For example, no mutations were identified in the complement receptor-2 gene (CR2; 120650), the membrane cofactor protein gene (MCP; 120920), or the decay accelerating factor gene (DAF; 125240). Animal Model The observation by Gemperle et al. (1996) of relapse in a renal transplant was of interest in light of the findings of Zhang et al. (1997) that mice in which the uteroglobin gene had been disrupted developed severe fibronectin-deposit renal glomerular disease.

Clinical Features Alper et al. (1970, 1970) and Abramson et al. (1971) reported a patient with increased susceptibility to infection and accelerated catabolism of C3 due to deficiency of the C3 inactivator.

Push-falling is effective in areas with slopes less than 30 percent and soil textures that are sandy to sandy loam. [4] Applications of chemical fumigation (such as chloropicrin) have been unsuccessful in dealing with Laminated root rot. [10] Economic importance [ edit ] The trees die from failure to take up water and nutrients because of the main roots are decayed. The death is also accelerated by wind that throws the trees down.

When the episodes are recurrent or severe, the definitive test is a hospitalization for a supervised diagnostic fast . This usually demonstrates "accelerated fasting"—a shorter time until the glucose begins to fall, but normal metabolic and counterregulatory responses as the glucose falls.

. ^ [1] External links [ edit ] Classification D ICD - 10 : I42.6 ICD - 9-CM : 425.5 MeSH : D002310 External resources MedlinePlus : 000174 eMedicine : med/286 v t e Psychoactive substance-related disorder General SID Substance intoxication / Drug overdose Substance-induced psychosis Withdrawal : Craving Neonatal withdrawal Post-acute-withdrawal syndrome (PAWS) SUD Substance abuse / Substance-related disorders Physical dependence / Psychological dependence / Substance dependence Combined substance use SUD Polysubstance dependence SID Combined drug intoxication (CDI) Alcohol SID Cardiovascular diseases Alcoholic cardiomyopathy Alcohol flush reaction (AFR) Gastrointestinal diseases Alcoholic liver disease (ALD): Alcoholic hepatitis Auto-brewery syndrome (ABS) Endocrine diseases Alcoholic ketoacidosis (AKA) Nervous system diseases Alcohol-related dementia (ARD) Alcohol intoxication Hangover Neurological disorders Alcoholic hallucinosis Alcoholic polyneuropathy Alcohol-related brain damage Alcohol withdrawal syndrome (AWS): Alcoholic hallucinosis Delirium tremens (DTs) Fetal alcohol spectrum disorder (FASD) Fetal alcohol syndrome (FAS) Korsakoff syndrome Positional alcohol nystagmus (PAN) Wernicke–Korsakoff syndrome (WKS, Korsakoff psychosis) Wernicke encephalopathy (WE) Respiratory tract diseases Alcohol-induced respiratory reactions Alcoholic lung disease SUD Alcoholism (alcohol use disorder (AUD)) Binge drinking Caffeine SID Caffeine-induced anxiety disorder Caffeine-induced sleep disorder Caffeinism SUD Caffeine dependence Cannabis SID Cannabis arteritis Cannabinoid hyperemesis syndrome (CHS) SUD Amotivational syndrome Cannabis use disorder (CUD) Synthetic cannabinoid use disorder Cocaine SID Cocaine intoxication Prenatal cocaine exposure (PCE) SUD Cocaine dependence Hallucinogen SID