The classic symptoms of diabetes are frequent urination ( polyuria ), increased thirst ( polydipsia ), increased hunger ( polyphagia ), and weight loss . [23] Other symptoms that are commonly present at diagnosis include a history of blurred vision , itchiness , peripheral neuropathy , recurrent vaginal infections , and fatigue . [13] Other symptoms may include loss of taste . [24] Many people, however, have no symptoms during the first few years and are diagnosed on routine testing. [13] A small number of people with type 2 diabetes can develop a hyperosmolar hyperglycemic state (a condition of very high blood sugar associated with a decreased level of consciousness and low blood pressure ). [13] Complications Main article: Complications of diabetes Type 2 diabetes is typically a chronic disease associated with a ten-year-shorter life expectancy. [10] This is partly due to a number of complications with which it is associated, including: two to four times the risk of cardiovascular disease , including ischemic heart disease and stroke ; a 20-fold increase in lower limb amputations , and increased rates of hospitalizations . [10] In the developed world, and increasingly elsewhere, type 2 diabetes is the largest cause of nontraumatic blindness and kidney failure . [25] It has also been associated with an increased risk of cognitive dysfunction and dementia through disease processes such as Alzheimer's disease and vascular dementia . [26] Other complications include hyperpigmentation of skin ( acanthosis nigricans ), sexual dysfunction , and frequent infections. [23] There is also an association between type 2 diabetes and mild hearing loss. [27] Causes The development of type 2 diabetes is caused by a combination of lifestyle and genetic factors. [25] [28] While some of these factors are under personal control, such as diet and obesity , other factors are not, such as increasing age, female gender, and genetics. [10] Obesity is more common in women than men in many parts of Africa. [29] The nutritional status of a mother during fetal development may also play a role, with one proposed mechanism being that of DNA methylation . [30] The intestinal bacteria Prevotella copri and Bacteroides vulgatus have been connected with type 2 diabetes. [31] Lifestyle Main article: Lifestyle causes of type 2 diabetes Lifestyle factors are important to the development of type 2 diabetes, including obesity and being overweight (defined by a body mass index of greater than 25), lack of physical activity, poor diet, stress , and urbanization . [10] [32] Excess body fat is associated with 30% of cases in those of Chinese and Japanese descent, 60–80% of cases in those of European and African descent, and 100% of cases in Pima Indians and Pacific Islanders. [13] Among those who are not obese, a high waist–hip ratio is often present. [13] Smoking appears to increase the risk of type 2 diabetes. [33] A lack of sleep has also been linked to type 2 diabetes. [34] Laboratory studies have linked short-term sleep deprivations to changes in glucose metabolism, nervous system activity, or hormonal factors that may lead to diabetes. [34] Dietary factors also influence the risk of developing type 2 diabetes. Consumption of sugar-sweetened drinks in excess is associated with an increased risk. [35] [36] The type of fats in the diet are important, with saturated fats and trans fatty acids increasing the risk, and polyunsaturated and monounsaturated fat decreasing the risk. [28] Eating a lot of white rice appears to play a role in increasing risk. [37] A lack of exercise is believed to cause 7% of cases. [38] Persistent organic pollutants may also play a role. [39] Genetics Main article: Genetic causes of type 2 diabetes Most cases of diabetes involve many genes , with each being a small contributor to an increased probability of becoming a type 2 diabetic. [10] The proportion of diabetes that is inherited is estimated at 72%. [40] More than 36 genes and 80 single nucleotide polymorphisms (SNPs) had been found that contribute to the risk of type 2 diabetes. [41] [42] All of these genes together still only account for 10% of the total heritable component of the disease. [41] The TCF7L2 allele , for example, increases the risk of developing diabetes by 1.5 times and is the greatest risk of the common genetic variants. [13] Most of the genes linked to diabetes are involved in pancreatic beta cell functions. [13] There are a number of rare cases of diabetes that arise due to an abnormality in a single gene (known as monogenic forms of diabetes or "other specific types of diabetes" ). [10] [13] These include maturity onset diabetes of the young (MODY), Donohue syndrome , and Rabson–Mendenhall syndrome , among others. [10] Maturity onset diabetes of the young constitute 1–5% of all cases of diabetes in young people. [43] Medical conditions There are a number of medications and other health problems that can predispose to diabetes. [44] Some of the medications include: glucocorticoids , thiazides , beta blockers , atypical antipsychotics , [45] and statins . [46] Those who have previously had gestational diabetes are at a higher risk of developing type 2 diabetes. [23] Other health problems that are associated include: acromegaly , Cushing's syndrome , hyperthyroidism , pheochromocytoma , and certain cancers such as glucagonomas . [44] Individuals with cancer may be at a higher risk of mortality if they also have diabetes. [47] Testosterone deficiency is also associated with type 2 diabetes. [48] [49] Eating disorders may also interact with type 2 diabetes, with bulimia nervosa increasing the risk and anorexia nervosa decreasing it. [50] Pathophysiology Type 2 diabetes is due to insufficient insulin production from beta cells in the setting of insulin resistance . [13] Insulin resistance, which is the inability of cells to respond adequately to normal levels of insulin, occurs primarily within the muscles, liver , and fat tissue. [51] In the liver, insulin normally suppresses glucose release. However, in the setting of insulin resistance, the liver inappropriately releases glucose into the blood. [10] The proportion of insulin resistance versus beta cell dysfunction differs among individuals, with some having primarily insulin resistance and only a minor defect in insulin secretion and others with slight insulin resistance and primarily a lack of insulin secretion. [13] Other potentially important mechanisms associated with type 2 diabetes and insulin resistance include: increased breakdown of lipids within fat cells , resistance to and lack of incretin , high glucagon levels in the blood, increased retention of salt and water by the kidneys, and inappropriate regulation of metabolism by the central nervous system . [10] However, not all people with insulin resistance develop diabetes since an impairment of insulin secretion by pancreatic beta cells is also required. [13] In the early stages of insulin resistance, the mass of beta cells expands, increasing the output of insulin to compensate for the insulin insensitivity. [52] But when type 2 diabetes has become manifest, a type 2 diabetic will have lost about half of their beta cells. [52] Fatty acids in the beta cells activate FOXO1 , resulting in apopotosis of the beta cells. [52] Diagnosis WHO diabetes diagnostic criteria [53] [54] edit Condition 2-hour glucose Fasting glucose HbA 1c Unit mmol/L mg/dL mmol/L mg/dL mmol/mol DCCT % Normal < 7.8 < 140 < 6.1 < 110 < 42 < 6.0 Impaired fasting glycaemia < 7.8 < 140 6.1–7.0 110–125 42–46 6.0–6.4 Impaired glucose tolerance ≥ 7.8 ≥ 140 < 7.0 < 126 42–46 6.0–6.4 Diabetes mellitus ≥ 11.1 ≥ 200 ≥ 7.0 ≥ 126 ≥ 48 ≥ 6.5 The World Health Organization definition of diabetes (both type 1 and type 2) is for a single raised glucose reading with symptoms, otherwise raised values on two occasions, of either: [55] fasting plasma glucose ≥ 7.0 mmol/l (126 mg/dl) or with a glucose tolerance test , two hours after the oral dose a plasma glucose ≥ 11.1 mmol/l (200 mg/dl) A random blood sugar of greater than 11.1 mmol/l (200 mg/dl) in association with typical symptoms [23] or a glycated hemoglobin (HbA 1c ) of ≥ 48 mmol/mol (≥ 6.5 DCCT %) is another method of diagnosing diabetes. [10] In 2009 an International Expert Committee that included representatives of the American Diabetes Association (ADA), the International Diabetes Federation (IDF), and the European Association for the Study of Diabetes (EASD) recommended that a threshold of ≥ 48 mmol/mol (≥ 6.5 DCCT %) should be used to diagnose diabetes. [56] This recommendation was adopted by the American Diabetes Association in 2010. [57] Positive tests should be repeated