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T-Cell Lymphoma
Wikipedia
Due to their rarity and high variability between the different subtypes, the prognosis of T-cell lymphoma is significantly worse than other Non-Hodgkin lymphoma. [1] The treatment of T-cell lymphoma is often similar to other Non-Hodgkin lymphomas with early-stage treatments consisting of chemotherapy and/or radiology . [2] The effectiveness of these treatments is often varied between subtypes with most receiving a poor outcome with high relapse rates. [4] Contents 1 Types 1.1 Common 1.2 Rare 2 Epidemiology 3 Cause 3.1 Risk Factors 4 Symptoms 4.1 The hemophagocytic syndrome (HPS) 4.2 Swollen Lymph nodes 4.3 Skin Infections 5 Diagnosis 6 Treatment 6.1 Chemotherapy 6.2 Radiotherapy 6.3 Stem Cell Transplant 6.4 Monoclonal Antibodies 6.5 Nucleoside analogs 6.6 Other 7 See also 8 References Types [ edit ] There are many types and variations of T-cell lymphoma, each with vastly different symptoms, survival, and prognosis. ... Anaplastic Lymphoma Kinase (ALK)-negative Anaplastic Lymphoma Kinase (ALK)-positive Adult T-cell leukemia/lymphoma (ATL): Aggressive T-cell lymphoma, associated with RNA retrovirus, human T-cell leukemia virus type-1 (HTLV1) Extranodal NK/T-cell lymphoma, nasal type (ENKTL): Aggressive T-cell lymphoma, usually associated with Epstein Barr virus (EBV) Cutaneous T-cell lymphoma (CTCL): can be insolent or aggressive Mycosis fungoides Sézary syndrome Rare [ edit ] Subcutaneous panniculitis-like T-cell lymphoma (SPTCL): Cutaneous gamma-delta T-cell lymphoma (CGD-TCL) Systemic Epstein Barr virus-positive T-Cell Lymphoproliferative Disorders of Childhood (EBVTCLD): A very aggressive group with association with Epstein Barr virus (EBV) Primary intestinal T-cell lymphomas Enteropathy-associated T-cell lymphoma (EATL) Monomorphic epitheliotropic intestinal T cell lymphoma (MEITL). ... As a result, there is almost no universally known symptom that can be applied to all T-cell lymphoma subtypes. [4] The hemophagocytic syndrome (HPS) [ edit ] Hemophagocytic syndrome has been associated with most T-cell lymphoma subtypes, and is commonly characterized by fevers , reduction of lymphocytes numbers, enlarged liver or spleen, and liver dysfunction . [2] These symptoms are especially common in Extranodal T cell lymphoma subtypes which develop outside the lymph nodes , these can include; Extranodal NK/T-cell lymphoma, nasal type , Cutaneous T-cell lymphoma (CTCL), etc. [5] Swollen Lymph nodes [ edit ] T-cell lymphoma which develops from the lymph nodes commonly causes symptoms as such swollen lymph nodes. [6] The swelling normally will not cause any pain and can be felt or seen as lumps on the surface of the skin. ... Classification D ICD - 10 : C86 , C84 OMIM : 186960 MeSH : D016399 SNOMED CT : 109978004 v t e Leukaemias , lymphomas and related disease B cell ( lymphoma , leukemia ) (most CD19 CD20 ) By development/ marker TdT+ ALL ( Precursor B acute lymphoblastic leukemia/lymphoma ) CD5 + naive B cell ( CLL/SLL ) mantle zone ( Mantle cell ) CD22 + Prolymphocytic CD11c+ ( Hairy cell leukemia ) CD79a + germinal center / follicular B cell ( Follicular Burkitt's GCB DLBCL Primary cutaneous follicle center lymphoma ) marginal zone / marginal zone B-cell ( Splenic marginal zone MALT Nodal marginal zone Primary cutaneous marginal zone lymphoma ) RS ( CD15 +, CD30 +) Classic Hodgkin lymphoma ( Nodular sclerosis ) CD20+ ( Nodular lymphocyte predominant Hodgkin lymphoma ) PCDs / PP ( CD38 +/ CD138 +) see immunoproliferative immunoglobulin disorders By infection KSHV ( Primary effusion ) EBV Lymphomatoid granulomatosis Post-transplant lymphoproliferative disorder Classic Hodgkin lymphoma Burkitt's lymphoma HCV Splenic marginal zone lymphoma HIV ( AIDS-related lymphoma ) Helicobacter pylori ( MALT lymphoma ) Cutaneous Diffuse large B-cell lymphoma Intravascular large B-cell lymphoma Primary cutaneous marginal zone lymphoma Primary cutaneous immunocytoma Plasmacytoma Plasmacytosis Primary cutaneous follicle center lymphoma T/NK T cell ( lymphoma , leukemia ) (most CD3 CD4 CD8 ) By development/ marker TdT+ : ALL ( Precursor T acute lymphoblastic leukemia/lymphoma ) prolymphocyte ( Prolymphocytic ) CD30+ ( Anaplastic large-cell lymphoma Lymphomatoid papulosis type A ) Cutaneous MF+variants indolent: Mycosis fungoides Pagetoid reticulosis Granulomatous slack skin aggressive: Sézary disease Adult T-cell leukemia/lymphoma Non-MF CD30 -: Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma Pleomorphic T-cell lymphoma Lymphomatoid papulosis type B CD30 +: CD30+ cutaneous T-cell lymphoma Secondary cutaneous CD30+ large-cell lymphoma Lymphomatoid papulosis type A Other peripheral Hepatosplenic Angioimmunoblastic Enteropathy-associated T-cell lymphoma Peripheral T-cell lymphoma not otherwise specified ( Lennert lymphoma ) Subcutaneous T-cell lymphoma By infection HTLV-1 ( Adult T-cell leukemia/lymphoma ) NK cell / (most CD56 ) Aggressive NK-cell leukemia Blastic NK cell lymphoma T or NK EBV ( Extranodal NK-T-cell lymphoma / Angiocentric lymphoma ) Large granular lymphocytic leukemia Lymphoid+ myeloid Acute biphenotypic leukaemia Lymphocytosis Lymphoproliferative disorders ( X-linked lymphoproliferative disease Autoimmune lymphoproliferative syndrome ) Leukemoid reaction Diffuse infiltrative lymphocytosis syndrome Cutaneous lymphoid hyperplasia Cutaneous lymphoid hyperplasia with bandlike and perivascular patterns with nodular pattern Jessner lymphocytic infiltrate of the skin General Hematological malignancy leukemia Lymphoproliferative disorders Lymphoid