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Autoimmune Hepatitis
Wikipedia
External links [ edit ] Classification D ICD - 10 : K75.4 ICD - 9-CM : 571.42 MeSH : D019693 DiseasesDB : 1150 External resources MedlinePlus : 000245 eMedicine : med/366 v t e Diseases of the digestive system Upper GI tract Esophagus Esophagitis Candidal Eosinophilic Herpetiform Rupture Boerhaave syndrome Mallory–Weiss syndrome UES Zenker's diverticulum LES Barrett's esophagus Esophageal motility disorder Nutcracker esophagus Achalasia Diffuse esophageal spasm Gastroesophageal reflux disease (GERD) Laryngopharyngeal reflux (LPR) Esophageal stricture Megaesophagus Esophageal intramural pseudodiverticulosis Stomach Gastritis Atrophic Ménétrier's disease Gastroenteritis Peptic (gastric) ulcer Cushing ulcer Dieulafoy's lesion Dyspepsia Pyloric stenosis Achlorhydria Gastroparesis Gastroptosis Portal hypertensive gastropathy Gastric antral vascular ectasia Gastric dumping syndrome Gastric volvulus Buried bumper syndrome Gastrinoma Zollinger–Ellison syndrome Lower GI tract Enteropathy Small intestine ( Duodenum / Jejunum / Ileum ) Enteritis Duodenitis Jejunitis Ileitis Peptic (duodenal) ulcer Curling's ulcer Malabsorption : Coeliac Tropical sprue Blind loop syndrome Small bowel bacterial overgrowth syndrome Whipple's Short bowel syndrome Steatorrhea Milroy disease Bile acid malabsorption Large intestine ( Appendix / Colon ) Appendicitis Colitis Pseudomembranous Ulcerative Ischemic Microscopic Collagenous Lymphocytic Functional colonic disease IBS Intestinal pseudoobstruction / Ogilvie syndrome Megacolon / Toxic megacolon Diverticulitis / Diverticulosis / SCAD Large and/or small Enterocolitis Necrotizing Gastroenterocolitis IBD Crohn's disease Vascular : Abdominal angina Mesenteric ischemia Angiodysplasia Bowel obstruction : Ileus Intussusception Volvulus Fecal impaction Constipation Diarrhea Infectious Intestinal adhesions Rectum Proctitis Radiation proctitis Proctalgia fugax Rectal prolapse Anismus Anal canal Anal fissure / Anal fistula Anal abscess Hemorrhoid Anal dysplasia Pruritus ani GI bleeding Blood in stool Upper Hematemesis Melena Lower Hematochezia Accessory Liver Hepatitis Viral hepatitis Autoimmune hepatitis Alcoholic hepatitis Cirrhosis PBC Fatty liver NASH Vascular Budd–Chiari syndrome Hepatic veno-occlusive disease Portal hypertension Nutmeg liver Alcoholic liver disease Liver failure Hepatic encephalopathy Acute liver failure Liver abscess Pyogenic Amoebic Hepatorenal syndrome Peliosis hepatis Metabolic disorders Wilson's disease Hemochromatosis Gallbladder Cholecystitis Gallstone / Cholelithiasis Cholesterolosis Adenomyomatosis Postcholecystectomy syndrome Porcelain gallbladder Bile duct / Other biliary tree Cholangitis Primary sclerosing cholangitis Secondary sclerosing cholangitis Ascending Cholestasis / Mirizzi's syndrome Biliary fistula Haemobilia Common bile duct Choledocholithiasis Biliary dyskinesia Sphincter of Oddi dysfunction Pancreatic Pancreatitis Acute Chronic Hereditary Pancreatic abscess Pancreatic pseudocyst Exocrine pancreatic insufficiency Pancreatic fistula Other Hernia Diaphragmatic Congenital Hiatus Inguinal Indirect Direct Umbilical Femoral Obturator Spigelian Lumbar Petit's Grynfeltt-Lesshaft Undefined location Incisional Internal hernia Richter's Peritoneal Peritonitis Spontaneous bacterial peritonitis Hemoperitoneum Pneumoperitoneum v t e Hypersensitivity and autoimmune diseases Type I / allergy / atopy ( IgE ) Foreign Atopic eczema Allergic urticaria Allergic rhinitis (Hay fever) Allergic asthma Anaphylaxis Food allergy common allergies include: Milk Egg Peanut Tree nut Seafood Soy Wheat Penicillin allergy Autoimmune Eosinophilic esophagitis Type II / ADCC IgM IgG Foreign Hemolytic disease of the newborn Autoimmune Cytotoxic Autoimmune hemolytic anemia Immune thrombocytopenic purpura Bullous pemphigoid Pemphigus vulgaris Rheumatic fever Goodpasture syndrome Guillain–Barré syndrome " Type V "/ receptor Graves' disease Myasthenia gravis Pernicious anemia Type III ( Immune complex ) Foreign Henoch–Schönlein purpura Hypersensitivity vasculitis Reactive arthritis Farmer's lung Post-streptococcal glomerulonephritis Serum sickness Arthus reaction Autoimmune Systemic lupus erythematosus Subacute bacterial endocarditis Rheumatoid arthritis Type IV / cell-mediated ( T cells ) Foreign Allergic contact dermatitis Mantoux test Autoimmune Diabetes mellitus type 1 Hashimoto's thyroiditis Multiple sclerosis Coeliac disease Giant-cell arteritis Postorgasmic illness syndrome Reactive arthritis GVHD Transfusion-associated graft versus host disease Unknown/ multiple Foreign Hypersensitivity pneumonitis Allergic bronchopulmonary aspergillosis Transplant rejection Latex allergy (I+IV) Autoimmune Sjögren syndrome Autoimmune hepatitis Autoimmune polyendocrine syndrome APS1 APS2 Autoimmune adrenalitis Systemic autoimmune diseaseIL10, IFNG, IL4, IL2, IL6, IL5, IL13, IL22, TGFB1, CXCL1, IL9, ALDOB, IL18, LEP, CCL2, CCL5, C1S, PDIA3, HLA-DQB1, SH2B3, HLA-DQA1, TNF, HLA-DQA2, HLA-DRB1, CYP2D6, ATXN2, RBM45, CTLA4, SEPSECS, GPT, AMELX, FOXP3, IL2RA, ISG20, PSC, HLA-DPB1, AIRE, VDR, PDCD1, FTCD, IL1B, HLA-DRB3, HLA-A, ENAM, TPMT, ACTB, HLA-DOA, GSTT1, HLA-DRB4, CYP1A2, LOC107987479, HPGDS, PPIG, PTPN22, CD28, IL17A, LGALS3BP, TRIM21, MIR223, IFNB1, LGALS9, CXCR1, KIR3DL1, TBX21, CXCL10, MLKL, CD274, HAVCR2, HAMP, RETN, IL1RN, MIF, CYP2D7, HLA-B, FH, GATA3, GEM, FAS, ALB, DLAT, HLA-C, CYP2B6, ICOS, IL37, IL17C, CD74, CD40LG, CARD10, ABCC4, SLC17A5, NOX4, CD1D, CASP1, C4A, GOLM1, KRT20, MS4A1, CHRNA4, CRP, SMUG1, MPRIP, NUDT15, KLRK1, ABCC2, RIPK3, BTG3, CCR7, FGL2, CCR3, TNFSF13B, TNIP1, IFNA1, ASPH, RNPC3, FASLG, ADA, KLRC4-KLRK1, CD24, SYCE1L, TEC, MIR155, MIR143, C6orf120, GSTK1, PGAM5, IL34, KLF14, SLCO6A1, IL17RE, FCRL3, WDR11, NLRP3, IL33, ARG1, JAM3, PDCD1LG2, TNFAIP8L2, IL25, HHIP, KLHL12, IL21, ARSA, KLHL1, TNFRSF14, MYDGF, MSC, UMOD, OGT, GABPA, CD200, MMP1, DNASE1, ATN1, FBL, FANCC, KRT18, KRT8, FCGR2A, KIR2DS1, FCGR2B, INPP5D, INS, IDO1, GATA2, CDR3, GCG, GLI2, CXCL8, IL7R, GPR39, NR3C1, IL4R, GSTM1, GSTM2, HK1, IL1A, HRAS, HSPD1, IFNA13, NFE2L2, NOS2, OCA2, OPRD1, YY1, IFNA2, TSHR, TRAF6, NR2C2, TPO, CYP2C19, TNFAIP3, CYP2C9, TLR3, TLR2, TG, TRBV20OR9-2, MAP3K7, STXBP2, STAT4, CYP2E1, SLC2A3, CXCL12, CYP3A4, DBT, DCK, S100B, S100A1, RPS20, RORC, PTPRC, POMC, PDC, ACTA1
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Torsades De Pointes
Wikipedia
At least one mention of the common over-the-counter medication loperamide causing TdP has been made in the literature, although the dose preceding this particular cardiac event was well beyond the therapeutic range of the medication. [5] In addition, patients with inherited long QT syndrome have a very high risk of episodes of TdP and that risk can be further increased by drugs and electrolyte disorders that further prolong QT. ... Torsades de pointes is associated with long QT syndrome , a condition whereby prolonged QT intervals are visible on an ECG. ... "Genotype and clinical characteristics of congenital long QT syndrome in Thailand" . Indian Pacing and Electrophysiology Journal . 18 (5): 165–171. doi : 10.1016/j.ipej.2018.07.007 . ... "Successful uses of magnesium sulfate for torsades de pointes in children with long QT syndrome". Pediatrics International . 48 (2): 112–117. doi : 10.1111/j.1442-200X.2006.02177.x . ... PMID 26318695 . ^ a b Moise NS (1999), "As Americans, we should get this right [correspondence and response]", Circulation , 100 (13): 1462, doi : 10.1161/01.CIR.100.13.1462 , PMID 10500317 . ^ Mullins ME (2011), "Mon bête noir (my pet peeve)", Journal of Medical Toxicology , 7 (2): 181, doi : 10.1007/s13181-011-0153-7 , PMID 21461788 Classification D MeSH : D016171 DiseasesDB : 29252 External resources eMedicine : med/2286 emerg/596 Patient UK : Torsades de pointes v t e Cardiovascular disease (heart) Ischaemic Coronary disease Coronary artery disease (CAD) Coronary artery aneurysm Spontaneous coronary artery dissection (SCAD) Coronary thrombosis Coronary vasospasm Myocardial bridge Active ischemia Angina pectoris Prinzmetal's angina Stable angina Acute coronary syndrome Myocardial infarction Unstable angina Sequelae hours Hibernating myocardium Myocardial stunning days Myocardial rupture weeks Aneurysm of heart / Ventricular aneurysm Dressler syndrome Layers Pericardium Pericarditis Acute Chronic / Constrictive Pericardial effusion Cardiac tamponade Hemopericardium Myocardium Myocarditis Chagas disease Cardiomyopathy Dilated Alcoholic Hypertrophic Tachycardia-induced Restrictive Loeffler endocarditis Cardiac amyloidosis Endocardial fibroelastosis Arrhythmogenic right ventricular dysplasia Endocardium / valves Endocarditis infective endocarditis Subacute bacterial endocarditis non-infective endocarditis Libman–Sacks endocarditis Nonbacterial thrombotic endocarditis Valves mitral regurgitation prolapse stenosis aortic stenosis insufficiency tricuspid stenosis insufficiency pulmonary stenosis insufficiency Conduction / arrhythmia Bradycardia Sinus bradycardia Sick sinus syndrome Heart block : Sinoatrial AV 1° 2° 3° Intraventricular Bundle branch block Right Left Left anterior fascicle Left posterior fascicle Bifascicular Trifascicular Adams–Stokes syndrome Tachycardia ( paroxysmal and sinus ) Supraventricular Atrial Multifocal Junctional AV nodal reentrant Junctional ectopic Ventricular Accelerated idioventricular rhythm Catecholaminergic polymorphic Torsades de pointes Premature contraction Atrial Junctional Ventricular Pre-excitation syndrome Lown–Ganong–Levine Wolff–Parkinson–White Flutter / fibrillation Atrial flutter Ventricular flutter Atrial fibrillation Familial Ventricular fibrillation Pacemaker Ectopic pacemaker / Ectopic beat Multifocal atrial tachycardia Pacemaker syndrome Parasystole Wandering atrial pacemaker Long QT syndrome Andersen–Tawil Jervell and Lange-Nielsen Romano–Ward Cardiac arrest Sudden cardiac death Asystole Pulseless electrical activity Sinoatrial arrest Other / ungrouped hexaxial reference system Right axis deviation Left axis deviation QT Short QT syndrome T T wave alternans ST Osborn wave ST elevation ST depression Strain pattern Cardiomegaly Ventricular hypertrophy Left Right / Cor pulmonale Atrial enlargement Left Right Athletic heart syndrome Other Cardiac fibrosis Heart failure Diastolic heart failure Cardiac asthma Rheumatic feverKCNH2, SCN5A, CYP3A4, KCNQ1, KCNE1, ANK2, KCNE2, NAA10, KCNJ5, SCN4B, SCN10A, SNTA1, ALG10B, CAV3, CALM2, CALM1, AKAP9, TRDN, C18orf21, NOS1AP, IL6, KCNK3, KCNA5, ATP12A, ATP4A, CYP19A1, KCNA4, ACE, SLC24A3, SLCO3A1, RAPGEF4, SLCO1B1, ATP5F1A, CRP, CYP2D6, NR1I2, TNF, SRL, SARDH, TLX2, HTR4, RYR2, RNPEP, ABCB1, ORM1, MSD, LBR, IL1A, ADRB1, IL1B, ADRA2C
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Glut1 Deficiency Syndrome 2
Omim
Allelic disorders with overlapping features include GLUT1 deficiency syndrome-1 (GLUT1DS1; 606777), dystonia-9 (DYT9; 601042), and idiopathic generalized epilepsy-12 (EIG12; 614847). Description GLUT1 deficiency syndrome-2 is an autosomal dominant disorder characterized primarily by onset in childhood of paroxysmal exercise-induced dyskinesia. ... One family has been reported with the additional feature of hemolytic anemia (Weber et al., 2008). GLUT1 deficiency syndrome-2 shows wide clinical variability both within and between affected families. ... Joshi et al. (2008) reported a 13-year-old boy with a history of ataxia since early childhood who was diagnosed with GLUT1 deficiency syndrome after onset of epilepsy at age 11 years. ... Roubergue et al. (2011) reported a 20-year-old girl with GLUT1 deficiency syndrome-2, confirmed by genetic analysis, who presented at age 11 years with action tremor and a 'jerky' voice.
