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Dysmenorrhea
Wikipedia
Further work-up includes a specific medical history of symptoms and menstrual cycles and a pelvic examination . [4] Based on results from these, additional exams and tests may be motivated, such as: Gynecologic ultrasonography [4] Laparoscopy [4] Management [ edit ] NSAIDs [ edit ] Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen are effective in relieving the pain of primary dysmenorrhea. [23] They can have side effects of nausea, dyspepsia , peptic ulcer , and diarrhea. [24] [23] Hormonal birth control [ edit ] Use of hormonal birth control may improve symptoms of primary dysmenorrhea. [25] [18] A 2009 systematic review found limited evidence that the low or medium doses of estrogen contained in the birth control pill reduces pain associated with dysmenorrhea. [26] In addition, no differences between different birth control pill preparations were found. [26] Norplant [27] and Depo-provera [28] [29] are also effective, since these methods often induce amenorrhea .AVP, OXT, LMNA, ANTXR1, INHBA, PPARG, AIP, FOS, BSCL2, CYP17A1, GPR101, CYB5A, AGPAT2, CAVIN1, CAV1, MUC16, PTGS2, BDNF, ANXA2, CYP1A1, CGB5, OTC, OXTR, MTCO2P12, SERPINE1, PCNA, PPIA, PTH, SLC4A1, CCL11, TNF, VEGFA, TRPV1, PERCC1, NGF, MYL12A, MYL12B, CGB8, HPGDS, NOS3, ALOX5, COX2, MOS, BGLAP, CD34, CGA, CGB3, CLCN3, CLTC, CREB1, CTNNB1, CYP2B6, CYP2D6, DNMT3B, ESR1, FCER2, MSTN, GSTM1, GSTT1, HIF1A, HTC2, CCN1, IL1A, IL1RN, IL6, IL7, CXCL8, IL15, MEFV, MMP14, LOC107987479
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Thought Disorder
Wikipedia
Common examples in mental status examination include: erotomanic (belief that someone is in love with oneself), grandiose (belief that one is the greatest, strongest, fastest, richest, and/or most intelligent person ever), persecutory (belief that the person, or someone to whom the person is close, is being malevolently treated in some way), reference (belief that insignificant remarks, events, or objects in one's environment have personal meaning or significance), thought broadcasting (belief that others can hear or are aware of one's thoughts), thought insertion (belief that one's thoughts are not one's own, but rather belong to someone else and have been inserted into one's mind), [28] thought withdrawal (belief that thoughts have been 'taken out' of one's mind, and one has no power over this), outside control (belief that outside forces are controlling one's thoughts, feelings, and actions), [29] infidelity (belief that a partner is cheating on oneself), somatic (belief that one has a disease or medical condition), and nihilistic (belief that the mind, body, the world at large, or parts thereof, no longer exist). [19] Delusions are common in people with mania , depression , schizoaffective disorder , delirium , dementia , substance use disorder , schizophrenia , and delusional disorders [22] Formal thought disorder [ edit ] Formal thought disorder (FTD), or simply thought disorder , is also known as disorganized speech – evident from disorganized thinking , and is one of the hallmark features of schizophrenia . [4] [6] Formal thought disorder is a disorder of the form of thought rather than of content of thought that covers hallucinations and delusions . [10] FTD, unlike hallucinations and delusions, is an observable objective sign of psychosis.
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Malnutrition
Wikipedia
COVID-19 could double the number of people at risk of suffering acute hunger by the end of 2020. [28] Contents 1 Definitions 1.1 Undernutrition and overnutrition 1.2 Protein-energy malnutrition 1.2.1 Kwashiorkor 1.2.2 Marasmus 1.3 Undernutrition, hunger 1.4 Definition by Gomez 1.5 Definition by Waterlow 2 Effects 2.1 Signs 2.2 Cognitive development 3 Causes 3.1 Diseases 3.2 Dietary practices 3.2.1 Undernutrition 3.2.2 Overnutrition 3.3 Poverty and food prices 3.4 Agricultural productivity 3.5 Future threats 4 Prevention 4.1 Food security 4.2 Economics 4.3 World population 4.4 Food sovereignty 4.5 Health facilities 4.6 Breastfeeding 4.6.1 Barriers to breastfeeding 4.7 21st century global initiatives 5 Treatment 5.1 Food 5.2 Micronutrients 5.3 Diarrhea 5.4 Low blood sugar 5.5 Hypothermia 6 Epidemiology 6.1 People affected 6.2 Mortality 7 History 8 Special populations 8.1 Children 8.2 Women 8.2.1 Physiology 8.2.2 Pregnancy and breastfeeding 8.2.3 Educating children 8.3 Elderly 9 See also 10 References 11 External links Definitions [ edit ] External video Daniel Quinn on Facts of World Hunger Unless specifically mentioned otherwise, the term malnutrition refers to undernutrition for the remainder of this article. ... This is using the UN's definition of 'undernourishment', where it refers to insufficient consumption of raw calories, and so does not necessarily include people who lack micro nutrients. [10] The undernourishment occurred despite the world's farmers producing enough food to feed around 12 billion people – almost double the current world population. [135] Malnutrition, as of 2010, was the cause of 1.4% of all disability adjusted life years . [22] Number of undernourished globally Year 