Acute intoxication from hallucinogens (bad trip) Hallucinogen persisting perception disorder (HPPD) Nicotine SID Nicotine poisoning Nicotine withdrawal SUD Nicotine dependence Opioids SID Opioid overdose SUD Opioid use disorder (OUD) Sedative / hypnotic SID Kindling (sedative–hypnotic withdrawal) benzodiazepine : SID Benzodiazepine overdose Benzodiazepine withdrawal SUD Benzodiazepine use disorder (BUD) Benzodiazepine dependence barbiturate : SID Barbiturate overdose SUD Barbiturate dependence Stimulants SID Stimulant psychosis amphetamine : SUD Amphetamine dependence Volatile solvent SID Sudden sniffing death syndrome (SSDS) Toluene toxicity SUD Inhalant abuse v t e Cardiovascular disease (heart) Ischaemic Coronary disease Coronary artery disease (CAD) Coronary artery aneurysm Spontaneous coronary artery dissection (SCAD) Coronary thrombosis Coronary vasospasm Myocardial bridge Active ischemia Angina pectoris Prinzmetal's angina Stable angina Acute coronary syndrome Myocardial infarction Unstable angina Sequelae hours Hibernating myocardium Myocardial stunning days Myocardial rupture weeks Aneurysm of heart / Ventricular aneurysm Dressler syndrome Layers Pericardium Pericarditis Acute Chronic / Constrictive Pericardial effusion Cardiac tamponade Hemopericardium Myocardium Myocarditis Chagas disease Cardiomyopathy Dilated Alcoholic Hypertrophic Tachycardia-induced Restrictive Loeffler endocarditis Cardiac amyloidosis Endocardial fibroelastosis Arrhythmogenic right ventricular dysplasia Endocardium / valves Endocarditis infective endocarditis Subacute bacterial endocarditis non-infective endocarditis Libman–Sacks endocarditis Nonbacterial thrombotic endocarditis Valves mitral regurgitation prolapse stenosis aortic stenosis insufficiency tricuspid stenosis insufficiency pulmonary stenosis insufficiency Conduction / arrhythmia Bradycardia Sinus bradycardia Sick sinus syndrome Heart block : Sinoatrial AV 1° 2° 3° Intraventricular Bundle branch block Right Left Left anterior fascicle Left posterior fascicle Bifascicular Trifascicular Adams–Stokes syndrome Tachycardia ( paroxysmal and sinus ) Supraventricular Atrial Multifocal Junctional AV nodal reentrant Junctional ectopic Ventricular Accelerated idioventricular rhythm Catecholaminergic polymorphic Torsades de pointes Premature contraction Atrial Junctional Ventricular Pre-excitation syndrome Lown–Ganong–Levine Wolff–Parkinson–White Flutter / fibrillation Atrial flutter Ventricular flutter Atrial fibrillation Familial Ventricular fibrillation Pacemaker Ectopic pacemaker / Ectopic beat Multifocal atrial tachycardia Pacemaker syndrome Parasystole Wandering atrial pacemaker Long QT syndrome Andersen–Tawil Jervell and Lange-Nielsen Romano–Ward Cardiac arrest Sudden cardiac death Asystole Pulseless electrical activity Sinoatrial arrest Other / ungrouped hexaxial reference system Right axis deviation Left axis deviation QT Short QT syndrome T T wave alternans ST Osborn wave ST elevation ST depression Strain pattern Cardiomegaly Ventricular hypertrophy Left Right / Cor pulmonale Atrial enlargement Left Right Athletic heart syndrome Other Cardiac fibrosis Heart failure Diastolic heart failure Cardiac asthma Rheumatic fever