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Peritonitis
Wikipedia
Peritonitis Other names Surgical abdomen, acute abdomen [1] Peritonitis from tuberculosis Pronunciation / p ɛ r ɪ t ə ˈ n aɪ t ɪ s / Specialty Emergency medicine , general surgery Symptoms Severe pain, swelling of the abdomen, fever [2] [3] Complications Shock , acute respiratory distress syndrome [4] [5] Usual onset Sudden [1] Types Primary, secondary [1] Causes Perforation of the intestinal tract , pancreatitis , pelvic inflammatory disease , cirrhosis , ruptured appendix [3] Risk factors Ascites , peritoneal dialysis [4] Diagnostic method Examination , blood tests , medical imaging [6] Treatment Antibiotics , intravenous fluids , pain medication , surgery [3] [4] Frequency Relatively common [1] Peritonitis is inflammation of the peritoneum , the lining of the inner wall of the abdomen and cover of the abdominal organs . [2] Symptoms may include severe pain, swelling of the abdomen, fever, or weight loss. [2] [3] One part or the entire abdomen may be tender. [1] Complications may include shock and acute respiratory distress syndrome . [4] [5] Causes include perforation of the intestinal tract , pancreatitis , pelvic inflammatory disease , stomach ulcer , cirrhosis , or a ruptured appendix . [3] Risk factors include ascites and peritoneal dialysis . [4] Diagnosis is generally based on examination , blood tests , and medical imaging . [6] Treatment often includes antibiotics , intravenous fluids , pain medication , and surgery. [3] [4] Other measures may include a nasogastric tube or blood transfusion . [4] Without treatment death may occur within a few days. [4] Approximately 7.5% of people have appendicitis at some point in time. [1] About 20% of people with cirrhosis who are hospitalized have peritonitis. [1] Contents 1 Signs and symptoms 1.1 Abdominal pain 1.2 Other symptoms 1.3 Complications 2 Causes 2.1 Infection 2.2 Non-infection 2.3 Risk factors 3 Diagnosis 3.1 Pathology 4 Treatment 5 Prognosis 6 Etymology 7 References 8 External links Signs and symptoms [ edit ] This section needs more medical references for verification or relies too heavily on primary sources . ... Examples include perforation of the distal esophagus ( Boerhaave syndrome ), of the stomach ( peptic ulcer , gastric carcinoma ), of the duodenum (peptic ulcer), of the remaining intestine (e.g., appendicitis, diverticulitis, Meckel diverticulum , inflammatory bowel disease (IBD), intestinal infarction , intestinal strangulation, colorectal carcinoma , meconium peritonitis ), or of the gallbladder ( cholecystitis ). ... Much rarer non-infectious causes may include familial Mediterranean fever , TNF receptor associated periodic syndrome , porphyria , and systemic lupus erythematosus . ... External links [ edit ] Classification D ICD - 10 : K65 ICD - 9-CM : 567 MeSH : D010538 DiseasesDB : 9860 External resources MedlinePlus : 001335 eMedicine : med/2737 Patient UK : Peritonitis v t e Diseases of the digestive system Upper GI tract Esophagus Esophagitis Candidal Eosinophilic Herpetiform Rupture Boerhaave syndrome Mallory–Weiss syndrome UES Zenker's diverticulum LES Barrett's esophagus Esophageal motility disorder Nutcracker esophagus Achalasia Diffuse esophageal spasm Gastroesophageal reflux disease (GERD) Laryngopharyngeal reflux (LPR) Esophageal stricture Megaesophagus Esophageal intramural pseudodiverticulosis Stomach Gastritis Atrophic Ménétrier's disease Gastroenteritis Peptic (gastric) ulcer Cushing ulcer Dieulafoy's lesion Dyspepsia Pyloric stenosis Achlorhydria Gastroparesis Gastroptosis Portal hypertensive gastropathy Gastric antral vascular ectasia Gastric dumping syndrome Gastric volvulus Buried bumper syndrome Gastrinoma Zollinger–Ellison syndrome Lower GI tract Enteropathy Small intestine ( Duodenum / Jejunum / Ileum ) Enteritis Duodenitis Jejunitis Ileitis Peptic (duodenal) ulcer Curling's ulcer Malabsorption : Coeliac Tropical sprue Blind loop syndrome Small bowel bacterial overgrowth syndrome Whipple's Short bowel syndrome Steatorrhea Milroy disease Bile acid malabsorption Large intestine ( Appendix / Colon ) Appendicitis Colitis Pseudomembranous Ulcerative Ischemic Microscopic Collagenous Lymphocytic Functional colonic disease IBS Intestinal pseudoobstruction / Ogilvie syndrome Megacolon / Toxic megacolon Diverticulitis / Diverticulosis / SCAD Large and/or small Enterocolitis Necrotizing Gastroenterocolitis IBD Crohn's disease Vascular : Abdominal angina Mesenteric ischemia Angiodysplasia Bowel obstruction : Ileus Intussusception Volvulus Fecal impaction Constipation Diarrhea Infectious Intestinal adhesions Rectum Proctitis Radiation proctitis Proctalgia fugax Rectal prolapse Anismus Anal canal Anal fissure / Anal fistula Anal abscess Hemorrhoid Anal dysplasia Pruritus ani GI bleeding Blood in stool Upper Hematemesis Melena Lower Hematochezia Accessory Liver Hepatitis Viral hepatitis Autoimmune hepatitis Alcoholic hepatitis Cirrhosis PBC Fatty liver NASH Vascular Budd–Chiari syndrome Hepatic veno-occlusive disease Portal hypertension Nutmeg liver Alcoholic liver disease Liver failure Hepatic encephalopathy Acute liver failure Liver abscess Pyogenic Amoebic Hepatorenal syndrome Peliosis hepatis Metabolic disorders Wilson's disease Hemochromatosis Gallbladder Cholecystitis Gallstone / Cholelithiasis Cholesterolosis Adenomyomatosis Postcholecystectomy syndrome Porcelain gallbladder Bile duct / Other biliary tree Cholangitis Primary sclerosing cholangitis Secondary sclerosing cholangitis Ascending Cholestasis / Mirizzi's syndrome Biliary fistula Haemobilia Common bile duct Choledocholithiasis Biliary dyskinesia Sphincter of Oddi dysfunction Pancreatic Pancreatitis Acute Chronic Hereditary Pancreatic abscess Pancreatic pseudocyst Exocrine pancreatic insufficiency Pancreatic fistula Other Hernia Diaphragmatic Congenital Hiatus Inguinal Indirect Direct Umbilical Femoral Obturator Spigelian Lumbar Petit's Grynfeltt-Lesshaft Undefined location Incisional Internal hernia Richter's Peritoneal Peritonitis Spontaneous bacterial peritonitis Hemoperitoneum Pneumoperitoneum Authority control NDL : 00563626 NSK : 001939329
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Neurological Disorder
Wikipedia
Identifiers MeSH D009422 Anatomical terminology [ edit on Wikidata ] Brain : Brain damage according to cerebral lobe (see also 'lower' brain areas such as basal ganglia , cerebellum , brainstem ) : Frontal lobe damage Parietal lobe damage Temporal lobe damage Occipital lobe damage Brain dysfunction according to type: Aphasia (language) Dysgraphia (writing) Dysarthria (speech) Apraxia (patterns or sequences of movements) Agnosia (identifying things or people) Amnesia (memory) Spinal cord disorders (see spinal pathology , injury , inflammation ) Peripheral neuropathy and other Peripheral nervous system disorders Cranial nerve disorder such as Trigeminal neuralgia Autonomic nervous system disorders such as dysautonomia , multiple system atrophy Seizure disorders such as epilepsy Movement disorders of the central and peripheral nervous system such as Parkinson's disease , essential tremor , amyotrophic lateral sclerosis , Tourette's syndrome , multiple sclerosis and various types of peripheral neuropathy Sleep disorders such as narcolepsy Migraines and other types of headache such as cluster headache and tension headache Lower back and neck pain (see back pain ) Central neuropathy (see neuropathic pain ) Neuropsychiatric illnesses (diseases and/or disorders with psychiatric features associated with known nervous system injury, underdevelopment, biochemical, anatomical, or electrical malfunction, and/or disease pathology e.g. attention deficit hyperactivity disorder , autism , Asperger syndrome , Tourette's syndrome and some cases of obsessive compulsive disorder as well as the neurobehavioral associated symptoms of degeneratives of the nervous system such as Parkinson's disease , essential tremor , Huntington's disease , Alzheimer's disease , multiple sclerosis and organic psychosis.) Many of the diseases and disorders listed above have neurosurgical treatments available (e.g. Tourette's syndrome , Parkinson's disease , essential tremor and obsessive compulsive disorder ). ... There are also conditions viewed as neurological where a person appears to consciously register neurological stimuli that cannot possibly be coming from the part of the nervous system to which they would normally be attributed, such as phantom pain or synesthesia , or where limbs act without conscious direction, as in alien hand syndrome . Theories and assumptions about consciousness , free will , moral responsibility and social stigma can play a part in this, whether from the perspective of the clinician or the patient. ... Retrieved 2010-01-27 . ^ Merck Veterinary Manual - Reproductive System ^ Butler, C (1 March 2005). "Neurological syndromes which can be mistaken for psychiatric conditions" . ... PMID 27719835 . ^ NIMH publications (2009) Neuroimaging and Mental Illness External links [ edit ] Classification D ICD - 10 : Xxx.x ICD - 9-CM : xxx MeSH : D009422 Disorder Index of the National Institute of Neurological Disorders and Stroke v t e Nervous system Central nervous system Meninges Spinal cord Brain Hindbrain Medulla Pons Cerebellum Midbrain Forebrain Diencephalon Retina Optic nerve Cerebrum Limbic system Peripheral nervous system Somatic Sensory nerve Motor nerve Cranial nerve Spinal nerve Autonomic Sympathetic Parasympathetic