leukemiasTP53, STAT3, AKT1, BCL6, STAT5B, RHOA, KMT2D, KDM1A, DDX3X, ARID1A, EP300, MGA, ASXL3, KDM4C, PPARG, HRAS, KDM2B, FAS, NBN, FASLG, RASGRP1, MS4A1, CASP10, TNFRSF8, NPM1, PRKCD, IL2, TRBV20OR9-2, NCAM1, PDLIM7, TNF, KRT20, ALK, CD274, BCL2, PRDM1, NOTCH1, IL10, TIAM1, NOS2, IL5, ABCB1, MYC, PDCD1, TET2, ASPG, PIM1, SLC16A1, PIK3CD, CTNNB1, MCTS1, RHOJ, MCAT, NOS1, CMA1, SOAT1, SMUG1, ASRGL1, PDGFRA, ATM, PIK3CB, CDKN2A, IL4, EZH2, PIK3CG, PIK3CA, ITK, DPP4, S100B, IGH, IGF1, TSPYL2, S100A1, PAEP, GZMB, HDAC8, MRPL28, CXCL13, KIT, CDKN2B, MCL1, NXT1, BMI1, PAX5, CD1D, DLX5, TNFRSF17, TAL1, IL15, IL13, MIR155, SUB1, RTEL1, H3P9, CTLA4, HAVCR2, H3P10, VEGFA, NOCT, IRF4, ABCC4, JAK2, JAK3, MAF, PSMB6, LAG3, TXN, LTA, TLR7, IFNG, PTPN6, IL9, LCK, IL2RG, IL2RA, PTEN, DLL1, TNFSF13B, HSPA4, CDK6, NFKB2, CD40, CD28, ZAP70, YY1, SYK, TCF3, SEPTIN9, CCK, WAS, TRG, TERT, TIA1, ASNS, TP73, AKT2, PLK2, MKI67, NKAIN2, SOX11, ARHGAP24, LONP1, MME, SOCS3, GATA3, MTOR, ABCC1, FGFR3, TP63, NR0B2, UBL7, MTDH, CSF1R, MAP3K8, CCR4, KIR3DL2, GNLY, TRIM13, PRG4, PARP2, NAT1, FRAT1, NRP1, YARS1, LMO4, CUL1, GFI1B, CDR3, TCL1A, CXCR4, ZMYM2, ZBTB17, MZF1, WRN, WIPF1, VDR, VAV1, UVRAG, UCP1, UCHL1, BECN1, ARHGEF7, BCL2L11, BCL10, NR1I3, MVP, DLEC1, NUAK1, MELK, SPATA2, ESPL1, TCL1B, BAG3, ITM2B, NCR1, TMPRSS11D, RECQL4, KL, CLDN10, PIAS2, NOL3, PRC1, IGHV3-69-1, CCR9, GNG8, MIR146A, MIR124-1, MIR10B, MALAT1, CRTC2, TMEM132D, TWIST2, TNFRSF13C, MIR155HG, FOXQ1, RAPH1, NAV3, PWWP3A, GLIS2, PHF6, SESN2, FIP1L1, PDCD1LG2, WLS, MLVI4, MIR150, MIR15A, MIR17, MIR18A, H3P42, LINC02605, ERVK-32, LOC102724971, LOC102723407, COMMD3-BMI1, RPL17-C18orf32, CD24, CXADRP1, MIR499A, MIR490, WG, TARP, MIR373, ZFAS1, MIR34A, MIR223, MIR205, MIR19B1, MARCKSL1, BCL11B, MALT1, TBC1D9, TBX21, IGHV3OR16-7, FBXO7, CADM1, PIK3R5, SUZ12, SIRT1, DICER1, ACSBG1, SEPTIN6, CLEC7A, EPB41L3, TPX2, KLRK1, ATXN2L, AKAP13, RASSF1, PSIP1, ADRM1, CKAP4, SMARCAL1, IGK, FOXP3, ASCC1, ERVK-6, KMT2C, PCDH10, HACE1, NDRG2, TIGAR, NLRP2, FBXW7, CEP55, CASZ1, MAP3K20, WWOX, EMCN, IL23A, ISYNA1, ECSIT, LEF1, GAL, DERL2, TYMS, RMRP, TRAF6, FN1, GZMM, GZMA, GTF2H4, MSH6, CXCR3, GNAQ, GLI1, GDNF, FUT4, FKBP4, HLA-DOA, FGFR1, ETV6, ESR2, ERCC5, ERCC2, EPHA3, EIF4EBP1, EGR1, EGFR, HIF1A, HLA-DQB1, TPT1, IFNA13, IL7, IL6, IL3, IL2RB, IL1B, IL1A, IKBKB, IGF1R, IFNGR2, IFNA1, HLA-G, IDH2, ID3, ID2, ICAM3, HTC2, HSP90AB1, HSP90AA1, HPR, HOXC5, DNMT3A, DLX6, GADD45A, BCR, CD3E, CCND3, CCND2, RUNX3, CAV1, CASR, CALR, CALCR, CA12, BCL3, DAP, CCND1, B2M, ATR, ARR3, AR, AQP4, BIRC3, ADA, ACVRL1, CD247, CD4, CD19, CD27, CYP1A1, CYBA, CXADR, CSF2, ATF2, CR2, CCR5, CCR1, CHKA, CDK7, CDK4, CDC25C, CD79A, CD70, CD68, CD47, CD44, CD40LG, CD37, IL7R, IL13RA1, IL16, RPE65, SCT, SATB1, SAI1, SAA2, SAA1, S100A4, RRBP1, RPL22, RPL17, ABO, PTPN2, REL, RB1, RASGRF2, RASGRF1, RARA, RAG1, PVT1, NECTIN2, PTPRK, CCL3, CCL17, CXCL12, SLC2A1, TLR3, TGFB1, TFRC, TF, TRGC1, TRD, GCFC2, ZEB1, STK4, STAT6, STAT5A, SPIB, SPG7, SPARC, SOX4, SOS1, SNCA, SLPI, SLC6A8, PTPRA, PSMB9, IL18, LGALS1, MTAP, MSX1, MRC1, KMT2A, MLH1, MET, MBL2, MATK, LRP1, LEPR, PRNP, LEP, RPSA, KRAS, KDR, KCNJ6, JUNB, JAK1, ITGB7, CXCL10, MTHFR, MTRR, MUC1, NF1, EIF2AK2, MAP2K1, MAPK8, PRKCQ, PRKAR1A, PRKAB1, POU2AF1, PON1, PNLIP, PLK1, PLA2G4A, PDCD2, FURIN, OPRM1, NME1, NGF, NFKB1, NFE2L2, NFATC1, H3P40
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Hypertensive Heart Disease
Wikipedia
"Hypertensive heart disease. A complex syndrome or a hypertensive 'cardiomyopathy'?" ... External links [ edit ] Classification D ICD - 10 : I11 , I13 ICD - 9-CM : 402 External resources MedlinePlus : 000163 eMedicine : article/162449 v t e Cardiovascular disease (vessels) Arteries , arterioles and capillaries Inflammation Arteritis Aortitis Buerger's disease Peripheral artery disease Arteriosclerosis Atherosclerosis Foam cell Fatty streak Atheroma Intermittent claudication Critical limb ischemia Monckeberg's arteriosclerosis Arteriolosclerosis Hyaline Hyperplastic Cholesterol LDL Oxycholesterol Trans fat Stenosis Carotid artery stenosis Renal artery stenosis Other Aortoiliac occlusive disease Degos disease Erythromelalgia Fibromuscular dysplasia Raynaud's phenomenon Aneurysm / dissection / pseudoaneurysm torso : Aortic aneurysm Abdominal aortic aneurysm Thoracic aortic aneurysm Aneurysm of sinus of Valsalva Aortic dissection Aortic rupture Coronary artery aneurysm head / neck Intracranial aneurysm Intracranial berry aneurysm Carotid artery dissection Vertebral artery dissection Familial aortic dissection Vascular malformation Arteriovenous fistula Arteriovenous malformation Telangiectasia Hereditary hemorrhagic telangiectasia Vascular nevus Cherry hemangioma Halo nevus Spider angioma Veins Inflammation Phlebitis Venous thrombosis / Thrombophlebitis primarily lower limb Deep vein thrombosis abdomen Hepatic veno-occlusive disease Budd–Chiari syndrome May–Thurner syndrome Portal vein thrombosis Renal vein thrombosis upper limb / torso Mondor's disease Paget–Schroetter disease head Cerebral venous sinus thrombosis Post-thrombotic syndrome Varicose veins Gastric varices Portacaval anastomosis Caput medusae Esophageal varices Hemorrhoid Varicocele Other Chronic venous insufficiency Chronic cerebrospinal venous insufficiency Superior vena cava syndrome Inferior vena cava syndrome Venous ulcer Arteries or veins Angiopathy Macroangiopathy Microangiopathy Embolism Pulmonary embolism Cholesterol embolism Paradoxical embolism Thrombosis Vasculitis Blood pressure Hypertension Hypertensive heart disease Hypertensive emergency Hypertensive nephropathy Essential hypertension Secondary hypertension Renovascular hypertension Benign hypertension Pulmonary hypertension Systolic hypertension White coat hypertension Hypotension Orthostatic hypotension
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Inclusion Body Myositis
Wikipedia