In a longitudinal follow-up of patients with MLS, Enzi et al. (2002) found that alcohol discontinuation was associated with a slight regression of lipomatous depots and that an increase in ethanol consumption seemed to accelerate the lipomatous growth. Molecular Genetics Holme et al. (1993) reported a woman with multiple symmetric lipomas in the neck and shoulder area associated with a heteroplasmic c.8344A-G mutation in the MTTK gene (590060.0001).

External links [ edit ] Classification D ICD - 10 : I31.9 , P25.3 , S26.8 ICD - 9-CM : 770.2 , 860.1 MeSH : D011026 SNOMED CT : 82542004 v t e Cardiovascular disease (heart) Ischaemic Coronary disease Coronary artery disease (CAD) Coronary artery aneurysm Spontaneous coronary artery dissection (SCAD) Coronary thrombosis Coronary vasospasm Myocardial bridge Active ischemia Angina pectoris Prinzmetal's angina Stable angina Acute coronary syndrome Myocardial infarction Unstable angina Sequelae hours Hibernating myocardium Myocardial stunning days Myocardial rupture weeks Aneurysm of heart / Ventricular aneurysm Dressler syndrome Layers Pericardium Pericarditis Acute Chronic / Constrictive Pericardial effusion Cardiac tamponade Hemopericardium Myocardium Myocarditis Chagas disease Cardiomyopathy Dilated Alcoholic Hypertrophic Tachycardia-induced Restrictive Loeffler endocarditis Cardiac amyloidosis Endocardial fibroelastosis Arrhythmogenic right ventricular dysplasia Endocardium / valves Endocarditis infective endocarditis Subacute bacterial endocarditis non-infective endocarditis Libman–Sacks endocarditis Nonbacterial thrombotic endocarditis Valves mitral regurgitation prolapse stenosis aortic stenosis insufficiency tricuspid stenosis insufficiency pulmonary stenosis insufficiency Conduction / arrhythmia Bradycardia Sinus bradycardia Sick sinus syndrome Heart block : Sinoatrial AV 1° 2° 3° Intraventricular Bundle branch block Right Left Left anterior fascicle Left posterior fascicle Bifascicular Trifascicular Adams–Stokes syndrome Tachycardia ( paroxysmal and sinus ) Supraventricular Atrial Multifocal Junctional AV nodal reentrant Junctional ectopic Ventricular Accelerated idioventricular rhythm Catecholaminergic polymorphic Torsades de pointes Premature contraction Atrial Junctional Ventricular Pre-excitation syndrome Lown–Ganong–Levine Wolff–Parkinson–White Flutter / fibrillation Atrial flutter Ventricular flutter Atrial fibrillation Familial Ventricular fibrillation Pacemaker Ectopic pacemaker / Ectopic beat Multifocal atrial tachycardia Pacemaker syndrome Parasystole Wandering atrial pacemaker Long QT syndrome Andersen–Tawil Jervell and Lange-Nielsen Romano–Ward Cardiac arrest Sudden cardiac death Asystole Pulseless electrical activity Sinoatrial arrest Other / ungrouped hexaxial reference system Right axis deviation Left axis deviation QT Short QT syndrome T T wave alternans ST Osborn wave ST elevation ST depression Strain pattern Cardiomegaly Ventricular hypertrophy Left Right / Cor pulmonale Atrial enlargement Left Right Athletic heart syndrome Other Cardiac fibrosis Heart failure Diastolic heart failure Cardiac asthma Rheumatic fever v t e Conditions originating in the perinatal period / fetal disease Maternal factors complicating pregnancy, labour or delivery placenta Placenta praevia Placental insufficiency Twin-to-twin transfusion syndrome chorion / amnion Chorioamnionitis umbilical cord Umbilical cord prolapse Nuchal cord Single umbilical artery presentation Breech birth Asynclitism Shoulder presentation Growth Small for gestational age / Large for gestational age Preterm birth / Postterm pregnancy Intrauterine growth restriction Birth trauma scalp Cephalohematoma Chignon Caput succedaneum Subgaleal hemorrhage Brachial plexus injury Erb's palsy Klumpke paralysis Affected systems Respiratory Intrauterine hypoxia Infant respiratory distress syndrome Transient tachypnea of the newborn Meconium aspiration syndrome Pleural disease Pneumothorax Pneumomediastinum Wilson–Mikity syndrome Bronchopulmonary dysplasia Cardiovascular Pneumopericardium Persistent fetal circulation Bleeding and hematologic disease Vitamin K deficiency bleeding HDN ABO Anti-Kell Rh c Rh D Rh E Hydrops fetalis Hyperbilirubinemia Kernicterus Neonatal jaundice Velamentous cord insertion Intraventricular hemorrhage Germinal matrix hemorrhage Anemia of prematurity Gastrointestinal Ileus Necrotizing enterocolitis Meconium peritonitis Integument and thermoregulation Erythema toxicum Sclerema neonatorum Nervous system Perinatal asphyxia Periventricular leukomalacia Musculoskeletal Gray baby syndrome muscle tone Congenital hypertonia Congenital hypotonia Infections Vertically transmitted infection Neonatal infection rubella herpes simplex mycoplasma hominis ureaplasma urealyticum Omphalitis Neonatal sepsis Group B streptococcal infection Neonatal conjunctivitis Other Miscarriage Perinatal mortality Stillbirth Infant mortality Neonatal withdrawal