Enteric v t e Mental and behavioral disorders Adult personality and behavior Gender dysphoria Ego-dystonic sexual orientation Paraphilia Fetishism Voyeurism Sexual maturation disorder Sexual relationship disorder Other Factitious disorder Munchausen syndrome Intermittent explosive disorder Dermatillomania Kleptomania Pyromania Trichotillomania Personality disorder Childhood and learning Emotional and behavioral ADHD Conduct disorder ODD Emotional and behavioral disorders Separation anxiety disorder Movement disorders Stereotypic Social functioning DAD RAD Selective mutism Speech Stuttering Cluttering Tic disorder Tourette syndrome Intellectual disability X-linked intellectual disability Lujan–Fryns syndrome Psychological development ( developmental disabilities ) Pervasive Specific Mood (affective) Bipolar Bipolar I Bipolar II Bipolar NOS Cyclothymia Depression Atypical depression Dysthymia Major depressive disorder Melancholic depression Seasonal affective disorder Mania Neurological and symptomatic Autism spectrum Autism Asperger syndrome High-functioning autism PDD-NOS Savant syndrome Dementia AIDS dementia complex Alzheimer's disease Creutzfeldt–Jakob disease Frontotemporal dementia Huntington's disease Mild cognitive impairment Parkinson's disease Pick's disease Sundowning Vascular dementia Wandering Other Delirium Organic brain syndrome Post-concussion syndrome Neurotic , stress -related and somatoform Adjustment Adjustment disorder with depressed mood Anxiety Phobia Agoraphobia Social anxiety Social phobia Anthropophobia Specific social phobia Specific phobia Claustrophobia Other Generalized anxiety disorder OCD Panic attack Panic disorder Stress Acute stress reaction PTSD Dissociative Depersonalization disorder Dissociative identity disorder Fugue state Psychogenic amnesia Somatic symptom Body dysmorphic disorder Conversion disorder Ganser syndrome Globus pharyngis Psychogenic non-epileptic seizures False pregnancy Hypochondriasis Mass psychogenic illness Nosophobia Psychogenic pain Somatization disorder Physiological and physical behavior Eating Anorexia nervosa Bulimia nervosa Rumination syndrome Other specified feeding or eating disorder Nonorganic sleep Hypersomnia Insomnia Parasomnia Night terror Nightmare REM sleep behavior disorder Postnatal Postpartum depression Postpartum psychosis Sexual dysfunction Arousal Erectile dysfunction Female sexual arousal disorder Desire Hypersexuality Hypoactive sexual desire disorder Orgasm Anorgasmia Delayed ejaculation Premature ejaculation Sexual anhedonia Pain Nonorganic dyspareunia Nonorganic vaginismus Psychoactive substances, substance abuse and substance-related Drug overdose Intoxication Physical dependence Rebound effect Stimulant psychosis Substance dependence Withdrawal Schizophrenia , schizotypal and delusional Delusional Delusional disorder Folie à deux Psychosis and schizophrenia-like Brief reactive psychosis Schizoaffective disorder Schizophreniform disorder Schizophrenia Childhood schizophrenia Disorganized (hebephrenic) schizophrenia Paranoid schizophrenia Pseudoneurotic schizophrenia Simple-type schizophrenia Other Catatonia Symptoms and uncategorized Impulse control disorder Klüver–Bucy syndrome Psychomotor agitation StereotypyTNF, BDNF, GFAP, SCN8A, ACHE, NGF, SOD1, TYMS, SLC2A1, SLC6A3, ABCB1, CASP3, NOTCH1, DPYD, TTPA, CSF3, CHRNA4, PTGS2, PRODH, MTHFR, DHFR, PENK, TTC19, NOS1, ATF3, SELENOP, SLC10A2, CASP9, ASCL1, GUSB, SLC18A2, KCNQ2, SLC19A1, SHMT1, HES5, NOD1, ABCC2, ABCG2, ATXN8OS, FOXG1, NEUROD1, NFATC2, ID3, CYP2C8, CYP2C9, ARFGAP1, MTRR, ADRB2, PNPLA6, FOS, EN1, SERPINE1, CAMKK1, TP53, TARDBP, SNCA, MECP2, HTT, MAPT, CACNA1A, NEFL, ATF7IP, APOE, AQP4, PRNP, NFE2L2, FXN, VEGFA, ATP1A3, CDK5, PRRT2, C9orf72, FMR1, TSPO, EPO, C20orf181, IL6, GAD1, NPC1, GRIN2B, HCRT, GABPA, UBE3A, ARX, L1CAM, TOR1A, OPA1, ACTB, IL10, GLP1R, MTOR, SLC1A2, REST, COMT, MAOA, THBS1, REN, MAOB, CSF2, SETX, APP, DRD2, GCG, LAMC2, MFN2, GLRA1, AR, CSF1R, POLG, PLAT, VCP, MOG, ALB, SIRT1, MIR21, CD46, HMGB1, ENO2, CNTNAP2, ERVW-1, UCHL1, BCHE, CDKL5, HPRT1, ATXN1, FUS, TPI1, WWOX, CHI3L1, SLC12A5, PIK3CA, PIK3CB, TNFRSF1B, MIR146A, DYRK1A, PIK3CD, SNAP25, LGI1, IL1B, PIK3CG, NR2E1, MCF2L, ERVK-20, EHMT1, LCN2, PLA2G6, HDAC6, ZGLP1, IGF1, GCH1, P2RX7, ABCC8, IL17A, XPA, SPTLC1, RELN, CP, CTNNB1, TTR, SCN1A, GAD2, CNR2, CNR1, ABCD1, GNAO1, AHR, ATL1, LRP2, MPZ, FTO, PNKP, AKT1, GRN, NLRP3, PPARG, GRM5, ATM, MGLL, HTR1A, NEFH, HTR7, IFNG, CYFIP2, NDUFS4, IDO1, NCL, EXOSC3, TOLLIP, ITPR1, KCNC3, KIF5A, IL2RB, APTX, LMNB1, GEMIN4, SIGLEC7, CXXC1, MMP9, PYCARD, MSMB, ATP6, DISC1, IGFALS, ITIH4, PSEN1, HSPB8, STXBP3, RIDA, SIGMAR1, TRBV20OR9-2, TCF3, MICU1, SURF1, CFDP1, AAVS1, SPAST, SOX10, SOX2, SLC9A6, SMPD1, SLC12A2, DNM1L, SLC12A6, TOP1, TRPM2, HDAC9, VRK2, ZIC1, SLC6A5, MANF, SLC7A5, EIF2S2, EIF2B2, EIF2B4, DENR, KHSRP, HDAC3, RNMT, CTCF, CCL5, SACS, PITX2, SIRT2, SV2C, PTPA, PLP1, PLG, CYFIP1, NCS1, CCL2, PAFAH1B1, NR4A2, AUTS2, NOVA1, NOTCH3, NHS, MAPK1, MAPK3, PSPN, SMPD3, PSMD2, PSPH, PTEN, PTN, PVALB, PSIP1, REG1A, RIT2, PPARGC1A, SORT1, S100B, ATXN2, SCT, VPS13D, BANF1, FRAXA, GRM2, EPHA4, CASP1, ERCC6, FAAH, CALCA, FANCD2, DDHD1, DDR1, BRCA2, PINK1, AVP, ATP7B, GLUL, ERVK-6, SLC25A19, CHCHD10, APOD, IGLON5, SEMA6A, EIF4G2, EIF2B1, MTDH, CRP, CST3, CUX1, CX3CR1, RBM45, CSH2, CSH1, DAPK1, HSPA4, ACE, DPYSL2, BPIFA2, CREB1, DECR1, DLG3, CLN3, DNMT1, TPP1, CLU, MIR132, CSTB, HDAC2, HDAC1, HLA-DQB1, ADAM10, HCLS1, NRG1, HLA-DRB1, MIR27B, CXCR6, PDIK1L, ARTN, CERS1, HSPB3, CELF2, NRG3, RGPD2, AP3D1, OGA, PROM2, AHSA1, MANEAL, NPC2, MAP7, PLB1, ZSWIM2, PPM1K, ABCA13, AMOT, CXCL13, CBLL2, KAT5, DNAAF4, MIR574, MARCHF10, OXER1, WASF1, NRG4, SEPTIN9, ERVK-18, SYNGAP1, PDCD10, POLG2, ERVK-32, FMR1-IT1, PROM1, WDR45, TPPP, ALKBH1, UPK3B, ACMSD, CDK5R1, IMMT, TCERG1, GPR151, GLIS3, NR1I2, TAAR1, PDE10A, TRIM40, NEU3, MIR147B, CDKN2B-AS1, PIWIL4, TTC36, OR2AG1, CPLX2, FBXL14, PWAR1, GCOM1, SEMA4D, USP14, RLS1, PIWIL1, MALAT1, RAPGEF5, KIAA0319, SV2A, TGM6, KBTBD11, VN1R17P, GRAP2, NACA2, CACNA2D2, SYT10, GPR166P, ABCB5, RAB7B, HDAC4, KRTAP10-1, ADGRG1, EFTUD2, CDNF, MAD2L1BP, CLOCK, LITAF, KL, MIR17HG, PICK1, ADIPOQ, MIR148A, GSTO1, MIR155, MIR212, NTN1, AKT3, LIN9, SRA1, NALCN, MPEG1, ZUP1, HAX1, TOMM40, RBM14, GPRC6A, ANKK1, TUBB4A, USP6, INA, HGS, MFSD8, ATXN7L3B, TUBB3, BDNF-AS, SLC9A9, IRF9, TUBA1B, MRGPRX1, IS1, EXOSC8, H19, PGP, PIGW, MPHOSPH6, PQBP1, BTBD8, ABCB6, LPAR2, SH2B3, PI4K2A, MORC2, NEU4, NGB, SLC40A1, CELF5, GAS5, LGR6, SHANK1, TRPV4, DMRT3, GBA2, NLRP1, TBC1D24, NDUFA13, SEPSECS, TLR7, RXFP3, DACT1, TRPV2, UBQLN1, UBQLN2, GPSM2, CXorf56, REEP1, TPK1, NOX1, NMNAT1, AGO2, CPEB1, HPGDS, ROBO3, TMEM97, NOD2, TRIB2, SLC39A8, GOLPH3, ACAD9, STRN4, MCOLN1, TRAPPC4, DCDC2, RNF20, KLHL7, TRPM7, TDP1, IARS2, VAC14, PRPF40A, SLC25A38, ANO1, AGGF1, ANO10, OSGEP, SLC30A10, DARS2, ASIC4, SHQ1, NDE1, TRPM4, PELI1, TMED9, ANO2, SLC17A7, TDP2, PDXP, ACKR3, UFM1, FAM20C, LGALS14, CD244, SUCLA2, ATP8A2, TREM2, RETREG1, CELF4, GTPBP2, STK33, SCNM1, METRN, KDM1A, SLC26A8, SMG1, SLC52A3, NMNAT2, ERC1, CDCA5, KIF1B, IQSEC2, FOXP2, CADPS2, SARM1, KANK1, MTG1, PMPCA, UBXN11, TNIK, NT5C2, SHANK3, SHANK2, WDR81, CANT1, JDP2, CNKSR2, LRRK2, NLGN1, RLN3, SLC16A10, MRGPRX4, WDR37, RPH3A, TRAK1, RAB3GAP1, MRGPRX3, GRIN3A, IL33, CNDP1, SLC52A2, EID1, QPCT, RNF19A, ARMC10, AKR1E2, NDEL1, WNT5B, POLDIP2, ABHD12, DGCR5, COL18A1, SRCIN1, SLC19A3, OPA3, UBA5, MUL1, CIZ1, FRRS1L, DDHD2, IBGC1, GPT2, BICD2, USP22, ATP13A2, SIRT5, ZNF469, CARD11, BRD4, SLC39A14, LPAR3, SETD3, SMUG1, SLITRK6, DAPK2, DTNBP1, AARS1, CXCL12, TNFRSF14, FGF2, FOXM1, FLNA, FOLH1, FRAXE, GABRA3, GABRG3, B4GALNT1, GAP43, GBA, GC, GCDH, GCHFR, GDF1, GGTA1P, GJB1, GLB1, GLRA2, GLUD1, GPI, FOXE1, FCN2, CXCR3, FABP7, DLX6, DNM1, DNM2, DPP4, DRD4, RCAN1, EBF1, ECM1, EDNRA, EEF1A2, ELK3, EMX2, EPHB1, EPHB2, ERBB4, ERCC2, ERG, ESR1, F2R, GPM6B, GPER1, RIPK1, HLA-DQB2, HMOX1, HNRNPA1, AGFG1, AGFG2, HRES1, HSPA9, HSPB1, HSPB2, HTC2, HTR2A, IDH3A, IDS, IDUA, IFNB1, IGF2, IL2, IL2RA, IL4, IL12A, HLA-DRB6, HLA-DQA1, GPR35, HLA-A, GPR42, GPX1, GPX4, GRIA2, GRIA3, GRIK1, GRIN2A, GRIN2D, GRM1, GRP, GRPR, GSK3B, H2AZ1, HSD17B10, HARS1, HCFC1, HCRTR2, HIP1, HK1, DLG4, DLD, NQO1, ANPEP, ANXA2, BIRC3, FAS, FASLG, ARNTL, ARSA, ASPA, ATP1A2, KIF1A, B2M, BACH1, BCS1L, BLM, DST, BRS3, BST2, BTN1A1, CACNA1D, CACNA1F, ANXA1, ANK3, CYB5R3, ALPL, ABCA1, ABCA2, ABO, ACR, ADAR, ADCYAP1, ADCYAP1R1, PARP1, ADRA1A, ADRA2B, GRK2, ADSL, AGER, JAG1, AGT, AGTR1, AHSG, ALDH3A2, ALOX15, CACNB4, CALB1, CALR, CAMK2B, COMP, COX15, CPE, CREBBP, CRK, CRMP1, CRYBB1, MAPK14, NCAN, CTLA4, CTSB, CYP1A2, CYP2B6, CYP2D6, CYP27A1, DARS1, DBH, DBN1, DCTN1, COL9A3, COL9A2, COL9A1, CD68, CAPN1, CAPN2, CAST, CASP6, CAV1, SERPINH1, CD1D, CD40LG, CDH13, CCR5, CDKN2A, CDKN2B, CEBPB, CEBPD, CHD2, ERCC8, CLCN2, CCR4, IL18, ILF2, CXCL10, SMARCA1, SNCG, SOD2, SPTAN1, SRY, SSTR4, STAT1, STAT3, ELOVL4, SULT1A1, VAMP1, TAC1, TBP, TERT, TGFBR2, TGM2, TH, THM, TIMP1, NKX2-1, SMARCA4, SLC22A4, NECTIN1, SLC6A2, QARS1, QDPR, RAB27A, RANBP2, RET, RGS4, RPA1, RPS27, S100A1, S100A6, SCN2A, CCL17, SFRP2, SLAMF1, SLC1A1, SLC1A3, SLC4A3, SLC2A4, SLC6A1, TLR2, TLR4, TMSB4X, CLEC3B, CXCR4, SCLC1, RAB7A, ST8SIA4, AIMP2, GAN, TAF15, AKAP1, FZD4, PLA2G10, ULK1, CUL1, SEMA7A, PIK3R3, DEGS1, KMO, TP63, PDE5A, BECN1, TUBA1A, ZIC2, YWHAZ, TXN, TNFAIP1, TPH1, TPO, TRPC3, TRPC6, TSC2, TTK, TWIST1, TXNRD1, YWHAG, UBB, UCP2, UTRN, VDAC1, VDR, VRK1, WNT1, XRCC1, ALDH18A1, PVR, INS, MITF, MME, MNAT1, MOV10, MPO, MST1R, COX1, ND6, MTR, RNR2, MYLK, NAGA, NCAM1, NDUFV1, NFKB1, NGFR, NQO2, NMT1, NOS2, NOVA2, ATXN3, MAP3K5, PURA, MEFV, INPPL1, ISG20, ITPR3, KCNJ5, KCNQ1, KIFC1, LEP, LIG4, LRPAP1, LTBP3, SH2D1A, LYZ, MAB21L1, MAG, MANBA, MAP1B, MDK, MEF2A, MEF2C, PNP, NPTX2, NRGN, NTF3, POLD2, POMC, PON1, PPARA, PPP2R2B, PPT1, PREP, PRF1, PRKCA, PRKCB, PRKD1, MAPK8, MAPK9, MAPK10, MAP2K7, EIF2AK2, HTRA1, PSMA1, PTX3, PMP22, PLA2G4A, PLA2G2A, PCSK2, DDR2, NTS, OGDH, OXA1L, P2RY6, PAK1, PRKN, PARN, PDE7A, PLA2G1B, PDGFB, PDGFRB, ENPP2, PDYN, SERPINF1, PEX1, PEX6, PITX3, STIN2-VNTR
