGR, PDCD1, PCNA, REG3A, OGG1, NRAS, NNMT, NGFR, NFATC4, NBN, MYO6, MYH6, MYC, MUC4, H3P10