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 Number in millions [10] 945 911 877 855 840 821 813 806 795 784 784 804 Percentage [10] 14.5% 13.8% 13.1% 12.6% 12.2% 11.8% 11.5% 11.3% 11.0% 10.7% 10.6% 10.8% Number of undernourished in the developing world Year 1969–71 1979–81 1990–92 1995–97 2001–03 2003–05 2005–07 2010–12 Number in millions [136] [137] [138] 820 790 825 848 927 805 Percentage [136] [137] [138] 37% 28% 20% 18% 17% 16% 17% 14% Mortality [ edit ] Deaths from nutritional deficiencies per million persons in 2012 0-4 5-8 9-13 14-23 24-34 35-56 57-91 92-220 221-365 366-1,207 Mortality due to malnutrition accounted for 58 percent of the total mortality in 2006: "In the world, approximately 62 million people, all causes of death combined, die each year.MTHFR, CBS, MTR, TP63, PURA, ACTG2, MSX1, POLG, EDNRB, CDH1, MYO5B, COX4I2, COL7A1, MMP1, SAR1B, CRP, SLC7A7, IGF1, LIPA, ARHGAP29, LEP, DLG1, DLX4, IRF6, BMP4, TYMP, ALB, ALDOB, NECTIN1, SAA1, SLC2A1, TTR, GH1, POMC, CA2, SERPINA1, CFTR, IGSF1, ABCA1, ADIPOQ, BCHE, ADAMTS13, SLC6A8, LIG4, IL6, PTH, PPARA, SGCA, TNF, TAP1, ARTN, SPNS1, NXF1, GHR, MECP2, MAOA, AGRP, IL18, ACE, SEC14L2, BRCA1, PON1, NR3C1, ZFP36, COPD, TLR4, APOE, USO1, SIRT1, SERPINC1, NARS1, GCG, FLNB, MSTN, IGF2, CBLIF, KHDRBS1, SMS, HCRT, HTT, IFNG, HLA-C, HMOX1, GHSR, GTF2H1, IL10, KL, SOD1, TAP2, SI, RFXAP, REN, PROS1, PROC, PRL, UBE2A, VWF, CFP, PAH, PAEP, APLN, PER2, MUC1, SQSTM1, MCL1, MAOB, NUP62, SMPD1, CYP2E1, AGT, CAT, CD55, SECISBP2, AMY1C, AMY1B, GHRL, AMY1A, AHSG, FSIP1, APOB, DCTN4, EPO, ABCA3, HAMP, NLRP3, IL22, COX8A, SERPING1, MTOR, NOX4, ACLY, FGF23, VDR, BEST1, PELI3, ZMYM2, H19, SLC6A19, NR1H2, VCAM1, DEK, ACAD8, SLC14A2, TSPAN33, MIA, DYSF, SNHG3, HJV, SLCO6A1, ISCA2, DGAT1, RIPK2, BANF1, MARS2, TWIST1, MIR132, ACTBL2, TLR2, SORD, STAT6, CBSL, LOC102723407, TCF21, TFRC, TGFB1, WASHC1, TGFBI, WASH6P, TH, TIMP1, NKX2-1, POTEM, GSTK1, TNFRSF1A, TPI1, POTEKP, TRH, TRPC3, MIR187, TSC2, TST, GADD45GIP1, SMIM20, SERPINA13P, ASPG, NDUFS7, MOB1B, DOT1L, CEP19, TTLL5, BCKDK, ABITRAM, LEPROT, AKR1A1, RRN3, OGA, MORF4, HDL3, SDS, RTEL1, ACOT7, SCARA3, CSAD, CNOT1, MCF2L2, TOPORS, TFDP3, GP6, ACSBG1, LEPROTL1, TNFRSF13B, SOST, SMUG1, AMACR, TBK1, PCSK1N, ANGPTL3, HPGDS, CNTNAP2, FGF21, MOB1A, PSME3, ADO, RECQL5, TRIM63, SPHK1, FOXD3, DTNBP1, MBD2, SOCS3, SPX, TET1, FLAD1, SMC3, EFL1, CORO7, RAPH1, ARHGEF28, SLC39A8, SMG9, FADS2, HPSE2, CYP7B1, FHL5, SOX13, RAPGEF5, ZBTB24, LRIG2, IL21, PUM3, PTBP2, RETN, BCL2L11, ABCB6, SERPINA3, PIK3CA, SMARCA1, GPT, ERCC6, ERCC4, ERCC2, EPRS1, EPHB1, ELK3, EIF4EBP1, EGFR, DRD2, DPYD, DNMT3B, SARDH, DMD, DKC1, DGUOK, DECR1, DDB2, FBL, F10, F11, GALT, UTS2R, GNA12, GLB1, GCH1, GATM, GATA2, GAMT, GAD2, FABP4, SLC37A4, G6PC, FOLH1, FLT3LG, FH, FCGR3B, FCGR3A, DAB2, CYP7A1, CYP2C9, AVP, C2, BTK, BST2, BRCA2, BLVRB, BDNF, B2M, FAS, CALR, APOC2, ANGPT2, ALDH2, APLNR, ACTG1, ACAT1, ABCA4, CALCR, CASP1, CYBB, CHRNE, CX3CR1, CSF3R, CRH, CP, COX10, CNR1, CLN3, CETN2, CCK, CEL, CDKN2A, CDB2, CDA, CD151, CD59, CD14, GRK5, GPX3, SLCO2A1, GRN, PLG, PLD2, PIN1, PIK3CG, PIK3CD, PIK3CB, AAVS1, PIGR, SERPINE2, ABCB4, PGR, PEX10, PEX1, PECAM1, PCK2, PC, OTC, PRPS1, PYY, PTBP1, SELP, SLC16A2, SLC6A4, SLC6A3, SLC6A2, SLC5A1, SLC2A4, SGCG, SDHB, PTPRZ1, CCL2, ROS1, RGS2, REG1B, RECQL, QARS1, PTX3, NUCB2, NPY, NDUFS4, HSPA4, IL2, IL1B, IGFBP3, IGFALS, IGF1R, ICAM1, HTR6, HSD3B1, IRS1, HNF4A, HMGB1, HIF1A, CFH, SERPIND1, HBB, H2AX, INSRR, KNG1, NDUFA2, MCM2, NCL, MPO, MMP9, MLH1, MITF, MGP, MAP3K3, LPA, KRAS, FADS1, LIG1, LGALS3, LEPR, LDHA, LCT, LCN2, H3P10
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Tooth Decay
Wikipedia
However, cariogenic bacteria (the ones that can cause the disease) are present in dental plaque, but they are usually in too low concentrations to cause problems unless there is a shift in the balance. [26] This is driven by local environmental change, such as frequent sugar intake or inadequate biofilm removal (toothbrushing). [27] If left untreated, the disease can lead to pain, tooth loss and infection . [28] The mouth contains a wide variety of oral bacteria , but only a few specific species of bacteria are believed to cause dental caries: Streptococcus mutans and Lactobacillus species among them.
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Cellulitis
Wikipedia
Elevation of the affected area is often recommended. [25] Steroids may speed recovery in those on antibiotics. [1] Antibiotics [ edit ] Antibiotics choices depend on regional availability, but a penicillinase-resistant semisynthetic penicillin or a first-generation cephalosporin is currently recommended for cellulitis without abscess. [12] A course of antibiotics is not effective in between 6 and 37% of cases. [26] Epidemiology [ edit ] Cellulitis in 2015 resulted in about 16,900 deaths worldwide, up from 12,600 in 2005. [8] Other animals [ edit ] Horses may acquire cellulitis, usually secondarily to a wound (which can be extremely small and superficial) or to a deep-tissue infection, such as an abscess or infected bone, tendon sheath or joint. [27] [28] Cellulitis from a superficial wound usually creates less lameness (grade 1–2 of 5) than that caused by septic arthritis (grade 4–5).