External links [ edit ] GeneReview/NIH/UW entry on Inclusion Body Myopathy 2 Classification D ICD - 10 : M60.8 ICD - 9-CM : 359.71 OMIM : 147421 MeSH : D018979 DiseasesDB : 30691 External resources eMedicine : neuro/422 GeneReviews : Inclusion Body Myopathy 2 Orphanet : 611 v t e Systemic connective tissue disorders General Systemic lupus erythematosus Drug-induced SLE Libman–Sacks endocarditis Inflammatory myopathy Myositis Dermatopolymyositis Dermatomyositis / Juvenile dermatomyositis Polymyositis * Inclusion body myositis Scleroderma Systemic scleroderma Progressive systemic sclerosis CREST syndrome Overlap syndrome / Mixed connective tissue disease Other hypersensitivity / autoimmune Sjögren syndrome Other Behçet's disease Polymyalgia rheumatica Eosinophilic fasciitis Eosinophilia–myalgia syndrome fibrillin Marfan syndrome Congenital contractural arachnodactyly v t e Symptoms and conditions relating to muscle Pain Myalgia Fibromyalgia Acute Delayed onset Inflammation Myositis Pyomyositis Destruction Muscle weakness Rhabdomyolysis Muscle atrophy / Amyotrophy Other Myositis ossificans Fibrodysplasia ossificans progressiva Compartment syndrome Anterior Diastasis of muscle Diastasis recti Muscle spasmGNE, NT5C1A, APP, TARDBP, HLA-DRB1, SQSTM1, APOE, KHDRBS1, NUP62, DCTN4, GTF2H1, SDC1, CDR3, GSN, MAPT, TRBV20OR9-2, HLA-C, PLAAT4, FYCO1, MSTN, TNFRSF12A, NFAT5, CCR2, UBB, MALAT1, VCP, RBM45, AOC3, DCD, UCN2, DNAJB6, OPTN, KLRG1, MAP1LC3A, LILRB1, KDELR1, ICOSLG, SYNM, ROBO3, DDX58, CHMP1B, PABPC1, TIMP1, RRM2B, TWNK, FOXP3, KRT20, TTR, ACTB, THBS1, CST3, HLA-DQA1, HK1, H1-0, NR3C1, EPHB2, EMD, DES, CD47, TGFB1, CD38, CD36, CD34, MS4A1, CAPN3, BCL2, AOC2, HLA-DRB3, HMGB1, IFN1@, IFNG, TRIM21, AGER, MOK, PTPRC, PSME1, PSMB10, MAPK1, POLG, PMP22, MMP9, MMP1, MLF1, LMNA, IL6, IL1B, LOC102723996
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Spondyloenchondrodysplasia With Immune Dysregulation
Omim
Clinical Features Roifman and Melamed (2003) described a syndrome of combined immunodeficiency, autoimmunity, and spondylometaphyseal dysplasia in 4 patients, 2 of whom were brother and sister. ... Roifman and Melamed (2003) compared the findings in their patients with those in patients with Roifman syndrome (300258), Schimke immunoosseous dysplasia (242900), ADA deficiency (102700), and cartilage-hair hypoplasia (250250). ... In addition, 1 patient had features consistent with diagnoses of Sjogren syndrome (270150), polymyositis, hypothyroidism, and severe scleroderma (see 181750), whereas the other had clinical manifestations and an autoantibody profile of SLE, further illustrating the association of SPENCD with immune dysregulation. ... In addition, Frydman et al. (1990) suggested that mental retardation, which was found in their patient 5 as well as patient 3 of Sauvegrain et al. (1980) and patient 1 of Menger et al. (1989), might be another variable manifestation of the syndrome. No features of immune dysregulation were reported in the patients of Frydman et al. (1990). ... Briggs et al. (2011) noted that these patients presented a diverse spectrum of autoimmune phenotypes, including systemic lupus erythematosus (152700), Sjogren syndrome (270150), hemolytic anemia (see 205700), thrombocytopenia, hypothyroidism (140300), inflammatory myositis (160750), Raynaud disease (179600), and vitiligo (see 606579).
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Contact Dermatitis
Wikipedia
External links [ edit ] Classification D ICD - 10 : L25.9 ICD - 9-CM : 692.9 MeSH : D003877 DiseasesDB : 29585 External resources MedlinePlus : 000869 eMedicine : emerg/131 ped/2569 oph/480 Wikimedia Commons has media related to Contact dermatitis . eMedicine Health article on contact dermatitis v t e Diseases of the skin and appendages by morphology Growths Epidermal Wart Callus Seborrheic keratosis Acrochordon Molluscum contagiosum Actinic keratosis Squamous-cell carcinoma Basal-cell carcinoma Merkel-cell carcinoma Nevus sebaceous Trichoepithelioma Pigmented Freckles Lentigo Melasma Nevus Melanoma Dermal and subcutaneous Epidermal inclusion cyst Hemangioma Dermatofibroma (benign fibrous histiocytoma) Keloid Lipoma Neurofibroma Xanthoma Kaposi's sarcoma Infantile digital fibromatosis Granular cell tumor Leiomyoma Lymphangioma circumscriptum Myxoid cyst Rashes With epidermal involvement Eczematous Contact dermatitis Atopic dermatitis Seborrheic dermatitis Stasis dermatitis Lichen simplex chronicus Darier's disease Glucagonoma syndrome Langerhans cell histiocytosis Lichen sclerosus Pemphigus foliaceus Wiskott–Aldrich syndrome Zinc deficiency Scaling Psoriasis Tinea ( Corporis Cruris Pedis Manuum Faciei ) Pityriasis rosea Secondary syphilis Mycosis fungoides Systemic lupus erythematosus Pityriasis rubra pilaris Parapsoriasis Ichthyosis Blistering Herpes simplex Herpes zoster Varicella Bullous impetigo Acute contact dermatitis Pemphigus vulgaris Bullous pemphigoid Dermatitis herpetiformis Porphyria cutanea tarda Epidermolysis bullosa simplex Papular Scabies Insect bite reactions Lichen planus Miliaria Keratosis pilaris Lichen spinulosus Transient acantholytic dermatosis Lichen nitidus Pityriasis lichenoides et varioliformis acuta Pustular Acne vulgaris Acne rosacea Folliculitis Impetigo Candidiasis Gonococcemia Dermatophyte Coccidioidomycosis Subcorneal pustular dermatosis Hypopigmented Tinea versicolor Vitiligo Pityriasis alba Postinflammatory hyperpigmentation Tuberous sclerosis Idiopathic guttate hypomelanosis Leprosy Hypopigmented mycosis fungoides Without epidermal involvement Red Blanchable Erythema Generalized Drug eruptions Viral exanthems Toxic erythema Systemic lupus erythematosus Localized Cellulitis Abscess Boil Erythema nodosum Carcinoid syndrome Fixed drug eruption Specialized Urticaria Erythema ( Multiforme Migrans Gyratum repens Annulare centrifugum Ab igne ) Nonblanchable Purpura Macular Thrombocytopenic purpura Actinic/solar