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Spontaneous Coronary Artery Dissection
Wikipedia
Evidence suggests that estrogen - and progesterone -related vascular changes affect the coronary arteries during this period, contributing to SCAD. [4] Some case reports and case series suggest associations with autoimmune inflammatory diseases, but there have not been larger studies to explore this relationship. [4] Underlying heritable conditions such as fibromuscular dysplasia and connective-tissue disorders (e.g., Marfan syndrome , Ehlers–Danlos syndrome , and Loeys–Dietz syndrome ) are associated with SCAD, [5] but SCAD otherwise lacks a significant genetic component. [4] SCAD triggers may include severe physical or emotional stress, but many cases have no obvious cause. [6] [7] Pathophysiology [ edit ] SCAD symptoms are the result of a restriction in the size of the affected coronary artery. ... Given the demographics of SCAD, it is important to maintain a high index of suspicion for the condition in otherwise low-risk women presenting with symptoms of acute coronary syndrome . Initial evaluation may show ECG changes of ST elevation, like heart attacks due to other causes. SCAD comprises 2-4% of all cases of acute coronary syndrome. [11] With typically elevated cardiac biomarkers and ECG changes, people will often undergo coronary angiography evaluation. [4] [12] [13] It is important to recognize SCAD through angiography as other confirmatory measures carry increased risks. [14] Angiography [ edit ] Angiographic appearances of SCAD fall into three categories. [11] Type 1 lesions appear as classic angiographic dissections , with a false lumen distinct from the true lumen. ... While prior studies had reported a SCAD prevalence of less than 1% in patients presenting with acute coronary syndrome, more recent data suggests the prevalence of SCAD in acute coronary syndrome patients may be between 2-4%. [23] History [ edit ] SCAD was first described in the year 1931, at postmortem examination, in a 42-year-old woman. [1] [23] Due to a lack of recognition and diagnostic technology though, SCAD literature until the 21st century included only case reports and series. [23] With the recent advent of coronary angiography and intracoronary imaging, recognition and diagnosis of SCAD has greatly increased, especially in the 2010s. [23] See also [ edit ] Dissection (medical) Aortic dissection , a similar condition affecting a different artery Kounis syndrome References [ edit ] ^ a b Pretty HC (18 April 1931). ... External links [ edit ] Classification D ICD - 10 : I25.4 ICD - 9-CM : 414.12 DiseasesDB : 3115 "Spontaneous Coronary Artery Dissection Postpartum" "Spontaneous-Coronary-Artery-Dissection-Case-Series-and-Review" v t e Cardiovascular disease (heart) Ischaemic Coronary disease Coronary artery disease (CAD) Coronary artery aneurysm Spontaneous coronary artery dissection (SCAD) Coronary thrombosis Coronary vasospasm Myocardial bridge Active ischemia Angina pectoris Prinzmetal's angina Stable angina Acute coronary syndrome Myocardial infarction Unstable angina Sequelae hours Hibernating myocardium Myocardial stunning days Myocardial rupture weeks Aneurysm of heart / Ventricular aneurysm Dressler syndrome Layers Pericardium Pericarditis Acute Chronic / Constrictive Pericardial effusion Cardiac tamponade Hemopericardium Myocardium Myocarditis Chagas disease Cardiomyopathy Dilated Alcoholic Hypertrophic Tachycardia-induced Restrictive Loeffler endocarditis Cardiac amyloidosis Endocardial fibroelastosis Arrhythmogenic right ventricular dysplasia Endocardium / valves Endocarditis infective endocarditis Subacute bacterial endocarditis non-infective endocarditis Libman–Sacks endocarditis Nonbacterial thrombotic endocarditis Valves mitral regurgitation prolapse stenosis aortic stenosis insufficiency tricuspid stenosis insufficiency pulmonary stenosis insufficiency Conduction / arrhythmia Bradycardia Sinus bradycardia Sick sinus syndrome Heart block : Sinoatrial AV 1° 2° 3° Intraventricular Bundle branch block Right Left Left anterior fascicle Left posterior fascicle Bifascicular Trifascicular Adams–Stokes syndrome Tachycardia ( paroxysmal and sinus ) Supraventricular Atrial Multifocal Junctional AV nodal reentrant Junctional ectopic Ventricular Accelerated idioventricular rhythm Catecholaminergic polymorphic Torsades de pointes Premature contraction Atrial Junctional Ventricular Pre-excitation syndrome Lown–Ganong–Levine Wolff–Parkinson–White Flutter / fibrillation Atrial flutter Ventricular flutter Atrial fibrillation Familial Ventricular fibrillation Pacemaker Ectopic pacemaker / Ectopic beat Multifocal atrial tachycardia Pacemaker syndrome Parasystole Wandering atrial pacemaker Long QT syndrome Andersen–Tawil Jervell and Lange-Nielsen Romano–Ward Cardiac arrest Sudden cardiac death Asystole Pulseless electrical activity Sinoatrial arrest Other / ungrouped hexaxial reference system Right axis deviation Left axis deviation QT Short QT syndrome T T wave alternans ST Osborn wave ST elevation ST depression Strain pattern Cardiomegaly Ventricular hypertrophy Left Right / Cor pulmonale Atrial enlargement Left Right Athletic heart syndrome Other Cardiac fibrosis Heart failure Diastolic heart failure Cardiac asthma Rheumatic fever
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Kniest-Like Dysplasia With Pursed Lips And Ectopia Lentis
Omim
The clinical and x-ray features resembled those observed in Kniest dysplasia (156550) and in Rolland-Desbuquois syndrome (see 224400) but important differences were noted, specifically, microstomia, pursed lips, and ectopia lentis. ... The mouth resembled that of the whistling face syndrome (277720) but other features were different. ... Both had developed severe myotonia and characteristic facial and skeletal features of Schwartz-Jampel syndrome (SJS1; 255800). The disorder in the sibs mapped to the SJS1 locus on chromosome 1p34-p36, supporting the claim that they had SJS1. ... INHERITANCE - Isolated cases GROWTH Height - Short stature HEAD & NECK Face - Deep philtrum Eyes - Ptosis - Ectopia lentis (in some patients) Mouth - Microstomia - Pursed lips - High-arched palate Neck - Short neck CHEST Ribs Sternum Clavicles & Scapulae - Pectus carinatum - Lateral curving of inferior scapular angle - Normal ribs SKELETAL - Joint stiffness (neck, shoulder, elbow, hips) - Joint contractures (elbows and knees) Spine - Platyspondyly - Cervical kyphosis - No coronal clefts Pelvis - Absent ossification of femoral capital epiphyses Limbs - Large ossification centers - Femoral bowing - Tibial bowing MISCELLANEOUS - Initial cases reclassified as having Schwartz-Jampel syndrome (SJS1, 255800 ) ▲ Close
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Kennerknecht Syndrome
Omim
Kennerknecht et al. (1995) suggested that the disorder in the 2 sisters represents a new autosomal recessive syndrome. INHERITANCE - Autosomal recessive GROWTH Height - Short stature Weight - Central obesity HEAD & NECK Face - Peculiar face - Low-set hairline Ears - Dysplastic ears - Broad helices Eyes - Hypotelorism - Sunken eyes - Long eyelashes Nose - Retracted nostrils - Broad, slightly convex nasal ridge Mouth - Inverted upper lip - High-arched palate Teeth - Hypodontia Neck - Short neck CHEST Breasts - Inverted nipples ABDOMEN External Features - Omphalocele (in patient 1) Gastrointestinal - Malrotation of colon (in patient 1) GENITOURINARY External Genitalia (Female) - Normal female external genitalia (46XY karyotype) Internal Genitalia (Female) - Agonadism - Blind ending vagina - Rudimentary Mullerian structures - Hypoplastic uterus Kidneys - Agenesis of right kidney (in patient 1) Ureters - Agenesis of right ureter (in patient 1) SKELETAL - Retarded bone age, severe Spine - Thoracolumbar scoliosis Pelvis - Acetabular dysplasia Feet - Clinodactyly of toes - Cutaneous partial syndactyly of toes II/III SKIN, NAILS, & HAIR Hair - Low-set hairline - Long eyelashes NEUROLOGIC Central Nervous System - Mental retardation ENDOCRINE FEATURES - Endocrine studies did not demonstrate functionally active gonads LABORATORY ABNORMALITIES - 46,XY karyotype MISCELLANEOUS - Two siblings of consanguineous Turkish parents have been reported ▲ Close
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Garre's Sclerosing Osteomyelitis
Wikipedia
PMID 17921638 . v t e Bone and joint disease Bone Inflammation endocrine : Osteitis fibrosa cystica Brown tumor infection : Osteomyelitis Sequestrum Involucrum Sesamoiditis Brodie abscess Periostitis Vertebral osteomyelitis Metabolic Bone density Osteoporosis Juvenile Osteopenia Osteomalacia Paget's disease of bone Hypophosphatasia Bone resorption Osteolysis Hajdu–Cheney syndrome Ainhum Gorham's disease Other Ischaemia Avascular necrosis Osteonecrosis of the jaw Complex regional pain syndrome Hypertrophic pulmonary osteoarthropathy Nonossifying fibroma Pseudarthrosis Stress fracture Fibrous dysplasia Monostotic Polyostotic Skeletal fluorosis bone cyst Aneurysmal bone cyst Hyperostosis Infantile cortical hyperostosis Osteosclerosis Melorheostosis Pycnodysostosis Joint Chondritis Relapsing polychondritis Other Tietze's syndrome Combined Osteochondritis Osteochondritis dissecans Child leg: hip Legg–Calvé–Perthes syndrome tibia Osgood–Schlatter disease Blount's disease foot Köhler disease Sever's disease spine Scheuermann's_disease arm: wrist Kienböck's disease elbow Panner disease This article about a disease of musculoskeletal and connective tissue is a stub .