External links [ edit ] Classification D ICD - 10 : I25.4 ICD - 9-CM : 414.11 MeSH : D003323 v t e Cardiovascular disease (heart) Ischaemic Coronary disease Coronary artery disease (CAD) Coronary artery aneurysm Spontaneous coronary artery dissection (SCAD) Coronary thrombosis Coronary vasospasm Myocardial bridge Active ischemia Angina pectoris Prinzmetal's angina Stable angina Acute coronary syndrome Myocardial infarction Unstable angina Sequelae hours Hibernating myocardium Myocardial stunning days Myocardial rupture weeks Aneurysm of heart / Ventricular aneurysm Dressler syndrome Layers Pericardium Pericarditis Acute Chronic / Constrictive Pericardial effusion Cardiac tamponade Hemopericardium Myocardium Myocarditis Chagas disease Cardiomyopathy Dilated Alcoholic Hypertrophic Tachycardia-induced Restrictive Loeffler endocarditis Cardiac amyloidosis Endocardial fibroelastosis Arrhythmogenic right ventricular dysplasia Endocardium / valves Endocarditis infective endocarditis Subacute bacterial endocarditis non-infective endocarditis Libman–Sacks endocarditis Nonbacterial thrombotic endocarditis Valves mitral regurgitation prolapse stenosis aortic stenosis insufficiency tricuspid stenosis insufficiency pulmonary stenosis insufficiency Conduction / arrhythmia Bradycardia Sinus bradycardia Sick sinus syndrome Heart block : Sinoatrial AV 1° 2° 3° Intraventricular Bundle branch block Right Left Left anterior fascicle Left posterior fascicle Bifascicular Trifascicular Adams–Stokes syndrome Tachycardia ( paroxysmal and sinus ) Supraventricular Atrial Multifocal Junctional AV nodal reentrant Junctional ectopic Ventricular Accelerated idioventricular rhythm Catecholaminergic polymorphic Torsades de pointes Premature contraction Atrial Junctional Ventricular Pre-excitation syndrome Lown–Ganong–Levine Wolff–Parkinson–White Flutter / fibrillation Atrial flutter Ventricular flutter Atrial fibrillation Familial Ventricular fibrillation Pacemaker Ectopic pacemaker / Ectopic beat Multifocal atrial tachycardia Pacemaker syndrome Parasystole Wandering atrial pacemaker Long QT syndrome Andersen–Tawil Jervell and Lange-Nielsen Romano–Ward Cardiac arrest Sudden cardiac death Asystole Pulseless electrical activity Sinoatrial arrest Other / ungrouped hexaxial reference system Right axis deviation Left axis deviation QT Short QT syndrome T T wave alternans ST Osborn wave ST elevation ST depression Strain pattern Cardiomegaly Ventricular hypertrophy Left Right / Cor pulmonale Atrial enlargement Left Right Athletic heart syndrome Other Cardiac fibrosis Heart failure Diastolic heart failure Cardiac asthma Rheumatic fever v t e Cardiovascular disease (vessels) Arteries , arterioles and capillaries Inflammation Arteritis Aortitis Buerger's disease Peripheral artery disease Arteriosclerosis Atherosclerosis Foam cell Fatty streak Atheroma Intermittent claudication Critical limb ischemia Monckeberg's arteriosclerosis Arteriolosclerosis Hyaline Hyperplastic Cholesterol LDL Oxycholesterol Trans fat Stenosis Carotid artery stenosis Renal artery stenosis Other Aortoiliac occlusive disease Degos disease Erythromelalgia Fibromuscular dysplasia Raynaud's phenomenon Aneurysm / dissection / pseudoaneurysm torso : Aortic aneurysm Abdominal aortic aneurysm Thoracic aortic aneurysm Aneurysm of sinus of Valsalva Aortic dissection Aortic rupture Coronary artery aneurysm head / neck Intracranial aneurysm Intracranial berry aneurysm Carotid artery dissection Vertebral artery dissection Familial aortic dissection Vascular malformation Arteriovenous fistula Arteriovenous malformation Telangiectasia Hereditary hemorrhagic telangiectasia Vascular nevus Cherry hemangioma Halo nevus Spider angioma Veins Inflammation Phlebitis Venous thrombosis / Thrombophlebitis primarily lower limb Deep vein thrombosis abdomen Hepatic veno-occlusive disease Budd–Chiari syndrome May–Thurner syndrome Portal vein thrombosis Renal vein thrombosis upper limb / torso Mondor's disease Paget–Schroetter disease head Cerebral venous sinus thrombosis Post-thrombotic syndrome Varicose veins Gastric varices Portacaval anastomosis Caput medusae Esophageal varices Hemorrhoid Varicocele Other Chronic venous insufficiency Chronic cerebrospinal venous insufficiency Superior vena cava syndrome Inferior vena cava syndrome Venous ulcer Arteries or veins Angiopathy Macroangiopathy Microangiopathy Embolism Pulmonary embolism Cholesterol embolism Paradoxical embolism Thrombosis Vasculitis Blood pressure Hypertension Hypertensive heart disease Hypertensive emergency Hypertensive nephropathy Essential hypertension Secondary hypertension Renovascular hypertension Benign hypertension Pulmonary hypertension Systolic hypertension White coat hypertension Hypotension Orthostatic hypotension This article about a medical condition affecting the circulatory system is a stub .