unless the person presents with typical symptoms and blood sugars >11.1 mmol/l (>200 mg/dl). [56] ADA diabetes diagnostic criteria in 2015 [58] edit Diabetes mellitus Prediabetes HbA 1c ≥6.5% 5.7-6.4% Fasting glucose ≥126 mg/dL 100-125 mg/dL 2h glucose ≥200 mg/dL 140-199 mg/dL Random glucose with classic symptoms ≥200 mg/dL Not available Threshold for diagnosis of diabetes is based on the relationship between results of glucose tolerance tests, fasting glucose or HbA 1c and complications such as retinal problems . [10] A fasting or random blood sugar is preferred over the glucose tolerance test, as they are more convenient for people. [10] HbA 1c has the advantages that fasting is not required and results are more stable but has the disadvantage that the test is more costly than measurement of blood glucose. [59] It is estimated that 20% of people with diabetes in the United States do not realize that they have the disease. [10] Type 2 diabetes is characterized by high blood glucose in the context of insulin resistance and relative insulin deficiency. [60] This is in contrast to type 1 diabetes in which there is an absolute insulin deficiency due to destruction of islet cells in the pancreas and gestational diabetes that is a new onset of high blood sugars associated with pregnancy. [13] Type 1 and type 2 diabetes can typically be distinguished based on the presenting circumstances. [56] If the diagnosis is in doubt antibody testing may be useful to confirm type 1 diabetes and C-peptide levels may be useful to confirm type 2 diabetes, [61] with C-peptide levels normal or high in type 2 diabetes, but low in type 1 diabetes. [62] Screening No major organization recommends universal screening for diabetes as there is no evidence that such a program improve outcomes. [63] [64] Screening is recommended by the United States Preventive Services Task Force (USPSTF) in adults without symptoms whose blood pressure is greater than 135/80 mmHg. [65] For those whose blood pressure is less, the evidence is insufficient to recommend for or against screening. [65] There is no evidence that it changes the risk of death in this group of people. [64] They also recommend screening among those who are overweight and between the ages of 40 and 70. [66] The World Health Organization recommends testing those groups at high risk [63] and in 2014 the USPSTF is considering a similar recommendation. [67] High-risk groups in the United States include: those over 45 years old; those with a first degree relative with diabetes; some ethnic groups, including Hispanics, African-Americans, and Native-Americans; a history of gestational diabetes ; polycystic ovary syndrome ; excess weight; and conditions associated with metabolic syndrome . [23] The American Diabetes Association recommends screening those who have a BMI over 25 (in people of Asian descent screening is recommended for a BMI over 23). [68] Prevention Main article: Prevention of type 2 diabetes Onset of type 2 diabetes can be delayed or prevented through proper nutrition and regular exercise. [69] [70] Intensive lifestyle measures may reduce the risk by over half. [25] [71] The benefit of exercise occurs regardless of the person's initial weight or subsequent weight loss. [72] High levels of physical activity reduce the risk of diabetes by about 28%. [73] Evidence for the benefit of dietary changes alone, however, is limited, [74] with some evidence for a diet high in green leafy vegetables [75] and some for limiting the intake of sugary drinks. [76] There is an association between higher intake of sugar-sweetened fruit juice and diabetes, but no evidence of an association with 100% fruit juice. [77] A 2019 review found evidence of benefit from dietary fiber . [78] In those with impaired glucose tolerance , diet and exercise either alone or in combination with metformin or acarbose may decrease the risk of developing diabetes. [25] [79] Lifestyle interventions are more effective than metformin. [25] A 2017 review found that, long term, lifestyle changes decreased the risk by 28%, while medication does not reduce risk after withdrawal. [80] While low vitamin D levels are associated with an increased risk of diabetes, correcting the levels by supplementing vitamin D3 does not improve that risk. [81] Management Further information: Diabetes management Management of type 2 diabetes focuses on lifestyle interventions, lowering other cardiovascular risk factors, and maintaining blood glucose levels in the normal range. [25] Self-monitoring of blood glucose for people with newly diagnosed type 2 diabetes may be used in combination with education, [82] although the benefit of self-monitoring in those not using multi-dose insulin is questionable. [25] In those who do not want to measure blood levels, measuring urine levels may be done. [82] Managing other cardiovascular risk factors, such as hypertension , high cholesterol , and microalbuminuria , improves a person's life expectancy. [25] Decreasing the systolic blood pressure to less than 140 mmHg is associated with a lower risk of death and better outcomes. [83] Intensive blood pressure management (less than 130/80 mmHg) as opposed to standard blood pressure management (less than 140-160 mmHg systolic to 85–100 mmHg diastolic) results in a slight decrease in stroke risk but no effect on overall risk of death. [84] Intensive blood sugar lowering (HbA 1c <6%) as opposed to standard blood sugar lowering (HbA 1c of 7–7.9%) does not appear to change mortality. [85] [86] The goal of treatment is typically an HbA 1c of 7 to 8% or a fasting glucose of less than 7.2 mmol/L (130 mg/dl); however these goals may be changed after professional clinical consultation, taking into account particular risks of hypoglycemia and life expectancy. [68] [87] [88] Hypoglycemia is associated with adverse outcomes in older people with type 2 diabetes. [89] Despite guidelines recommending that intensive blood sugar control be based on balancing immediate harms with long-term benefits, many people – for example people with a life expectancy of less than nine years who will not benefit, are over-treated . [90] It is recommended that all people with type 2 diabetes get regular eye examinations . [13] There is weak evidence suggesting that treating gum disease by scaling and root planing may result in a small short-term improvement in blood sugar levels for people with diabetes. [91] There is no evidence to suggest that this improvement in blood sugar levels is maintained longer than four months. [91] There is also not enough evidence to determine if medications to treat gum disease are effective at lowering blood sugar levels. [91] Lifestyle A proper diet and exercise are the foundations of diabetic care, [23] with a greater amount of exercise yielding better results. [92] Exercise improves blood sugar control, decreases body fat content and decreases blood lipid levels, and these effects are evident even without weight loss. [93] Aerobic exercise leads to a decrease in HbA 1c and improved insulin sensitivity. [94] Resistance training is also useful and the combination of both types of exercise may be most effective. [94] A diabetic diet which includes calorie restriction to promote weight loss is generally recommended. [95] [58] Other recommendations include emphasizing intake of fruits, vegetables, reduced saturated fat and low-fat dairy products, and with a macronutrient intake tailored to the individual, to distribute calories and carbohydrates throughout the day. [58] [96] Several diets may be effective such as the Dietary Approaches to Stop Hypertension (DASH), Mediterranean diet , low-fat diet , or monitored carbohydrate diets such as a low carbohydrate diet . [58] [97] [98] Viscous fiber supplements may be useful in those with diabetes. [99] Vegetarian diets in general have been related to lower diabetes risk, but do not offer advantages compared with diets which allow moderate amounts of animal products. [100] There is not enough evidence to suggest that cinnamon improves blood sugar levels in people with type 2 diabetes. [101] Culturally appropriate education may help people with type 2 diabetes control their blood sugar levels, for up to 24 months. [102] If changes in lifestyle in those with mild diabetes has not resulted in improved blood sugars within six weeks, medications should then be considered. [23] There is not enough evidence to determine if lifestyle interventions affect mortality in those who already have DM2. [71] As of 2015 [update] , there is insufficient data to recommend nonnutritive sweeteners, but note they may help reduce caloric intake. [103] Medications Metformin 500mg tablets.