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Idiopathic Hypersomnia
Wikipedia
In addition to medications, "behavioral approaches and sleep hygiene techniques are recommended, although they have little overall positive impact on this disease." [28] "Planned naps are unhelpful, as they are both long and unrefreshing." [22] Although behavioral approaches have not been shown to improve EDS, the goal, as in CBT ( cognitive behavioral therapy ), is often to help patients learn to reduce their negative emotional responses (e.g. frustration , anger , depression ) to their disease symptoms. ... "Use of subcutaneous flumazenil preparations for the treatment of idiopathic hypersomnia: A case report". Journal of Psychopharmacology . 28 (7): 703–706. doi : 10.1177/0269881114523865 . ... "Improvement in daytime sleepiness with clarithromycin in patients with GABA-related hypersomnia: Clinical experience". Journal of Psychopharmacology . 28 (7): 697–702. doi : 10.1177/0269881113515062 .
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Appendicitis
Wikipedia
Studies have implicated a transition to a Western diet lower in fibre in rising frequencies of appendicitis as well as the other aforementioned colonic diseases in these communities. [24] [25] And acute appendicitis has been shown to occur antecedent to cancer in the colon and rectum. [26] Several studies offer evidence that a low fiber intake is involved in the pathogenesis of appendicitis. [27] [28] [29] This low intake of dietary fiber is in accordance with the occurrence of a right-sided fecal reservoir and the fact that dietary fiber reduces transit time. [30] Diagnosis [ edit ] Appendicitis as seen on CT imaging Diagnosis is based on a medical history (symptoms) and physical examination, which can be supported by an elevation of neutrophilic white blood cells and imaging studies if needed. ... Recovery time depends on age, condition, complications, and other circumstances, including the amount of alcohol consumption, but usually is between 10 and 28 days. For young children (around ten years old), the recovery takes three weeks. ... An unusual complication of an appendectomy is "stump appendicitis": inflammation occurs in the remnant appendiceal stump left after a prior incomplete appendectomy. [83] Stump appendicitis can occur months to years after initial appendectomy and can be identified with imaging modalities like ultrasound. [84] Epidemiology [ edit ] Appendicitis deaths per million persons in 2012 0 1 2 3 4 5-7 8-11 12-33 34-77 Disability-adjusted life year for appendicitis per 100,000 inhabitants in 2004. [85] no data less than 2.5 2.5-5 5-7.5 7.5-10 10-12.5 12.5-15 15-17.5 17.5-20 20-22.5 22.5-25 25-27.5 more than 27.5 Appendicitis is most common between the ages of 5 and 40; [86] the median age is 28. Risk factors include being male, higher household income or living in a rural area. [87] In 2013, it resulted in 72,000 deaths globally, down from 88,000 in 1990. [88] In the United States, there were nearly 293,000 hospitalizations involving appendicitis in 2010. [13] Appendicitis is one of the most frequent diagnoses for emergency department visits resulting in hospitalization among children ages 5–17 years in the United States. [89] See Also [ edit ] Deaths from appendicitis References [ edit ] ^ "appendicitis" .
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Catatonia
Wikipedia
Other disorders (additional code 293.89 [F06.1] to indicate the presence of the co-morbid catatonia): Catatonia associated with autism spectrum disorder Catatonia associated with schizophrenia spectrum and other psychotic disorders Catatonia associated with brief psychotic disorder Catatonia associated with schizophreniform disorder Catatonia associated with schizoaffective disorder Catatonia associated with substance-induced psychotic disorder Catatonia associated with bipolar and related disorders Catatonia associated with major depressive disorder Catatonic disorder due to another medical condition If catatonic symptoms are present but do not form the catatonic syndrome , a medication- or substance-induced aetiology should first be considered. [27] Rating scale [ edit ] Various rating scales for catatonia have been developed. [28] The most commonly used scale is the Bush-Francis Catatonia Rating Scale (BFCRS). [29] A diagnosis can be supported by the lorazepam challenge [30] or the zolpidem challenge. [31] While proven useful in the past, barbiturates are no longer commonly used in psychiatry ; thus the option of either benzodiazepines or ECT.
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Cardiac Amyloidosis
Wikipedia
Trends in Cardiovascular Medicine . 28 (1): 10–21. doi : 10.1016/j.tcm.2017.07.004 .
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Amenorrhea
Wikipedia
Breastfeeding [ edit ] Breastfeeding is a common cause of secondary amenorrhoea, and often the condition lasts for over six months. [27] Breastfeeding typically lasts longer than lactational amenorrhoea , and the duration of amenorrhoea varies depending on how often a woman breastfeeds. [28] Lactational amenorrhoea has been advocated as a method of family planning, especially in developing countries where access to other methods of contraception may be limited.
- Choking Wikipedia
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Sluggish Cognitive Tempo
Wikipedia
But there are rating scales that can be used to screen for SCT symptoms such as the Concentration Inventory (for children and adults) or the Barkley Sluggish Cognitive Tempo Scale-Children and Adolescents (BSCTS-CA) . [28] [12] The Comprehensive Behaviour Rating Scale for Children (CBRSC), an older scale, can also be used for SCT as this case study shows. [29] Additional requirements for a proposed SCT diagnosis (such as the number and duration of symptoms or the impact on functioning) are continuing to be investigated.