purpura Papular Disseminated intravascular coagulation Vasculitis Indurated Scleroderma / morphea Granuloma annulare Lichen sclerosis et atrophicus Necrobiosis lipoidica Miscellaneous disorders Ulcers Hair Telogen effluvium Androgenic alopecia Alopecia areata Systemic lupus erythematosus Tinea capitis Loose anagen syndrome Lichen planopilaris Folliculitis decalvans Acne keloidalis nuchae Nail Onychomycosis Psoriasis Paronychia Ingrown nail Mucous membrane Aphthous stomatitis Oral candidiasis Lichen planus Leukoplakia Pemphigus vulgaris Mucous membrane pemphigoid Cicatricial pemphigoid Herpesvirus Coxsackievirus Syphilis Systemic histoplasmosis Squamous-cell carcinoma v t e Dermatitis and eczema Atopic dermatitis Besnier's prurigo Seborrheic dermatitis Pityriasis simplex capillitii Cradle cap Contact dermatitis ( allergic , irritant ) plants: Urushiol-induced contact dermatitis African blackwood dermatitis Tulip fingers other: Abietic acid dermatitis Diaper rash Airbag dermatitis Baboon syndrome Contact stomatitis Protein contact dermatitis Eczema Autoimmune estrogen dermatitis Autoimmune progesterone dermatitis Breast eczema Ear eczema Eyelid dermatitis Topical steroid addiction Hand eczema Chronic vesiculobullous hand eczema Hyperkeratotic hand dermatitis Autosensitization dermatitis / Id reaction Candidid Dermatophytid Molluscum dermatitis Circumostomy eczema Dyshidrosis Juvenile plantar dermatosis Nummular eczema Nutritional deficiency eczema Sulzberger–Garbe syndrome Xerotic eczema Pruritus / Itch / Prurigo Lichen simplex chronicus / Prurigo nodularis by location: Pruritus ani Pruritus scroti Pruritus vulvae Scalp pruritus Drug-induced pruritus Hydroxyethyl starch-induced pruritus Senile pruritus Aquagenic pruritus Aquadynia Adult blaschkitis due to liver disease Biliary pruritus Cholestatic pruritus Prion pruritus Prurigo pigmentosa Prurigo simplex Puncta pruritica Uremic pruritus Other substances taken internally: Bromoderma Fixed drug reaction Nummular dermatitis Pityriasis alba Papuloerythroderma of OfujiFLG, CLDN1, LCN2, HMOX1, ING1, MMP10, MMP8, KRT10, KRT4, KRT2, IL18, NRG1, AHR, KIF2C, SLC7A11, IGFBP6, IGFBP2, HSP90AA1, HSPB1, NQO2, CCL27, OSM, PRDX6, TNFSF9, PIR, VEGFA, TXNRD1, TXN, TPSAB1, TLR4, SOD3, PI3, SOD1, SERPINB4, SERPINB3, SAA1, S100A8, PSMD12, HDAC4, HLA-DMA, CXCL14, DDIT3, MLANA, AKR1B10, CRHR1, CD44, CCN2, UGT1A1, CTSS, CYP1A1, CYP1B1, AKR1C2, STOML2, DEFB1, NQO1, UGT1A6, DUSP1, FABP4, GCLC, CASP8, GSTP1, BCL2, GSS, GSR, CXCR3, CCR1, CD86, GLB1, G6PD, FTH1, TLR8, TNF, IL1B, MRGPRX2, IL25, CD70, IL10, CCL2, IL1A, IFNG, MYDGF, IL23A, AGO2, TSLP, IL37, IL31, VSX1, GRK2, TRPA1, CCN6, ALOX15, CASP1, CD27, CD58, CCR4, CSF2, CTSB, SLC26A3, EPHB2, FN1, HSD17B10, HLA-C, HPD, IL4, IL6, IL9, OPRM1, MAPK1, TRBV20OR9-2, MIR150
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Erythropoietic Protoporphyria
Wikipedia
"Erythropoietic protoporphyria. A new porphyria syndrome with solar urticaria due to protoporphyrinæmia". ... External links [ edit ] Erythropoietic protoporphyria at NLM Genetics Home Reference Classification D ICD - 10 : E80.0 ( ILDS E80.010) ICD - 9-CM : 277.1 OMIM : 177000 MeSH : D046351 DiseasesDB : 4484 External resources eMedicine : derm/473 Orphanet : 79278 v t e Heme metabolism disorders Porphyria , hepatic and erythropoietic ( porphyrin ) early mitochondrial: ALAD porphyria Acute intermittent porphyria cytoplasmic: Gunther disease/congenital erythropoietic porphyria Porphyria cutanea tarda / Hepatoerythropoietic porphyria late mitochondrial: Hereditary coproporphyria Harderoporphyria Variegate porphyria Erythropoietic protoporphyria Hereditary hyperbilirubinemia ( bilirubin ) unconjugated: Gilbert's syndrome Crigler–Najjar syndrome Lucey–Driscoll syndrome conjugated: Dubin–Johnson syndrome nd sheet Rotor syndrome
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Staph Infections
Mayo_clinic
Sores or areas of oozing discharge may develop, too. Staphylococcal scalded skin syndrome. Toxins produced by the staph bacteria may cause staphylococcal scalded skin syndrome. ... The bacteria can travel to locations deep within your body to cause infections that affect: Internal organs, such as your brain (meningitis), heart (endocarditis) or lungs (pneumonia) Bones and muscles Surgically implanted devices, such as artificial joints or cardiac pacemakers Toxic shock syndrome This life-threatening condition results from toxins produced by some strains of staph bacteria. ... Reduce tampon risks. Toxic shock syndrome is caused by staph bacteria. Tampons left in for long periods can grow staph bacteria. You can reduce your chances of getting toxic shock syndrome by changing your tampon frequently — at least every 4 to 8 hours.
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Geleophysic Dysplasia
Gene_reviews
Differential Diagnosis The acromelic dysplasia group includes four rare disorders: geleophysic dysplasia, Weill-Marchesani syndrome, acromicric dysplasia, and Myhre syndrome. ... Disorders to Consider in the Differential Diagnosis of Geleophysic Dysplasia View in own window Disorder Gene(s) MOI Clinical Features of the Disorder Overlapping w/Geleophysic Dysplasia Distinguishing from Geleophysic Dysplasia Acromicric dysplasia FBN1 LTBP3 AD See Table 2 See Table 2 Weill-Marchesani syndrome FBN1 AD ADAMTS10 ADAMTS17 LTBP2 AR Myhre syndrome SMAD4 AD 1 IUGR Short stature Short hands & feet Progressive joint limitation & contractures Thickened skin Heart involvement Facial features w/prognathism Cranial skull anomalies Variable degree of cognitive impairment Deafness MOI = mode of inheritance AD = autosomal dominant AR = autosomal recessive IUGR = intrauterine growth restriction 1. All probands with Myhre syndrome reported to date have had a de novo SMAD4 pathogenic variant.