PPP1R3A,
HNF4A,
PAX4,
AKT2,
GCK,
IRS1,
KCNJ11,
HNF1A,
HNF1B,
SLC2A4,
NEUROD1,
PDX1,
SLC2A2,
IRS2,
WFS1,
HMGA1,
ABCC8,
CDKAL1,
INS,
INSR,
ENPP1,
ADCY5,
CAPN10,
TCF7L2,
PPARG,
TGFB1,
LIPC,
BCL2,
MAPK8IP1,
HP,
NOS3,
PPARGC1A,
HMOX1,
LEPR,
ICAM1,
UCP2,
LEP,
SIRT1,
ADIPOQ,
EDNRA,
EDN1,
TNF,
TNFRSF1A,
NOS2,
KL,
CPT1A,
SNAP25,
ATP2A2,
EDNRB,
RETN,
GCKR,
SLC30A8,
GLIS3,
GCGR,
FTO,
GLP1R,
PTPN1,
JAZF1,
KCNQ1,
IGF2BP2,
MTNR1B,
THADA,
HMG20A,
NOTCH2,
PROX1,
KCNK16,
GPD2,
UBE2E2,
AP3S2,
MAEA,
CMIP,
PEPD,
GRB14,
CCND2,
PLEKHA1,
DGKD,
ZFAND3,
ITGA1,
PSMD6,
PAM,
KSR2,
NFATC2,
CAT,
SHBG,
MIR375,
SLC2A1,
BRAF,
SLC1A2,
ST6GAL1,
HHEX,
JADE2,
IL13RA1,
MIR126,
SOD2,
VPS26A,
GSTM1,
MOK,
GNB3,
GCG,
CNKSR2,
AUTS2,
IGF2,
GP2,
INPPL1,
SREBF1,
SOD1,
FGF21,
LPL,
ZNF257,
FBN1,
USP48,
PPARA,
SCTR,
EPC2,
IAPP,
FAM234A,
KLF14,
CYBA,
RNF6,
IDE,
ETS1,
GIPR,
CASP3,
TNFRSF1B,
SFRP4,
OGG1,
ND1,
ADAMTS9,
GPX1,
AR,
NFKB1,
MIR27A,
EGFR,
MIR192,
PCSK2,
COX2,
PRKCB,
MIR144,
HBA1,
TIMP1,
C2CD4A,
ATF3,
SLC22A3,
MIR221,
TMEM18,
C3,
C2CD4B,
MIR483,
MIR222,
MIR423,
RELA,
FAS,
CISD2,
CBS,
HK1,
ATP2A3,
MIR130B,
HLA-DRB5,
MIR203A,
MIR142,
CCDC92,
MIR140,
MIR200A,
MIR98,
MIR204,
PAX6,
ECE1,
MIR214,
ITLN1,
MIR10B,
MIR30A,
MIR377,
MIR1260A,
CDO1,
RARRES2,
CCR5,
SMAD5,
MAT1A,
NUS1,
MIR1249,
MIR1296,
MAPK8,
MIR1226,
MIR1306,
MRAS,
MIR1228,
MIR744,
MIR939,
CD36,
MIR885,
MIR1307,
MIR151A,
GPT,
RBP4,
IGF1,
ID1,
MIR127,
MIR215,
HSD11B1,
MIR205,
HPX,
MIR195,
MTOR,
MIR141,
GIP,
HIF1A,
MIR181C,
GH1,
UCP3,
SOCS3,
MIR17HG,
MIR125B1,
MIR432,
MIR92B,
MIR628,
MIR532,
MIR487B,
BCL2L11,
CYP1A2,
S100A6,
IL6,
MIR485,
MIR409,
MIRLET7D,
CCL2,
MIR339,
MIR335,
MIR1301,
MIR33B,
MIR1908,
MIR3173,
MIR4482,
BCL2L1,
MIR4516,
MIR8061,
MIR6741,
PRKAA1,
PCK1,
PCSK1,
NFE2L2,
BHMT,
MIR7704,
PPARD,
MIR1260B,
NUCB2,
NKX6-1,
ADRA2A,
SERPINF1,
AKT1,
ZC3HC1,
AGER,
SERPINE1,
MIR6803,
KCNU1,
AVP,
MIR2116,
MAPK1,
TMEM155,
MMP9,
CASP8,
PTGS2,
G6PC,
NR3C1,
GSK3B,
IGF1R,
CCN2,
REG3A,
PIK3R1,
CALCA,
MAPK3,
MAFA,
HMGCR,
MMP3,
NPPB,
SERPINA12,
CRTC2,
PC,
ABCG2,
CD38,
BECN1,
BAX,
MMP1,
PRKCZ,
PTGDS,
PRKN,
MADD,
HTR2C,
AGTR2,
TRPC1,
ARRB2,
LNPEP,
AOC3,
TRPC6,
DCX,
DEFB1,
SMAD4,
MIF,
DNMT1,
SLC9A1,
CARTPT,
NOG,
PLAT,
PLN,
MTNR1A,
UGT1A1,
NFE2L1,
DNM1L,
CYP2E1,
PPP1R3C,
FOXM1,
UGT1A6,
SRD5A1,
NR1D1,
NOS1,
THBD,
AGRP,
GJA1,
PRKCE,
CYB5R4,
MAPK9,
TGFBR2,
CCKAR,
CDKN2B,
MAPK14,
ACOT2,
CYTB,
MKI67,
CTF1,
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DAG1,
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OXCT1,
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SRC,
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ABCC2,
ASIP,
CASP12,
PHOX2A,
EPAS1,
ATP2A1,
PPP2CA,
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GADD45GIP1,
AANAT,
ATP5F1B,
SLC16A11,
STAR,
BEST1,
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MTR,
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CCHCR1,
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LMNA,
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SDF2L1,
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ATF6,
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CAMK1D,
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DUSP9,
NOX4,
ABO,
CYP19A1,
ARL15,
ELN,
SRR,
TP53INP1,
CASR,
TM6SF2,
PTPN22,
KIF11,
CUBN,
MAP2K7,
TMEM163,
GPR55,
SCGN,
TFAP2B,
AGMO,
HMGA2,
DNER,
ALDH7A1,
RBMS1,
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LIMK1,
PPP2R2C,
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PRKAA2,
RTN4RL1,
TCF7,
TTC8,
MAK,
PYY,
CYB5D2,
TTC39C,
MAP6,
DLEU7,
MFAP1,
CFAP77,
RELN,
MBNL1,
RFLNA,
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LINC02694,
LINC01344,
RPSAP52,
PSMD9,
PCARE,
TNFRSF11B,
NTRK2,
PRKAB1,
MMP2,
PDE6G,
NRG4,
ST6GALNAC3,
APOA5,
LPA,
CTTNBP2,