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Periodontal Disease
Wikipedia
Associated conditions [ edit ] Periodontitis has been linked to increased inflammation in the body, such as indicated by raised levels of C-reactive protein and interleukin-6 . [7] [8] [9] [10] It is associated with an increased risk of stroke, [11] [12] myocardial infarction , [13] atherosclerosis [14] [15] [16] [17] [18] [19] [20] and hypertension . [21] It also linked in those over 60 years of age to impairments in delayed memory and calculation abilities. [22] [23] Individuals with impaired fasting glucose and diabetes mellitus have higher degrees of periodontal inflammation, and often have difficulties with balancing their blood glucose level owing to the constant systemic inflammatory state, caused by the periodontal inflammation. [24] [25] Although no causal association was proven, there is an association between chronic periodontitis and erectile dysfunction , [26] inflammatory bowel disease , [27] heart disease, [28] and pancreatic cancer. [29] Causes [ edit ] Periodontitis is an inflammation of the periodontium , i.e., the tissues that support the teeth. ... Journal of Clinical Periodontology . 28 (7): 680–5. doi : 10.1034/j.1600-051x.2001.028007680.x . ... "The effect of local and systemic statin use as an adjunct to non-surgical and surgical periodontal therapy-A systematic review and meta-analysis". Journal of Dentistry . 67 : 18–28. doi : 10.1016/j.jdent.2017.08.011 . hdl : 2043/23307 .CRP, MMP9, FPR1, GGT1, TNF, IL1B, IL10, CD14, MMP2, CCL2, MMP3, HMGB1, MMP13, NTRK1, AGER, VIP, NAMPT, ADRB1, MET, VCAM1, PPARA, LBP, CLDN1, POSTN, CXCL2, PLG, ELANE, GLT6D1, ITGB2, MFSD1, SIGLEC5, CTC1, NOTCH2, COL3A1, LYST, GFI1, USB1, OCRL, MMP8, TNFRSF11B, FGF3, CRACR2A, PARN, MPO, NOP10, MMP1, TENM2, NHP2, RTEL1, IL17A, ICAM1, DKC1, ADGRE1, NKAIN2, CXCL8, WRAP53, SLC35C1, FERMT1, IL1A, IFNG, GORAB, IL6, TINF2, TLR2, C1R, C1S, SRP54, TCIRG1, MCM3AP, TERC, TERT, BIRC5, PTGS2, TNFSF11, LINC02022, AP3B1, TLR4, PKN2-AS1, VDR, DEFB1, VEGFA, IL1RN, TLR9, CDKN2B-AS1, DEFB4B, SOST, TGFB1, DEFB4A, NLRP3, IL4, S100A8, F2RL1, PPARG, DEFB103A, DEFB103B, IL17F, IL13, BTF3P11, IL18, COX2, CASP3, PTX3, CSF1, MAPK1, TIMP3, ESR1, TNFRSF11A, CTLA4, MIR146A, CCR5, CAMP, HSPD1, CASP1, IL22, SERPINF2, FOXP3, HSPA14, BSG, ITGAM, MTCO2P12, SERPINE1, NFKB1, S100A9, HIF1A, OLFM1, HLA-DRB1, NFE2L2, GABPA, NOD2, MYD88, WNT5A, NPY, RNF19A, LEP, POLDIP2, COL25A1, LTA, EDIL3, INPP5D, LTF, MIF, CXCL12, GRAP2, SLC52A1, SOD2, REN, IL2RA, ADAM17, NR1I2, MMP7, PTH, TIMP1, PRTN3, AHSA1, AIMP2, FCGR3A, IL33, CRK, MIR142, MAPK14, ALB, AHR, CTSK, FCGR2B, IL34, COX8A, PCSK9, CD40LG, MIR21, CD36, RUNX2, TRAP, C20orf181, MBL3P, BCL2, CD274, TRBV20OR9-2, MEFV, MBL2, MALAT1, CSF3, CTNNB1, GCFC2, TREM1, ATM, MLKL, CTSS, RTL1, CYP1A1, IFNL1, SYT1, TREM2, STAT1, ADIPOQ, CLU, SIRT1, ANP32B, TNFSF13B, CAT, PTPN2, RARRES2, CALCA, P2RX7, RELA, RNASE3, DKK1, CD68, TMPRSS13, SFRP5, PADI4, CDK9, NFATC1, MUC4, CTSC, SELE, MST1, MSMB, TUG1, SETMAR, MMP12, ODAM, PON1, IL11, THBS1, IGF1, TIMP2, EGF, ELN, TIMP4, LMLN, TLR1, FGD5-AS1, AGT, GIP, SLC52A2, F2R, TNFSF13, WNK1, GORASP1, HGF, ALDH2, GSTM1, FCGR2A, IGFBP5, CXCR4, ATN1, IL6ST, THNSL2, APOE, IL2, APP, PWAR1, ST8SIA4, FOXO1, DNMT1, FN1, FGF2, NR1H4, LINC00687, MIR584, ZBTB18, OIP5-AS1, HAX1, DEFA1B, LRPPRC, BHLHE40, NOD1, CDR1-AS, EBI3, RECK, LOH19CR1, YAP1, DEFB104B, MIR381, CRISP3, EDS8, CDR3, DDX39A, MIR335, ARHGEF5, MAEA, UPK3B, DEFA1A3, MIR4435-2HG, PLPPR4, VAMP8, SDC3, PTGES, SLC33A1, P2RX6, MAFD4, BOP, NRP1, CCRL2, HDAC3, SOCS3, TNFSF12-TNFSF13, HAP1, SELENBP1, HSPB3, TIMELESS, PROM1, ZNF667-AS1, SQSTM1, MAFD6, MIR1226, IL18R1, IL32, MIR543, NCR1, NCR2, ZGLP1, MYMX, SOCS1, CDK5R1, NTN1, TNFSF12, PDLIM7, PGR-AS1, PTCSC3, P2RX5-TAX1BP3, VAMP3, CD163, SOCS6, MRLN, NLRC5, ANGPTL2, MIR27A, DDX53, ZNF513, YOD1, MEG3, CD200R1, DEFB104A, NEK7, IL23R, DRAM1, GHS, LBX2-AS1, ASPN, IL22RA2, NLRP6, FAM20A, COPD, LEPROT, CCHCR1, IFNL3, LINC01566, IL23A, NME8, TLR8, MRGPRX2, UCN3, MIR23A, ACE2, MIXL1, MAP1LC3B, DCSTAMP, PTGES2, DHDDS, ABCC11, EHMT1, DHX40, PANK3, BACH2, IL21, CDCA5, NLRC4, ZNF410, MTG1, SLAMF7, DNER, SFXN1, CHPT1, FAM20C, KCNQ5, SLC50A1, TLR7, BFAR, DCTN4, SLC7A9, CAMTA1, MIR200A, MIR200C, JMJD6, P2RX2, HSPA4L, PARK7, PADI2, ADAMTS7, WDHD1, RIPK3, NLRP10, IL24, FASTK, LILRB1, HPSE, TOB2, NES, PTGES3, KHDRBS1, MIR214, MIR22, MIR182, MIR17, HEY1, NUP62, GPR141, DELEC1, TBX21, SETD2, HPGDS, IL31, GTF2H5, MIR100, MIR125A, IL17C, MIR126, IL37, HAVCR1, MIR132, MIR143, MIR144, MIR148A, MIR155, PART1, QPCT, IL17RA, ACP5, RBP4, TFEB, ENO1, FGF7, FGB, FCN2, FCGR3B, FBN1, PTK2B, FABP4, ETS1, ERCC2, EPO, EPHB2, EPHA3, ENO3, ELAVL1, FOS, S1PR1, ECE1, DSG1, RCAN1, DSC3, DSC1, DMP1, DMD, DLX5, DLD, DEFA4, DEFA1, DECR1, FOLR1, FOSB, DDX39B, CXCL1, IFN1@, IBSP, TNC, HSPB2, HSPB1, HPX, HNRNPL, HMOX1, HLA-B, HDC, HBB, GTF2H1, GSTT1, GRN, GAD1, GPX1, GPT, FFAR1, CXCR3, GLP1R, GIPR, GHRHR, GH1, GEM, GCHFR, GCG, GC, GATA3, DDOST, CYP2E1, CYP1B1, APRT, C5, C3, C1QA, BMP4, BMP2, BMP1, PRDM1, CEACAM1, BGLAP, AZU1, ATF4, AR, AQP3, APOH, CTSG, APOB, XIAP, BIRC3, APEX1, APAF1, ANXA1, ANPEP, ALPP, AKT1, AGTR1, JAG1, ADRB2, ADM, CALR, CASP8, CASP9, CAV1, CSF3R, CSF1R, CRYGD, COL5A1, CMKLR1, CCR6, CCR4, CCR1, CISH, CHGA, CEACAM7, CFTR, CEACAM5, CDKN2B, CDKN2A, LRBA, CD81, CD74, CD69, CD44, CD40, CD38, CD28, CD27, CD1D, CD1A, CBS, IFNB1, IFNGR1, JCHAIN, RXRA, SHBG, SH3BP2, SET, SELP, SELL, CXCL5, CCL25, CCL5, CCL3, S100B, S100A4, S100A2, S100A1, RPS19, PIK3CD, ROS1, RCN1, ADA, RAC2, PTPRA, PTHLH, PROS1, PPP1R1A, PPIA, PLTP, PLEK, PLAU, PIN1, SLC2A1, SLC2A4, SLIT3, SP1, CRSA, IL1R2, BEST1, VEGFC, VAV1, TYRO3, TWIST1, TRAF6, TPM3, TP53, TLR3, TLL1, TH, TGM4, TFRC, PRDX2, TCF12, TCF7L2, TAC1, SYK, ABCC8, SULT1A1, STAT2, SSTR2, SST, SPIB, SPG7, PIK3CG, PIK3CB, IL1R1, JAK1, MFAP1, MAFD2, MAFD1, SMAD6, LPO, LEPR, LDLR, LAD1, KRT19, KRT13, KLRB1, KIR3DL1, KDR, ITGB6, PIK3CA, ITGAL, ITGAE, ISG20, IRF5, IRF4, IL16, IL12RB2, IL12B, IL12A, CXCR2, IL6R, IL5, IL4R, MFGE8, MME, MMP10, MNAT1, PI3, PGF, PF4, PCNA, SERPINB2, PRDX1, P2RY2, P2RY1, P2RX5, P2RX4, P2RX3, P2RX1, OSM, OPRM1, NT5E, NPM1, PNP, NOS3, NOS2, NM, NGF, NFYA, NFKBIL1, GADD45B, MT1A, MSX2, CD200, LOC107984137
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Haltlose Personality Disorder
Wikipedia
Personality disorder Haltlose personality disorder Other names - Willenlosen Psychopath [1] [2] [3] - Unstable psychopath [4] - Unstable drifter [5] [6] [7] - Disinhibited Personality [8] Specialty Psychiatry Usual onset Early adulthood [9] Duration Long term Causes - Maternal indolence (proposed) [10] - Childhood institutionalization (proposed) [10] - Parental rejection (proposed) [11] - Hereditary predisposition through the mother (proposed) [12] [13] Risk factors Parental neglect [10] Maternal alcoholism [14] Diagnostic method Based on reported symptoms Symptoms can be tested using TCI and ZKPQ [15] Differential diagnosis - ADHD [16] - Asthenic PD [17] - Delayed maturity [18] - Simplex or Disorganized schizophrenia [18] [19] - Epilepsy (When Haltlose is combined with alcoholism ) [20] [21] - Dependant PD [22] Prognosis - "Particularly unfavorable" regarding relapse [23] and long-term decline [24] - Can be controlled by external influence [25] [26] [18] - Although ideation and threats are common, typically lack the courage to commit suicide . [27] - Normal intelligence [28] Frequency Equal representation between males and females [13] Haltlose personality disorder is an ICD-10 personality disorder [29] in which affected individuals possess psychopathic traits built upon short-sighted selfishness [21] and irresponsible hedonism , combined with an inability to anchor one's identity to a future or past. [30] [31] The symptoms of Haltlose share similarities with frontal lobe syndrome , sociopathic and histrionic personality traits, [30] [32] and are characterized by a lack of inhibition [33] and "the immaturity of moral and volitional qualities...and the absence of positive ethical attitudes." [34] [ unreliable source?
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Wernicke–korsakoff Syndrome
Wikipedia
To date, no such proposals have been enacted. [27] [28] [29] [30] [31] [ excessive citations ] Daily recommendations of thiamine requirements are 0.66 mg/2,000kcal daily or 1.2 mg for adult men and 1.1 mg for adult women per day. [32] Treatment [ edit ] The onset of Wernicke encephalopathy is considered a medical emergency, and thus thiamine administration should be initiated immediately when the disease is suspected. [6] Prompt administration of thiamine to patients with Wernicke encephalopathy can prevent the disorder from developing into Wernicke–Korsakoff syndrome, or reduce its severity.
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Synesthesia
Wikipedia
This form of synesthesia was named as OLP in the contemporary literature by Julia Simner and colleagues [28] although it is now also widely recognised by the term "sequence-personality" synesthesia. ... S2CID 8641750 . ^ a b Herman, Laura M. (28 December 2018). "Synesthesia" . Encyclopaedia Britannica . ... Insight into perception, emotion, and consciousness" . Current Opinion in Neurology . 28 (1): 36–44. doi : 10.1097/WCO.0000000000000169 .