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Pneumonitis
Wikipedia
Pneumonia Radiation therapy Inhaling chemicals, such as sodium hydroxide [10] Interstitial lung disease Sepsis Adverse reaction to medications Hypersensitivity to inhaled agents [4] Inhalation of spores of some species of mushroom (bronchoalveolar allergic syndrome) [11] Mercury exposure Smoking Overexposure to chlorine Bronchial obstruction ( obstructive pneumonitis or post-obstructive pneumonitis ) Ascariasis (during parasite migration) Aspirin overdose, some antibiotics, and chemotherapy drugs [3] “Farmer’s lung” and “hot tub lung” are common names for types of hypersensitivity pneumonitis that result from exposure to some types of thermophilic actinomyces, mycobacteria and molds. [3] [7] Avian proteins in bird feces and feathers [3] [7] Whole body or chest radiation therapy used for cancer treatment [3] Symptoms [ edit ] Physical manifestations of Pneumonitis range from mild cold-like symptoms to respiratory failure. ... External links [ edit ] Classification D MeSH : D011014 DiseasesDB : 10166 External resources Patient UK : Pneumonitis v t e Diseases of the respiratory system Upper RT (including URTIs , common cold ) Head sinuses Sinusitis nose Rhinitis Vasomotor rhinitis Atrophic rhinitis Hay fever Nasal polyp Rhinorrhea nasal septum Nasal septum deviation Nasal septum perforation Nasal septal hematoma tonsil Tonsillitis Adenoid hypertrophy Peritonsillar abscess Neck pharynx Pharyngitis Strep throat Laryngopharyngeal reflux (LPR) Retropharyngeal abscess larynx Croup Laryngomalacia Laryngeal cyst Laryngitis Laryngopharyngeal reflux (LPR) Laryngospasm vocal cords Laryngopharyngeal reflux (LPR) Vocal fold nodule Vocal fold paresis Vocal cord dysfunction epiglottis Epiglottitis trachea Tracheitis Laryngotracheal stenosis Lower RT / lung disease (including LRTIs ) Bronchial / obstructive acute Acute bronchitis chronic COPD Chronic bronchitis Acute exacerbation of COPD ) Asthma ( Status asthmaticus Aspirin-induced Exercise-induced Bronchiectasis Cystic fibrosis unspecified Bronchitis Bronchiolitis Bronchiolitis obliterans Diffuse panbronchiolitis Interstitial / restrictive ( fibrosis ) External agents/ occupational lung disease Pneumoconiosis Aluminosis Asbestosis Baritosis Bauxite fibrosis Berylliosis Caplan's syndrome Chalicosis Coalworker's pneumoconiosis Siderosis Silicosis Talcosis Byssinosis Hypersensitivity pneumonitis Bagassosis Bird fancier's lung Farmer's lung Lycoperdonosis Other ARDS Combined pulmonary fibrosis and emphysema Pulmonary edema Löffler's syndrome / Eosinophilic pneumonia Respiratory hypersensitivity Allergic bronchopulmonary aspergillosis Hamman-Rich syndrome Idiopathic pulmonary fibrosis Sarcoidosis Vaping-associated pulmonary injury Obstructive / Restrictive Pneumonia / pneumonitis By pathogen Viral Bacterial Pneumococcal Klebsiella Atypical bacterial Mycoplasma Legionnaires' disease Chlamydiae Fungal Pneumocystis Parasitic noninfectious Chemical / Mendelson's syndrome Aspiration / Lipid By vector/route Community-acquired Healthcare-associated Hospital-acquired By distribution Broncho- Lobar IIP UIP DIP BOOP-COP NSIP RB Other Atelectasis circulatory Pulmonary hypertension Pulmonary embolism Lung abscess Pleural cavity / mediastinum Pleural disease Pleuritis/pleurisy Pneumothorax / Hemopneumothorax Pleural effusion Hemothorax Hydrothorax Chylothorax Empyema/pyothorax Malignant Fibrothorax Mediastinal disease Mediastinitis Mediastinal emphysema Other/general Respiratory failure Influenza Common cold SARS Coronavirus disease 2019 Idiopathic pulmonary haemosiderosis Pulmonary alveolar proteinosisCCL2, TGFB1, TLR4, TNF, IL17A, IL33, IL13, IL6, IL1B, IFNG, MYD88, HMOX1, IL4, CCL11, SIRT1, CXCL1, CXCL5, CCL24, PARP1, IKBKB, CXCR2, AHR, MYLK, IL18, CCR2, CSF2, CCL17, EGR1, IL6ST, CCL8, PF4, TNFRSF1B, SPP1, IL1R1, CCL19, CASP1, CXCR3, AGT, TNFRSF1A, ABCF1, IL1R2, ITGB2, CX3CL1, POMC, CCL4, CCR9, CXCL9, CCR1, CCL7, IL2RB, CD40LG, IL5RA, CCR6, CCL20, COPD, NLRP3, CFTR, IL10, CXCL8, SFTPD, CD274, HMGB1, PDCD1, MPO, GABPA, NFE2L2, EGFR, MAPK14, IL5, AIMP2, PPARG, GRAP2, POLDIP2, RNF19A, CRK, MAPK1, HIF1A, AHSA1, ICAM1, CXCL2, IL1A, STAT3, MYDGF, ROS1, SERPINE1, PIK3CG, PIK3CD, SCGB1A1, IL9, ACE, DECR1, GPT, VEGFA, PTGS2, ELANE, TLR2, ALOX5, NM, PIK3CA, PIK3CB, CYBB, TP53, CAV1, IL25, PRMT1, SMUG1, IL22, WDR26, TLR3, HSPB1, IL17D, COX2, PTGDS, PDE4A, IL27, ATM, MIR155, SOCS3, MTOR, ITGAX, SFTPB, FPR1, FOS, FOXP3, FOXM1, PLA2G1B, FCGR3A, ACE2, RAC1, IFNA13, NMU, IFNA1, JUN, NOS3, JUNB, MUC1, JUND, MMP9, MIP, HPGDS, HSPB2, FOSB, TRPM8, ELN, TSLP, HSPB3, CCN2, NR1I2, LTB4R, CCR4, CEL, CD44, TIMP1, MIR125A, ARG1, SEMA7A, VCAM1, ANGPT1, AKT1, MTCO2P12, ADAM8, PARP9, SLC27A5, SFTPC, F2R, MARK2, DEGS1, MRC1, PTAFR, ARSA, TNNI3, MMP8, IL37, ALDH7A1, BCL2, MIF, IL17C, MCL1, TNFAIP6, LGALS3, TSPO, THBS1, LEP, TM7SF2, CASP3, CAT, PLXNC1, RUNX1, AOC3, HDAC6, CXCL10, RGS2, ENTPD1, AR, MIR21, MTHFR, MUC5AC, CXCR4, SELL, F3, ADORA2B, VIP, PI3, RIPK3, ARHGEF5, PGF, PLD2, F2RL1, PTGDR2, KLHL2, SFTPA2, ALK, ALOX15, CXCL12, ICOSLG, SFTPA1, OSM, MIR511, NOS2, APEX1, APOA1, NFATC2, MAPK3, HAVCR1, CRLF2, NKX2-1, SLC52A2, CCN1, GDF15, TREM1, SCGB3A2, ADAM17, SGPL1, CREBBP, CSF1, HSPA1B, TIMELESS, HP, CTLA4, CCL3, CTNNB1, CTSG, GZMB, TRPA1, FPR2, DNASE1, HSH2D, NR3C1, HAVCR2, ACKR3, SLC12A2, CCL18, SIGIRR, S100A9, HSPA1A, ABCA3, CCR8, FOXO3, IL2RA, IL2, RPS19, PWAR1, CLOCK, CLDN1, RNGTT, TRAF3IP2, JTB, TNFSF14, KCNK6, LRPPRC, CYSLTR1, MSC, USP13, SCAF11, RIPK1, AREL1, SART3, TNFRSF25, SLIT2, FOSL1, CXCR6, ADIPOQ, SOCS1, BECN1, SMC3, GPRC5A, XPR1, MIA, PROCR, EXO1, TNFRSF6B, ATG7, PRDX4, PER2, LPAR2, FST, ARHGEF2, CXCL13, SOCS2, IRF9, IL27RA, KLF4, PDE5A, GGPS1, PIAS1, AIM2, IKBKG, S1PR2, ITM2B, CCL26, BTRC, FOXN1, PLA2G6, IMMT, POSTN, PTGES, LOH19CR1, ABCA1, LILRB4, MMP28, SPESP1, PRSS55, TRIM65, PIKFYVE, MLKL, PGAM5, CBLL2, PTPRVP, IL31RA, IL17RE, DCD, IL22RA2, UCN3, BUD23, IL17F, CLEC6A, BPIFB1, NLRP12, ESAM, ATG16L2, RETNLB, SPZ1, CARD11, ASCC2, ITCH, ZC3H12A, MAP3K19, TNFAIP8L2, MUL1, LCLAT1, OR10A4, CLEC9A, MIR27A, H3P42, LINC02605, IRAIN, LOC102723996, OCLN, LINC01672, MIR1246, MIR636, LINC00273, MIR146B, MIR326, MIR17HG, MIR34B, MIR24-1, KCNRG, MIR23A, MIR223, MIR199A2, MIR199A1, MIR17, MIR150, MIR141, MIR127, MIR122, LIN28B, IL31, MALAT1, LAMA1, SPAG16, COLEC11, WWP2, WNK4, ISYNA1, TRPV2, BPIFA1, CLEC1B, CKLF, GEMIN4, IL20, TBX21, IL19, ICOS, CARD10, TBK1, DROSHA, STK39, IL17B, SIGLEC8, NAAA, CHIA, SND1, LATS2, SLC17A5, IBTK, LY96, BRD4, SULF1, PHLPP2, TPX2, IRAK3, PSIP1, NELFCD, XRCC1, IL23A, CEMIP, MPPE1, P2RY12, CLEC7A, SEMA4A, IFIH1, NOD2, VSIR, TRPV4, SCAF1, NLRC4, EPG5, CFAP97, ABHD6, SPHK2, FXYD5, CHST7, LTB4R2, GSDMB, IL26, SLC52A1, MARCHF1, SARS2, TEX10, FEV, DGCR8, WNT4, TLR9, IL20RA, ZFP36, RORA, WNT5A, EPHX2, FDPS, FCGR3B, FCGR2B, FCGR1A, FABP5, FABP4, F8, ETS2, ESR2, ESR1, ESAT, ERBB2, EPO, SERPINB1, IL1RN, EPHA2, EGF, EDNRA, EDN1, S1PR1, ECE1, HBEGF, DPP4, CFD, CYP2B6, CYP2A13, CYP1A2, CUX1, FER, FES, FKBP4, FOXF1, IGF1, IFNB1, IFNAR1, HSPA4, HSD11B1, HRG, HPX, HLA-E, HLA-DOA, HLA-C, CFHR1, GTF2H4, GSTP1, GSTM1, GSR, GRN, GPX1, GCLM, GCLC, GLA, GHRHR, GDF2, GATA3, GAS6, FXN, FLT3LG, FOXD1, CTSS, VCAN, CSF3, BRAF, BMP4, BDKRB1, BCL6, ATF3, AQP5, AQP4, AQP1, FASLG, FAS, APRT, APOE, AOC2, AOAH, ANXA5, ANXA2, ANK1, ANGPT2, ALOX12, AKR1B1, ALB, AKT2, AGER, ADRB2, ADORA3, ADORA2A, ADA, ABL1, BMP6, SERPING1, CRP, C3AR1, CLDN7, MAP3K8, COL3A1, COL1A1, CNR2, CNC2, CMKLR1, CCR7, CCR3, CLCN3, CIRBP, CHUK, CHRNA4, CHRM3, CHI3L1, CEACAM5, CDKN2A, CD74, CD40, TNFRSF8, CD28, CD14, CD5L, CD2, CALR, CALCR, C5AR1, IGF2R, IL7, VWF, CCL13, SMPD1, SLC10A1, SLC8A1, SLC6A8, SLC5A1, PMEL, SGK1, SFRP5, SDC4, SDC2, SDC1, CCL22, CCL21, CCL5, IL11, SCT, SARS1, SAA3P, S100B, S100A12, S100A1, RRBP1, RNASE3, RASA1, PLAAT4, RARA, RAP1B, MOK, SMPD2, SOD2, TRIM21, SST, VTN, TRPV1, VHL, VDR, TXN, TNFSF4, TTF1, TRPM2, TRAF5, NR2C2, CRISP2, TNFAIP3, KLF10, THOP1, THBS2, TGFA, TFRC, TFPI, TERT, PPP1R11, TRBV20OR9-2, ZEB1, MAP3K7, TAGLN, TAC1, STAT1, ST2, RAD51, PTX3, PTHLH, NFKB1, NEO1, NCF4, COX1, CD200, MMP12, MMP3, MMP2, MFAP1, CD46, MCAM, MAS1, NBR1, LSP1, LIG4, LGALS9, LAIR1, KNG1, JAK1, ITGB6, ITGB4, ITGAV, ITGA5, ISG20, IRF4, IDO1, IL16, IL15, NFATC3, NFKB2, PTGS1, NINJ1, PTGER4, PTGER3, MAPK8, PRKCD, PRKCA, PRKAR1A, PTPA, CTSA, PLD1, PLCL1, PLA2G5, PLA2G4A, PLA2G2A, SERPINA1, PHB, CFP, PER1, PECAM1, PDE7A, PCP4, PRKN, PEBP1, P4HB, P2RY6, OAS3, NPR1, NOTCH1, H3P10
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Low-Functioning Autism
Wikipedia
Sleep problems, aggressiveness, and self-injurious behavior are also possible frequent occurrences. [10] LFA is not a recognized diagnosis in the DSM-5 or ICD-10 . Synonyms include Kanner 's syndrome , Kannerian autism and classic autism . [11] The terms overlap with severe autism and profound autism (as opposed to "mild" or "moderate"), which may be vaguely defined and not necessarily correlate with severe and profound levels of intellectual disability (where profound is the most severe level). [12] [13] Contents 1 Characterization 2 Causes 3 Diagnosis 4 Therapy 4.1 Augmentative and alternative communication 4.2 Speech-language therapy 4.3 Occupational therapy 4.4 Sensory integration therapy 4.5 Applied behavioral analysis (ABA) 4.6 Medication 5 Criticism of functioning labels 6 See also 7 References Characterization [ edit ] People who display symptoms for LFA usually have "impairments in all the three areas of psychopathology : reciprocal social interaction, communication, and restricted, stereotyped , repetitive behaviour". [14] Severe impairment of social skills can be seen in people with LFA. ... This major change, if it comes about, will involve using the word ‘autism’ to apply only to what has been variously termed Kanner's syndrome, classic autism, autistic disorder, or low-functioning autism, whilst using ‘Asperger syndrome’ synonymously with high-functioning autism. [...] ... PMID 31417436 . ^ a b "What is Autism, Asperger Syndrome, and Pervasive Developmental Disorders?" ... S2CID 24004979 . ^ "What is Autism, Asperger Syndrome, and Pervasive Developmental Disorders?"
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Side Effects Of Penicillin
Wikipedia
., Museum of the History of Science, Oxford Food and Drug Administration (US) information on Penicillin v t e Antibacterials active on the cell wall and envelope ( J01C - J01D ) Intracellular Inhibit peptidoglycan subunit synthesis and transport: NAM synthesis inhibition ( Fosfomycin ) DADAL / AR inhibitors ( Cycloserine ) bactoprenol inhibitors ( Bacitracin ) Glycopeptide Inhibit PG chain elongation: Vancomycin # ( Oritavancin Telavancin ) Teicoplanin ( Dalbavancin ) Ramoplanin § β-lactams / (inhibit PBP cross-links) Penicillins ( Penams ) Narrow spectrum β-lactamase sensitive (1st generation) Benzylpenicillin (G) # Benzathine benzylpenicillin # Procaine benzylpenicillin # Phenoxymethylpenicillin (V) # Propicillin ‡ Pheneticillin ‡ Azidocillin ‡ Clometocillin ‡ Penamecillin ‡ β-lactamase resistant (2nd generation) Cloxacillin # ( Dicloxacillin Flucloxacillin ) Oxacillin Nafcillin Methicillin ‡ Extended spectrum Aminopenicillins (3rd generation) Amoxicillin # Ampicillin # ( Pivampicillin Hetacillin ‡ Bacampicillin ‡ Metampicillin ‡ Talampicillin ‡ ) Epicillin ‡ Carboxypenicillins (4th generation) Ticarcillin Carbenicillin ‡ / Carindacillin ‡ Temocillin ‡ Ureidopenicillins (4th generation) Piperacillin Azlocillin ‡ Mezlocillin ‡ Other Mecillinam ‡ ( Pivmecillinam ‡ ) Sulbenicillin ‡ Penems Faropenem ‡ Ritipenem § Carbapenems Ertapenem Antipseudomonal ( Doripenem Imipenem Meropenem ) Biapenem ‡ Panipenem ‡ Cephalosporins / Cephamycins ( Cephems ) 1st generation Cefazolin # Cefalexin # Cefadroxil Cefapirin Cefazedone ‡ Cefazaflur ‡ Cefradine ‡ Cefroxadine ‡ Ceftezole ‡ Cefaloglycin ‡ Cefacetrile ‡ Cefalonium ‡ Cefaloridine ‡ Cefalotin ‡ Cefatrizine ‡ 2nd generation Cefaclor Cefotetan Cephamycin ( Cefoxitin Cefprozil Cefuroxime Cefuroxime axetil Cefamandole ‡ Cefminox ‡ Cefonicid ‡ Ceforanide ‡ Cefbuperazone ‡ Cefuzonam ‡ Cefmetazole ‡ ) Carbacephem ‡ ( Loracarbef ‡ ) 3rd generation Cefixime # Ceftriaxone # Cefotaxime # Antipseudomonal ( Ceftazidime # Cefoperazone ‡ ) Cefdinir Cefcapene Cefdaloxime Ceftizoxime Cefmenoxime Cefpiramide Cefpodoxime Ceftibuten Cefditoren Cefotiam ‡ Cefetamet ‡ Cefodizime ‡ Cefpimizole ‡ Cefsulodin ‡ Cefteram ‡ Ceftiolene ‡ Oxacephem ( Flomoxef ‡ Latamoxef ‡ ) 4th generation Cefepime Cefozopran ‡ Cefpirome ‡ Cefquinome ‡ 5th generation Ceftaroline fosamil Ceftolozane Ceftobiprole Siderophore Cefiderocol Veterinary Ceftiofur Cefquinome Cefovecin Monobactams Aztreonam Tigemonam ‡ Carumonam ‡ Nocardicin A ‡ β-lactamase inhibitors Penam ( Sulbactam Tazobactam ) Clavam ( Clavulanic acid ) non-β-lactam ( Relebactam Avibactam Vaborbactam ) Combinations Amoxicillin/clavulanic acid # Ampicillin/flucloxacillin Ampicillin/sulbactam ( Sultamicillin ) Benzathine benzylpenicillin/procaine benzylpenicillin Cefoperazone/sulbactam Ceftazidime/avibactam Ceftolozane/tazobactam Imipenem/cilastatin # Imipenem/cilastatin/relebactam Meropenem/vaborbactam Piperacillin/tazobactam Other polymyxins / detergent Colistin Polymyxin B depolarizing Daptomycin Hydrolyze NAM-NAG lysozyme Tyrothricin Gramicidin Tyrocidine Isoniazid # Teixobactin # WHO-EM ‡ Withdrawn from market Clinical trials : † Phase III § Never to phase III v t e Hypersensitivity and autoimmune diseases Type I / allergy / atopy ( IgE ) Foreign Atopic eczema Allergic urticaria Allergic rhinitis (Hay fever) Allergic asthma Anaphylaxis Food allergy common allergies include: Milk Egg Peanut Tree nut Seafood Soy Wheat Penicillin allergy Autoimmune Eosinophilic esophagitis Type II / ADCC IgM IgG Foreign Hemolytic disease of the newborn Autoimmune Cytotoxic Autoimmune hemolytic anemia Immune thrombocytopenic purpura Bullous pemphigoid Pemphigus vulgaris Rheumatic fever Goodpasture syndrome Guillain–Barré syndrome " Type V "/ receptor Graves' disease Myasthenia gravis Pernicious anemia Type III ( Immune complex ) Foreign Henoch–Schönlein purpura Hypersensitivity vasculitis Reactive arthritis Farmer's lung Post-streptococcal glomerulonephritis Serum sickness Arthus reaction Autoimmune Systemic lupus erythematosus Subacute bacterial endocarditis Rheumatoid arthritis Type IV / cell-mediated ( T cells ) Foreign Allergic contact dermatitis Mantoux test Autoimmune Diabetes mellitus type 1 Hashimoto's thyroiditis Multiple sclerosis Coeliac disease Giant-cell arteritis Postorgasmic illness syndrome Reactive arthritis GVHD Transfusion-associated graft versus host disease Unknown/ multiple Foreign Hypersensitivity pneumonitis Allergic bronchopulmonary aspergillosis Transplant rejection Latex allergy (I+IV) Autoimmune Sjögren syndrome Autoimmune hepatitis Autoimmune polyendocrine syndrome APS1 APS2 Autoimmune adrenalitis Systemic autoimmune disease Medicine portal
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Hemolytic Disease Of The Newborn (Abo)
Wikipedia
. ^ Hemolytic Disease of Newborn~followup at eMedicine External links [ edit ] Classification D ICD - 9-CM : 773.1 External resources MedlinePlus : 001298 v t e Conditions originating in the perinatal period / fetal disease Maternal factors complicating pregnancy, labour or delivery placenta Placenta praevia Placental insufficiency Twin-to-twin transfusion syndrome chorion / amnion Chorioamnionitis umbilical cord Umbilical cord prolapse Nuchal cord Single umbilical artery presentation Breech birth Asynclitism Shoulder presentation Growth Small for gestational age / Large for gestational age Preterm birth / Postterm pregnancy Intrauterine growth restriction Birth trauma scalp Cephalohematoma Chignon Caput succedaneum Subgaleal hemorrhage Brachial plexus injury Erb's palsy Klumpke paralysis Affected systems Respiratory Intrauterine hypoxia Infant respiratory distress syndrome Transient tachypnea of the newborn Meconium aspiration syndrome Pleural disease Pneumothorax Pneumomediastinum Wilson–Mikity syndrome Bronchopulmonary dysplasia Cardiovascular Pneumopericardium Persistent fetal circulation Bleeding and hematologic disease Vitamin K deficiency bleeding HDN ABO Anti-Kell Rh c Rh D Rh E Hydrops fetalis Hyperbilirubinemia Kernicterus Neonatal jaundice Velamentous cord insertion Intraventricular hemorrhage Germinal matrix hemorrhage Anemia of prematurity Gastrointestinal Ileus Necrotizing enterocolitis Meconium peritonitis Integument and thermoregulation Erythema toxicum Sclerema neonatorum Nervous system Perinatal asphyxia Periventricular leukomalacia Musculoskeletal Gray baby syndrome muscle tone Congenital hypertonia Congenital hypotonia Infections Vertically transmitted infection Neonatal infection rubella herpes simplex mycoplasma hominis ureaplasma urealyticum Omphalitis Neonatal sepsis Group B streptococcal infection Neonatal conjunctivitis Other Miscarriage Perinatal mortality Stillbirth Infant mortality Neonatal withdrawal
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Thromboangiitis Obliterans
Wikipedia
External links [ edit ] Classification D ICD - 10 : I73.1 ICD - 9-CM : 443.1 OMIM : 211480 MeSH : D013919 DiseasesDB : 1762 External resources MedlinePlus : 000172 eMedicine : med/253 Patient UK : Thromboangiitis obliterans 00394 at CHORUS Arkkila, PE, (2006), Thromboangiitis obliterans (Buerger's disease), Orphanet Journal of Rare Diseases v t e Cardiovascular disease (vessels) Arteries , arterioles and capillaries Inflammation Arteritis Aortitis Buerger's disease Peripheral artery disease Arteriosclerosis Atherosclerosis Foam cell Fatty streak Atheroma Intermittent claudication Critical limb ischemia Monckeberg's arteriosclerosis Arteriolosclerosis Hyaline Hyperplastic Cholesterol LDL Oxycholesterol Trans fat Stenosis Carotid artery stenosis Renal artery stenosis Other Aortoiliac occlusive disease Degos disease Erythromelalgia Fibromuscular dysplasia Raynaud's phenomenon Aneurysm / dissection / pseudoaneurysm torso : Aortic aneurysm Abdominal aortic aneurysm Thoracic aortic aneurysm Aneurysm of sinus of Valsalva Aortic dissection Aortic rupture Coronary artery aneurysm head / neck Intracranial aneurysm Intracranial berry aneurysm Carotid artery dissection Vertebral artery dissection Familial aortic dissection Vascular malformation Arteriovenous fistula Arteriovenous malformation Telangiectasia Hereditary hemorrhagic telangiectasia Vascular nevus Cherry hemangioma Halo nevus Spider angioma Veins Inflammation Phlebitis Venous thrombosis / Thrombophlebitis primarily lower limb Deep vein thrombosis abdomen Hepatic veno-occlusive disease Budd–Chiari syndrome May–Thurner syndrome Portal vein thrombosis Renal vein thrombosis upper limb / torso Mondor's disease Paget–Schroetter disease head Cerebral venous sinus thrombosis Post-thrombotic syndrome Varicose veins Gastric varices Portacaval anastomosis Caput medusae Esophageal varices Hemorrhoid Varicocele Other Chronic venous insufficiency Chronic cerebrospinal venous insufficiency Superior vena cava syndrome Inferior vena cava syndrome Venous ulcer Arteries or veins Angiopathy Macroangiopathy Microangiopathy Embolism Pulmonary embolism Cholesterol embolism Paradoxical embolism Thrombosis Vasculitis Blood pressure Hypertension Hypertensive heart disease Hypertensive emergency Hypertensive nephropathy Essential hypertension Secondary hypertension Renovascular hypertension Benign hypertension Pulmonary hypertension Systolic hypertension White coat hypertension Hypotension Orthostatic hypotensionVCAM1, AGER, UCN, CRHR1, TSHR, IL1B, IL6, CD34, IGF1, ICAM1, TNF, IFNG, IGF1R, IL1A, MTCO2P12, HLA-DRB1, IL13, CXCL8, IL10, HLA-DPB1, IL17A, VEGFA, COX2, NOS3, HLA-DQA1, PTGS2, FGF1, F2, RBM45, MIR21, CD44, HAVCR2, EDN1, MIR146A, STAT1, SPAM1, CCL5, SELE, MICA, ST8SIA1, TLR4, TMX2-CTNND1, THY1, SRP9, STAT3, SRP54, GATD3B, TGFB2, UCP1, TGFB1, TG, SYK, PDCD4, GATD3A, LINC01193, BCAR1, RNU1-1, SS18L1, UBE2C, HPSE, IL21R, SLC38A2, SEMA5B, ZNF263, PTX3, IL23R, SMC3, CASS4, IL17RC, ST3GAL5, PRRT2, SAT2, NLRP3, FOXP1, SLIT2, ACTA2, PTPRC, CTNND1, HLA-B, HLA-A, HGF, CXCL1, NR3C1, GATA3, NR5A1, FLT1, PTK2B, FABP4, CSF1, HMGB1, CSE1L, CD40LG, CD40, CD14, BMP4, OPN1SW, BCL2, APOA1, AKT1, JAG1, HLA-DOA, HOXB2, PSMD1, NOTCH1, MAPK8, PRKCB, PRKCA, PPARG, PIK3CG, PIK3CD, PIK3CB, PIK3CA, SERPINE1, ADAM10, MYD88, HOXB3, MMP3, MKI67, SMAD2, LOX, LGALS9, KNG1, CXCL10, IL16, IL1RN, HES1, OMG