It's important to monitor your blood sugar levels regularly and keep track of how you're feeling when your blood sugar is low. ... Questions you may want to ask include: How often do I need to check my blood sugar? What is my target blood sugar range? How do diet, exercise and weight changes affect my blood sugar? How can I prevent low blood sugar? Do I need to worry about high blood sugar? ... What's a typical day's diet like? Are you exercising? If so, how often? Do your family, friends and co-workers know what to do if you have severe hypoglycemia?

But you can treat it with moisturizers and prescription creams to help improve how the skin looks. The condition usually disappears by age 30. ... In the meantime, you might use one of the many products available to help improve how the skin looks. If moisturizing and other self-care measures don't help, your health care provider may prescribe medicated creams. ... Your health care provider can advise you on the best option and how often to apply. The acids in these creams may cause inflamed skin or stinging, so they aren't recommended for young children. ... Using medicated cream regularly may improve how the skin looks. But if you stop, the condition returns. ... Lifestyle and home remedies Self-help measures won't prevent keratosis pilaris or make it go away. But they may improve how the affected skin looks. When using a product new to you, test it on one area of affected skin first, such as an arm.

Please help improve it or discuss these issues on the talk page . ( Learn how and when to remove these template messages ) This article may need to be rewritten to comply with Wikipedia's quality standards . ... The specific problem is: Needs to be written in an encyclopedic tone. Presently written as a "how to" manual. Please help improve this article if you can. ( April 2018 ) ( Learn how and when to remove this template message ) This article needs additional citations for verification . ... Find sources: "Ventilation perfusion mismatch" – news · newspapers · books · scholar · JSTOR ( December 2014 ) ( Learn how and when to remove this template message ) ( Learn how and when to remove this template message ) Ventilation perfusion mismatch or "V/Q defects" are defects in total lung ventilation perfusion ratio. ... These pictures show us the part of lung devoid of tracer gas and then we correlate it with different types of lung pathology. How the test is performed - by using a mouth piece while closing nose with the help of clip, person is asked to inhale the radioactive tracer gas for few minutes and pictures are taken at regular intervals.

"A Novel Form of Transducin-Dependent Retinal Degeneration: Accelerated Retinal Degeneration in the Absence of Rod Transducin" . ... "A Novel Form of Transducin-Dependent Retinal Degeneration: Accelerated Retinal Degeneration in the Absence of Rod Transducin" . ... "A Novel Form of Transducin-Dependent Retinal Degeneration: Accelerated Retinal Degeneration in the Absence of Rod Transducin" .

Familial Alzheimer's disease and familial Parkinson's disease are two well-known accelerated-aging diseases that are more frequent in older individuals. ... This condition is caused by dysfunctional lamin which is unable to maintain the nuclear shape ( normal at top, abnormal at bottom ) Main article: Progeria Hutchinson–Gilford progeria syndrome is an extremely rare developmental autosomal dominant condition, characterized by premature and accelerated aging (~7 times the normal rate) [65] beginning at childhood. ... Most affected individuals die in the uterus or are stillbirths, and liveborns usually die within a week. [ citation needed ] Defects in FBN1 [ edit ] Patients with Marfan-progeroid-lipodystrophy syndrome typically exhibit congenital lipodystrophy and a neonatal progeroid appearance. [80] [81] Sometimes identified as having neonatal progeroid syndrome , the term is a misnomer since they do not exhibit accelerated aging. [82] The condition is caused by mutations near the 3'-terminus of the FBN1 gene. [80] [81] [82] [83] [84] [85] [ excessive citations ] A common cause for premature aging [ edit ] Hutchinson–Gilford progeria syndrome, Werner syndrome, and Cockayne syndrome are the three genetic disorders in which patients have premature aging features.

This procedure usually works after one or two treatments. Your doctor will likely teach you how to perform the procedure on yourself so that you can do it at home if needed. ... What you can do Write down your symptoms, including when they started and how often they occur. Note any recent blows to your head, including even minor accidents or injuries. ... Do I need to restrict my activities? For how long? Am I at risk of this problem recurring? I have these other health conditions. How can I manage these conditions together? ... What to expect from your doctor A doctor who sees you for symptoms common to BPPV may ask a number of questions, such as: What are your symptoms, and when did you first notice them? Do your symptoms come and go? How often? How long do your symptoms last?