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Dwarfism
Wikipedia
Severe shortness with skeletal distortion also occurs in several of the Mucopolysaccharidoses and other storage disorders . [28] Hypogonadotropic hypogonadism may cause proportionate, yet temporary, dwarfism.TRAIP, ORC1, XRCC4, POC1A, LARP7, WDR4, TG, AMMECR1, DONSON, GMNN, FBXL3, SIN3A, PLK4, EIF4A3, GH1, ERCC4, RSPH4A, PUS7, ACAN, IGF1, WNT4, IGFALS, KDM3B, IQSEC1, HAPLN1, DNMT3A, SLC10A7, SLC2A2, FGFR3, SHOX, IGF1R, RMRP, GHR, PTPN11, PROP1, PWAR1, HMGA2, STAT5B, FBN1, POU1F1, COMP, RTTN, GHSR, ANKRD11, ADAMTS17, PTHLH, GNAS, COL2A1, NBAS, SOX3, DPH1, ORC4, PIK3R1, LMNA, VDR, LEMD3, IGF2, IHH, STAT1, STAT3, SRY, TP53, CDT1, CUL7, ADAMTS10, OBSL1, MCM9, GLB1, OTX2, KMT2D, MMP13, PCNT, RAF1, PTCH1, IDH2, MAP2K1, HOXD13, HRAS, INPP5K, CYP19A1, MAPK1, WWOX, CCDC8, CRIPT, IARS2, PRKAR1A, HSPA9, PDE4D, PPP3CA, ADAMTSL2, PIK3C2A, FLNB, FLNA, ARID1B, COG5, GPD1, RBBP8, FGFR2, THOC2, SRCAP, TRPV4, FGD1, RIT1, IFT57, NR5A1, NSD1, PUF60, SIL1, PPP1R15B, ERCC6, RPS6KA3, SLC29A3, PGM1, GLI2, ATP8B1, PRMT7, HMGB3, B4GALT7, GINS1, SLC35C1, CENPJ, PHEX, SLC39A8, WDR73, ASAH1, LEPR, TSHR, NRAS, NSMCE2, CDK6, TRPS1, TRH, CDC6, TBX1, LMX1B, RUNX2, TOP3A, AVPR2, MLYCD, SMAD4, MMP2, CFAP410, GDF5, ORC6, CTSK, TGM1, NF1, BRCA2, KDM5C, MECP2, BMP2, ASXL1, TWIST1, BMPR1A, KRAS, NLRP3, COL9A3, NSD2, COL9A2, TRMT10A, SPART, INSR, KDM6A, COL1A2, PAPSS2, CCN6, COX2, STS, ARSL, RNU4ATAC, ACP5, CLCN5, SH2B1, KAT6B, SDCCAG8, CPLX1, PARS2, NECAP1, ATP6V0A2, POLR1A, SAMHD1, SHPK, DSTYK, COG4, RAI1, GJB6, NIPBL, NPAP1, RAB3GAP2, KIF1C, TXNL4A, SEPTIN9, IFT27, SPIDR, VPS13A, DMXL2, CNKSR2, NCAPD3, DDHD2, CEP164, KIAA0556, TRAK1, EXOC6B, RAB3GAP1, PNPLA6, ANKLE2, RAB18, POGZ, TAB2, TRIM32, IQSEC2, SIX2, CEP152, CHSY1, SATB2, WASHC4, MRAS, POP1, MAPRE2, SPINK5, HAAO, TLK2, TGDS, CIT, GPR161, POLR3A, AP4E1, EXOSC2, ADNP, AP4S1, RPL35, SPECC1L, TREX1, SZT2, KDM1A, AARS1, STAG2, SYNGAP1, IKBKG, CDK10, CASK, PDE8B, TP63, DCHS1, ABCB11, STX16, MBTPS1, TNFRSF11A, PEX11B, SUCLA2, BANF1, HESX1, SYNJ1, TRIP13, AP1S2, HERC2, FOXH1, BAZ1B, SEMA5A, SLC7A7, SMC3, CTDP1, AP4M1, BUB3, HACD1, BMP15, LARGE1, NOG, KCNAB2, PEX3, PPM1D, OFD1, XPC, XRCC2, YWHAG, ZIC2, MKRN3, ZBTB16, ZNF148, RNF113A, ALMS1, PAX8, AIMP2, KAT6A, LHX3, SHOC2, FGF23, AAAS, AP3B2, MKKS, DGCR6, LZTR1, ESS2, USP9X, SMC1A, NAA10, LAGE3, ARID1A, TRRAP, CDC45, CUL4B, COPB2, TRIP11, YME1L1, MAD2L2, FARSB, ABCB6, HUWE1, PQBP1, MKRN3-AS1, WIPI2, RAD50, AASS, CD96, SF3B4, ZMPSTE24, CWC27, TUBB4A, EMG1, ZBTB18, SNAP29, SEC23B, SEC23A, SEMA3C, DEAF1, HYOU1, RNASEH2A, SLC19A2, COLEC10, MTHFS, KLF1, CTCF, EBP, DLL3, AP4B1, DGCR2, MED12, KIF14, NCAPD2, EFTUD2, LONP1, RECQL4, PEX16, ECEL1, EIF2AK3, CHST3, KIF23, TBX4, ADAMTS2, GTF2IRD1, PREPL, SEC24C, TTC37, IQCB1, CEP135, PUM1, CEP57, SEMA3E, IFT140, HDAC4, PTDSS1, ZBTB24, KIAA0753, SEC24D, TECPR2, FIG4, WASHC5, ARNT2, AUTS2, PAM16, TCTN3, RSPRY1, PHF6, SLX4, GNPTG, KISS1R, HES7, LOXL3, ORAI1, MFSD2A, DISP1, COL27A1, TUBGCP6, LHX4, WDR34, UBE3B, TSR2, RNASEH2C, TMEM67, SLC39A13, ATPAF2, RFT1, COG7, CCNQ, GORAB, BBIP1, MARS2, IFT43, TP53RK, ADAT3, NUS1, ANTXR2, ANTXR1, ATRIP, SDR9C7, PALB2, PORCN, ACD, CPLANE1, DDRGK1, SECISBP2, GNPTAB, RNASEH2B, EFL1, FAT4, ROGDI, MCPH1, USB1, DYNC2H1, TBL1XR1, BBS10, ARL6, TTC21B, CLMP, UBA5, DHDDS, GRHL2, PGAP1, CTC1, CEP290, TTI2, CEP63, LAS1L, CDCA7, SPRTN, BRIP1, CYP2R1, SP7, KIFBP, NIPAL4, STAC3, TCTEX1D2, NALCN, ASPM, NPHP4, SLC13A5, WDR62, SUMF1, PNPLA1, FAM149B1, SNORD115-1, NAT8L, SLC6A19, TUBB2B, HCN1, RSPH9, KIF7, IFITM5, IYD, MYMK, CHCHD10, SOHLH1, GTF2H5, DUOXA2, MIR17HG, LIPN, SDHAF1, PWRN1, SNORD116-1, KLLN, SEMA3D, JMJD1C, TRAPPC6B, A2ML1, TTC8, CANT1, WDR81, CYP4F22, B3GALT6, GJB4, TBC1D20, PROKR2, BBS5, UROC1, DNAJC21, RIPPLY2, AMER1, SLC34A3, GSC, CERS3, MESP2, CKAP2L, CEP120, ESCO2, C8orf37, VPS13B, SASS6, RNF168, BBS12, ARX, ARID2, UBR1, FLCN, TUBB, ARV1, GZF