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Tubulointerstitial Nephritis And Uveitis
Wikipedia
Tubulointerstitial nephritis and uveitis Other names Acute tubulointerstitial nephritis and uveitis syndrome Specialty Ophthalmology Tubulointerstitial nephritis and uveitis ( TINU ) is a rare medical condition in which there is uveitis (inflammation of the uvea in the eye) together with tubulointerstitial nephritis (inflammation of the tubules inside the kidney). ... "Tubulointerstitial nephritis and uveitis syndrome". Current Opinion in Ophthalmology . 20 (6): 525–31. doi : 10.1097/ICU.0b013e3283318f9a . ... "A report of an adult case of tubulointerstitial nephritis and uveitis (TINU) syndrome, with a review of 102 Japanese cases" . ... "Acute eosinophilic interstitial nephritis and renal failure with bone marrow-lymph node granulomas and anterior uveitis. A new syndrome". The American Journal of Medicine . 59 (3): 325–33. doi : 10.1016/0002-9343(75)90390-3 .
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Mondini Dysplasia
Wikipedia
The Mondini dysplasia can occur in cases of Pendred Syndrome and Branchio-oto-renal syndrome and in other syndromes, but can occur in non-syndromic deafness .
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Visual Pathway Lesions
Wikipedia
It is located at the bottom of the brain immediately inferior to the hypothalamus . [6] Signs and symptoms associated with optic chiasm lesions are also known as chiasmal syndrome . Chiasmal syndrome has been classified into three types; anterior, middle and posterior chiasmal syndromes. [1] Another type is lateral chiasmal syndrome. [7] Causes [ edit ] Causes of chiasmal syndromes may be classified into intrinsic and extrinsic forms. [8] Intrinsic causes are due to thickening of the chiasm itself and extrinsic implies compression by another structure. Other less common causes of chiasmal syndrome are metabolic, toxic, traumatic or infectious in nature. [1] Compression of the optic chiasm is associated with pituitary adenoma , [9] Craniopharyngioma , [10] Meningioma [11] etc. ... Such lesions produce optic tract syndrome type II. [1] Extrinsic or compressive lesions are caused by pituitary craniopharyngioma, [15] tumours of optic thalamus. ... "Absent relative afferent pupillary defect in an asymptomatic case of lateral chiasmal syndrome from cerebral aneurysm" . Optometry and Vision Science . 78 (4): 195–205. doi : 10.1097/00006324-200104000-00008 . ... "Pearls & Oy-sters: Optic tract syndrome" (PDF) . Cite journal requires |journal= ( help ) ^ "Craniopharyngioma Signs and Symptoms" . www.pedsoncologyeducation.com . ^ Tomy, Ritamary (2019).
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Neurasthenia
Wikipedia
Despite being omitted by the American Psychiatric Association 's DSM in 1980, neurasthenia is listed in an appendix as the culture-bound syndrome shenjing shuairuo as well as appearing in the ICD-10 . ... id=rX2w6QELtKgC&pg=PA362&lpg=PA362&dq=freud+neurasthenia+coitus&source=bl&ots=t8xg8MjzZ6&sig=JpinNvDo0RXuKn6bgFmS-s2tmLo&hl=en&sa=X&ei=qTtiUK-bFYrK9gS0moHwBQ&ved=0CC8Q6AEwAA#v=onepage&q=freud%20neurasthenia%20coitus&f=false ^ a b Ayonrinde, Oyedeji A. (2020-06-26). " ' Brain fag': a syndrome associated with 'overstudy' and mental exhaustion in 19th century Britain" . ... L. (Nov 1999). "Chronic fatigue syndrome: new insights and old ignorance" . ... "Neuraesthenia revisited: ICD-10 and DSM-III-R psychiatric syndromes in chronic fatigue patients and comparison subjects". ... External links [ edit ] Classification D ICD - 10 : F48.0 ICD - 9-CM : 300.5 MeSH : D009440 v t e Mental and behavioral disorders Adult personality and behavior Gender dysphoria Ego-dystonic sexual orientation Paraphilia Fetishism Voyeurism Sexual maturation disorder Sexual relationship disorder Other Factitious disorder Munchausen syndrome Intermittent explosive disorder Dermatillomania Kleptomania Pyromania Trichotillomania Personality disorder Childhood and learning Emotional and behavioral ADHD Conduct disorder ODD Emotional and behavioral disorders Separation anxiety disorder Movement disorders Stereotypic Social functioning DAD RAD Selective mutism Speech Stuttering Cluttering Tic disorder Tourette syndrome Intellectual disability X-linked intellectual disability Lujan–Fryns syndrome Psychological development ( developmental disabilities ) Pervasive Specific Mood (affective) Bipolar Bipolar I Bipolar II Bipolar NOS Cyclothymia Depression Atypical depression Dysthymia Major depressive disorder Melancholic depression Seasonal affective disorder Mania Neurological and symptomatic Autism spectrum Autism Asperger syndrome High-functioning autism PDD-NOS Savant syndrome Dementia AIDS dementia complex Alzheimer's disease Creutzfeldt–Jakob disease Frontotemporal dementia Huntington's disease Mild cognitive impairment Parkinson's disease Pick's disease Sundowning Vascular dementia Wandering Other Delirium Organic brain syndrome Post-concussion syndrome Neurotic , stress -related and somatoform Adjustment Adjustment disorder with depressed mood Anxiety Phobia Agoraphobia Social anxiety Social phobia Anthropophobia Specific social phobia Specific phobia Claustrophobia Other Generalized anxiety disorder OCD Panic attack Panic disorder Stress Acute stress reaction PTSD Dissociative Depersonalization disorder Dissociative identity disorder Fugue state Psychogenic amnesia Somatic symptom Body dysmorphic disorder Conversion disorder Ganser syndrome Globus pharyngis Psychogenic non-epileptic seizures False pregnancy Hypochondriasis Mass psychogenic illness Nosophobia Psychogenic pain Somatization disorder Physiological and physical behavior Eating Anorexia nervosa Bulimia nervosa Rumination syndrome Other specified feeding or eating disorder Nonorganic sleep Hypersomnia Insomnia Parasomnia Night terror Nightmare REM sleep behavior disorder Postnatal Postpartum depression Postpartum psychosis Sexual dysfunction Arousal Erectile dysfunction Female sexual arousal disorder Desire Hypersexuality Hypoactive sexual desire disorder Orgasm Anorgasmia Delayed ejaculation Premature ejaculation Sexual anhedonia Pain Nonorganic dyspareunia Nonorganic vaginismus Psychoactive substances, substance abuse and substance-related Drug overdose Intoxication Physical dependence Rebound effect Stimulant psychosis Substance dependence Withdrawal Schizophrenia , schizotypal and delusional Delusional Delusional disorder Folie à deux Psychosis and schizophrenia-like Brief reactive psychosis Schizoaffective disorder Schizophreniform disorder Schizophrenia Childhood schizophrenia Disorganized (hebephrenic) schizophrenia Paranoid schizophrenia Pseudoneurotic schizophrenia Simple-type schizophrenia Other Catatonia Symptoms and uncategorized Impulse control disorder Klüver–Bucy syndrome Psychomotor agitation Stereotypy
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Vogt–koyanagi–harada Disease
Wikipedia
Vogt–Koyanagi–Harada disease Other names Vogt–Koyanagi–Harada syndrome, uveomeningitis syndrome, uveomeningoencephalitic syndrome [1] Dermatologic manifestation of VKH Specialty Ophthalmology Vogt–Koyanagi–Harada disease ( VKH ) is a multisystem disease of presumed autoimmune cause that affects pigmented tissues, which have melanin . ... For example, VKH has been associated with human leukocyte antigens (HLA) HLA-DR4 and DRB1/DQA1, [10] copy-number variations (CNV) of complement component 4 , [10] a variant IL-23R locus [10] and with various other non-HLA genes. [10] HLA-DRB1*0405 in particular appears to play an important susceptibility role. [2] [4] [8] [6] Diagnosis [ edit ] If tested in the prodromal phase, CSF pleocytosis is found in more than 80%, [6] [7] mainly lymphocytes . [7] This pleocytosis resolves in about 8 weeks even if chronic uveitis persists. [7] Functional tests may include electroretinogram and visual field testing . [2] Diagnostic confirmation and an estimation of disease severity may involve imaging tests such as retinography , fluorescein or indocyanine green angiography , optical coherence tomography and ultrasound . [2] [5] [9] [7] For example, indocyanine green angiography may detect continuing choroidal inflammation in the eyes without clinical symptoms or signs. [5] [8] Ocular MRI may be helpful [6] and auditory symptoms should undergo audiologic testing. [6] Histopathology findings from eye and skin are discussed by Walton. [6] The diagnosis of VKH is based on the clinical presentation; the diagnostic differential is extensive, and includes (among others) sympathetic ophthalmia , sarcoidosis , primary intraocular B-cell lymphoma , posterior scleritis , uveal effusion syndrome, tuberculosis, syphilis, and multifocal choroidopathy syndromes. [3] [6] Types [ edit ] Based on the presence of extraocular findings, such as neurological, auditory and integumentary manifestations, the "revised diagnostic criteria" of 2001 [2] [11] classify the disease as complete (eyes