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Autonomic Dysreflexia
Wikipedia
Medical condition Autonomic dysreflexia Other names Autonomic hyperreflexia [1] Specialty Neurology Autonomic dysreflexia ( AD ), also previously known as mass reflex , [2] is a potential medical emergency classically characterized by uncontrolled hypertension and bradycardia , although tachycardia is known to commonly occur. [3] [4] AD occurs most often in individuals with spinal cord injuries with lesions at or above the T6 spinal cord level, although it has been reported in patients with lesions as low as T10 . [5] Guillain–Barré syndrome may also cause Autonomic Dysreflexia. [1] The uncontrolled hypertension in AD may result in mild symptoms, such as sweating above the lesion level, goosebumps, blurred vision, or headache; However, severe hypertension may result in potentially life-threatening complications including seizure , intracranial bleed , or retinal detachment . [3] AD is triggered by either noxious or non-noxious stimuli, resulting in sympathetic stimulation and hyperactivity. [6] The most common causes include bladder or bowel over-distension, from urinary retention and fecal compaction, respectively. [7] The resulting sympathetic surge transmits through intact peripheral nerves , resulting in systemic vasoconstriction below the level of the spinal cord lesion. [8] The peripheral arterial vasoconstriction and hypertension activates the baroreceptors , resulting in a parasympathetic surge originating in the central nervous system to inhibit the sympathetic outflow; however, the parasympathetic signal is unable to transmit below the level of the spinal cord lesion. [8] This results in bradycardia, vasodilation , flushing , pupillary constriction and nasal stuffiness above the spinal lesion, while there's piloerection , pale and cool skin below the lesion due to the prevailing sympathetic outflow. [8] Initial treatment involves sitting the patient upright, removing any constrictive clothing (including abdominal binders and support stockings), rechecking blood pressure frequently, and then checking for and removing the inciting issue, which may require urinary catheterization or bowel disimpaction. [3] [2] If systolic blood pressure remains elevated (over 150 mm Hg) after initial steps, fast-acting short-duration antihypertensives are considered, [9] while other inciting causes must be investigated for the symptoms to resolve. [3] Prevention of AD involves educating the patient, family and caregivers of the precipitating cause, if known, and how to avoid it, as well as other triggers. [2] Since bladder and bowel are common causes, prevention involves routine bladder and bowel programs and urological follow-up for cystoscopy / urodynamic studies. [3] Contents 1 Signs and symptoms 1.1 Complications 2 Causes 2.1 Pain 3 Mechanism 4 Diagnosis 5 Treatment 6 Prognosis 7 See also 8 References 9 Further reading 10 External links Signs and symptoms [ edit ] This condition is distinct and usually episodic, with the people potentially experiencing remarkably high blood pressure, intense headaches, profuse sweating, facial erythema , goosebumps, nasal stuffiness, a "feeling of doom" or apprehension, and blurred vision. [5] An elevation of 20 mm Hg over baseline systolic blood pressure, with a potential source below the neurological level of injury, meets the current definition of dysreflexia. [10] Complications [ edit ] Autonomic dysreflexia can become chronic and recurrent, often in response to longstanding medical problems like soft tissue pressure injuries or hemorrhoids . ... External links [ edit ] Classification D ICD - 10-CM : G90.4 ICD - 9-CM : 337.3 MeSH : D020211 DiseasesDB : 1155 External resources MedlinePlus : 001431 eMedicine : article/322809 v t e Diseases of the autonomic nervous system General Dysautonomia Autonomic dysreflexia Autonomic neuropathy Pure autonomic failure Hereditary Hereditary sensory and autonomic neuropathy Familial dysautonomia Congenital insensitivity to pain with anhidrosis Orthostatic intolerance Orthostatic hypotension Postural orthostatic tachycardia syndrome Other Horner's syndrome Multiple system atrophy v t e Shock Distributive Septic shock Neurogenic shock Anaphylactic shock Toxic shock syndrome Obstructive Abdominal compartment syndrome Low volume Hemorrhage Hypovolemia Osmotic shock Other Spinal shock Cryptic shock Vasodilatory shock
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Congenital Extrahepatic Portosystemic Shunt
Gard
The cause for CEPS is unknown, but it sometimes occurs along with other conditions such as Down syndrome or congenital heart disease. CEPS can be diagnosed by different kinds of imaging studies, including ultrasound and CT scan.
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Congenital Corneal Opacities, Cornea Guttata, And Corectopia
Omim
Clinical Features Hwang et al. (2003) described a mother and son with a seemingly distinct syndrome of congenital bilateral superior full-thickness V-shaped corneal opacities, cornea guttata (focal accumulations of collagen on the posterior surface of Descemet membrane), and corectopia (updrawn pupils).
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Anosmia, Isolated Congenital
Omim
Clinical Features The main reason for considering anosmia separately is that it is not clear whether it is always merely part of the Kallmann syndrome (see 147950 and 308700) or a distinct disorder.
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Teratoma, Pineal
Omim
As noted by Wakai et al. (1980), medulloblastoma has been reported in sibs on a number of occasions and occurs as part of the basal cell nevus syndrome (109400). Schimke (1983) described a paraventricular germinoma in a 22-year-old male whose paternal uncle had a benign cystic teratoma removed from his mediastinum at the age of 18 years.
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Localized Lichen Myxedematosus With Mixed Features Of Different Subtypes
Orphanet
One case is reported as having features of both acral persistent papular mucinosis and self-healing juvenile cutaneous mucinosis (see this term) with carpal tunnel syndrome. Etiology As all primitive mucinosis, the pathogenesis of localized LM with mixed features of different subtypes is still unknown.
- Bifid Uvula Orphanet