NTRK3,
LRMDA,
PDE6A,
ZSWIM3,
LTA,
HFE,
PTH1R,
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PTGFRN,
PCNT,
REG1A,
RHO,
OSBPL1A,
SLC5A2,
ZNF513,
SELE,
CCDC149,
C8orf37,
CCNQ,
PRRX1,
PLCD1,
IFNG,
SLC5A1,
IDH3B,
IMPDH1,
LINC01010,
PLCB3,
IL17A,
IDH3A,
IL18,
SLC9B2,
C17orf58,
ND6,
PPARGC1B,
SELP,
ZNF775,
IL10,
PLG,
TRNQ,
TRNS1,
TRNS2,
TRNK,
SI,
TRNH,
TRNW,
IL1RN,
TRNF,
IL4,
IL1B,
TRNE,
IL1A,
ST3GAL4,
ST3GAL3,
PPIL6,
PDILT,
CXCL8,
ARL9,
NEK2,
ND4,
REN,
RP1,
EYS,
KCNQ3,
PIK3CD,
SPP1,
HORMAD2,
CHCHD6,
RP2,
PIK3CB,
PIK3CA,
NLRP3,
MTHFR,
SLCO4C1,
SDHAF4,
MSH3,
RLBP1,
KIF9-AS1,
RGS13,
RGS7,
RGR,
RFC1,
NFKBIL1,
RPGR,
RPE65,
MRPL12,
CNDP1,
CDHR1,
COX3,
REEP6,
COX1,
FFAR4,
GPBAR1,
SCD,
ATXN7,
ATXN2,
SLC22A1,
SAG,
HNF1A-AS1,
ZNF101,
GOLGA6A,
PON1,
PIK3CG,
TTLL8,
CHMP4B,
IL17REL,
EHMT1,
LINC01122,
KCNQ1OT1,
INTS8,
RAB3GAP1,
ENPP7P10,
RALY,
NLGN1,
CPEB3,
MGLL,
MINDY1,
SPATA7,
CD59,
CD81,
UBAP2,
ARHGAP15,
CDK5,
NUDT6,
POLR3A,
KIZ,
CDKN2A,
TRIOBP,
SNRNP200,
PALLD,
ZHX3,
LINC00844,
ABCB9,
ABCB10,
CRB1,
PRC1-AS1,
BRS3,
ARHGEF18,
RPGRIP1L,
ADAMTS9-AS2,
LINC01426,
CAD,
UBE2E2-AS1,
PROX1-AS1,
CA4,
OSER1-DT,
SLC30A10,
FBXL7,
CEP68,
ZZEF1,
ANGPTL8,
APOM,
ARPIN-AP3S2,
LMCD1-AS1,
CNR1,
ZBED3-AS1,
ACKR3,
MERTK,
PDSS2,
ATP8B2,
DLEU1,
LRFN2,
RAMP2,
CALCOCO2,
CPA1,
GPR158,
TOPORS,
STARD9,
NAMPT,
FRY,
CRP,
CRX,
PITPNM2,
CNGA1,
CNGB1,
GTF2I,
NFAT5,
PNPLA6,
CETP,
KLHL7,
TEX14,
ANKH,
LINC00271,
RAI1,
HMGA2-AS1,
CXCR6,
PRPF8,
SUMO2P17,
CHUK,
YKT6,
ZGLP1,
TXNIP,
CLCNKB,
C1GALT1,
PRCD,
ARL2BP,
BLM,
NR2E3,
LOC102723407,
AGT,
AGTR1,
LRP12,
LINC02030,
AHSG,
PURG,
LINC02484,
ALB,
LINC02841,
PELO,
AKR1B1,
EXOC6,
HPGDS,
PALD1,
FOXP1,
CCND2-AS1,
NSG1,
LINC02576,
SND1,
LRP1B,
FSCN3,
ADRB3,
ADIPOR1,
ABCA1,
ANKFY1,
SNX7,
PEX5L,
GLRX5,
HSD17B12,
ASB3,
ANGPTL4,
ADA,
ADRB2,
ADARB1,
SOST,
IMPG2,
GHRL,
SCAPER,
LINC01611,
ADRA1A,
ADRA2B,
TBL2,
ANPEP,
RCBTB1,
VPS33B,
HNF4A-AS1,
OSBPL3,
SCAANT1,
TXNL4B,
PTPN23,
MIR5094,
ABI3BP,
PINX1,
SAMM50,
FSCN2,
BBS2,
PRPF6,
SRBD1,
DIANPH,
BDNF,
DARS2,
BGLAP,
SBNO1,
AMACR,
LINC00824,
ASCL2,
LINC02010,
APP,
GIN1,
APOA1,
APOB,
APOC3,
HORMAD2-AS1,
IFT172,
APOE,
CNTLN,
APRT,
POLDIP2,
ETS1-AS1,
PABPC4-AS1,
LINC01339,
TSBP1-AS1,
C5orf67,
ARL3,
PKN2-AS1,
GPSM1,
TSPAN3,
PCSK6,
CST3,
AGBL5,
PABPC4,
PEA15,
EXT2,
EYA2,
OASL,
FABP4,
GDAP1L1,
FABP2,
OFD1,
GCC1,
ADIPOR2,
NPRL3,
IFT88,
FGF23,
FGF14,
ZNF408,
BEST3,
MIR29A,
ESR1,
ALDH1A2,
PRPF3,
PIM3,
NRXN1,
NRXN3,
PIEZO2,
LRAT,
LPAR2,
XYLT1,
PRPF4,
APLN,
KIF9,
SEMA4A,
SELENBP1,
CLN8,
MGAM,
MTMR3,
AKTIP,
ZSCAN20,
ZIC1,
THSD4,
TLR4,
TULP1,
TNKS2,
ZNF34,
GOT2,
TP53,
TNFAIP6,
SLC2A10,
FFAR1,
UCP1,
C16orf74,
GPR42,
TGFBR3,
MLX,
LINC02245,
GSTP1,
GSTT1,
SPHKAP,
MIR146A,
FOXO1,
GABPA,
XRCC4,
SCD5,
CPED1,
PCNX2,
VWF,
VSNL1,
BICC1,
GABRA4,
USH2A,
GABRG3,
GAD1,
GAD2,
VEGFA,
VDR,
VCAM1,
CLRN1,
MED23,
YTHDC2,
DPP4,
UBE3C,
GTF2IRD1,
DSPP,
RHOBTB1,
ACE,
G6PC2,
DECR1,
MAGI2,
DBP,
SLC7A14,
CLOCK,
FCHSD2,
ACE2,
SINHCAF,
USP3,
CELSR1,
RBM19,
FGF19,
MIR4435-2HG,
RAPGEF5,
GDF15,
MTSS1,
UVSSA,
SFI1,
CYP2C9,
WSCD2,
DEPDC5,
TRIB3,
DHX38,
IFT140,
SENP2,
CYP21A2,
KIAA1549,
DOCK4,
DARS1,
MRPS35,
BCHE,
LIPE,
AIMP2,
RNF19A,
LDLR,
USF1,
ARNTL,
NOS1AP,
AHSA1,
GSTK1,
PTEN,
RBM45,
RENBP,
CTLA4,
IGFBP1,
CRK,
GRAP2,
DMD,
GYS1,
PON2,
CCL5,
POMC,
IGFBP3,
MME,
STAT3,
LGALS3,
CYP2C19,
SLCO6A1,
LPIN1,
F3,
STAP2,
APOA2,
AQP7,
FOXA2,
SST,
SLC17A5,
MET,
HMGB1,
GPR151,
NIDDM1,
SELENOP,
NIDDM2,
GPRC6A,
PCK2,
GGT1,
OR10A4,
DIO2,
HSPA5,
GC,
CYP3A4,
LINC01672,
MPO,
GGTLC5P,
SIRT6,
TLR2,
GLO1,
ELMO1,
BCL11A,
MLXIPL,
ARID4B,
NRF1,
P2RX7,
MIR155,
MSTN,
CYP2B6,
ACR,
GGTLC3,
MRGPRX1,
ALDH2,
PDR,
GGT2,
MRGPRX3,
APOL1,
HSPA1A,
SIRT3,
GPR166P,
VN1R17P,
OXER1,
SLC2A11,
FZD4,
FNDC5,
SNCA,
MRGPRX4,
MIR21,
HSPA4,
ABCG1,
HSPA1B,
LPAR3,
CHI3L1,
NR3C2,
FGF2,
CD14,
ISL1,
HAMP,