along with both neurological and skin), incomplete (eyes along with either neurological or skin) or probable (eyes without either neurological or skin) . [1] [3] [5] [6] [11] By definition, for research homogeneity purposes, there are two exclusion criteria: previous ocular penetrating trauma or surgery, and other concomitant ocular disease similar to VKH disease. [2] [6] [11] Management [ edit ] The acute uveitis phase of VKH is usually responsive to high-dose oral corticosteroids ; parenteral administration is usually not required. [2] [3] [6] However, ocular complications may require a subtenon [6] or intra vitreous injection of corticosteroids [4] [6] or bevacizumab . [9] In refractory situations, other immunosuppressives such as cyclosporine , [2] [3] or tacrolimus , [9] antimetabolites ( azathioprine , mycophenolate mofetil or methotrexate [9] ), or biological agents such as intravenous immunoglobulins (IVIG) or infliximab may be needed. [2] [6] Outcomes [ edit ] Visual prognosis is generally good with prompt diagnosis and aggressive immunomodulatory treatment. [2] [3] [8] Inner ear symptoms usually respond to corticosteroid therapy within weeks to months; hearing usually recovers completely. [6] Chronic eye effects such as cataracts , glaucoma , and optic atrophy can occur. [6] Skin changes usually persist despite therapy. [6] Eponym [ edit ] VKH syndrome is named for ophthalmologists Alfred Vogt from Switzerland and Yoshizo Koyanagi and Einosuke Harada from Japan. [12] [13] [14] [15] Several authors, including the Arabic doctor Mohammad-al-Ghâfiqî in the 12th century as well as Jacobi, Nettelship and Tay in the 19th century, had described poliosis, neuralgias and hearing disorders. [15] This constellation was probably often due to sympathetic ophthalmia but likely included examples of VKH. [15] Koyanagi's first description of the disease was in 1914, but was preceded by Jujiro Komoto, Professor of Ophthalmology at the University of Tokyo, in 1911. [15] It was the much later article, published in 1929, that definitively associated Koyanagi with the disease. [15] Harada's 1926 paper is recognized for its comprehensive description of what is now known as Vogt–Koyanagi–Harada disease. [15] References [ edit ] ^ a b "Vogt-Koyanagi-Harada Disease" . ... CS1 maint: uses authors parameter ( link ) ^ a b c d e f g h i j Greco A, Fusconi M, Gallo A et al. (2013). "Vogt-Koyanagi-Harada syndrome". Autoimmun Rev . 12 (11): 1033–8. doi : 10.1016/j.autrev.2013.01.004 . ... CS1 maint: uses authors parameter ( link ) External links [ edit ] Classification D ICD - 10 : H20.8 H30.8 MeSH : D014607 External resources Orphanet : 3437 American Academy of Ophthalmology: Identify and Treat Vogt-Koyanagi-Harada Syndrome v t e Diseases of the human eye Adnexa Eyelid Inflammation Stye Chalazion Blepharitis Entropion Ectropion Lagophthalmos Blepharochalasis Ptosis Blepharophimosis Xanthelasma Ankyloblepharon Eyelash Trichiasis Madarosis Lacrimal apparatus Dacryoadenitis Epiphora Dacryocystitis Xerophthalmia Orbit Exophthalmos Enophthalmos Orbital cellulitis Orbital lymphoma Periorbital cellulitis Conjunctiva Conjunctivitis allergic Pterygium Pseudopterygium Pinguecula Subconjunctival hemorrhage Globe Fibrous tunic Sclera Scleritis Episcleritis Cornea Keratitis herpetic acanthamoebic fungal Exposure Photokeratitis Corneal ulcer Thygeson's superficial punctate keratopathy Corneal dystrophy Fuchs' Meesmann Corneal ectasia Keratoconus Pellucid marginal degeneration Keratoglobus Terrien's marginal degeneration Post-LASIK ectasia Keratoconjunctivitis sicca Corneal opacity Corneal neovascularization Kayser–Fleischer ring Haab's striae Arcus senilis Band keratopathy Vascular tunic Iris Ciliary body Uveitis Intermediate uveitis Hyphema Rubeosis iridis Persistent pupillary membrane Iridodialysis Synechia Choroid Choroideremia Choroiditis Chorioretinitis Lens Cataract Congenital cataract Childhood cataract Aphakia Ectopia lentis Retina Retinitis Chorioretinitis Cytomegalovirus retinitis Retinal detachment Retinoschisis Ocular ischemic syndrome / Central retinal vein occlusion Central retinal artery occlusion Branch retinal artery occlusion Retinopathy diabetic hypertensive Purtscher's of prematurity Bietti's crystalline dystrophy Coats' disease Sickle cell Macular degeneration Retinitis pigmentosa Retinal haemorrhage Central serous retinopathy Macular edema Epiretinal membrane (Macular pucker) Vitelliform macular dystrophy Leber's congenital amaurosis Birdshot chorioretinopathy Other Glaucoma / Ocular hypertension / Primary juvenile glaucoma Floater Leber's hereditary optic neuropathy Red eye Globe rupture Keratomycosis Phthisis bulbi Persistent fetal vasculature / Persistent hyperplastic primary vitreous Persistent tunica vasculosa lentis Familial exudative vitreoretinopathy Pathways Optic nerve Optic disc Optic neuritis optic papillitis Papilledema Foster Kennedy syndrome Optic atrophy Optic disc drusen Optic neuropathy Ischemic anterior (AION) posterior (PION) Kjer's Leber's hereditary Toxic and nutritional Strabismus Extraocular muscles Binocular vision Accommodation Paralytic strabismus Ophthalmoparesis Chronic progressive external ophthalmoplegia Kearns–Sayre syndrome palsies Oculomotor (III) Fourth-nerve (IV) Sixth-nerve (VI) Other strabismus Esotropia / Exotropia Hypertropia Heterophoria Esophoria Exophoria Cyclotropia Brown's syndrome Duane syndrome Other binocular Conjugate gaze palsy Convergence insufficiency Internuclear ophthalmoplegia One and a half syndrome Refraction Refractive error Hyperopia Myopia Astigmatism Anisometropia / Aniseikonia Presbyopia Vision disorders Blindness Amblyopia Leber's congenital amaurosis Diplopia Scotoma Color blindness Achromatopsia Dichromacy Monochromacy Nyctalopia Oguchi disease Blindness / Vision loss / Visual impairment Anopsia Hemianopsia binasal bitemporal homonymous Quadrantanopia subjective Asthenopia Hemeralopia Photophobia Scintillating scotoma Pupil Anisocoria Argyll Robertson pupil Marcus Gunn pupil Adie syndrome Miosis Mydriasis Cycloplegia Parinaud's syndrome Other Nystagmus Childhood blindness Infections Trachoma OnchocerciasisPTPN22, FAS, IFNA2, CYP2R1, HLA-DRB1, IL23R, C1orf141, HLA-DRB9, HLA-DQA1, RBM45, IL17A, ADO, IL17F, TYR, TNFAIP3, KIR3DL1, IL10, MIR146A, HLA-DRB4, ZNF365, CCL2, EGR2, NR3C1, HLA-B, HLA-A, GEM, CD40, IL21, UACA, IL23A, LINC00328, FOXP3, IL37, ELF3, ETS1, CLEC16A, NOD2, NLRP1, PSIP1, TRAF3IP2, NOD1, TNIP1, ATG5, BACH2, HLA-DQB1, ARMC9, ATG10, MIR23A, MIR20A, MIR182, MIR155, C3AR1, RTL1, SUMO4, LINC01193, CTLA4, HT, CYP24A1, DAB2, FCRL3, DUSP1, TNFRSF10A, XPR1, TRAF5, VEGFA, IL9, GATA3, KIR2DS1, JAK2, JAK1, IL12RB2, IL12RB1, IL12B, IL6, FOXO1, IL4, IL2RA, IL2, IL1B, IFNG, CFI, IRF8, KIR3DL2, MIF, NOS2, NOS3, HLA-C, MLANA, TNF, TLR4, TLR3, TLR2, TGFBR3, STAT4, STAT3, SPP1, BCL2, CCL1, RPE, PLXNA2, PDCD1, MIR301A
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Exocrine Pancreatic Insufficiency
Wikipedia
EPI is found in humans afflicted with cystic fibrosis and Shwachman–Diamond syndrome , and is common in dogs . EPI is caused by a progressive loss of the pancreatic cells that make digestive enzymes; loss of digestive enzymes leads to maldigestion and malabsorption of nutrients from normal digestive processes. ... EPI results from progressive failure in the exocrine function of the pancreas to provide its digestive enzymes , often in response to a genetic condition or other disease state, resulting in the inability of the animal involved to properly digest food. [ citation needed ] Contents 1 Signs and symptoms 2 Causes and pathogenesis 3 Diagnosis 4 Treatment 5 Other animals 5.1 Causes and pathogenesis 5.2 Symptoms 5.3 Diagnosis and treatment 6 References 7 External links Signs and symptoms [ edit ] Loss of pancreatic enzymes leads to maldigestion and malabsorption, which may in turn lead to: [ citation needed ] anemia ( Vitamin B12 , iron , folate deficiency) bleeding disorders ( Vitamin K malabsorption) edema ( hypoalbuminemia ) fatigue flatulence and abdominal distention (bacterial fermentation of unabsorbed food) hypocalcemia metabolic bone disease ( Vitamin D deficiency ) neurologic manifestation steatorrhea weight loss Causes and pathogenesis [ edit ] In humans, the most common causes of EPI are chronic pancreatitis and cystic fibrosis , the former a longstanding inflammation of the pancreas altering the organ's normal structure and function that can arise as a result of malnutrition, heredity, or (in the Western world especially), behaviour (alcohol use, smoking), [ citation needed ] [3] and the latter a recessive hereditary disease most common in Europeans and Ashkenazi Jews where the molecular culprit is an altered, CFTR -encoded chloride channel . [ citation needed ] According to WebMD, "Crohn's disease and celiac disease can also lead to EPI in some people". [4] In children, another common cause is Shwachman-Bodian-Diamond syndrome , a rare autosomal recessive genetic disorder resulting from mutation in the SBDS gene. [ citation needed ] Diagnosis [ edit ] The three main tests used in considering a diagnosis of EPI are: fecal elastase test, fecal fat test, and a direct pancreatic function test. [5] The latter is a limitedly used test that assesses exocrine function in the pancreas by inserting a tube into the small intestine to collect pancreatic secretions. ... CS1 maint: uses authors parameter ( link ) External links [ edit ] Classification D ICD - 10 : K86.8 ICD - 9-CM : 577.8 MeSH : D010188 v t e Diseases of the digestive system Upper GI tract Esophagus Esophagitis Candidal Eosinophilic Herpetiform Rupture Boerhaave syndrome Mallory–Weiss syndrome UES Zenker's diverticulum LES Barrett's esophagus Esophageal motility disorder Nutcracker esophagus Achalasia Diffuse esophageal spasm Gastroesophageal reflux disease (GERD) Laryngopharyngeal reflux (LPR) Esophageal stricture Megaesophagus Esophageal intramural pseudodiverticulosis Stomach Gastritis Atrophic Ménétrier's disease Gastroenteritis Peptic (gastric) ulcer Cushing ulcer Dieulafoy's lesion Dyspepsia Pyloric stenosis Achlorhydria Gastroparesis Gastroptosis Portal hypertensive gastropathy Gastric antral vascular ectasia Gastric dumping syndrome Gastric volvulus Buried bumper syndrome Gastrinoma Zollinger–Ellison syndrome Lower GI tract Enteropathy Small intestine ( Duodenum / Jejunum / Ileum ) Enteritis Duodenitis Jejunitis Ileitis Peptic (duodenal) ulcer Curling's ulcer Malabsorption : Coeliac Tropical sprue Blind loop syndrome Small bowel bacterial overgrowth syndrome Whipple's Short bowel syndrome Steatorrhea Milroy disease Bile acid malabsorption Large intestine ( Appendix / Colon ) Appendicitis Colitis Pseudomembranous Ulcerative Ischemic Microscopic Collagenous Lymphocytic Functional colonic disease IBS Intestinal pseudoobstruction / Ogilvie syndrome Megacolon / Toxic megacolon Diverticulitis / Diverticulosis / SCAD Large and/or small Enterocolitis Necrotizing Gastroenterocolitis IBD Crohn's disease Vascular : Abdominal angina Mesenteric ischemia Angiodysplasia Bowel obstruction : Ileus Intussusception Volvulus Fecal impaction Constipation Diarrhea Infectious Intestinal adhesions Rectum Proctitis Radiation proctitis Proctalgia fugax Rectal prolapse Anismus Anal canal Anal fissure / Anal fistula Anal abscess Hemorrhoid Anal dysplasia Pruritus ani GI bleeding Blood in stool Upper Hematemesis Melena Lower Hematochezia Accessory Liver Hepatitis Viral hepatitis Autoimmune hepatitis Alcoholic hepatitis Cirrhosis PBC Fatty liver NASH Vascular Budd–Chiari syndrome Hepatic veno-occlusive disease Portal hypertension Nutmeg liver Alcoholic liver disease Liver failure Hepatic encephalopathy Acute liver failure Liver abscess Pyogenic Amoebic Hepatorenal syndrome Peliosis hepatis Metabolic disorders Wilson's disease Hemochromatosis Gallbladder Cholecystitis Gallstone / Cholelithiasis Cholesterolosis Adenomyomatosis Postcholecystectomy syndrome Porcelain gallbladder Bile duct / Other biliary tree Cholangitis Primary sclerosing cholangitis Secondary sclerosing cholangitis Ascending Cholestasis / Mirizzi's syndrome Biliary fistula Haemobilia Common bile duct Choledocholithiasis Biliary dyskinesia Sphincter of Oddi dysfunction Pancreatic Pancreatitis Acute Chronic Hereditary Pancreatic abscess Pancreatic pseudocyst Exocrine pancreatic insufficiency Pancreatic fistula Other Hernia Diaphragmatic Congenital Hiatus Inguinal Indirect Direct Umbilical Femoral Obturator Spigelian Lumbar Petit's Grynfeltt-Lesshaft Undefined location Incisional Internal hernia Richter's Peritoneal Peritonitis Spontaneous bacterial peritonitis Hemoperitoneum PneumoperitoneumCELA3B, MTOR, CFTR, SPINK1, PDX1, GATA6, UBR1, SBDS, COX4I2, CEL, HNF1B, TGFB1, JAG1, SRP54, STX1A, ABCC8, HNF1A, SLC12A2, PRSS2, TP53, PALB2, PAX4, EFL1, DCTN4, KLF11, OFD1, APPL1, EIF2AK3, PALLD, CTRC, PRSS1, CLCA4, PUF60, HNF4A, CDKN2A, CTNS, BLK, ARX, BPTF, FCGR2A, GCK, NEUROD1, BRCA1, HFE, INS, KCNJ11, KRAS, DNAJC21, SMAD4, ATP6AP1, BRCA2, TFPI, SCT, CELA1, CELA3A, GSTP1, PLF, GLIS3, HPGDS, MUS81, KCNIP4, MUC16, ADRB2, SST, SLC9A6, KEAP1, ALB, CHEK1, CTRL, GIP, KRT8, MLN, OGG1, REG1A, CCL21, TNF, TTR, TXNRD1, VWF, XRCC1, HSD17B6, PANCR
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Hypoprothrombinemia
Wikipedia
For example, 5-10% of patients with systemic lupus erythematosus exhibit acquired hypoprothrombinemia due to the presence of autoantibodies which bind to prothrombin and remove it from the bloodstream (lupus anticoagulant-hypoprothrombinemia syndrome). [4] The most common viral pathogen that is involved is Adenovirus, with a prevalence of 50% in postviral cases. [5] Inheritance: Autosomal recessive condition in which both parents must carry the recessive gene in order to pass the disease on to offspring. ... "A mechanism for the hypoprothrombinemia of the acquired hypoprothrombinemia-lupus anticoagulant syndrome" . Blood . 61 (4): 684–92. doi : 10.1182/blood.V61.4.684.684 . ... "A mechanism for the hypoprothrombinemia of the acquired hypoprothrombinemia-lupus anticoagulant syndrome" . Blood . 61 (4): 684–92. doi : 10.1182/blood.V61.4.684.684 . ... External links [ edit ] Classification D ICD - 10 : D68.2 ICD - 9-CM : 286.3 , 776.3 OMIM : 613679 MeSH : D007020 External resources eMedicine : ped/1133 v t e Disorders of bleeding and clotting Coagulation · coagulopathy · Bleeding diathesis Clotting By cause Clotting factors Antithrombin III deficiency Protein C deficiency Activated protein C resistance Protein S deficiency Factor V Leiden Prothrombin G20210A Platelets Sticky platelet syndrome Thrombocytosis Essential thrombocythemia DIC Purpura fulminans Antiphospholipid syndrome Clots Thrombophilia Thrombus Thrombosis Virchow's triad Trousseau sign of malignancy By site Deep vein thrombosis Bancroft's sign Homans sign Lisker's sign Louvel's sign Lowenberg's sign Peabody's sign Pratt's sign Rose's sign Pulmonary embolism Renal vein thrombosis Bleeding By cause Thrombocytopenia Thrombocytopenic purpura : ITP Evans syndrome TM TTP Upshaw–Schulman syndrome Heparin-induced thrombocytopenia May–Hegglin anomaly Platelet function adhesion Bernard–Soulier syndrome aggregation Glanzmann's thrombasthenia platelet storage pool deficiency Hermansky–Pudlak syndrome Gray platelet syndrome Clotting factor Hemophilia A/VIII B/IX C/XI von Willebrand disease Hypoprothrombinemia/II Factor VII deficiency Factor X deficiency Factor XII deficiency Factor XIII deficiency Dysfibrinogenemia Congenital afibrinogenemia Signs and symptoms Bleeding Bruise Hematoma Petechia Purpura Nonthrombocytopenic purpura By site head Epistaxis Hemoptysis Intracranial hemorrhage Hyphema Subconjunctival hemorrhage torso Hemothorax Hemopericardium Pulmonary hematoma abdomen Gastrointestinal bleeding Hemobilia Hemoperitoneum Hematocele Hematosalpinx joint Hemarthrosis v t e Conditions originating in the perinatal period / fetal disease Maternal factors complicating pregnancy, labour or delivery placenta Placenta praevia Placental insufficiency Twin-to-twin transfusion syndrome chorion / amnion Chorioamnionitis umbilical cord Umbilical cord prolapse Nuchal cord Single umbilical artery presentation Breech birth Asynclitism Shoulder presentation Growth Small for gestational age / Large for gestational age Preterm birth / Postterm pregnancy Intrauterine growth restriction Birth trauma scalp Cephalohematoma Chignon Caput succedaneum Subgaleal hemorrhage Brachial plexus injury Erb's palsy Klumpke paralysis Affected systems Respiratory Intrauterine hypoxia Infant respiratory distress syndrome Transient tachypnea of the newborn Meconium aspiration syndrome Pleural disease Pneumothorax Pneumomediastinum Wilson–Mikity syndrome Bronchopulmonary dysplasia Cardiovascular Pneumopericardium Persistent fetal circulation Bleeding and hematologic disease Vitamin K deficiency bleeding HDN ABO Anti-Kell Rh c Rh D Rh E Hydrops fetalis Hyperbilirubinemia Kernicterus Neonatal jaundice Velamentous cord insertion Intraventricular hemorrhage Germinal matrix hemorrhage Anemia of prematurity Gastrointestinal Ileus Necrotizing enterocolitis Meconium peritonitis Integument and thermoregulation Erythema toxicum Sclerema neonatorum Nervous system Perinatal asphyxia Periventricular leukomalacia Musculoskeletal Gray baby syndrome muscle tone Congenital hypertonia Congenital hypotonia Infections Vertically transmitted infection Neonatal infection rubella herpes simplex mycoplasma hominis ureaplasma urealyticum Omphalitis Neonatal sepsis Group B streptococcal infection Neonatal conjunctivitis Other Miscarriage Perinatal mortality Stillbirth Infant mortality Neonatal withdrawal
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Mitochondrial Dna Depletion Syndrome 6 (Hepatocerebral Type)
Omim
A number sign (#) is used with this entry because mitochondrial DNA depletion syndrome-6 (MTDPS6), also known as Navajo neurohepatopathy (NNH), is caused by homozygous or compound heterozygous mutation in the MPV17 gene (137960) on chromosome 2p23. ... Description Mitochondrial DNA depletion syndrome-6 is an autosomal recessive disorder characterized by infantile onset of progressive liver failure, often leading to death in the first year of life. ... For a discussion of genetic heterogeneity of autosomal recessive mtDNA depletion syndromes, see MTDPS1 (603041). Clinical Features Appenzeller et al. (1976) described 4 Navajo children with a mutilating neuropathy with severe motor involvement. ... The liver disease presented as hepatomegaly, persistent neonatal jaundice, and even a Reye-like syndrome of acute hepatic failure. Brain imaging showed progressive CNS white matter lesions. ... This locus includes the MPV17 gene, which, when mutated, was known to cause hepatocerebral mtDNA depletion syndrome. Molecular Genetics In affected members of an Italian and Moroccan family with the hepatocerebral form of mtDNA depletion syndrome, Spinazzola et al. (2006) identified homozygous mutations in the MPV17 gene (137960.0001-137960.0002).