1, NXN, DYNC2LI1, WT1, WDPCP, MLXIPL, IFT52, ABHD5, RDH11, SBDS, RLIM, NIN, TMEM216, DACT1, MBTPS2, ACTL6B, UFC1, OTUD6B, SOST, PTRH2, SUFU, RAB23, RTEL1, ATP8A2, MAP3K20, ADA2, FGFRL1, RIN2, RNF216, DGCR8, TMCO1, NDUFB11, MAGEL2, TPRKB, TBX22, LMBR1, TUBGCP4, ZBTB20, TRAF3IP1, ABCA12, IFT172, PTPN22, PHGDH, B3GAT3, TINF2, TBL2, CYFIP2, NPHP3, AFF4, INVS, INTU, BBS9, PDE11A, PCLO, DLL1, CCDC22, LAMTOR2, OSTM1, SETD2, UBE2T, PSMC3IP, PYCR2, GMPPA, SEC61A1, SLC25A24, DUOX2, CDON, LZTFL1, SAMD9, NDE1, WDR35, MCTP2, TMEM165, HDAC8, ZC4H2, MRPS22, FAM20C, KIF15, KNL1, PNPLA2, NUP107, SALL4, SELENON, SHROOM4, HACE1, IFT80, BCOR, FANCM, EPG5, WDR19, NLRC4, ALOXE3, FKBP10, TRAPPC11, PIEZO2, FAM111A, PRDM16, SMOC1, XYLT1, IFIH1, STRA6, MBD5, TBC1D23, CDK5RAP2, NUP133, NSUN2, NCAPG2, MKS1, IMPAD1, PPP2R3C, WDR60, FANCL, RBM28, WRAP53, MSTO1, RFWD3, SETD5, BBS7, FANCI, MAP11, VPS53, UFSP2, ACER3, NOP10, RNPC3, SLC39A4, CHD7, OSGEP, NHP2, PEX26, VAC14, POLR3B, WDR11, HHAT, XPA, VCP, WRN, GYS2, GLI3, GM2A, GP1BB, GRIA3, GRIA4, GRIN2A, GRIN2D, GRM1, GTF2E2, GTF2I, BRF1, GUSB, HBA1, GLA, HBA2, HCCS, HCFC1, HELLS, HLA-DQA1, HLA-DQB1, HNF4A, HNRNPA1, HNRNPA2B1, HNRNPH2, HNRNPU, HPRT1, GLE1, GK, GPC4, FZD2, FGF12, FGFR1, FOXE1, FLI1, FLII, FMR1, AFF2, FN1, FSHR, FUCA1, FUT8, KDSR, G6PC, GJB3, SLC37A4, GABRB2, GABRD, GABRG2, GAS1, GATA1, GATA4, GBA, GDNF, GHRHR, GJA1, GJB2, HSD11B2, HSD17B4, HSPG2, RNR1, KMT2A, MMP9, MPL, MPV17, MRE11, ATP6, COX1, COX3, ND1, ND4, ND5, ND6, TRNF, HYAL1, TRNH, TRNK, TRNL1, TRNP, TRNQ, TRNS1, TRNS2, TRNW, TRIM37, MVK, MYH3, MYH7, MGP, MGAT2, MEIS2, MAF, IDH1, IDS, IDUA, IGBP1, INPPL1, IPW, ITGA7, ITGB6, WNT7A, KCNA4, KCNB1, KCNC3, KCNJ1, KIF11, KIF22, L1CAM, LETM1, LFNG, LHX1, LIFR, LIG4, LIMK1, LRP5, LTBP2, LTBP3, FGF8, FANCG, MYL2, CACNA1A, BDNF, BLM, BMPR1B, BRCA1, BRAF, BTK, BUB1, BUB1B, C1R, C1S, CA2, CA8, CACNA1B, BBS4, CASP8, CASR, CAV1, SERPINH1, CDH3, CDKN1C, CDSN, CENPE, CHD4, CHRNA7, CHRNG, CLCN7, BCR, BBS2, FANCF, ANK1, ACTA1, ACTB, ADAR, AGA, AGL, AHSG, AKT1, ALDH3A2, ALDOA, ALOX12B, ALPL, AMPD2, FAS, BBS1, AQP2, ARVCF, ASL, ATM, RERE, ATP5F1D, ATP6V1A, ATP6V1B2, ATP6V1E1, ATP7A, ATR, ATRX, CLTC, COL1A1, COL3A1, ERCC1, SLC26A2, DVL1, DVL3, ECE1, EDN3, EDNRB, PHC1, EEF1A2, EFNB1, EHHADH, ELN, EP300, ERCC2, COL5A1, ERCC3, ERCC5, ERF, EXT1, EXT2, EYA1, FANCA, FANCC, FANCD2, FANCE, BPTF, FANCB, DPP6, DNMT3B, DYNC1I2, DNA2, COL5A2, COL6A2, COL9A1, COL11A1, COL11A2, COMT, COX7B, CREBBP, CRKL, NKX2-5, CTBP1, CTNS, CTNND2, CYB5A, CYP11B1, CYP17A1, CYP27B1, DDB2, DDOST, DHCR7, DHCR24, DIAPH1, DKC1, DMP1, DNM1, MYH8, KCNA2, RPS28, STIM1, RB1, TBCE, MAP3K7, TAF13, TAF6, SULT2B1, DPF2, RET, RFC2, STXBP1, ROBO1, RAP1B, RPL5, RPL10, RPL11, RPL15, RPL18, RPL26, RPL27, RPL35A, RPS7, RPS10, RASA2, RAP1A, TFAP2A, PEX2, PPP1CB, PRKACA, MAP2K2, DNAJC3, PRPS1, TERT, PTEN, PTH1R, TERC, PEX19, TDGF1, TBX2, PEX5, PYCR1, HNF1B, ALDH18A1, PYGL, TBX3, RAD51, TBX15, RAD51C, TBX6, RPS15A, RPS17, RPS19, SLC4A1, SON, STIL, SIM1, SIX3, SKI, SKIV2L, SLC1A2, SNRPN, SNRPB, SLC2A1, SLC5A5, RPS23, SMS, SLC6A8, SLC12A1, SLC34A1, SMPD1, SMARCA2, SMARCA4, SMARCB1, SMARCC2, SMARCE1, SOS1, SHH, SDHD, SOS2, RPS24, RPS26, RPS27, NBN, RPS29, RRAS, RREB1, SALL1, MSMO1, SRP54, SPARC, SCN3A, SCN4A, SOX11, SOX9, SCN8A, SOX4, SDHA, SOX2, SDHB, SDHC, CTSA, RAD21, PCCA, PCYT1A, PDE6D, NRTN, ENPP1, TTN, SLC26A4, PEX1, NPR2, PEX6, TPO, PEX7, PARN, PEX12, PEX13, NPHP1, TPM3, TPM2, PEX14, PDE3A, PCNA, PHKA2, PCCB, PAX1, ABL1, P4HB, UROS, VLDLR, SIX6, TNFRSF11B, PAX6, SLC35A2, UFD1, UBE3A, OGDH, HIRA, OCRL, ROR2, NTRK2, POR, PGM3, PEX10, NEK1, WHCR, PLEC, TGIF1, POLA1, NFE2L2, WNT5A, NODAL, WNT1, NEU1, POLE, PLP1, TGFB3, NOTCH2, PLOD2, PHKG2, PHKB, CLIP2, TNNI2, TNNT3, PIK3CA, NDN, NOTCH3, NKX2-1, NPPC, PTH, IGFBP3, PRL, SLC52A2, NR1I2, F2R, COL10A1, SLC20A1, DMD, PAPPA2, BRD2, GHRH, EVC2, MRX49, NELL1, HIP1, REN, THRA, ADIPOQ, SMPD3, RAC1, COX4I1, CSH2, ZFY, H19-ICR, CSH1, CSF2RA, MIRLET7B, MIR140, CSF2, SNCA, NF1P1, DIRAS3, MAP3K8, SOAT1, KALRN, MTCO2P12, SOD1, BEST1, SPRED2, TWIST2, CD38, RUNX1, DSG4, PPP4R2, SERPINA7, TIMP3, NPAS4, SHOC1, TH, CYP2C19, HNF1A, AVP, AZF1, CND, LCORL, ZBTB38, TGFBR2, CCND1, BCL2, BLVRB, TGFB1, BGN, SLC4A4, OSR1, VCAM1, CDKN2A, CNP, UGDH, CLCN4, ERCC8, ALPP, SST, TYRP1, AR, ARSB, STAT5A, FIGLA, STC1, CYP26C1, CHD2, SULT1E1, GBF1, NEXMIF, CDKN3, CDKN2D, DIS3L2, ATHS, CYP2B6, ORC3, CYP2C9, ECA1, SOX21, HGH1, IL3RA, IL3, IGSF1, IGHD, CCN1, VTA1, SIRT6, IL23A, IGFBP1, LSR, ATP6V1H, SDS, HTC2, CCL27, POLD1, POMC, HOXB2, HOXA5, PPA1, SLC38A2, HLA-DRB5, DYM, H1-3, IGF2BP3, GSS, CRYL1, LEP, CYP2C18, NEUROG3, MUC1, NFIX, NFKB1, TONSL, SIRT1, ATRNL1, ABHD12, MTR, ODC1, NBEA, PMPCA, MMP14, SLC39A1, KITLG, CUL9, PDLIM3, SLCO1B3, MDK, MCM5, MCM4, COA3, MCM2, MCL1, PHPT1, MAP4, PAX7, SLC39A2, ATG7, GPT, GP1BA, NAT10, F8, KMT2B, HHIP, RMND5B, RMND5A, ESR1, CCL18, WNK4, EPHB2, EPHA4, EPHA3, EIF4G1, EIF4E, EGR3, MEGF8, NR1D1, H6PD, TBPL1, DYRK1A, ASRGL1, NAPSA, DRD2, COASY, DRD1, ITCH, SLC6A3, SLPI, F9, NCAPG, F10, GAPDH, GLUD1, QRSL1, GPC3, REG1A, SEMA3A, MMDK, GFPT1, NBPF1, KATNB1, GCK, GCH1, GCG, GALNS, RB1CC1, CSGALNACT1, PAG1, ROS1, CEBPZ, MOSPD1, RETN, RPL13, FSHB, PPP4R3B, FHL1, FGF13, FGF2, H3P13
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Biphobia
Wikipedia
This is despite the fact that bisexual people are as capable of monogamy or serial monogamy as homosexuals or heterosexuals. [28] Effects [ edit ] The mental and sexual health effects of biphobia on bisexual people are numerous. ... Bisexuality and the Eroticism of Everyday Life , pp. 20–21, 28, 39. Fraser, M., Identity Without Selfhood: Simone de Beauvoir and Bisexuality , Cambridge and New York: Cambridge University Press 1999. p. 124–140.
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Fecal Incontinence
Wikipedia
The ICD-10 classifies nonorganic encopresis under "behavioural and emotional disorders with onset usually occurring in childhood and adolescence" and organic causes of encopresis along with FI. [28] FI can also be classified according to gender, since the cause in females may be different from males, for example it may develop following radical prostatectomy in males, [29] whereas females may develop FI as an immediate or delayed consequence of damage whilst giving birth.TBX1, ZFYVE26, TBCD, HIRA, UFD1, VCP, USP7, TP63, SEC24C, LRIG2, SLC9A6, NOP56, ATP13A2, DSTYK, SLC16A2, FLVCR1, DACT1, GATAD2B, HPSE2, IRF2BPL, FA2H, FUZ, SPG11, VANGL1, C19orf12, HGSNAT, ABCD1, JMJD1C, GP1BB, B2M, BCR, ARVCF, COMT, CRKL, ARSA, FMR1, SGSH, ISL1, KMT2A, NAGLU, PLP1, MAPK1, PSAP, RREB1, RTN2, SALL1, SCN4A, SCN8A, ADGRB2, PAEP, AMBP, CREB3L1, ARMC9, SLC6A8, CALCR, CALR, DNMT3B, RYBP, AKR1A1, ACHE
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Porphyria
Wikipedia
In the United Kingdom, supplies of NormoSang are kept at two national centers; emergency supply is available from St Thomas's Hospital , London. [27] In the United States, Lundbeck manufactures and supplies Panhematin for infusion. [28] Heme arginate (NormoSang) is used during crises but also in preventive treatment to avoid crises, one treatment every 10 days. [ citation needed ] Any sign of low blood sodium ( hyponatremia ) or weakness should be treated with the addition of hematin, heme arginate, or even tin mesoporphyrin , as these are signs of impending syndrome of inappropriate antidiuretic hormone (SIADH) or peripheral nervous system involvement that may be localized or severe, progressing to bulbar paresis and respiratory paralysis. [ citation needed ] Cimetidine [ edit ] Cimetidine has also been reported to be effective for acute porphyric crisis and possibly effective for long-term prophylaxis. [29] Symptom control [ edit ] Pain is severe, frequently out of proportion to physical signs, and often requires the use of opiates to reduce it to tolerable levels.