LGR6,
ARNT,
ZBTB7C,
CAV1,
GGTLC4P,
SGK1,
PSEN1,
NR1H4,
CISD1,
SELENOS,
CD163,
TMBIM4,
VIP,
CCN4,
MFN2,
ROCK1,
IL22,
GGTLC1,
VIM,
SLC22A2,
SOD3,
PLIN1,
OGA,
CNBP,
PLA2G2A,
SAT1,
HAVCR1,
FETUB,
SFRP5,
NAT2,
EPO,
IARS1,
GLUL,
LBP,
MIR27B,
STS,
APOA4,
ACACB,
KNG1,
MIR29B1,
GAS6,
IL15,
CD44,
HLA-DQA1,
ATN1,
FXN,
CD68,
ADM,
MIR29B2,
LOC102724197,
MEFV,
CRY2,
HGF,
FGF1,
MTTP,
DDIT3,
ANGPTL3,
BCL2A1,
SIRT2,
DKK1,
INSRR,
KCNJ4,
IL33,
FADS2,
CASP1,
IL6R,
IL37,
CCK,
SORT1,
TBC1D4,
MT1A,
HEBP1,
PRL,
MBL2,
PARP1,
GRK2,
ARHGEF11,
ROS1,
TRPM5,
PTX3,
FADS1,
PYCARD,
IL2RA,
KRT16,
IL5,
XPR1,
IL2,
BMP4,
HIRA,
LPAL2,
FABP1,
PADI4,
CHDH,
FANCD2,
PTK2B,
BRCA2,
SOCS1,
FN1,
XBP1,
SLC47A1,
FOXC2,
SLBP,
PLA2G7,
FGB,
GHSR,
DGAT1,
LIPG,
EPHB2,
IGFBP2,
MIR34A,
ELANE,
MT2A,
HSPG2,
SOAT1,
DPPA3,
SULT1E1,
TPD52,
SH2B1,
HHIP,
HDLBP,
NR1I2,
AZU1,
MIR122,
BTC,
CPE,
MAP4K4,
PDHX,
STAM2,
NCAM1,
ACP1,
CMKLR1,
NGF,
NHS,
PKD1,
UTS2,
MYH9,
PGC,
MTCO2P12,
IFNL3,
RAPGEF1,
SORCS1,
KIR3DL1,
GPX3,
KDR,
P2RY12,
TIMP3,
SNAP23,
FLVCR1,
GRN,
HDAC9,
AMY2A,
TNFSF14,
COMT,
RPL29,
GPD1,
PDE3B,
RAPSN,
DACT1,
SPX,
TRAF6,
PVT1,
CYP2D6,
AKR1A1,
KEAP1,
MIR223,
ALOX12,
HDAC3,
MARCHF1,
ISG20,
RNU1-1,
ANGPT1,
C1QTNF9,
TNMD,
GAS5,
IL13,
CXCL12,
SPARC,
ENO1,
CCL16,
GPR142,
CXCL10,
ENHO,
STRA6,
ST13,
TFRC,
NPC1,
CACNA1E,
STK11,
STX1A,
CCR2,
PDK4,
RUNX2,
NRG1,
ERBB2,
S100A9,
SQSTM1,
C1QL3,
BCAR1,
CLPS,
LRG1,
TOMM40,
GEM,
ACACA,
DDAH2,
FKBP5,
CISH,
CDK4,
LGR5,
METRN,
MUSK,
CREB1,
MIR17,
FLAD1,
TAS2R13,
CD40LG,
PSMA6,
MIR143,
SLC39A7,
CLU,
POU2F1,
NR1H3,
PTGES2,
FOXP3,
OLR1,
PCNA,
LRP5,
GAPDH,
SLC2A9,
ABCB6,
PRKCA,
NR0B2,
XRCC1,
ENSA,
CXCR4,
F5,
PLA2G10,
NR4A1,
PLA2G6,
ABCG5,
ACHE,
FOXO3,
FBRS,
STAT5A,
P2RX3,
CACNA1D,
FSD1,
HPSE,
NPPA,
FGFR1,
KLK3,
ARSA,
PRMT1,
IGF2R,
CHGA,
KLF4,
PPP1R3B,
DHX40,
ANXA1,
PNPLA2,
ELAVL2,
ERP44,
CIDEC,
PRDM16,
FBXO8,
BMP7,
VPS13C,
STEAP4,
NNMT,
CCNL1,
MCIDAS,
HSPA2,
APOD,
KHDRBS1,
APOH,
DST,
MIR30D,
ADAM17,
FCGR3B,
FCGR3A,
ISYNA1,
POU2F3,
OSM,
MIR145,
SMUG1,
B2M,
NR1H2,
NTS,
MIR152,
TNFSF10,
WNK1,
UTS2R,
TM7SF2,
GGCT,
WNT5B,
TNFRSF12A,
NUP62,
DDAH1,
COL18A1,
CMA1,
IMPACT,
HEMGN,
GFAP,
TNFSF11,
F2,
SP6,
F2R,
OGN,
FAAH,
PDE5A,
BTF3P11,
IL18R1,
PBX1,
ERBB4,
NBEAL2,
SIRT4,
TCF4,
SIRT5,
HCCS,
ELOVL6,
GTF2H1,
TTR,
CILP2,
TEK,
FSD1L,
TERF1,
TFAM,
PHLPP1,
BACE2,
TRPV1,
MIR182,
G6PD,
ESR2,
VEGFC,
TGFBI,
GRB10,
TGM2,
BMP2,
OPA1,
PARL,
LINC01194,
SLC6A4,
ENTPD1,
PRKG1,
CENPJ,
DRD2,
LOX,
KCNJ1,
DCTN4,
MC3R,
PPIG,
TUBB4B,
JAK2,
JAK1,
S100A8,
CERS6,
ITGAM,
NOD1,
SPRY2,
RNR2,
JPH3,
ITGA2B,
LAD1,
TMEM154,
LITAF,
STK38,
PTPN2,
RPS6KB1,
KLB,
PLF,
MBOAT4,
UCN3,
KCNMA1,
ALOX5,
KCNJ15,
TIMM8A,
SGSM3,
BRD2,
PLTP,
CEACAM5,
RRAD,
PRTN3,
KCNJ9,
H6PD,
RXRA,
MUTYH,
PSAT1,
PROS1,
IRAK1,
ITGA2,
ANGPTL2,
PGR,
AMD1P2,
EBI3,
LRP2,
C1QTNF5,
CREBRF,
PPIA,
ADCY3,
PHOSPHO1,
ABCB1,
RAC1,
LRP1,
SFTPD,
EGR1,
CYP2J2,
FOXD3,
CAPN1,
RN7SL263P,
BMS1,
COPA,
RAD1,
TFB1M,
TMPRSS6,
SERPINA1,
C1QTNF1,
AMD1,
NTN1,
C5AR2,
CDK9,
CD33,
MMP8,
CASQ1,
METRNL,
ALX4,
CYP2C18,
NPC1L1,
TLR9,
SCARB1,
INTU,
SELL,
LARS2,
CYBB,
ARID1B,
KLF7,
MIR495,
SLCO1B1,
CX3CR1,
DOK5,
CYP2C8,
CYP1A1,
P2RY1,
NCOA5,
SLC27A4,
MAGEE1,
FST,
GFPT2,
DUSP12,
LRPPRC,
CDKN1B,
CELA3A,
RNLS,
FAT1,
FBN2,
SLC52A2,
FCGR2B,
ATP6AP2,
CDKN1C,
PREX1,
KMT2D,
SEMA6A,
KLHL42,
CHRM3,
MICA,
CPT2,
CDKN1A,
CP,
CRYZ,
CDC42,
COX4I1,
NR1I3,
FCN3,
CTSD,
FABP6,
MIR486-1,
COX8A,
PDLIM5,
PTPRU,
CDK2,
IVNS1ABP,
ABCC5,
POSTN,
OGT,
CSF2,
HOTAIR,
NISCH,
AGXT2,
BSG,
P2RX2,
DEFB103A,
XYLT2,
COL9A3,
DYRK1A,
MIR30C2,
P2RX6,
CIB1,
EP300,
RCAN1,
FAM3A,
MIR30C1,
ABCG8,
ATG7,
MIR29C,
SLC30A6,
CAV3,
EPHX2,
ARID3A,
CEBPB,
GGA3,
CEL,
DNAJB3,
MIR33A,
MIR34C,
MIR320A,
CELA1,
CAMP,
CPB2,
CALR,
EGF,
IL32,
CAPN2,
ADAM28,
CES1,
LILRB1,
SLC25A20,
CAPN3,
SULF2,
NOD2,
HSPB3,
EPOR,
ARHGEF12,
VASH1,
ESRRA,