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Fecal Impaction
Wikipedia
Specific conditions, such as irritable bowel syndrome , neurological disorders , paralytic ileus , gastroparesis , diabetes , dehydration , enlarged prostate gland , distended colon , ingested foreign object , inflammatory bowel diseases such as crohn's disease and colitis , and autoimmune diseases such as amyloidosis , celiac disease , lupus , and scleroderma can cause constipation. ... External links [ edit ] Classification D ICD - 9-CM : 560.32 MeSH : D005244 DiseasesDB : 9450 External resources MedlinePlus : 000230 v t e Diseases of the digestive system Upper GI tract Esophagus Esophagitis Candidal Eosinophilic Herpetiform Rupture Boerhaave syndrome Mallory–Weiss syndrome UES Zenker's diverticulum LES Barrett's esophagus Esophageal motility disorder Nutcracker esophagus Achalasia Diffuse esophageal spasm Gastroesophageal reflux disease (GERD) Laryngopharyngeal reflux (LPR) Esophageal stricture Megaesophagus Esophageal intramural pseudodiverticulosis Stomach Gastritis Atrophic Ménétrier's disease Gastroenteritis Peptic (gastric) ulcer Cushing ulcer Dieulafoy's lesion Dyspepsia Pyloric stenosis Achlorhydria Gastroparesis Gastroptosis Portal hypertensive gastropathy Gastric antral vascular ectasia Gastric dumping syndrome Gastric volvulus Buried bumper syndrome Gastrinoma Zollinger–Ellison syndrome Lower GI tract Enteropathy Small intestine ( Duodenum / Jejunum / Ileum ) Enteritis Duodenitis Jejunitis Ileitis Peptic (duodenal) ulcer Curling's ulcer Malabsorption : Coeliac Tropical sprue Blind loop syndrome Small bowel bacterial overgrowth syndrome Whipple's Short bowel syndrome Steatorrhea Milroy disease Bile acid malabsorption Large intestine ( Appendix / Colon ) Appendicitis Colitis Pseudomembranous Ulcerative Ischemic Microscopic Collagenous Lymphocytic Functional colonic disease IBS Intestinal pseudoobstruction / Ogilvie syndrome Megacolon / Toxic megacolon Diverticulitis / Diverticulosis / SCAD Large and/or small Enterocolitis Necrotizing Gastroenterocolitis IBD Crohn's disease Vascular : Abdominal angina Mesenteric ischemia Angiodysplasia Bowel obstruction : Ileus Intussusception Volvulus Fecal impaction Constipation Diarrhea Infectious Intestinal adhesions Rectum Proctitis Radiation proctitis Proctalgia fugax Rectal prolapse Anismus Anal canal Anal fissure / Anal fistula Anal abscess Hemorrhoid Anal dysplasia Pruritus ani GI bleeding Blood in stool Upper Hematemesis Melena Lower Hematochezia Accessory Liver Hepatitis Viral hepatitis Autoimmune hepatitis Alcoholic hepatitis Cirrhosis PBC Fatty liver NASH Vascular Budd–Chiari syndrome Hepatic veno-occlusive disease Portal hypertension Nutmeg liver Alcoholic liver disease Liver failure Hepatic encephalopathy Acute liver failure Liver abscess Pyogenic Amoebic Hepatorenal syndrome Peliosis hepatis Metabolic disorders Wilson's disease Hemochromatosis Gallbladder Cholecystitis Gallstone / Cholelithiasis Cholesterolosis Adenomyomatosis Postcholecystectomy syndrome Porcelain gallbladder Bile duct / Other biliary tree Cholangitis Primary sclerosing cholangitis Secondary sclerosing cholangitis Ascending Cholestasis / Mirizzi's syndrome Biliary fistula Haemobilia Common bile duct Choledocholithiasis Biliary dyskinesia Sphincter of Oddi dysfunction Pancreatic Pancreatitis Acute Chronic Hereditary Pancreatic abscess Pancreatic pseudocyst Exocrine pancreatic insufficiency Pancreatic fistula Other Hernia Diaphragmatic Congenital Hiatus Inguinal Indirect Direct Umbilical Femoral Obturator Spigelian Lumbar Petit's Grynfeltt-Lesshaft Undefined location Incisional Internal hernia Richter's Peritoneal Peritonitis Spontaneous bacterial peritonitis Hemoperitoneum Pneumoperitoneum
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Antibody-Dependent Cellular Cytotoxicity
Wikipedia
External links [ edit ] University of Leicester , Virus Immunopathology Notes Antibody-Dependent+Cell+Cytotoxicity at the US National Library of Medicine Medical Subject Headings (MeSH) v t e Hypersensitivity and autoimmune diseases Type I / allergy / atopy ( IgE ) Foreign Atopic eczema Allergic urticaria Allergic rhinitis (Hay fever) Allergic asthma Anaphylaxis Food allergy common allergies include: Milk Egg Peanut Tree nut Seafood Soy Wheat Penicillin allergy Autoimmune Eosinophilic esophagitis Type II / ADCC IgM IgG Foreign Hemolytic disease of the newborn Autoimmune Cytotoxic Autoimmune hemolytic anemia Immune thrombocytopenic purpura Bullous pemphigoid Pemphigus vulgaris Rheumatic fever Goodpasture syndrome Guillain–Barré syndrome " Type V "/ receptor Graves' disease Myasthenia gravis Pernicious anemia Type III ( Immune complex ) Foreign Henoch–Schönlein purpura Hypersensitivity vasculitis Reactive arthritis Farmer's lung Post-streptococcal glomerulonephritis Serum sickness Arthus reaction Autoimmune Systemic lupus erythematosus Subacute bacterial endocarditis Rheumatoid arthritis Type IV / cell-mediated ( T cells ) Foreign Allergic contact dermatitis Mantoux test Autoimmune Diabetes mellitus type 1 Hashimoto's thyroiditis Multiple sclerosis Coeliac disease Giant-cell arteritis Postorgasmic illness syndrome Reactive arthritis GVHD Transfusion-associated graft versus host disease Unknown/ multiple Foreign Hypersensitivity pneumonitis Allergic bronchopulmonary aspergillosis Transplant rejection Latex allergy (I+IV) Autoimmune Sjögren syndrome Autoimmune hepatitis Autoimmune polyendocrine syndrome APS1 APS2 Autoimmune adrenalitis Systemic autoimmune disease v t e Lymphoid and complement disorders causing immunodeficiency Primary Antibody / humoral ( B ) Hypogammaglobulinemia X-linked agammaglobulinemia Transient hypogammaglobulinemia of infancy Dysgammaglobulinemia IgA deficiency IgG deficiency IgM deficiency Hyper IgM syndrome ( 1 2 3 4 5 ) Wiskott–Aldrich syndrome Hyper-IgE syndrome Other Common variable immunodeficiency ICF syndrome T cell deficiency ( T ) thymic hypoplasia : hypoparathyroid ( Di George's syndrome ) euparathyroid ( Nezelof syndrome Ataxia–telangiectasia ) peripheral: Purine nucleoside phosphorylase deficiency Hyper IgM syndrome ( 1 ) Severe combined (B+T) x-linked: X-SCID autosomal: Adenosine deaminase deficiency Omenn syndrome ZAP70 deficiency Bare lymphocyte syndrome Acquired HIV/AIDS Leukopenia : Lymphocytopenia Idiopathic CD4+ lymphocytopenia Complement deficiency C1-inhibitor ( Angioedema / Hereditary angioedema ) Complement 2 deficiency / Complement 4 deficiency MBL deficiency Properdin deficiency Complement 3 deficiency Terminal complement pathway deficiency Paroxysmal nocturnal hemoglobinuria Complement receptor deficiency
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Clinical Lycanthropy
Wikipedia
Not to be confused with Werewolf syndrome . Clinical lycanthropy Other names Zoanthropy Specialty Psychiatry Clinical lycanthropy is defined as a rare psychiatric syndrome that involves a delusion that the affected person can transform into, has transformed into, or is, an animal . [1] Its name is associated with the mythical condition of lycanthropy , a supernatural affliction in which humans are said to physically shapeshift into wolves. ... "Co-Existence of Lycanthropy and Cotard's Syndrome in a Single Case". Acta Psychiatrica Scandinavica 111: 250–252. ^ Kattimani, S, Menon, V., Srivastava, M.K. & Aniruddha Mukharjee, A. (2010). ... "Lycanthropy as a Culture-Bound Syndrome: A Case Report and Review of the Literature" . ... External links [ edit ] "Real-Life Werewolves: Psychiatry Re-Examines Rare Delusion" v t e Mental and behavioral disorders Adult personality and behavior Gender dysphoria Ego-dystonic sexual orientation Paraphilia Fetishism Voyeurism Sexual maturation disorder Sexual relationship disorder Other Factitious disorder Munchausen syndrome Intermittent explosive disorder Dermatillomania Kleptomania Pyromania Trichotillomania Personality disorder Childhood and learning Emotional and behavioral ADHD Conduct disorder ODD Emotional and behavioral disorders Separation anxiety disorder Movement disorders Stereotypic Social functioning DAD RAD Selective mutism Speech Stuttering Cluttering Tic disorder Tourette syndrome Intellectual disability X-linked intellectual disability Lujan–Fryns syndrome Psychological development ( developmental disabilities ) Pervasive Specific Mood (affective) Bipolar Bipolar I Bipolar II Bipolar NOS Cyclothymia Depression Atypical depression Dysthymia Major depressive disorder Melancholic depression Seasonal affective disorder Mania Neurological and symptomatic Autism spectrum Autism Asperger syndrome High-functioning autism PDD-NOS Savant syndrome Dementia AIDS dementia complex Alzheimer's disease Creutzfeldt–Jakob disease Frontotemporal dementia Huntington's disease Mild cognitive impairment Parkinson's disease Pick's disease Sundowning Vascular dementia Wandering Other Delirium Organic brain syndrome Post-concussion syndrome Neurotic , stress -related and somatoform Adjustment Adjustment disorder with depressed mood Anxiety Phobia Agoraphobia Social anxiety Social phobia Anthropophobia Specific social phobia Specific phobia Claustrophobia Other Generalized anxiety disorder OCD Panic attack Panic disorder Stress Acute stress reaction PTSD Dissociative Depersonalization disorder Dissociative identity disorder Fugue state Psychogenic amnesia Somatic symptom Body dysmorphic disorder Conversion disorder Ganser syndrome Globus pharyngis Psychogenic non-epileptic seizures False pregnancy Hypochondriasis Mass psychogenic illness Nosophobia Psychogenic pain Somatization disorder Physiological and physical behavior Eating Anorexia nervosa Bulimia nervosa Rumination syndrome Other specified feeding or eating disorder Nonorganic sleep Hypersomnia Insomnia Parasomnia Night terror Nightmare REM sleep behavior disorder Postnatal Postpartum depression Postpartum psychosis Sexual dysfunction Arousal Erectile dysfunction Female sexual arousal disorder Desire Hypersexuality Hypoactive sexual desire disorder Orgasm Anorgasmia Delayed ejaculation Premature ejaculation Sexual anhedonia Pain Nonorganic dyspareunia Nonorganic vaginismus Psychoactive substances, substance abuse and substance-related Drug overdose Intoxication Physical dependence Rebound effect Stimulant psychosis Substance dependence Withdrawal Schizophrenia , schizotypal and delusional Delusional Delusional disorder Folie à deux Psychosis and schizophrenia-like Brief reactive psychosis Schizoaffective disorder Schizophreniform disorder Schizophrenia Childhood schizophrenia Disorganized (hebephrenic) schizophrenia Paranoid schizophrenia Pseudoneurotic schizophrenia Simple-type schizophrenia Other Catatonia Symptoms and uncategorized Impulse control disorder Klüver–Bucy syndrome Psychomotor agitation Stereotypy