Please help improve it or discuss these issues on the talk page . ( Learn how and when to remove these template messages ) This article provides insufficient context for those unfamiliar with the subject . Please help improve the article by providing more context for the reader . ( July 2020 ) ( Learn how and when to remove this template message ) The neutrality of this article is disputed . ... Please do not remove this message until conditions to do so are met . ( July 2020 ) ( Learn how and when to remove this template message ) This article relies too much on references to primary sources . Please improve this by adding secondary or tertiary sources . ( July 2020 ) ( Learn how and when to remove this template message ) This article may lend undue weight to certain ideas, incidents, or controversies . ... Find sources: "Maladaptive daydreaming" – news · newspapers · books · scholar · JSTOR ( December 2020 ) ( Learn how and when to remove this template message ) ( Learn how and when to remove this template message ) Maladaptive daydreaming , also called excessive daydreaming, is a proposed diagnosis of a disordered form of dissociative absorption associated with excessive fantasy that is not recognized by any major medical or psychological criteria.

Talk to your health care provider about how to lower your blood sugar level safely. ... For some people, especially older adults and those with certain medical conditions, a higher A1C level of 8% or more may be appropriate. How often you need the A1C test depends on the type of diabetes you have and how well you're managing your blood sugar. ... For hyperglycemia, questions you may want to ask include: How often do I need to monitor my blood sugar? What is my target range? How do diet and exercise affect my blood sugar? When do I test for ketones? How can I prevent high blood sugar? Do I need to worry about low blood sugar?

A ventricular septal defect (VSD) changes how blood flows through the heart and lungs. ... Rarely, a ventricular septal defect can occur later in life after a heart attack or certain heart procedures. How the heart works To understand more about ventricular septal defect (VSD), it may be helpful to know how the heart typically works. ... This quick and painless test records the electrical activity of the heart. It can show how fast or how slowly the heart is beating. ... How can we monitor for complications? What treatment do you recommend? How often should we schedule follow-up exams and tests?

Train you how to respond to an emergency, such as a chemical spill. ... These include: Spirometry. This noninvasive test measures how well you breathe. It is the preferred test for diagnosing asthma. ... You may be asked to carry a small hand-held device that measures how fast you can force air out of your lungs (peak flow meter). ... Is my condition likely temporary or chronic? How do I treat occupational asthma? Do I have to quit my job? ... Are you exposed to fumes, gases, smoke, irritants, chemicals, or plant or animal substances at work? If so, how often and for how long? Do you work in unusual environmental conditions, such as extreme heat, cold or dryness?

In Chapter II, five disciples of Rabbi Yochanan ben Zakai give advice on how to follow the good path in life and avoid the bad. ... Such gestures include scratching one's testicles (for men), as well as the mano cornuta gesture and the fig sign ; a fist with the thumb pressed between the index and middle fingers, representing the phallus within the vagina. ... In Latin America , carvings of the fist with the thumb pressed between the index and middle fingers continue to be carried as good luck charms. ... Unsourced material may be challenged and removed. ( June 2011 ) ( Learn how and when to remove this template message ) Mal de ojo (Mal: Illness - de ojo: Of eye. ... The amulet is in the shape of a fist with a protruding index finger knuckle. Azabache bracelet charm with a first and protruding index finger knuckle Eggs are the most common method to cure Mal De Ojo.

Additionally, the WHO scheme recognizes mixed tumors with both neuroendocrine and epithelial carcinoma features, such as goblet cell cancer , a rare gastrointestinal tract tumor . [4] Placing a given tumor into one of these categories depends on well-defined histological features: size, lymphovascular invasion , mitotic counts, Ki-67 labelling index, invasion of adjacent organs, presence of metastases and whether they produce hormones . [2] [3] Anatomic distribution [ edit ] Traditionally, neuroendocrine tumors have been classified by their anatomic site of origin. ... G Mitotic count (per 10 HPF ) Ki-67 index (%) GX Grade cannot be assessed G1 < 2 < 3% G2 2 to 20 3–20% G3 > 20 > 20% If mitotic count and Ki-67 are discordant, the figure which gives the highest grade is used. ... Unsourced material may be challenged and removed. ( November 2015 ) ( Learn how and when to remove this template message ) Markers [ edit ] Symptoms from secreted hormones may prompt measurement of the corresponding hormones in the blood or their associated urinary products, for initial diagnosis or to assess the interval change in the tumor. ... Unsourced material may be challenged and removed. ( November 2015 ) ( Learn how and when to remove this template message ) NETs from a particular anatomical origin often show similar behavior as a group, such as the foregut (which conceptually includes pancreas, and even thymus, airway and lung NETs), midgut and hindgut ; individual tumors within these sites can differ from these group benchmarks: Foregut NETs are argentaffin negative.