TRIM72,
SERPING1,
ZNF410,
COMP,
MIR20B,
PINK1,
ICOSLG,
CD5L,
CHPT1,
DAPK3,
ABHD6,
CYP17A1,
CYP11B2,
KLF5,
MEG3,
PDAP1,
CYP3A5,
SUCLA2,
TXNRD2,
CNDP2,
ARHGAP22,
TBC1D1,
MEPE,
KLRK1,
SEMA3A,
NPEPPS,
AAA1,
SPHK1,
ATF7IP,
PER2,
DNASE1,
FOXO6,
SORBS1,
TSC22D1,
SARDH,
NQO1,
DHCR7,
SOCS2,
GDF11,
P2RY2,
NR4A3,
SLAMF1,
LDHA,
LECT2,
LGALS1,
LIF,
C1QTNF3,
FAM3B,
LMX1A,
DUOX1,
PVALB,
ICOS,
PTPRN,
PTPN9,
RMC1,
CYP2R1,
APLNR,
AFP,
AFM,
KIF6,
SMAD7,
KCNIP1,
ADORA1,
MAPT,
DUOX2,
MBP,
IL20,
ADH1B,
PLIN2,
MDM2,
MEF2A,
NANS,
FRMD3,
TERF2IP,
ALOX5AP,
IL1R1,
IL6ST,
SLC39A1,
IL12B,
SDC2,
SDC1,
CXCL5,
SRL,
ALOX15,
SPINK4,
ITGAX,
MSMO1,
TSPAN31,
S100B,
COPD,
SFXN1,
GHS,
RXRG,
KCNJ6,
DESI1,
RRAS,
PRRT2,
DLL1,
RORC,
NPAS4,
KISS1,
KLK1,
KRT18,
PRSS55,
PRKCD,
LARP1BP2,
HDAC7,
PIK3C2G,
TAAR1,
NM,
SLC25A3,
PHB,
ATP6V1H,
PGF,
PFKM,
NOTCH1,
NT5C3A,
PEG3,
NPHS1,
BFAR,
IL23A,
ERFE,
TRPM6,
ACAT1,
PDCD1,
PWAR1,
PCYT1A,
OCA2,
R3HDML,
PCBD1,
OPRM1,
P2RX1,
P2RX4,
P2RX5,
PAK1,
ACLY,
NFKBIA,
PRKAR1A,
POR,
PRKAB2,
MMP7,
MMP12,
MMP13,
SRGN,
PTPA,
MMP14,
MRC1,
RNU6-392P,
GPRC5B,
GAL,
MT1E,
FITM2,
MT1X,
NF2,
MTHFD1,
METTL9,
PLXNA2,
SLC35G1,
PLK1,
GNPDA2,
PLD1,
PLCG1,
PLAGL1,
PLAG1,
PLA2G1B,
PKNOX1,
PKLR,
IKBKB,
CHIT1,
CRISPLD2,
AZGP1,
GSN,
KLRC4-KLRK1,
GSR,
UGT2B15,
TF,
TERT,
GATA6,
SERPINA3,
ANGPTL6,
TERC,
TXN2,
VIPR1,
UCHL1,
TMEM132A,
TAPBP,
CFH,
VLDLR,
ERVK-18,
C1QTNF12,
HLA-DMA,
ATP5PF,
GAST,
VTN,
STX4,
BID,
GFER,
STAT5B,
TLR3,
TRH,
ACAD10,
CRISP2,
GLA,
CEP55,
CD2AP,
CBLIF,
P2RX5-TAX1BP3,
MIR107,
BCR,
CIMT,
GPR39,
THBS1,
TTN,
GHR,
FFAR2,
TLE1,
TKT,
TXN,
GCA,
GPS2,
KLF10,
SESN2,
GFPT1,
ARID5B,
GORASP2,
MIR199A1,
FGL1,
SPINK1,
AQP9,
SOX4,
SORD,
SNRNP70,
FKBP4,
AOC2,
ANXA6,
SPZ1,
HTN1,
SLC30A1,
APPL1,
HTR2A,
SLC16A1,
TRPM7,
ANGPT2,
GPC5,
SLC6A2,
ST8SIA4,
SLC2A5,
ANKRD55,
IGFALS,
QRSL1,
FHL1,
MIR199A2,
MIR20A,
STAT4,
LINC-ROR,
PGR-AS1,
SSTR5,
WNT5A,
MIR130A,
ONECUT1,
FLT1,
SREBF2,
NAT10,
C4B_2,
MYDGF,
LOC107832851,
DMAP1,
LARP6,
LY75-CD302,
RASD1,
RBM14-RBM4,
LSR,
NBAS,
DEFB4B,
MCS+9.7,
HMGA1P8,
LOC110806263,
MMP26,
RHOT1,
CCL28,
ALG1,
METTL3,
LIN7C,
LINC00994,
DIP,
RPS10-NUDT3,
GNG12-AS1,
RAB14,
WASHC1,
CYRIB,
VIM-AS1,
NDUFA12,
SLC50A1,
NEIL3,
LOC102723996,
SIRT1-AS,
THRIL,
MIR1910,
SLC38A2,
ALL2,
NLGN3,
CASZ1,
ENAH,
ZFAND6,
OPN1MW3,
VPS35,
EXOSC4,
RNPC3,
UGT1A10,
UGT1A8,
UGT1A7,
ERRFI1,
UGT1A5,
UGT1A9,
MIR3188,
TEMPS,
UGT1A4,
BNC2,
TRPM4,
TET2,
FBLIM1,
SALRNA1,
CBSL,
LOC102723971,
UGT1A3,
TREM2,
MIR3939,
APPL2,
MOCOS,
ZC4H2,
LGR4,
DEFB103B,
COMMD3-BMI1,
MIR4756,
USE1,
ASAH2,
ENOX1,
BOP,
CAMK2N1,
SLC6A20,
SLC52A1,
CST12P,
SAGE1,
PLUT,
WWOX,
LRP1-AS,
ADA2,
MIR3666,
IL17D,
SHC3,
CERNA3,
HDL3,
FXYD5,
MIR4463,
PERCC1,
SOX6,
UGGT2,
ROBO4,
DUSP26,
SUCNR1,
IGSF21,
CISD3,
TIMD4,
TRIM47,
KCTD1,
MIF-AS1,
TTC28-AS1,
EXOC3L2,
SLC9C1,
UCN2,
CYP4V2,
WNT3A,
GALP,
SLC22A16,
LY86-AS1,
KRT90P,
DSEL,
HCCAT5,
GORAB,
BIRC8,
AD7,
RNU12,
AQP11,
H19,
TXNRD3,
SLC46A1,
OPN4,
PRDM6,
CGB8,
CGB5,
MUC19,
LINC00523,
PGP,
TRMT10A,
ABCC11,
BPIFA4P,
HS6ST3,
MMAB,
PHF6,
ZACN,
SLC27A1,
LINC-PINT,
MALAT1,
PPP1R1B,
KAT8,
CHKB-CPT1B,
SLC41A2,
HORMAD1,
IMMP2L,
LEKR1,
SAMD12,
MIXL1,
GPR61,
LINC01193,
PWAR4,
C7orf50,
GLYR1,
UBASH3B,
ORAI1,
PTPN5,
GPIHBP1,
MFSD9,
HCAR2,
ZNF469,
ZBED3,
ZGPAT,
BRINP3,
ZFP69,
HSD17B13,
ACTBL2,
L3MBTL3,
TIRAP,
TAS2R12P,
TAS1R3,
NRK,
CLDN19,
SIK1,
UPP2,
PPM1K,
SLC2A12,
CBLL2,
FAM3D,
ACVR1C,
DQX1,
SGMS2,
NLRP6,
ARID2,
PIFO,
MLKL,
TET3,
PDIK1L,
MTPN,
LRGUK,
ROMO1,
OR2AG1,
PIWIL4,
SESN3,
FGFBP3,
GSC,
MT1P3,
HT,
GPAT4,
BEAN1,
CD300LG,
PTPRVP,
SLC30A7,
IL23R,
FAM78B,
CENPX,
KLHDC7A,
SGMS1,
MED19,
CADM2,
ANGPTL5,
DCD,
THEM4,
TADA1,
AKNAD1,
SLC41A1,
OLIG1,
SLC22A12,
CASC2,
ANKK1,
OSBPL8,
PTF1A,
WDR72,
NEGR1,
HCG27,
IL27,
SPESP1,
MARCHF8,
FOLH1B,
TPRG1L,
LYPLAL1,
UNC5B,
TCHHL1,
SKA1,
MSI2,
GGTA2P,
JMJD1C,
SLC39A12,
TPPP2,
SPIC,
RFX6,
SLC29A4,
SETDB2,
INHBE,
MICC,
MT1IP,
CCAR2,
MIR323B,
MARK4,
MIR146B,
MIR202,
SPTBN4,
MIR496,
MIR499A,
MIER1,
USP37,
NPS,
CHD8,
POTEM,
TSHZ3,
ECSCR,
HNP1,
MIR424,
MIR382,
SLC25A19,
EIF2AK4,
IGAN1,
NIF3L1,
ELOVL5,
BACH2,
EXOC4,
RNASEK,
MIR378A,
PLIN5,
POTEKP,
PGBP,
UBL5,
CXCL16,
NEUROD4,
POU5F1P3,
CHCHD2P9,
TNFSF12-TNFSF13,
USP36,
KMT5AP1,
MUC5B,
OPN1MW2,
CPA6,
HYMAI,
CDK11A,
SLC12A9,
ARNTL2,
CA10,
SMARCAD1,
OCTN3,
CELF4,
SPHK2,
MIR708,
C20orf181,
MIR661,
GOPC,
PELI1,
KIDINS220,
POU5F1P4,
CXADRP1,
NCF1,
CFAP97,
WASH6P,
XPO5,
MIR590,
MIR657,
MIR593,
PLEKHG5,
MRS2,
GJD2,
ATP10A,
SLC39A10,
PROK2,
MIR99A,
TOMM5,
MUL1,
ASRGL1,
MIR15A,
MIR15B,
MIR18A,
MIR187,
STN1,
MIR200B,
ADM2,
PRR5L,
BBS10,
LIN28A,
NLRX1,
NEIL1,
MIR206,
TNFAIP8L2,
MIR154,
MOGAT2,
MIR147A,
MIR106B,
MFRP,
MED25,
TLR10,
NIPA2,
MOB2,
COLEC12,
SETD7,
ALPK1,
TAS1R2,
MIR125A,
MIR128-1,
TSEN2,
MIR132,
COASY,
MIR210,
IRX3,
MIR95,
MBOAT7,
WDR13,
MIR296,
PDIA2,
GORASP1,
DCLRE1C,
GMCL2,
GMCL1,
NFKBIZ,
NSD1,
MIR30E,
FN3K,
DMRTA1,
MIR31,
SLC17A9,
UBE2O,
FNDC4,
GNPNAT1,
RFX7,
GRAMD2B,
MIR217,
LY6G6E,
MIR219A1,
KCTD15,
MIR22,
VKORC1,
MIR23A,
SLC30A5,
MIR23B,
BRD9,
WNK4,
MIR26B,
FRTS1,
ACD,
SCLY,
UTRN,
LARS1,
HACD3,
IK,
IGH,
IGFBP5,
IGFBP4,
IFNA13,
IFNA1,
ICAM3,
HTR4,
HTR2B,
HTC2,
HSPD1,
HSP90AA1,
HSPB2,
HSPB1,
HSPA9,
HSD11B2,
HES1,
HRC,
HRAS,
HOXA5,
HNRNPK,
HNRNPF,
HNRNPA1,
FOXA3,
HMBS,
IL3,
IL4R,
IL7,
KCNJ10,
L1CAM,
KRT31,
KRT19,
KRT7,
KPNA1,
KIR3DL2,
KIR2DS1,
KEL,
KCNN3,
KCNN2,
KCNK3,
KCNJ3,
CXCR1,
KCND3,
KCNC4,
KCNB1,
ITGB2,
INSIG1,
IMPA1,
ILK,
TNFRSF9,
IL16,
IL15RA,
IL12A,
HLF,
HLA-DRA,
HLA-DQB2,
GDF1,
GNAO1,
GLRX,
GLS,
GCLC,
GLB1,
GK,
GJA8,
GJA4,
GH2,
GDNF,
GDF2,
OPN1MW,
SFN,
GCH1,
GBP2,
GATA4,
GATA3,
GAP43,
GALNT2,
GABRG2,
GABPB1,
FUT6,
FUT2,
NR5A1,
GOLGB1,
GPI,
HLA-DQA2,
HSD17B10,
HLA-DPB1,
HLA-DOA,
HLA-DMB,
HLA-A,
CFHR2,
HCRT,
HBA2,
HAS3,
HARS1,
HADH,
HADHA,
GZMB,
GPM6A,
GYG1,
GTF3A,
GSTA4,
GSTA1,
GRB2,
FFAR3,
GPR35,
GPER1,
GPR21,
CXCR3,
GPR1,
LAMB3,
LAMP1,
LAMC2,
CCN3,
OAS3,
NR4A2,
NUCB1,
NTRK1,
YBX1,
SLC11A2,
NPY2R,
NPR3,
NPR2,
NPR1,
NPM1,
NME1,
P4HB,
NGFR,
NFYC,
NFYB,
NFYA,
NFATC1,
NEFL,
NDUFS4,
NAGLU,
MYO5A,
MYLK,
MYL2,
OMG,
PAEP,
MYF5,
PDK2,
PIN1,
PIK3C3,
PIK3C2A,
SERPINE2,
SERPINB6,
PGM1,
PFKFB3,
PFKFB2,
PFDN2,
PER1,
PECAM1,
PDHB,
PRDX1,
PDGFRB,
PDGFB,
PDE4D,
PDC,
PDB1,
PCOLCE,
SERPINA5,
PCDH8,
PAWR,
PAPPA,
SERPINB2,
MYH6,
MYD88,
LAMP2,
SH2D1A,
MAX,
MAS1,
MAOA,
MAN2A1,
MAN1A1,
MAFD2,
SMAD3,
SMAD2,
SMAD1,
MXD1,
LYZ,
LY75,
MC5R,
LY9,
LTF,
LTBR,
CYP4F3,
LRP6,
LPP,
LOXL2,
FADS3,
LIPA,
LCN1,
STMN1,
MB,
SMCP,
MUC1,
MST1,
MTRR,
RNR1,
ATP8,
MT1L,
MT1M,
MT1JP,
MT1H,
MT1G,
MT1F,
MT1B,
MSX2,
MSH5,
ADAM11,
MSH2,
MPI,
ALDH6A1,
KMT2A,
MGST3,
MGP,
MGAT2,
MFAP2,
MAP3K5,
MEF2C,
ME1,
FOS,
FOLR2,
FOLR1,
CA5A,
CCND3,
CCKBR,
CBR3,
CBR1,
RUNX3,
RUNX1,
CAV2,
CAMK2A,
CALCR,
CACNB3,
CACNA1C,
CA2,
CD4,
VPS51,
C5,
CAPN5,
C4B,
C4A,
TSPO,
BRCA1,
BPI,
BNIP3,
BMP6,
BMI1,
CD247,
CD86,
BLK,
CGA,
AP3S1,
CKM,
CKB,
CIDEA,
CHRNB4,
CHRNA4,
CHN2,
CHM,
CEACAM7,
CEACAM3,
CGB3,
CFTR,
CD34,
CTSC,
CENPA,
CECR,
CEBPA,
CDX2,
CDKN3,
CDK6,
CDH13,
CDH2,
CD48,
ENTPD3,
BLVRA,
BGN,
CLCN3,
AIF1,
AMY1C,
AMY1B,
AMY1A,
BIN1,
AMPD1,
AMH,
ALPP,
ALPL,
ALDH3B1,
ALCAM,
ALAS1,
AIC,
ANXA5,
ADORA3,
ADORA2B,
ADH1C,
ADD1,
ADCYAP1,
ACVR2B,
ACTG2,
ACTG1,
ACTB,
ACAA1,
AAVS1,
ANK2,
APCS,
CFB,
ATIC,
BCS1L,
OPN1SW,
HCN2,
BCAT1,
AVPR2,
ATP5PO,
ATP7A,
ATP5MC1,
ATP4A,
ATP2B1,
ATP12A,
ATHS,
BIRC2,
SERPINC1,
ARSL,
ARR3,
RND3,
RHOA,
AQP5,
AQP2,
FASLG,
APOC4,
APOC2,
BIRC3,
CLCN2,
CLCN5,
FOLH1,
EFNB3,
EPHA4,
ENO2,
MARK2,
ELK3,
ELAVL1,
EIF4G1,
EIF4EBP1,
EIF4A2,
EGR3,
EGR2,
CELSR2,
EFNB2,
EPHX1,
LPAR1,
TYMP,
EBM,
E2F1,
DUSP6,
DRD3,
DPYS,
DPYD,
DPT,
DNTT,
DMP1,
EPHB1,
ERBB3,
DLD,
FASN,
FMO3,
FLNA,
FLII,
FHIT,
FGFR4,
FGF11,
GPC4,
FDXR,
FCP1,
FCGRT,
FBP1,
FAP,
ERG,
FABP5,
FABP3,
F2RL2,
F2RL1,
EXT1,
EVC,
ETV3,
ETFA,
ESRRG,
ESRRB,
FBL,
DMBT1,
SEPTIN1,
CLK2,
COL17A1,
CS,
CRMP1,
CREM,
CREBBP,
CRABP2,
CPT1B,
COX10,
COX7A1,
COX5B,
MAP3K8,
CORT,
COL9A2,
CSHL1,
COL9A1,
COL8A1,
COL6A3,
COL4A5,
COL4A2,
COL2A1,
COL1A1,
CNTF,
CNR2,
CMM,
CCR1,
CSF3,
CST2,
DIAPH2,
BRINP1,
CFD,
DES,
DEFB4A,
DEFA3,
DEFA1,
DDX3X,
DDT,
AKR1C2,
DCN,
DBI,
DBH,
CYP27B1,
CTAA1,
CYP27A1,
CYP8B1,
CYP7A1,
CYP2A6,
CYP1B1,
CYB5A,
CXADR,
CUX1,
CTSL,
CTSH,
CTRL,
PKM,
PLA2G4A,
PLEK,
RBM14,
SPTLC1,
AGPAT1,
PROCR,
HYOU1,
CARM1,
UNC13B,
CAP1,
TIMM44,
FAM3C,
IFI30,
LYPLA1,
SPON1,
SLC19A2,
SPON2,
NSA2,
PEMT,
ATP8A1,
DLC1,
CITED2,
KLF2,
WARS2,
TCIRG1,
SIGMAR1,
FSTL3,
SLC35A1,
OLFM4,
OLIG2,
CCL27,
BTN2A1,
ADAMTS13,
ESM1,
LIAS,
METAP2,
EHD1,
MALT1,
FGL2,
NMU,
CD300C,
CYP46A1,
PPP1R13L,
NPC2,
CPLX1,
WASF3,
STARD10,
SLC17A3,
CAPN9,
EBP,
CD226,
CTCF,
IGF2BP3,
IGF2BP1,
USP16,
ZMPSTE24,
FLOT1,
TREH,
AIM2,
GDF3,
CXCL14,
STXBP5L,
GAL3ST1,
ADAMTS2,
ATG5,
AKAP6,
CHST3,
FHL5,
HOMER1,
EIF2AK3,
ITM2B,
KIF20B,
NCR1,
TJP2,
PEX16,
TMPRSS11D,
TGFBRAP1,
ADGRG1,
PIWIL1,
ITGB1BP1,
MSC,
LARGE1,
HACD1,
SOX13,
WTAP,
TRIM13,
MAFB,
NUTF2,
MPHOSPH10,
TSHZ1,
RBM6,
HIPK3,
PREB,
AKT3,
SCO2,
KCNE2,
THRAP3,
EXOG,
RNF10,
NCOR1,
SGSM2,
HEPH,
IP6K1,
TOX,
HDAC4,
SART3,
ECE2,
AQR,
EIF5B,
LPIN2,
NCOR2,
PTPRT,
MAP4K5,
SLC16A7,
DHDH,
MCTS1,
RGCC,
SLC27A6,
REM1,
TRBV7-8,
IGHD1-14,
SLCO1B3,
PCLO,
MCAT,
EIF3K,
PDLIM3,
SESN1,
KLF15,
SIT1,
SERP1,
IL17B,
DISC1,
DKK4,
SIGLEC7,
ACAD8,
GREM1,
BSCL2,
PCOLCE2,
CNNM1,
DBNL,
TBK1,
HSPB8,
MBL3P,
CSAD,
WAC,
BPIFA1,
TLR7,
DNAJC27,
IGF2-AS,
GP6,
IPO11,
HSPA14,
IRAK4,
SLC35B3,
G0S2,
MYLIP,
SLC40A1,
TBX21,
ERO1A,
SLC2A8,
SLC39A3,
RHOD,
PADI1,
GPR132,
HOOK2,
CD274,
CTNNA3,
NUPR1,
MYCBP,
CHEK2,
FAIM2,
PSD3,
SYNE1,
TTC28,
COBL,
ARC,
SIK2,
FBXO28,
SYT11,
TBC1D9,
CAND2,
KDM1A,
NT5C2,
DICER1,
RAB18,
SACM1L,
SBNO2,
CARD8,
MLXIP,
COG2,
ACOT7,
MGAT4A,
SLCO2B1,
PTGDR2,
AKAP13,
CRTC1,
NCS1,
KLHL3,
PANX1,
PITPNC1,
KIFBP,
ATRNL1,
TENM4,
TKFC,
PART1,
MGAT4C,
ARIH1,
KLK5,
TAFA5,
SLC39A6,
LY96,
ZFPM2,
BACE1,
ZMYND8,
DAPK2,
FAM215A,
SEC14L2,
PES1,
BRD4,
TRAM1,
NPTXR,
TRS-AGA2-3,
MLYCD,
SLC33A1,
ZBED1,
SERPINF2,
XCL1,
SLC2A3,
SLC1A7,
SLC1A5,
SKP2,
SKIL,
SIX3,
SHC1,
SRSF5,
SELPLG,
SDHA,
CX3CL1,
CCL22,
SLC6A8,
CCL20,
CCL11,
CCL8,
CCL7,
CCL4,
CCL3,
SCO1,
SCN8A,
SCN7A,
SCN2A,
SAA2,
SLC5A5,
SLC8A1,
S100A12,
SRI,
TADA2A,
TACR3,
TAC3,
TAC1,
SYT4,
SYT1,
STXBP3,
STX5,
STIM1,
STC1,
SSTR2,
SRD5A2,
SLC9A3,
SPRR2A,
SPG7,
SOX5,
SOX2,
SORL1,
SIGLEC1,
SMPD1,
SLPI,
SLCO1A2,
SLC18A2,
SLC10A2,
SAA1,
S100A4,
TAL1,
DNAJC3,
PTMAP4,
PTMA,
PTGER3,
PTBP1,
PTAFR,
PSMD3,
PSMD2,
PSMB6,
PSMA7,
PSG2,
TMPRSS15,
EIF2AK2,
PTPN6,
MAPK7,
PRKD1,
PPP1R2,
POU3F1,
POU2F2,
PODXL,
SEPTIN5,
PNLIP,
PMM2,
PML,
PMAIP1,
PTPN4,
PTPN11,
RYR2,
REG1B,
RTN1,
CLIP1,
RPS19,
RPS6KA3,
RPS6KA2,
RPN2,
RPE,
RORB,
RNH1,
RIT2,
REV3L,
REL,
PTPRB,
RCN2,
RARB,
RANGAP1,
RAG1,
RAB27A,
RAB5B,
RAB4A,
PYGB,
PTPRS,
PTPRF,
PTPRC,
TAF1,
TCP1,
HTR3B,
API5,
ADAM19,
MBTPS1,
TNFRSF25,
PAGE1,
VAMP4,
VAMP8,
HSD17B6,
JRK,
KHSRP,
DENR,
PIAS1,
CST7,
TNFRSF14,
DGKZ,
IRS4,
DOC2B,
DYRK3,
LOH19CR1,
BRAP,
PICALM,
ZNF239,
SLC14A2,
AAAS,
FOSL1,
TNFSF12,
RAB11A,
MAFK,
NOL3,
PCSK7,
HGS,
MTMR7,
USP2,
USP14,
PAPSS2,
RPL14,
CCRL2,
TAF1C,
F2RL3,
KALRN,
TRPA1,
RIPK2,
EIF2B5,
ZPR1,
FUBP1,
PER3,
TMEM11,
BANF1,
GALR2,
TNFRSF11A,
DLK1,
TNFRSF18,
SIGLEC5,
ECB2,
HBFQTL2,
PRDX2,
TLL1,
HSP90B1,
NR2C2,
TPO,
TPM4,
TPM1,
TOP2A,
TOP1,
TNFAIP3,
NR2E1,
TLR5,
TLR1,
TLE3,
TRPM2,
TJP1,
TIMP2,
TIAM1,
THBS4,
THBS2,
TGFB2,
TGFA,
TFPI,
TFAP2A,
TERF2,
TEP1,
TRAF3,
TST,
TFEB,
NSD2,
LAP,
PRRC2A,
MANF,
SLMAP,
ZNF236,
ZFP36,
SF1,
YWHAG,
YY1,
XDH,
XBP1P1,
WARS1,
TNFRSF4,
VPREB1,
VEGFB,
VDAC1,
UPK2,
UGT1A,
UGCG,
SCGB1A1,
UBE2B,
TYROBP,
TYK2,
TXNRD1,
LINC02605
